{"id":14387,"date":"2021-08-17T17:07:19","date_gmt":"2021-08-17T20:07:19","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=14387"},"modified":"2024-12-05T15:52:16","modified_gmt":"2024-12-05T18:52:16","slug":"what-is-dmt-everything-researchers-know-about-it","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/dmt-ne-dir-her-sey-arastirmacilar-bu-hakkinda-biliyor\/","title":{"rendered":"DMT Nedir? Ara\u015ft\u0131rmac\u0131lar\u0131n Hakk\u0131nda Bildi\u011fi Her \u015eey"},"content":{"rendered":"

DMT nedir?<\/h2>\n\n\n\n

DMT ya da N, N-dimetiltriptamin, amazon bitkisinin yapraklar\u0131nda bulunan do\u011fal bir maddedir. Psychotria Viridis<\/em>Ayahuasca i\u00e7ece\u011finde kullan\u0131lan ve bunu deneyimleyenler i\u00e7in hal\u00fcsinasyonlar ve alg\u0131, duygu ve bili\u015fte de\u011fi\u015fiklikler \u00fcreten.<\/p>\n\n\n\n

Psikoaktif bir alkaloid madde olarak s\u0131n\u0131fland\u0131r\u0131lan DMT, 1971 y\u0131l\u0131nda Uluslararas\u0131 Psikotrop Maddeler Konvansiyonu taraf\u0131ndan k\u00fcresel olarak yasaklanm\u0131\u015f, dini ve rit\u00fcel uygulamalarda sadece Ayahuasca ad\u0131 verilen inf\u00fczyon i\u00e7ece\u011finde t\u00fcketimine izin verilmi\u015ftir.<\/p>\n\n\n\n

\"Galeri'de<\/a>
\"Molek\u00fcller\" i\u00e7in Mind the Graph Galerisi'nde ara\u015ft\u0131rma yap\u0131n.<\/figcaption><\/figure>\n\n\n\n

Ayahuasca y\u00fczy\u0131l\u0131 a\u015fk\u0131n bir s\u00fcredir var olmas\u0131na ra\u011fmen, (hen\u00fcz) kan\u0131tlanmam\u0131\u015f faydalar\u0131 nedeniyle ancak son birka\u00e7 y\u0131lda bilim insanlar\u0131n\u0131n dikkatini \u00e7ekmi\u015ftir.<\/p>\n\n\n\n

\u0130\u00e7ecek, depresyon, anksiyete ve ba\u011f\u0131ml\u0131l\u0131k gibi n\u00f6rolojik ve duygusal bozukluklar\u0131 olan hastalar\u0131n ya\u015fam kalitesini art\u0131rmak ve tedavi etmek i\u00e7in sunulmu\u015ftur. <\/p>\n\n\n\n

\"Ne<\/a><\/figure>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar DMT hakk\u0131nda ne biliyor?<\/h2>\n\n\n\n

taraf\u0131ndan yay\u0131nlanan bir makale Journal of Affective Disorders Raporlar\u0131<\/a> K\u00fcresel Ayahuasca Projesi'nin (GAP) bu i\u00e7ece\u011fi deneyimlemi\u015f 11.912 ki\u015fiyi kapsayan anketinden elde edilen verileri analiz etti. Ankette, ayahuasca t\u00fcketmeden \u00f6nce depresyon veya anksiyete ya\u015fad\u0131\u011f\u0131n\u0131 bildiren kat\u0131l\u0131mc\u0131lar, deneyimden sonra semptomlar\u0131nda bir miktar iyile\u015fme fark ettiklerini s\u00f6yledi. B\u00f6ylece ya\u015fam kaliteleri de artm\u0131\u015ft\u0131r. <\/p>\n\n\n\n

GAP taraf\u0131ndan toplanan bu rapor gibi hasta raporlar\u0131 son birka\u00e7 y\u0131ld\u0131r artmaktad\u0131r. \u0130yi bir haber olmas\u0131na ra\u011fmen, bilim insanlar\u0131 ve doktorlar Ayahuasca'n\u0131n bu faydalar\u0131n\u0131n kayna\u011f\u0131n\u0131 anlamak i\u00e7in daha eksiksiz ve detayl\u0131 fizyolojik \u00e7al\u0131\u015fmalara ihtiya\u00e7 duymaktad\u0131r. \u0130nf\u00fczyon bitkisi i\u00e7ece\u011finin i\u00e7inde \u00e7e\u015fitli maddeler vard\u0131r ve bunlar\u0131n her biri insan v\u00fccudunda farkl\u0131 t\u00fcrde bir tepkiyi tetikleyebilir. <\/p>\n\n\n\n

