{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/esrar-ve-vucut-agrisi\/","title":{"rendered":"Esrar ve V\u00fccut A\u011fr\u0131s\u0131"},"content":{"rendered":"

Ge\u00e7ti\u011fimiz on y\u0131lda bir\u00e7ok klinik \u00e7al\u0131\u015fma, n\u00f6ropatik a\u011fr\u0131 tedavileri i\u00e7in esrar bazl\u0131 ila\u00e7lar\u0131n kullan\u0131m\u0131nda olumlu ve umut verici sonu\u00e7lar bildirmi\u015ftir. <\/p>\n\n\n\n

Diyabet, kemoterapi, multipl skleroz, fibromiyalji, osteoartrit ve di\u011fer bir\u00e7ok hastal\u0131kla ilgili a\u011fr\u0131lar Kenevir ile tedavi edilmi\u015ftir. <\/p>\n\n\n\n

G\u00f6r\u00fcn\u00fc\u015fe g\u00f6re, eksojen kannabinoidler ile opioid resept\u00f6rleri aras\u0131nda bir ba\u011flant\u0131 vard\u0131r ve bu da hastan\u0131n analjezisinde - a\u011fr\u0131 hissedememe - bir art\u0131\u015fa neden olur. <\/p>\n\n\n\n

Kenevir bazl\u0131 ila\u00e7larla birlikte opioidlerle tedavi edilen hastalar, opioid etkinli\u011finin kenevir bitkisindeki ba\u015fl\u0131ca psikoaktif molek\u00fcl olan tetrahidrokanabinol - THC taraf\u0131ndan art\u0131r\u0131ld\u0131\u011f\u0131 bir ila\u00e7 sinerjik etkisi sergiler. <\/p>\n\n\n\n

Bilim insanlar\u0131 bu sonu\u00e7lara, opioid ila\u00e7 dozaj\u0131n\u0131n azalt\u0131lmas\u0131 ve b\u00f6ylece a\u011fr\u0131 \u00e7eken hastalar\u0131n daha kaliteli bir ya\u015fam s\u00fcrmesi olas\u0131l\u0131\u011f\u0131 nedeniyle olumlu bir bak\u0131\u015f a\u00e7\u0131s\u0131yla bak\u0131yor.<\/p>\n\n\n\n

Endokannabinoid sistem, di\u011fer metabolik yollar gibi insan v\u00fccudunun izole bir sistemi de\u011fildir, di\u011fer sinyal yollar\u0131n\u0131 etkileyebilir ve bunlardan etkilenebilir, bunlardan biri g\u00f6r\u00fcn\u00fc\u015fe g\u00f6re opioidler ve resept\u00f6rleri ile ilgilidir. <\/p>\n\n\n\n

Opioid resept\u00f6rleri, a\u011fr\u0131 hissini sinyalize etme i\u015flevinin yan\u0131 s\u0131ra, termal d\u00fczenleme, hormonal stabilite, analjezik aktivite gibi baz\u0131 v\u00fccut fonksiyonlar\u0131n\u0131 mod\u00fcle etme rol\u00fcne de sahiptir. <\/p>\n\n\n\n

Hem kannabinoid hem de opioid resept\u00f6rleri, beyin ve omurilikte a\u011fr\u0131 yay\u0131l\u0131m\u0131ndan sorumlu n\u00f6rotransmisyonlar\u0131 etkileme kapasitesine sahip proteinler olan G-protein-ba\u011flant\u0131l\u0131 ailenin \u00fcyeleridir. <\/p>\n\n\n\n

Kronik a\u011fr\u0131s\u0131 olan hastalar\u0131n tedavisi genellikle kademeli olarak artan dozlarda opioid almay\u0131 i\u00e7erir ve bu da s\u0131kl\u0131kla sedasyon, solunum bozukluklar\u0131 ve kab\u0131zl\u0131k gibi istenmeyen yan etkilere yol a\u00e7ar. <\/p>\n\n\n\n

