{"id":16424,"date":"2022-08-17T19:00:25","date_gmt":"2022-08-17T22:00:25","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16424"},"modified":"2022-10-18T08:23:41","modified_gmt":"2022-10-18T11:23:41","slug":"what-is-a-fecal-transplant","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/diski-nakli-nedir\/","title":{"rendered":"D\u0131\u015fk\u0131 Nakli: Ne oldu\u011funu, nas\u0131l \u00e7al\u0131\u015ft\u0131\u011f\u0131n\u0131 ve yan etkilerini anlay\u0131n"},"content":{"rendered":"<p>\u0130nsan ba\u011f\u0131rsak mikrobiyomunun kontrol edilmesiyle ili\u015fkili terap\u00f6tik faydalar\u0131 daha iyi anlamay\u0131 ama\u00e7layan ara\u015ft\u0131rmalarda bir art\u0131\u015f olmu\u015ftur. FMT'ler, d\u0131\u015fk\u0131 nakilleri, bakteriyoterapi ve ba\u011f\u0131rsak mikrobiyota nakilleri de fekal transplantasyon i\u00e7in kullan\u0131lan terimlerdir. Doktorlar, sa\u011fl\u0131kl\u0131 don\u00f6rlerden d\u0131\u015fk\u0131 naklederek ki\u015finin ba\u011f\u0131rsa\u011f\u0131ndaki do\u011fal bakteri dengesini yenilemek i\u00e7in d\u0131\u015fk\u0131 nakli ger\u00e7ekle\u015ftirmektedir. Gastrointestinal enfeksiyonlar gibi di\u011fer durumlar fekal transplantlar kullan\u0131larak tedavi edilebilir.<\/p>\n\n\n\n<p>Baz\u0131 t\u0131bbi durumlar ve antibiyotikler sindirim sistemindeki yararl\u0131 bakterileri yok ederek besinlerin emilmesini engelleyebilir. \u0130yi bakterilerin yeniden kazand\u0131r\u0131lmas\u0131 d\u0131\u015fk\u0131 nakli yoluyla ger\u00e7ekle\u015ftirilebilir.<\/p>\n\n\n\n<p>Fekal mikrobiyota transplantasyonunun (FMT) amac\u0131, bir don\u00f6rden al\u0131nan d\u0131\u015fk\u0131 sol\u00fcsyonunu al\u0131c\u0131n\u0131n ba\u011f\u0131rsak sistemine uygulayarak al\u0131c\u0131n\u0131n ba\u011f\u0131rsak mikrobiyomunu de\u011fi\u015ftirmektir. Clostridium difficile enfeksiyonunun n\u00fcksetmesi FMT ile ba\u015far\u0131l\u0131 bir \u015fekilde tedavi edilmi\u015ftir. Okumaya devam ettik\u00e7e d\u0131\u015fk\u0131 nakli hakk\u0131nda daha fazla bilgi edinece\u011fiz.<\/p>\n\n\n\n<h2><strong><strong>Fekal transplantasyon i\u00e7in prosed\u00fcr nedir?<\/strong><\/strong><\/h2>\n\n\n\n<p>Ge Hong, d\u00f6rd\u00fcnc\u00fc y\u00fczy\u0131l \u00c7in'inde d\u0131\u015fk\u0131y\u0131 ishal tedavisi olarak tan\u0131mlam\u0131\u015ft\u0131r; bu, d\u0131\u015fk\u0131n\u0131n tedavi amac\u0131yla ilk kez kullan\u0131ld\u0131\u011f\u0131 d\u00f6nemdir. Naklin nas\u0131l yap\u0131ld\u0131\u011f\u0131na ba\u011fl\u0131 olarak farkl\u0131 FMT prosed\u00fcrleri vard\u0131r. Kolonoskopi s\u00fcrecinin bir par\u00e7as\u0131 olarak gastroenterolog, nakli ger\u00e7ekle\u015ftirmeden \u00f6nce bir tuzlu su sol\u00fcsyonunu don\u00f6r d\u0131\u015fk\u0131s\u0131 \u00f6rne\u011fi ile kar\u0131\u015ft\u0131r\u0131r. D\u0131\u015fk\u0131 naklinde kat\u0131 bir bile\u015fen yoktur. Doktorlar potansiyel don\u00f6rleri \u015fu a\u00e7\u0131lardan taramal\u0131d\u0131r:<\/p>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Hepatit A, B ve C gibi vir\u00fcsler<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>HIV\/AIDS<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Frengi<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Giardiasis veya solucanlar gibi ba\u011f\u0131rsak parazitleri ile enfeksiyonlar<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>C. difficile<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Doktorun \u00f6nerdi\u011fi di\u011fer durumlar<\/li><\/ul>\n\n\n\n<p>Nakil tamamland\u0131ktan sonra size sakinle\u015ftirici bir ila\u00e7 verilecek ve kolonoskopi i\u00e7in uygun bir pozisyonda yan yat\u0131r\u0131lacaks\u0131n\u0131z. An\u00fcs yoluyla, kameral\u0131 bir endoskop veya kolonoskop esnek bir t\u00fcp ile birlikte kolona y\u00f6nlendirilir. Fekal transplantasyon s\u0131ras\u0131nda, doktor skopu geri \u00e7ekerken kolon duvarlar\u0131na p\u00fcsk\u00fcrt\u00fclen bir s\u0131v\u0131 p\u00fcsk\u00fcrt\u00fcl\u00fcr.