{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Zika vir\u00fcs\u00fc yeti\u015fkin insan beyin dokusunda \u00e7o\u011fal\u0131r ve farelerde sinapslar\u0131 ve haf\u0131zay\u0131 bozar Paper Review"},"content":{"rendered":"

ZIKV d\u00fcnyay\u0131 kas\u0131p kavuran tehlikeli bir vir\u00fcst\u00fcr. Bu nedenle, bu durumda yazar, yeti\u015fkin insan beynindeki replikasyonunu incelemektedir.<\/p>\n\n\n\n

Zika vir\u00fcs\u00fc (ZIKV) yeti\u015fkin beyin dokusunu enfekte eder ve farelerde haf\u0131za bozuklu\u011funa neden olur<\/strong><\/h2>\n\n\n\n

Eczac\u0131l\u0131k Fak\u00fcltesi'nden Claudia Figueiredo (2019) liderli\u011findeki bir grup, zika vir\u00fcs\u00fcn\u00fcn yeti\u015fkin insan beyin dokusunda nas\u0131l \u00e7o\u011fald\u0131\u011f\u0131n\u0131 ve farelerde sinapslar\u0131 ve haf\u0131zay\u0131 nas\u0131l bozdu\u011funu inceledi. Zika vir\u00fcs\u00fc, Flaviviridae ailesine ait bir arbovir\u00fcs olup Latin Amerika'da yak\u0131n zamanda g\u00f6r\u00fclen b\u00fcy\u00fck bir salg\u0131ndan sorumludur. <\/p>\n\n\n\n

ZIKV yeti\u015fkin hastalar\u0131n beyinlerinde ve CSF'lerinde bulunmu\u015ftur. NS2B imm\u00fcnoreaktivitesi NeuN-imm\u00fcnoreaktif h\u00fccrelerle kolokalize olmu\u015f, ancak GFAP veya F4\/80 ile kolokalize olmam\u0131\u015ft\u0131r, bu da olgun insan dokusunda n\u00f6ronlar\u0131n ZikV taraf\u0131ndan hedeflendi\u011fini g\u00f6stermektedir. ZIKV'nin intraserebroventrik\u00fcler inf\u00fczyonu ile enfekte edilen yeti\u015fkin imm\u00fcnokompetan farelerde, frontal korteks ve hipokampusta y\u00fcksek d\u00fczeyde ZikV RNA tespit edilmi\u015ftir ve olgun n\u00f6ronlar enfekte olan ana h\u00fccre tipidir. <\/p>\n\n\n\n

Y\u00fcksek beyin TNF-\u03b1 seviyeleri, yo\u011fun mikrogliozis, kompleman sistemi proteinlerinin (C1q ve C3) yukar\u0131 do\u011fru d\u00fczenlenmi\u015f ifadesi ve hipokampal sinaps hasar\u0131 do\u011frulanm\u0131\u015ft\u0131r.<\/p>\n\n\n\n

\u00c7al\u0131\u015fma 9 e\u015fit \u00e7eyrekten olu\u015fmu\u015ftur.<\/strong><\/p>\n\n\n\n

Kontrol edin orijinal makale burada<\/a>.<\/p>\n\n\n\n

Mind the Graph taraf\u0131ndan desteklenen Grafiksel \u00d6zetler<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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\"\"<\/a>
ile yap\u0131lm\u0131\u015ft\u0131r Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u0130lk \u015fekil, insan temporal lob kortikal doku par\u00e7alar\u0131n\u0131n 400 \u00b5m'lik dilimler halinde kesildi\u011fi ve 1 saat boyunca ZIKV (107 PFU) veya sahte ortam ile ink\u00fcbasyondan \u00f6nce 4 g\u00fcn boyunca k\u00fclt\u00fcrde tutuldu\u011fu ve ard\u0131ndan y\u0131kand\u0131\u011f\u0131 durumu temsil etmektedir. <\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
ile yap\u0131lm\u0131\u015ft\u0131r Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u0130kincisi, yeti\u015fkin farelerin serebral lateral ventrik\u00fcle 105 PFU ZIKV, UV ile inaktive edilmi\u015f ZIKV veya sahte ortam inf\u00fczyonu ald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\n\n\n\n

Sonu\u00e7lar, bu konuda daha \u00f6nce bilinenleri destekliyor gibi g\u00f6r\u00fcn\u00fcyor: \"ZIKV, enfeksiyon yolunun merkezi ya da periferik olmas\u0131ndan ba\u011f\u0131ms\u0131z olarak haf\u0131zayla ilgili beyin b\u00f6lgelerini hedef almaktad\u0131r. Vir\u00fcs, n\u00f6rolojik komplikasyonlar\u0131 olan yeti\u015fkin hastalar\u0131n BOS'unda tespit edilmi\u015ftir,\" diyor Figueiredo.<\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar, ZIKV enfeksiyonunun uzun vadeli n\u00f6rodejeneratif etkisini incelemeyi ama\u00e7layan gelecekteki \u00e7al\u0131\u015fmalar\u0131n gerekli oldu\u011funu ileri s\u00fcrmektedir. Beyin i\u015flev bozuklu\u011funa yol a\u00e7an sinyal anormalliklerini \u00f6nlemenin yollar\u0131n\u0131n belirlenmesi, \u00f6nemli n\u00f6rolojik durumlar\u0131n geli\u015fimini geciktirmek veya \u00f6nlemek i\u00e7in m\u00fcdahale stratejilerinin yolunu a\u00e7abilir.<\/p>\n\n\n\n

Belgeler Etki ve Performans<\/strong><\/h2>\n\n\n\n

ile analiz edebiliriz Altmetric<\/a> Bu makalenin \u00e7evrimi\u00e7i dikkat puan\u0131n\u0131n daha y\u00fcksek oldu\u011fu veriler daha 95%<\/strong><\/strong> Do\u011fa'daki benzer ya\u015ftaki di\u011fer t\u00fcm makalelerin<\/strong> Dergiler.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Kaynak Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u0130nfografiklerin g\u00fcc\u00fcn\u00fc makalenizi g\u00fc\u00e7lendirmek i\u00e7in de kullan\u0131n! Mind the Graph'de bir eser olu\u015fturmaya ba\u015flay\u0131n.<\/p>\n\n\n\n

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Mind the Graph'yi deneyin<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u00c7al\u0131\u015fma, d\u00fcnyay\u0131 kas\u0131p kavuran tehlikeli bir vir\u00fcs olan yeti\u015fkin insan beynindeki ZIKV ile ilgilidir. S\u00fcre\u00e7 Mind the Graph \u00e7izimlerini kullanmaktad\u0131r.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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