Bir s\u00fcre sonra hastalar opioid dozaj\u0131na kar\u015f\u0131 tolerans ve diren\u00e7 g\u00f6stermeye ba\u015flar, terap\u00f6tik etkilerine ula\u015famaz ve doktorlar\u0131 ayn\u0131 d\u00fczeyde a\u011fr\u0131 kesici elde etmek i\u00e7in dozu tekrar tekrar art\u0131rmaya zorlar.<\/p>\n\n\n\n

Tek ba\u015f\u0131na y\u00fcksek doz THC analjezik olarak kabul edilir, ancak genellikle anksiyete, ba\u015f a\u011fr\u0131s\u0131, a\u011f\u0131z kurulu\u011fu, ba\u015f d\u00f6nmesi, \u00f6fori ve ta\u015fikardi gibi istenmeyen yan etkiler izler, bu arada d\u00fc\u015f\u00fck dozlar hi\u00e7 analjezi etkisi yaratmaz. <\/p>\n\n\n\n

Bununla birlikte, opioidlerle birle\u015ftirildi\u011finde bu etki tamamen de\u011fi\u015febilir.<\/p>\n\n\n\n

Hayvan modellerinde yap\u0131lan \u00e7al\u0131\u015fmalar, THC gibi eksojen kannabinoidlerin morfin gibi opioid ila\u00e7lar\u0131n etkinli\u011fini art\u0131rabildi\u011fini g\u00f6stermi\u015ftir. <\/p>\n\n\n\n

THC analjezik aktivitesinin opioid resept\u00f6rleri arac\u0131l\u0131\u011f\u0131yla ger\u00e7ekle\u015fti\u011fi ve kannabinoidler ile opioid sinyal yollar\u0131 aras\u0131nda bir \u00e7apraz etkile\u015fim oldu\u011fu g\u00f6r\u00fclmektedir. <\/p>\n\n\n\n

Kenevir ara\u015ft\u0131rmac\u0131lar\u0131, THC uygulamas\u0131n\u0131n v\u00fccutta endojen opioid peptidlerinin \u00fcretimini uyarabildi\u011fini ve bunun da zaten bilinen opioid resept\u00f6rlerine - delta ve kappa - ba\u011flanarak kannabinoid etkisine arac\u0131l\u0131k etti\u011fini bildirmektedir. <\/p>\n\n\n\n

Morfin uyguland\u0131\u011f\u0131nda \u00fc\u00e7\u00fcnc\u00fc bir opioid resept\u00f6r\u00fc olan mu da aktive olur. Bu \u00fc\u00e7 opioid resept\u00f6r\u00fcn\u00fcn aktivasyonu, tek ba\u015f\u0131na morfin veya THC tedavilerinin sonu\u00e7lar\u0131yla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda antinosiseptif etkinin (a\u011fr\u0131l\u0131 bir uyaran\u0131n alg\u0131lanmas\u0131n\u0131 engelleyen analjezi s\u00fcreci) etkinlik art\u0131\u015f\u0131n\u0131n a\u00e7\u0131klamas\u0131 olabilir.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A Ya\u015fam Bilimleri dergisi taraf\u0131ndan 2004 y\u0131l\u0131nda yay\u0131nlanan \u00e7al\u0131\u015fma<\/a> spesifik molek\u00fcller kullanarak opioid resept\u00f6r\u00fcn\u00fc inhibe ederek THC ve morfin aras\u0131ndaki ba\u011flant\u0131y\u0131 do\u011frulad\u0131. <\/p>\n\n\n\n

Engelleyici molek\u00fcllerin varl\u0131\u011f\u0131, morfinin etkinli\u011finin ve buna ba\u011fl\u0131 olarak terap\u00f6tik etkilerinin azalmas\u0131na neden olmu\u015ftur. <\/p>\n\n\n\n

