{"id":16636,"date":"2022-09-10T18:27:00","date_gmt":"2022-09-10T21:27:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16636"},"modified":"2023-03-17T14:47:45","modified_gmt":"2023-03-17T17:47:45","slug":"success-case-fgf-signalling-in-the-self-renewal-of-colon-cancer-organoids","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/kolon-kanseri-organoidlerinin-kendini-yenilemesinde-basari-durumu-fgf-sinyali\/","title":{"rendered":"Kolon Kanseri Organoidlerinin Kendini Yenilemesinde FGF Sinyali Makale \u0130ncelemesi"},"content":{"rendered":"

Hasta t\u00fcrevli CRC h\u00fccrelerinde FGFR inhibisyonu ile Engelli sferoid ve organoid olu\u015fumunu Mind the Graph'nin ill\u00fcstrasyonlar\u0131n\u0131 kullanarak anlamak \u00e7ok daha kolayd\u0131r. <\/p>\n\n\n\n

Yazar taraf\u0131ndan olu\u015fturulan \u015fema, cerrahi biyopsilerin tek h\u00fccrelerden olu\u015fan bir s\u00fcspansiyon elde etmek i\u00e7in enzimatik olarak sindirildi\u011fini g\u00f6stermektedir. Tasnif edilmemi\u015f naif h\u00fccreler FGF2 i\u00e7eren CSC-ortam\u0131nda veya FGFR-inhibit\u00f6r\u00fc SU-5402 ile k\u00fclt\u00fcre edilmi\u015ftir.<\/p>\n\n\n\n

Kolorektal kanser k\u00f6k h\u00fccrelerinin kendini yenilemesinde fibroblast b\u00fcy\u00fcme fakt\u00f6r\u00fc 2'nin (FGF2) rol\u00fc ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r<\/strong><\/h2>\n\n\n\n

J\u00f6rg Otte ve meslekta\u015flar\u0131 (2019), 'Kolon Kanseri Organoidlerinin Kendini Yenilemesinde FGF Sinyali' ba\u015fl\u0131kl\u0131 \u00e7al\u0131\u015fmalar\u0131nda, naif tek h\u00fccreler Matrigel i\u00e7ine g\u00f6m\u00fcld\u00fc\u011f\u00fcnde ve CSC-ortam\u0131nda k\u00fclt\u00fcrlendi\u011finde, analiz edilen t\u00fcm hastalarda daha karma\u015f\u0131k bir kendi kendine organizasyon g\u00f6zlendi\u011fini bildirmi\u015flerdir. <\/p>\n\n\n\n

Mezenkimal ve kendini yenileyen bir fenotip ile birlikte EMT ile do\u011frudan ili\u015fkili genlerin (TGFB3, ID1, ID2 ve ID4) organoidlerde a\u015f\u0131r\u0131 eksprese edildi\u011fi bulunmu\u015ftur. <\/p>\n\n\n\n

FGFR inhibisyonu MAPK sinyalinin artmas\u0131na yol a\u00e7arken, ind\u00fcklenmi\u015f farkl\u0131la\u015fma, \u00e7o\u011fu k\u00f6k h\u00fccre belirtecinin kayb\u0131 ve epitelyal bir fenotip g\u00f6zlemlediler. <\/p>\n\n\n\n

Kanser k\u00f6k h\u00fccreleri, kendi kendini yenileyebilen ve farkl\u0131la\u015fm\u0131\u015f t\u00fcm\u00f6r h\u00fccreleri i\u00e7in s\u00fcrekli bir kaynak olarak hizmet edebilen malign h\u00fccrelerin bir alt pop\u00fclasyonudur. Baz\u0131 CSC k\u00fclt\u00fcr\u00fc protokollerinde Fibroblast b\u00fcy\u00fcme fakt\u00f6r\u00fc 2, k\u00f6k h\u00fccreli\u011fin korunmas\u0131 i\u00e7in \u00f6nemli bir bile\u015fendir. <\/p>\n\n\n\n

