{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/basari-durumu-yuksek-cozunurluklu-senkrotron-tabanli-x-isini-mikrotomografisi-beynin-uc-boyutlu-noronal-mimarisini-ortaya-cikarmak-icin-bir-arac-olarak\/","title":{"rendered":"Beynin \u00fc\u00e7 boyutlu n\u00f6ronal mimarisini ortaya \u00e7\u0131karmak i\u00e7in bir ara\u00e7 olarak y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc sinkrotron tabanl\u0131 X-\u0131\u015f\u0131n\u0131 mikrotomografisi Makale \u0130ncelemesi"},"content":{"rendered":"

X-\u0131\u015f\u0131n\u0131 mikrotomografisi, beynin sito-mimarisini ve ba\u011flant\u0131s\u0131n\u0131 de\u015fifre etmek i\u00e7in yeni bir y\u00f6ntem olarak ortaya \u00e7\u0131km\u0131\u015ft\u0131r ve burada t\u00fcm n\u00f6ronlar\u0131 g\u00f6r\u00fcnt\u00fclemek i\u00e7in bir y\u00f6ntem sunuyoruz.<\/p>\n\n\n\n

Beynin \u00fc\u00e7 boyutlu n\u00f6ronal mimarisini ortaya \u00e7\u0131karmak i\u00e7in bir ara\u00e7 olarak y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc sinkrotron tabanl\u0131 X-\u0131\u015f\u0131n\u0131 mikrotomografisi<\/strong><\/h2>\n\n\n\n

'High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain' ba\u015fl\u0131kl\u0131 makalede Matheus de Castro Fonseca ve arkada\u015flar\u0131 (2018), n\u00f6ronlar\u0131n bireyselle\u015ftirilmi\u015f b\u00fct\u00fcnl\u00fckler olarak incelenmesinin ba\u015flang\u0131c\u0131n\u0131n 19. y\u00fczy\u0131lda N\u00f6ron Doktrini'nin olu\u015fturulmas\u0131yla oldu\u011funu belirtmi\u015ftir. <\/p>\n\n\n\n

Son birka\u00e7 y\u0131lda, bozulmam\u0131\u015f beyin \u00f6rneklerinde n\u00f6ronal organizasyonu ve ba\u011flant\u0131y\u0131 anlamak i\u00e7in b\u00fcy\u00fck \u00e7aba sarf edilmi\u015ftir. Golgi-Cox etiketleme tekni\u011fi, X-\u0131\u015f\u0131n\u0131 mikrotomografisi i\u00e7in n\u00f6ronlar\u0131n spesifik etiketlenmesi i\u00e7in uygun kontrast sunmaktad\u0131r. <\/p>\n\n\n\n

N\u00f6ronlar, d\u00fczg\u00fcn i\u015fleyi\u015fleri i\u00e7in gerekli olan farkl\u0131 bir morfolojiye ve belirli ba\u011flant\u0131 modellerine sahiptir. Ara\u015ft\u0131rmac\u0131lar, senkrotron tabanl\u0131 X-\u0131\u015f\u0131n\u0131 mikrotomografisini Golgi-Cox emprenye protokol\u00fc ile birle\u015ftiren bir g\u00f6r\u00fcnt\u00fcleme y\u00f6ntemi sunuyor. <\/p>\n\n\n\n

Y\u00f6ntem, doku i\u00e7inde nispeten seyrek da\u011f\u0131lm\u0131\u015f t\u00fcm n\u00f6ronlar\u0131n daha y\u00fcksek ve daha homojen bir kontrast\u0131n\u0131 sunar.<\/p>\n\n\n\n

Beyinler Golgi-Cox boyama sol\u00fcsyonunda 14 g\u00fcn boyunca \u0131\u015f\u0131ktan korunarak ink\u00fcbe edilmi\u015ftir. \u0130nk\u00fcbasyon s\u00fcresinin ard\u0131ndan, beyinler bir vibratom kullan\u0131larak seri olarak kesildi.<\/strong><\/p>\n\n\n\n

Kontrol edin orijinal makale burada<\/a>.<\/p>\n\n\n\n

Mind the Graph taraf\u0131ndan desteklenen Grafik \u00d6zet<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
ile yap\u0131lm\u0131\u015ft\u0131r Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Yazar \u015funlar\u0131 kullanm\u0131\u015ft\u0131r Mind the Graph<\/a> Yeti\u015fkin bir fareye i.p. olarak salin veya pilokarpin sol\u00fcsyonu (280 mg\/kg) enjekte edilmesini temsil eden \u015fematik bir ill\u00fcstrasyon olu\u015fturmak. Karma\u015f\u0131k s\u00fcre\u00e7leri infografiklerle temsil etmek, ayr\u0131nt\u0131lar\u0131 ve \u00f6nemli bilgileri bir kenara b\u0131rakmadan bunlar\u0131 kolayca anla\u015f\u0131l\u0131r hale getirmenin iyi bir yoludur.<\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar\u0131n elde etti\u011fi sonu\u00e7lardan baz\u0131lar\u0131, bu alanla ilgili daha \u00f6nce bilinenleri peki\u015ftiriyor gibi g\u00f6r\u00fcn\u00fcyor: de Castro Fonseca, \"Burada g\u00f6sterilen c\u0131va bazl\u0131 n\u00f6ron emdirme i\u015flemi, h\u00fccrelerin daha s\u00fcrekli ve homojen bir \u015fekilde emdirilmesi ve artefakt yo\u011funlu\u011funun \u00e7ok daha az olmas\u0131 nedeniyle t\u00fcm n\u00f6ronlar\u0131 net bir \u015fekilde tan\u0131mlamam\u0131z\u0131 sa\u011flad\u0131\" dedi.<\/p>\n\n\n\n

Belgeler Etki ve Performans<\/strong><\/h2>\n\n\n\n

ile analiz edebiliriz Altmetric<\/a> Bu makalenin \u00e7evrimi\u00e7i dikkat puan\u0131n\u0131n daha y\u00fcksek oldu\u011fu veriler daha 64%<\/strong><\/strong> Scientific Reports'taki benzer ya\u015ftaki di\u011fer t\u00fcm makalelerin.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Kaynak Altmetrikler<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u0130nfografiklerin g\u00fcc\u00fcyle makalenizin eri\u015filebilirli\u011fini de art\u0131r\u0131n.<\/p>\n\n\n\n

\n
Mind the Graph'yi deneyin<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Mind the Graph'nin \u00e7izimleriyle temsil edilen beynin sito-mimarisini ve ba\u011flanabilirli\u011fini de\u015fifre etmek i\u00e7in yeni y\u00f6ntemi inceleyin.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/basari-durumu-yuksek-cozunurluklu-senkrotron-tabanli-x-isini-mikrotomografisi-beynin-uc-boyutlu-noronal-mimarisini-ortaya-cikarmak-icin-bir-arac-olarak\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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