Bu sonu\u00e7, bu resept\u00f6rlerin mevcudiyetinin ve morfin - ve THC - tedavi etkinli\u011fi i\u00e7in aktivasyonunun ne kadar \u00f6nemli oldu\u011funu do\u011frulamaktad\u0131r. Bir opioid antagonisti olan Naloxone ile yap\u0131lan ba\u015fka bir deney, ventral tegmental alan, hipotalamus ve periaqueductal gri (PAG) gibi beynin \u00e7e\u015fitli b\u00f6lgelerindeki THC aktivitesini bloke ederek bu b\u00f6lgelerin opioid-kanabinoid etkile\u015fimi i\u00e7in bir \u015fekilde \u00f6nemli oldu\u011funu d\u00fc\u015f\u00fcnd\u00fcrmektedir. <\/p>\n\n\n\n

\u00c7al\u0131\u015fmada ayr\u0131ca farelerin d\u00fc\u015f\u00fck dozlarda THC ve morfin ile birlikte tedavi edilmesinin dozaj opioid tolerans\u0131na yol a\u00e7mad\u0131\u011f\u0131 da bildirildi.<\/p>\n\n\n\n

Bu \u00e7al\u0131\u015fma ve di\u011fer bir\u00e7ok \u00e7al\u0131\u015fma, kannabinoidlerin bir araya geldiklerinde opioidlerin etkisini art\u0131rabilece\u011fi fikrini desteklemektedir. <\/p>\n\n\n\n

G\u00f6r\u00fcn\u00fc\u015fe g\u00f6re kannabinoidler opioidlerin tolerans\u0131n\u0131 ve ba\u011f\u0131ml\u0131l\u0131\u011f\u0131n\u0131 da de\u011fi\u015ftirebilmektedir. <\/p>\n\n\n\n

Opioidlerin uzun s\u00fcreli kullan\u0131mlar\u0131 genellikle hastalar\u0131n ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 ile ili\u015fkilidir ve ba\u015flang\u0131\u00e7ta sadece tedavi ama\u00e7l\u0131 olan bir maddenin k\u00f6t\u00fcye kullan\u0131lmas\u0131na yol a\u00e7ar. <\/p>\n\n\n\n

Bu nedenle, kannabinoid-opioid kombinasyonu - \u00f6rne\u011fin THC ve morfin - yeni bir analjezik kombine tedavi stratejisine d\u00f6n\u00fc\u015febilir ve doktorlar\u0131n hastalar\u0131n\u0131n y\u00fcksek opioid dozlar\u0131n\u0131 azaltmas\u0131na ve ayr\u0131ca hastalar\u0131n opioid k\u00f6t\u00fcye kullan\u0131m\u0131 ve ba\u011f\u0131ml\u0131l\u0131k d\u00fczeyini azaltmas\u0131na olanak tan\u0131yabilir. <\/p>\n\n\n\n

Kannabinoidlerin endojen opioidleri uyarmas\u0131 teorisinin yan\u0131 s\u0131ra, kannabinoid-opioid etkile\u015fim sisteminin ayr\u0131nt\u0131l\u0131 mekanizmas\u0131 hala belirsizli\u011fini korumaktad\u0131r. <\/p>\n\n\n\n

Potansiyel etki mekanizmas\u0131n\u0131 a\u00e7\u0131klamaya \u00e7al\u0131\u015fan hipotez, kannabinoidlerin opioid peptidlerin sentezini veya sal\u0131n\u0131m\u0131n\u0131 - her ikisini de - ind\u00fckleyebilece\u011fi, aktive olan opioid resept\u00f6rlerinin say\u0131s\u0131n\u0131 art\u0131rarak analjezik seviyelerle sonu\u00e7lanabilece\u011fidir. <\/p>\n\n\n\n