\u00d6te yandan, CSC-orta k\u00fclt\u00fcrl\u00fc organoidlerde, TGF-\u03b2 ve farkl\u0131la\u015fma inhibit\u00f6r\u00fc gen ailesinin d\u00f6rt \u00fcyesinin de ind\u00fcklendi\u011fini tespit etmi\u015flerdir.<\/p>\n\n\n\n

9 ard\u0131\u015f\u0131k se\u00e7ilmemi\u015f KRK hastas\u0131 ara\u015ft\u0131rmaya dahil edilmi\u015ftir.<\/strong><\/p>\n\n\n\n

Kontrol edin orijinal makale burada<\/a>.<\/p>\n\n\n\n

Mind the Graph taraf\u0131ndan desteklenen Grafik \u00d6zet<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
ile yap\u0131lm\u0131\u015ft\u0131r Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Elde ettikleri sonu\u00e7lardan baz\u0131lar\u0131, bu alanda daha \u00f6nce bilinenleri potansiyel olarak g\u00fc\u00e7lendirmektedir: \"Pluripotensi ile ili\u015fkili genler NANOG, LIN28 ve SALL1 sadece hESC'ler taraf\u0131ndan ifade edilmi\u015ftir. Otte, \"BMP sinyal yolunun negatif d\u00fczenlenmesi\" ve \"SMAD protein sinyal iletimi\" GO terimleri hESC k\u00fclt\u00fcr\u00fcm\u00fczde tespit edildi\" dedi.<\/p>\n\n\n\n

Yazarlar, \"Bu gen k\u00fcmesinin GO terim analizi, yayg\u0131n olarak d\u00fczenlenen genlerin say\u0131s\u0131n\u0131n d\u00fc\u015f\u00fck olmas\u0131 nedeniyle yaln\u0131zca birka\u00e7 \u00f6nemli sonu\u00e7 vermi\u015ftir. CSC-orta durumu i\u00e7in bu GO terimlerinin \u00e7o\u011fu aktif transkripsiyon, h\u00fccre proliferasyonu veya artan glikoz al\u0131m\u0131 ile ili\u015fkiliydi. <\/p>\n\n\n\n

FGFR inhibisyonundan sonra, h\u00fccre d\u00f6ng\u00fcs\u00fc d\u00fczenleyicilerinin yan\u0131 s\u0131ra \"epitel h\u00fccre farkl\u0131la\u015fmas\u0131\", \"sindirim\" veya \"safra asidi ve safra tuzu ta\u015f\u0131nmas\u0131\" ile a\u00e7\u0131klanan bir\u00e7ok gen bulduk.\"<\/p>\n\n\n\n

Belgeler Etki ve Performans<\/strong><\/h2>\n\n\n\n

ile analiz edebiliriz Altmetric<\/a> Bu makalenin \u00e7evrimi\u00e7i dikkat puan\u0131n\u0131n daha y\u00fcksek oldu\u011fu veriler daha 68%<\/strong><\/strong> Scientific Reports'taki benzer ya\u015ftaki di\u011fer t\u00fcm makalelerin.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Kaynak Altmetrikler<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u0130nfografiklerin g\u00fcc\u00fcyle makalenizin eri\u015filebilirli\u011fini de art\u0131r\u0131n.<\/p>\n\n\n\n

\n
Mind the Graph'yi deneyin<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Hasta t\u00fcrevli KRK h\u00fccrelerinde FGFR inhibisyonu ile engelli sferoid ve organoid olu\u015fumu, \u00e7izimlerimizle daha kolay anla\u015f\u0131lmaktad\u0131r.<\/p>","protected":false},"author":29,"featured_media":20014,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,1],"tags":[96,554,775,963],"yoast_head":"\nFGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/kolon-kanseri-organoidlerinin-kendini-yenilemesinde-basari-durumu-fgf-sinyali\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The Disabled spheroid and organoid formation by FGFR-inhibition in patient-derived CRC cells are easier to understand with our illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/tr\/kolon-kanseri-organoidlerinin-kendini-yenilemesinde-basari-durumu-fgf-sinyali\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-10T21:27:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_4.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"FGF Signalling in the Self-Renewal of Colon Cancer Organoids Paper Review - 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