{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: bir sinyal yolu \u00e7apraz konu\u015fma veritaban\u0131 Makale \u0130ncelemesi"},"content":{"rendered":"

Bu harika makale, XTALKDB'deki verileri \u00f6zetleyen istatistikleri ortaya koyuyor. Yazar sadece birka\u00e7 dakika i\u00e7inde XTALKDB'deki t\u00fcrlerin da\u011f\u0131l\u0131m\u0131n\u0131 a\u00e7\u0131klayan bir infografik olu\u015fturdu.<\/p>\n\n\n\n

Kontrol edin orijinal makale burada<\/a>.<\/p>\n\n\n\n

\u0130nsano\u011flu g\u00f6rsel bir varl\u0131k oldu\u011fu i\u00e7in, g\u00f6rseller ara\u015ft\u0131rman\u0131z\u0131 istedi\u011finiz kadar ayr\u0131nt\u0131yla anlatman\u0131n hala en iyi yoludur.<\/p>\n\n\n\n

Bilim insanlar\u0131, belirli sinyal yollar\u0131 \u00e7iftleri ile bunlar\u0131n g\u00f6zlemlendi\u011fi t\u00fcrler ve dokular aras\u0131ndaki kar\u015f\u0131l\u0131kl\u0131 etkile\u015fimi belgeleyen bir veri taban\u0131 geli\u015ftirdi<\/strong><\/h2>\n\n\n\n

Biyolojik Bilimler B\u00f6l\u00fcm\u00fc'nden Sarah Sam liderli\u011findeki bir ara\u015ft\u0131rma grubu (2016), harici bir sinyalin resept\u00f6rler taraf\u0131ndan alg\u0131lanmas\u0131n\u0131n ara proteinlerin faaliyetlerinin de\u011fi\u015fmesine neden oldu\u011funu bildirdi. <\/p>\n\n\n\n

Bu, hedef genlerin ifadesini mod\u00fcle eden transkripsiyon fakt\u00f6rlerinin d\u00fczenlenmesiyle sonu\u00e7lan\u0131r. Her yol \u00e7ifti i\u00e7in XTalkDB, \u00e7apraz etkile\u015fimin ke\u015ffedildi\u011fi deneysel ko\u015fullar\u0131 a\u00e7\u0131klayan ayr\u0131nt\u0131l\u0131 bilgileri kaydeder. <\/p>\n\n\n\n

H\u00fccreler \u00e7evrelerini sinyal yollar\u0131 arac\u0131l\u0131\u011f\u0131yla de\u011ferlendirir ve yan\u0131t verir. Bir sinyal yolu tipik olarak resept\u00f6rler, ara sinyal proteinleri, transkripsiyon fakt\u00f6rleri ve hedef genler aras\u0131nda iyi tan\u0131mlanm\u0131\u015f bir dizi d\u00fczenleyici ve fiziksel etkile\u015fim i\u00e7erir. <\/p>\n\n\n\n

XTalkDB web sitesi, bilim insanlar\u0131n\u0131n ilgilendikleri bir veya daha fazla yola\u011f\u0131 veya molek\u00fcl\u00fc sorgulayarak \u00e7apraz konu\u015fma bilgilerine g\u00f6z atmalar\u0131 i\u00e7in kullan\u0131m\u0131 kolay bir aray\u00fcz sa\u011flar.<\/p>\n\n\n\n

\u00c7al\u0131\u015fmaya 650 \u00e7ift dahil edilmi\u015ftir.<\/strong><\/p>\n\n\n\n

Mind the Graph taraf\u0131ndan desteklenen Grafik \u00d6zet<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
ile yap\u0131lm\u0131\u015ft\u0131r Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Olas\u0131 iyile\u015ftirmelerden s\u00f6z ederken, \"XTalkDB'nin alt\u0131nda yatan manuel k\u00fcrat\u00f6rl\u00fck s\u00fcrecinin, \u00f6zellikle de veritaban\u0131n\u0131n kapsam\u0131n\u0131 geni\u015fletmeye \u00e7al\u0131\u015ft\u0131\u011f\u0131m\u0131z i\u00e7in s\u0131n\u0131rlamalar\u0131 var. <\/p>\n\n\n\n

\u00c7apraz konu\u015fmay\u0131 belgeleme olas\u0131l\u0131klar\u0131na g\u00f6re yay\u0131nlar\u0131 derecelendirecek bir do\u011fal dil i\u015fleme \u00e7er\u00e7evesi geli\u015ftirmeyi planl\u0131yoruz. Bir k\u00fcrat\u00f6r daha sonra y\u00fcksek dereceli yay\u0131nlara odaklanabilir.\"<\/p>\n\n\n\n

Belgeler Etki ve Performans<\/strong><\/h2>\n\n\n\n

ile analiz edebiliriz Altmetric<\/a> Bu makalenin \u00fczerinde oldu\u011fu veriler Boyutlarda NIH taraf\u0131ndan finanse edilen t\u00fcm makalelerdeki t\u00fcm metriklerin en \u00fcst k\u0131sm\u0131. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Kaynak: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Makalenizi g\u00fc\u00e7lendirmek i\u00e7in infografiklerin g\u00fcc\u00fcn\u00fc de kullan\u0131n. Mind the Graph'yi deneyin!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Mind the Graph'yi deneyin<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u0130nfografiklerin g\u00fcc\u00fcn\u00fc \u00e7oktan ke\u015ffetmi\u015f olanlarla birlikte \u00f6\u011frenin. Bu makalede Mind the Graph ile yap\u0131lm\u0131\u015f grafik \u00f6zetler bulunmaktad\u0131r. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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