Hangi peptitlerin bu s\u00fcrece dahil oldu\u011fu da net de\u011fildir ya da bilinmemektedir; bu nedenle bilim insanlar\u0131n\u0131n bu molek\u00fcllerin yap\u0131s\u0131n\u0131 ve kannabinoidlerin opioid ba\u011f\u0131ml\u0131l\u0131\u011f\u0131na yard\u0131mc\u0131 olman\u0131n \u00f6tesinde analjezik etkiler \u00fcretmek i\u00e7in nas\u0131l kullan\u0131labilece\u011fini tam olarak anlamalar\u0131 \u00e7ok \u00f6nemli olacakt\u0131r. <\/p>\n\n\n\n

Bununla birlikte, genel olarak kannabinoidler \u015fa\u015f\u0131rt\u0131c\u0131 sonu\u00e7lar g\u00f6stermekte, t\u0131p uzmanlar\u0131 aras\u0131nda s\u00fcrekli yer edinmekte ve alternatif bir ila\u00e7 olarak potansiyelini kan\u0131tlamaktad\u0131r. <\/p>\n\n\n\n

Ara\u015ft\u0131rmac\u0131lar\u0131n kenevir bazl\u0131 ila\u00e7lar\u0131n insan v\u00fccudu i\u00e7in ger\u00e7ek faydalar\u0131n\u0131 ve olanaklar\u0131n\u0131 ve kenevir bitkisinin bir tedavi olarak kullan\u0131lmas\u0131n\u0131n m\u00fcmk\u00fcn olan en iyi se\u00e7enek oldu\u011funu tam olarak anlamalar\u0131 i\u00e7in birka\u00e7 \u00e7al\u0131\u015fma daha yap\u0131lmas\u0131 gerekmektedir.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Bu makaledeki infografi\u011fi be\u011fendiniz mi? T\u00fcm\u00fc simgeler<\/a> Bu makalede kullan\u0131lan - ve daha pek \u00e7o\u011fu - Mind the Graph'de mevcuttur. Mevcut \u00e7izimleri \u015furadan kontrol edebilirsiniz galeri<\/a>.<\/p>\n\n\n\n

Ve infografi\u011finize s\u0131f\u0131rdan ba\u015flaman\u0131za gerek yok, kullan\u0131c\u0131lar\u0131m\u0131za d\u00fczenlenebilir infografik \u015fablonlar\u0131 sunuyoruz, b\u00f6ylece bo\u015f bir tuvalden ba\u015flamalar\u0131na gerek kalm\u0131yor. Burada infografik \u015fablonlar\u0131n\u0131 g\u00f6rebilirsiniz.<\/a><\/p>\n\n\n\n

Ayr\u0131ca \u00fcst d\u00fczey bir aboneli\u011fe sahip olabilir ve s\u0131n\u0131rs\u0131z fig\u00fcr olu\u015fturabilirsiniz, ba\u015flamak i\u00e7in buraya t\u0131klay\u0131n<\/a>!<\/p>\n\n\n\n

Referanslar <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. T\u0131bbi ve T\u00fcketici Kannabidiol (CBD) Kullan\u0131m\u0131 ile Potansiyel Advers \u0130la\u00e7 Olaylar\u0131 ve \u0130la\u00e7-\u0130la\u00e7 Etkile\u015fimleri. Klinik T\u0131p Dergisi, s. 8, n. 7, 8 Temmuz 2019.<\/p>\n\n\n\n

CICHEWICZ, D. L. Kannabinoid ve opioid analjezikler aras\u0131ndaki sinerjik etkile\u015fimler. Life Sciences, v. 74, n. 11, p. 1317-1324, 30 jan. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. A\u011f\u0131r marihuana i\u00e7icilerinde naltrekson ve oral THC aras\u0131ndaki etkile\u015fim. Psychopharmacology, v. 166, n. 1, p. 77-85, 1 fev. 2003.<\/p>\n\n\n\n