Bu maddeler aras\u0131nda DMT de bulunmaktad\u0131r. Bu Ayahuasca maddesi, belirgin n\u00f6rogenez potansiyeli nedeniyle ara\u015ft\u0131rmac\u0131lar\u0131n dikkatini \u00e7ekmektedir.   <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

N\u00f6rogenez nedir?<\/h3>\n\n\n\n

Neurogenesis<\/strong> d\u00f6n\u00fc\u015f\u00fcm s\u00fcreci olarak tan\u0131mlanmaktad\u0131r. n\u00f6ral k\u00f6k h\u00fccreler<\/strong> veya progenit\u00f6r<\/strong> h\u00fccreleri yeni n\u00f6ronlara d\u00f6n\u00fc\u015ft\u00fcr\u00fcr. Ayr\u0131ca h\u00fccrelerin \u00e7o\u011falmas\u0131, g\u00f6\u00e7\u00fc ve farkl\u0131la\u015fmas\u0131 da dahil olmak \u00fczere bir\u00e7ok farkl\u0131 h\u00fccresel aktiviteyi i\u00e7erir.<\/p>\n\n\n\n

S\u0131rayla, n\u00f6ral k\u00f6k h\u00fccreler<\/strong> n\u00f6ronlar veya glial h\u00fccreler gibi yeni sinir sistemi h\u00fccreleri \u00fcreten kapsaml\u0131 bir kendini yenileme yetene\u011fine sahiptir. Beynimizin i\u00e7inde, n\u00f6ral k\u00f6k h\u00fccrelerin bulundu\u011fu bir ni\u015f vard\u0131r. subgran\u00fcler b\u00f6lge<\/strong> hipokamp\u00fcsteki dentat girus. <\/p>\n\n\n\n

Hipokampus, beynin haf\u0131za ve \u00f6\u011frenme yeteneklerimizden sorumlu b\u00f6l\u00fcm\u00fcd\u00fcr. Bu beyin b\u00f6lgesi limbik sistemin bir par\u00e7as\u0131d\u0131r ve k\u0131sa s\u00fcreli haf\u0131zan\u0131n uzun s\u00fcreli haf\u0131zaya d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesinde \u00f6nemli bir role sahiptir. <\/p>\n\n\n\n

Alzheimer gibi n\u00f6rodejeneratif hastal\u0131klarda, hipokampus ilk zarar g\u00f6ren b\u00f6lgedir ve haf\u0131za kayb\u0131na yol a\u00e7ar. <\/p>\n\n\n\n

DMT beyni nas\u0131l etkiler?<\/h3>\n\n\n\n

Bir s\u00fcre i\u00e7in DMT'nin sadece hal\u00fcsinasyon etkilerini \u00fcreten serotonin resept\u00f6rleri 5-HT'ye ba\u011fland\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclm\u00fc\u015ft\u00fcr. Ancak, son \u00e7al\u0131\u015fmalar DMT'nin serotonerjik olmayan ba\u015fka bir resept\u00f6r tipine de ba\u011fland\u0131\u011f\u0131n\u0131 bildirmektedir sigma-1 resept\u00f6r\u00fc<\/strong> veya S1R<\/strong>. <\/p>\n\n\n\n

Bu resept\u00f6r merkezi sinir sisteminde, \u00f6zellikle prefrontal korteks ve hipokampusta yayg\u0131nd\u0131r. <\/p>\n\n\n\n

Dahas\u0131, ara\u015ft\u0131rmac\u0131lar bu resept\u00f6r S1R'ye ba\u011flanan DMT'nin psikoaktif etkilerini kaybetti\u011fini, hal\u00fcsinasyon ya da alg\u0131da de\u011fi\u015fiklik yaratmad\u0131\u011f\u0131n\u0131 ke\u015ffetmi\u015flerdir. <\/p>\n\n\n\n

\u0130n vitro ve in vivo ara\u015ft\u0131rmalar<\/h3>\n\n\n\n

Dergide yay\u0131nlanan bir \u00e7al\u0131\u015fma Translasyonel Psikiyatri Dergisi<\/a> 2020'de sigma-1 resept\u00f6r\u00fc arac\u0131l\u0131\u011f\u0131yla beyindeki DMT etkilerini incelemeye odakland\u0131. <\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar, 5-HT antagonistlerini kullanarak DMT'nin S1R arac\u0131l\u0131\u011f\u0131yla n\u00f6rogenezi uyard\u0131\u011f\u0131n\u0131 g\u00f6zlemlemi\u015flerdir. <\/p>\n\n\n\n