<\/p>\n\n\n\n<p>Kolonunuzdaki d\u0131\u015fk\u0131 naklinin korunmas\u0131na yard\u0131mc\u0131 olmak i\u00e7in siz ayr\u0131lmadan \u00f6nce ishali \u00f6nlemeye yard\u0131mc\u0131 olacak ila\u00e7lar re\u00e7ete edilebilir. \u0130\u015flemden sonra evinize gidebilir ya da g\u00fcn\u00fcn geri kalan\u0131n\u0131 hastane odan\u0131zda ge\u00e7irebilirsiniz.<\/p>\n\n\n\n<h2><strong>Bu prosed\u00fcr\u00fc kimlerin yapt\u0131rmas\u0131 gerekir?<\/strong><\/h2>\n\n\n\n<p>C. difficile gibi ciddi bakteriyel enfeksiyonlar\u0131n tedavisi fekal transplantasyon yoluyla sa\u011flanmaktad\u0131r.  \u00c7o\u011fu enfeksiyonda oldu\u011fu gibi C. diff tedavisinde de genellikle antibiyotikler kullan\u0131l\u0131r. Ancak zaman zaman enfeksiyon baz\u0131 ki\u015filerde geri d\u00f6nebilir. Antibiyotiklerin art\u0131r\u0131lmas\u0131na yan\u0131t al\u0131namayacakt\u0131r.<\/p>\n\n\n\n<p>Tekrarlayan C. diff, antibiyotiklere k\u0131yasla d\u0131\u015fk\u0131 nakli ile daha ba\u015far\u0131l\u0131 bir \u015fekilde tedavi edilir. Enfeksiyonlar genellikle bu tedaviden sonra k\u0131sa bir s\u00fcre i\u00e7inde kaybolur.<\/p>\n\n\n\n<p>Kan\u0131tlar, inflamatuar ba\u011f\u0131rsak hastal\u0131\u011f\u0131, obezite, metabolik sendrom ve fonksiyonel gastrointestinal hastal\u0131k gibi di\u011fer durumlar i\u00e7in de faydal\u0131 olabilece\u011fini g\u00f6stermektedir.<\/p>\n\n\n\n<h2><strong><strong>Zamana ba\u011fl\u0131 yan etkiler<\/strong><\/strong><\/h2>\n\n\n\n<p>Bir naklin ger\u00e7ekle\u015ftirilme y\u00f6ntemi genellikle yan etkilerinin nedenidir. D\u0131\u015fk\u0131 nakli yapt\u0131rman\u0131n en yayg\u0131n yolu (kolonoskopi) a\u015fa\u011f\u0131daki gibi ge\u00e7ici yan etkilere neden olabilir:<\/p>\n\n\n\n<ul class=\"has-black-color has-cyan-bluish-gray-background-color has-text-color has-background\"><li>Gastrit ve \u015fi\u015fkinlik<\/li><li>K\u0131zar\u0131kl\u0131k ve mide bulant\u0131s\u0131<\/li><li>Bir prosed\u00fcr s\u0131ras\u0131nda, hava cebi kolonda kramplara neden olabilir<\/li><li>\u0130shale ba\u011fl\u0131 kab\u0131zl\u0131k<\/li><li>An\u00fcs birka\u00e7 damla nakil sol\u00fcsyonu s\u0131zd\u0131r\u0131r<\/li><\/ul>\n\n\n\n<p>Olumsuz yan etki olas\u0131l\u0131\u011f\u0131 nadirdir, ancak mevcuttur. Birka\u00e7 \u00f6rnek verilebilir:<\/p>\n\n\n\n<ul class=\"has-black-color has-cyan-bluish-gray-background-color has-text-color has-background\"><li>Dikkatli bir \u015fekilde de\u011ferlendirilmeyen ve test edilmeyen don\u00f6rler ba\u015fka bir bakteri veya vir\u00fcs ile enfekte olabilir.<\/li><li>Bir hasta, nazogastrik t\u00fcp veya burun t\u00fcp\u00fc i\u00e7eren FMT s\u0131ras\u0131nda pn\u00f6moniye yakalan\u0131r.<\/li><li>Kolonoskopilerin veya endoskopilerin tipik riskleri aras\u0131nda enfeksiyon, kanama, delinme, y\u0131rt\u0131lma ve anestezi riskleri yer al\u0131r.<\/li><\/ul>\n\n\n\n<p>Ancak yap\u0131lan ara\u015ft\u0131rmalarda, bu etkilerin genellikle olumsuz olmad\u0131\u011f\u0131 ve genellikle zamanla ortadan kalkt\u0131\u011f\u0131 g\u00f6r\u00fclm\u00fc\u015ft\u00fcr.<\/p>\n\n\n\n<h2><strong><strong>Fekal Transplantasyon Haz\u0131rl\u0131klar\u0131<\/strong><\/strong><\/h2>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>T\u00fcm ila\u00e7lar ve alerjiler doktorunuza bildirilmelidir.<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Haz\u0131rl\u0131k talimatlar\u0131, i\u015fleminizden \u00f6nce doktorunuz taraf\u0131ndan sizinle g\u00f6r\u00fc\u015f\u00fclecektir. Y\u00f6nergeleri yak\u0131ndan takip etmek \u00e7ok \u00f6nemlidir.