KUHLEN, M. ve ark. Pediatrik palyatif bak\u0131mda dronabinol kullanarak spastisitenin etkili tedavisi. European Journal of Paediatric Neurology, v. 20, n. 6, p. 898-903, 1 nov. 2016.<\/p>\n\n\n\n

L\u00d6TSCH, J. ve ark. Hasta Kontroll\u00fc Analjezi ile \u0130la\u00e7 Etkile\u015fimleri. Clinical Pharmacokinetics, v. 41, n. 1, p. 31-57, 1 jan. 2002.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Esrar, Kanser D\u0131\u015f\u0131 Kronik A\u011fr\u0131 Tedavisinde Opioid Dozunu Azalt\u0131yor. Journal of Pain and Symptom Management, v. 25, n. 6, p. 496-498, 1 jun. 2003.<\/p>\n\n\n\n

MANZANARES, J. ve di\u011ferleri. Opioidler ve kannabinoidler aras\u0131ndaki farmakolojik ve biyokimyasal etkile\u015fimler. Trends in Pharmacological Sciences, v. 20, n. 7, p. 287-294, 1 jul. 1999.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. S\u0131\u00e7anlarda ayr\u0131mc\u0131l\u0131k, antinosisepsiyon ve lokomosyon \u00fczerinde THC-metadon ve THC-naltrekson etkile\u015fimleri. Behavioural Pharmacology, v. 22, n. 5 ve 6, s. 489-497, set. 2011.<\/p>\n\n\n\n

WELCH, S. P. Nosisepsiyonun mod\u00fclasyonunda kannabinoid ve opioid sistemlerinin etkile\u015fimi. International Review of Psychiatry, v. 21, n. 2, p. 143-151, 1 jan. 2009.<\/p>","protected":false},"excerpt":{"rendered":"

Ge\u00e7ti\u011fimiz on y\u0131lda bir\u00e7ok klinik \u00e7al\u0131\u015fma, n\u00f6ropatik a\u011fr\u0131 tedavileri i\u00e7in esrar bazl\u0131 ila\u00e7lar\u0131n kullan\u0131m\u0131nda olumlu ve umut verici sonu\u00e7lar bildirmi\u015ftir. Diyabet, kemoterapi, multipl skleroz, fibromiyalji, osteoartrit ve di\u011fer baz\u0131 hastal\u0131klara ba\u011fl\u0131 a\u011fr\u0131lar kenevir ile tedavi edilmi\u015ftir. G\u00f6r\u00fcn\u00fc\u015fe g\u00f6re, eksojen kannabinoidler ve opioid resept\u00f6rleri aras\u0131nda bir ba\u011flant\u0131 vard\u0131r ve bu da [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/esrar-ve-vucut-agrisi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/tr\/esrar-ve-vucut-agrisi\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-10T11:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T16:46:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cannabis and Body Pain - MTG","description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/tr\/esrar-ve-vucut-agrisi\/","og_locale":"tr_TR","og_type":"article","og_title":"Cannabis and Body Pain - MTG","og_description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","og_url":"https:\/\/mindthegraph.com\/blog\/tr\/esrar-ve-vucut-agrisi\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-02-10T11:13:00+00:00","article_modified_time":"2023-01-05T16:46:34+00:00","og_image":[{"width":1123,"height":612,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/","url":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/","name":"Cannabis and Body Pain - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-02-10T11:13:00+00:00","dateModified":"2023-01-05T16:46:34+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/#breadcrumb"},"inLanguage":"tr-TR","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Cannabis and Body Pain"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr-TR"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"tr-TR","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/tr\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/12274"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/comments?post=12274"}],"version-history":[{"count":3,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/12274\/revisions"}],"predecessor-version":[{"id":26008,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/posts\/12274\/revisions\/26008"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media\/12276"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/media?parent=12274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/categories?post=12274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/tr\/wp-json\/wp\/v2\/tags?post=12274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}