Buna ek olarak, veriler DMT'nin sadece n\u00f6ral k\u00f6k h\u00fccrelerin olgunla\u015fmas\u0131n\u0131, \u00e7o\u011falmas\u0131n\u0131 ve in vitro g\u00f6\u00e7 etmesini te\u015fvik eden bir uyar\u0131c\u0131 olarak hareket etmedi\u011fini, ayn\u0131 zamanda in vivo \u00f6\u011frenme ve haf\u0131za yetene\u011fini de art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. <\/p>\n\n\n\n

\u00c7al\u0131\u015fman\u0131n yazarlar\u0131, in vitro ortamda DMT'nin hipokampus yeti\u015fkin n\u00f6rojenik ni\u015finden n\u00f6ral progenit\u00f6r h\u00fccrelerin \u00e7o\u011falmas\u0131n\u0131 destekledi\u011fini bildirmi\u015ftir. Bu etki, n\u00f6ral progenit\u00f6r h\u00fccrelerin say\u0131s\u0131n\u0131 ve boyutunu art\u0131rm\u0131\u015ft\u0131r. neurospheres<\/strong> DMT ile bir haftal\u0131k tedaviden sonra. <\/p>\n\n\n\n

Ayr\u0131ca, ara\u015ft\u0131rmac\u0131lar belirli proteinlerin ifadesine dayanarak DMT'nin bu n\u00f6ral k\u00f6k h\u00fccrelerin farkl\u0131la\u015fmas\u0131n\u0131 destekledi\u011fini de fark etmi\u015flerdir. <\/p>\n\n\n\n

Sadece gen\u00e7 ve olgun n\u00f6ronlarda bulunan \u03b2-III-tubulin ve MAP-2 adl\u0131 proteinlerin, DMT ile tedavi edilen n\u00f6rosferlerde ekspresyonlar\u0131 artm\u0131\u015ft\u0131r. Bu da DMT'nin n\u00f6ronal fenotipe farkl\u0131la\u015fmay\u0131 destekledi\u011fi anlam\u0131na gelmektedir. <\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar ayr\u0131ca S1R arac\u0131l\u0131\u011f\u0131yla astrositler ve oligodendrositler gibi di\u011fer h\u00fccre fenotiplerine terfi edildi\u011fini fark etti.<\/p>\n\n\n\n

\u0130n vivo olarak, DMT'nin S1R arac\u0131l\u0131\u011f\u0131yla subgran\u00fcler b\u00f6lge ni\u015fini aktive etti\u011fi g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. <\/p>\n\n\n\n

Makaleye g\u00f6re, DMT ile tedavi edilen yeti\u015fkin farelerde \"subgran\u00fcler b\u00f6lgede n\u00f6ral \u00f6nc\u00fcllerin \u00e7o\u011falmas\u0131 ve g\u00f6\u00e7\u00fc artm\u0131\u015ft\u0131r\". Bu sonu\u00e7, DMT'nin hipokamp\u00fcs n\u00f6rogenezi \u00fczerinde modelleyici bir etkiye sahip oldu\u011funu ve yeni n\u00f6ron say\u0131s\u0131n\u0131 art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. <\/p>\n\n\n\n

Uygulamada, DMT ile tedavi edilen yeti\u015fkin fareler, tedavi edilmeyenlere k\u0131yasla davran\u0131\u015fsal g\u00f6revlerde daha iyi sonu\u00e7lar g\u00f6stermi\u015ftir. Tedavi edilen grup, \u00f6\u011frenme ve haf\u0131za g\u00f6revlerinde iyile\u015fme sonu\u00e7lar\u0131 sunmu\u015ftur. <\/p>\n\n\n\n

\"DMT<\/a><\/figure>\n\n\n\n

Sonu\u00e7<\/h2>\n\n\n\n

T\u00fcm bu sonu\u00e7lar t\u0131p camias\u0131 i\u00e7in harika bir haber. <\/p>\n\n\n\n

Bu da DMT ile sadece n\u00f6rogenezi uyarman\u0131n de\u011fil, ayn\u0131 zamanda spesifik bir resept\u00f6r arac\u0131l\u0131\u011f\u0131yla hal\u00fcsinojen etkileri olmadan da bu sonu\u00e7lar\u0131 elde etmenin m\u00fcmk\u00fcn oldu\u011funu g\u00f6stermektedir. <\/p>\n\n\n\n