<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>\u0130\u015flemden iki g\u00fcn \u00f6nce t\u00fcm antibiyotikleri kesmelisiniz.<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Re\u00e7eteli ila\u00e7lara ek olarak, doktorunuza re\u00e7etesiz sat\u0131lan ila\u00e7lar, do\u011fal ila\u00e7lar ve besin takviyeleri hakk\u0131nda da bilgi verin. Doktorunuz bu ila\u00e7lar\u0131 ne zaman ve nas\u0131l alaca\u011f\u0131n\u0131z\u0131 size a\u00e7\u0131klayarak nakil i\u00e7in haz\u0131rlanman\u0131za yard\u0131mc\u0131 olacakt\u0131r.<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>Nakliniz kolonoskopi ile yap\u0131lacaksa kolonoskopi i\u00e7in ba\u011f\u0131rsak haz\u0131rlama rejimi takip edilecektir. \u0130\u015flemden \u00f6nce doktorunuz size berrak s\u0131v\u0131lar t\u00fcketmenizi ve m\u00fcshil kullanman\u0131z\u0131 s\u00f6yleyebilir.<\/li><\/ul>\n\n\n\n<ul class=\"has-white-color has-text-color has-background\" style=\"background-color:#dc1866\"><li>FMT endoskopi veya kolonoskopi yoluyla uygulanacaksa sakinle\u015ftirici ila\u00e7 verilecektir.&nbsp;<\/li><\/ul>\n\n\n\n<p>Sa\u011fl\u0131kl\u0131 bir don\u00f6rden d\u0131\u015fk\u0131 kabul etmek tuhaf g\u00f6r\u00fcnebilir, ancak d\u0131\u015fk\u0131 nakli bilim sayesinde daha yayg\u0131n hale geliyor.<\/p>\n\n\n\n<p>Ba\u011f\u0131rsak sa\u011fl\u0131\u011f\u0131n\u0131 destekleyen etkili bir tedavi, di\u011fer tedaviler i\u015fe yaramad\u0131\u011f\u0131nda ideal bir \u00e7\u00f6z\u00fcm olabilir, yararl\u0131 bakterilerin \u00e7o\u011falmas\u0131n\u0131 te\u015fvik eder, ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu g\u00fc\u00e7lendirir ve bireyin refah\u0131na katk\u0131da bulunur. D\u0131\u015fk\u0131 nakli yayg\u0131n olarak doktorlar taraf\u0131ndan yap\u0131lmamaktad\u0131r, bu nedenle bu alanda yeterli uzmanl\u0131\u011fa sahip bir uzmandan tavsiye almal\u0131s\u0131n\u0131z.<\/p>\n\n\n\n<h2><strong>Bilimsel ill\u00fcstrasyonunuzun yerinde oldu\u011fundan emin olun<\/strong><\/h2>\n\n\n\n<p>Mind the graph ile herhangi bir ara\u015ft\u0131rmay\u0131 g\u00f6rsel olarak a\u00e7\u0131klayabilir ve \u00e7al\u0131\u015fman\u0131zla geni\u015f bir kitleye ula\u015fabilirsiniz. Projelerinizde size yard\u0131mc\u0131 olmak i\u00e7in k\u00fct\u00fcphanemizde geni\u015f bir ill\u00fcstrasyon koleksiyonumuz var. Ayr\u0131ca, uzman ekibimizden ihtiya\u00e7lar\u0131n\u0131za g\u00f6re \u00f6zelle\u015ftirmesini isteyebilirsiniz. Daha fazla bilgi i\u00e7in l\u00fctfen <a href=\"https:\/\/mindthegraph.com\/\">web sitesi<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe loading=\"lazy\" title=\"E\u011fitim | Bilimsel Poster Olu\u015fturma\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/NdSYKg-QyII?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<p><\/p>\n\n\n\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>Fekal Transplantasyonun ne oldu\u011funu, kimlerin ihtiyac\u0131 oldu\u011funu, yan etkilerini ve prosed\u00fcrle ilgili her \u015feyi \u00f6\u011frenmenin zaman\u0131 geldi.<\/p>","protected":false},"author":27,"featured_media":16428,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28,956],"tags":[913,554,775,914],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Fecal Transplant: Understand what it is, how it works and the side effects<\/title>\n<meta name=\"description\" content=\"It&#039;s time to learn what Fecal Transplant is, who needs it, the side effects and everything about the procedure.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/czym-jest-przeszczep-kalu\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fecal Transplant: Understand 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