Jos\u00e9 \u00c1ngel Morales, \"Beyin plastisitesini mod\u00fcle etme kapasitesi, n\u00f6rodejeneratif hastal\u0131klar da dahil olmak \u00fczere \u00e7ok \u00e7e\u015fitli psikiyatrik ve n\u00f6rolojik bozukluklar i\u00e7in b\u00fcy\u00fck bir terap\u00f6tik potansiyele sahip oldu\u011funu g\u00f6stermektedir\" dedi. A\u00e7\u0131klama<\/a>makalenin yazarlar\u0131ndan biri. <\/p>\n\n\n\n

Bu sonu\u00e7lar Ayahuasca ve DMT'yi i\u00e7eren gelecekteki \u00e7al\u0131\u015fmalar\u0131 g\u00fc\u00e7l\u00fc bir \u015fekilde etkileyebilir. N\u00f6rogenez s\u00fcrecinin nas\u0131l kontrol edilece\u011fini ve nas\u0131l etkilenece\u011fini anlamak, n\u00f6rodejenerasyon hastal\u0131klar\u0131n\u0131n tedavi \u015feklini tamamen de\u011fi\u015ftirebilir.<\/p>\n\n\n\n

Bununla birlikte, bilim insanlar\u0131n\u0131n DMT gibi maddelerin ve sigma-1 resept\u00f6r\u00fc gibi umut verici resept\u00f6rlerin n\u00f6rogenezdeki rol\u00fcn\u00fc tam olarak anlamalar\u0131na y\u00f6nelik \u00e7al\u0131\u015fmalara b\u00fcy\u00fck bir talep vard\u0131r. <\/p>\n\n\n\n

Olumlu bir bak\u0131\u015f a\u00e7\u0131s\u0131yla, bu sadece yeni n\u00f6rodejeneratif hastal\u0131k tedavilerine de\u011fil, ayn\u0131 zamanda hastal\u0131klar\u0131n iyile\u015ftirilmesine de yol a\u00e7abilir. <\/p>\n\n\n\n

__________________________<\/p>\n\n\n\n

Bilimsel makalede sunulan sonu\u00e7larla yap\u0131lan infografikleri be\u011fendiniz mi?<\/p>\n\n\n\n

Bu infografikler \u015fu adreste bulunan haz\u0131r \u015fablonlar kullan\u0131larak haz\u0131rlanm\u0131\u015ft\u0131r Mind the Graph<\/a>, bu bir<\/a> ve bu di\u011fer bir<\/a>. Birka\u00e7 de\u011fi\u015fiklik yapt\u0131m ve k\u0131sa s\u00fcrede haz\u0131r oldu!<\/p>\n\n\n\n

Ayn\u0131 \u015feyi ara\u015ft\u0131rma \u00e7al\u0131\u015fman\u0131z i\u00e7in de yapabilirsiniz, s\u0131f\u0131rdan ba\u015flaman\u0131za gerek yok. Kontrol edin t\u00fcm \u015fablonlar<\/a> i\u00e7inde mevcut Mind the Graph<\/a>. <\/p>\n\n\n\n

Ve infografi\u011finiz \u00fczerinde \u00e7al\u0131\u015fmaya ba\u015flay\u0131n Hemen \u015fimdi.<\/a>! <\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

DMT nedir? DMT veya N, N-dimetiltriptamin, Psychotria Viridis adl\u0131 bir amazon bitkisinin yapraklar\u0131nda bulunan ve Ayahuasca i\u00e7ece\u011finde kullan\u0131lan, deneyimleyenler i\u00e7in hal\u00fcsinasyonlar ve alg\u0131, duygu ve bili\u015fte de\u011fi\u015fiklikler \u00fcreten do\u011fal bir maddedir. Psikoaktif bir alkaloid madde olarak s\u0131n\u0131fland\u0131r\u0131lan DMT k\u00fcresel olarak yasaklanm\u0131\u015ft\u0131r [...]<\/p>","protected":false},"author":18,"featured_media":14389,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[840,841,51,839,554,250,775,838],"yoast_head":"\nWhat is DMT? Everything Researchers Know About It - MTG<\/title>\n<meta name=\"description\" content=\"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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Everything Researchers Know About It","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/08\/what-is-dmt-twitter.jpg","twitter_misc":{"Written by":"Bruna Soldera","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","url":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","name":"What is DMT? Everything Researchers Know About It - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-08-17T20:07:19+00:00","dateModified":"2024-12-05T18:52:16+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/6a3f0be2cd19879e0b9b54457a069602"},"description":"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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