{"id":10456,"date":"2019-09-23T09:21:14","date_gmt":"2019-09-23T12:21:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10456"},"modified":"2022-10-14T11:21:45","modified_gmt":"2022-10-14T14:21:45","slug":"immune-cell-signalling","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/tr\/bagisiklik-hucre-sinyalleme\/","title":{"rendered":"Yeni bilimsel veriler: Ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi sinyalizasyonu i\u00e7in cevap zaman"},"content":{"rendered":"

Globulos brancos, v\u00fccudumuzu tehlikelere kar\u015f\u0131 korumaktan ve ya\u015fam\u0131m\u0131z\u0131 s\u00fcrd\u00fcrmekten sorumludur. <\/span>Peki, bu h\u00fccreler bir anneyi nas\u0131l tan\u0131mlar? <\/span>\u0130nsan v\u00fccudunun i\u00e7inde, trilh\u00f5es de c\u00e9lulas ile birlikte, elas precisam serec\u00edficas and precisas. <\/span>Tam tersi durumda, bize i\u00e7eriden sald\u0131rmaya geliyorlar. <\/span>Bu sorumluluk, zararl\u0131 antijenleri belirleme ve yok etmek \u00fczere i\u015faretleme konusunda uzmanla\u015fm\u0131\u015f ajanlar olan T c\u00e9lulas ombros'lar\u0131na aittir. <\/span>\u0130munes h\u00fccrelerinin s\u0131n\u0131fland\u0131r\u0131lmas\u0131yla ilgili en \u00f6nemli sorulardan biri, T h\u00fccrelerinin kendi \u00f6zel sa\u011fl\u0131k h\u00fccrelerimizden nas\u0131l ay\u0131rt edilece\u011fi ve hangisinin bizim i\u00e7in \u00f6nyarg\u0131l\u0131 oldu\u011fudur.<\/span><\/span><\/p>\n

\"c\u00e9lulas<\/a><\/p>\n

Geli\u015fme s\u0131ras\u0131nda, v\u00fccut farkl\u0131 tipte al\u0131c\u0131lara sahip milyonlarca T h\u00fccresi \u00fcretir. <\/span>Son olarak, v\u00fccudumuz gelece\u011fin ne saklad\u0131\u011f\u0131n\u0131 tam olarak bilmiyor. <\/span>Ama bu stratejide bir sorun var. <\/span>V\u00fccuda ait peptitleri tan\u0131mlayan resept\u00f6rlerle h\u00fccreler \u00fcretiyoruz. <\/span>Geli\u015fim s\u0131ras\u0131nda, bu \"\u00f6ncelikli\" molek\u00fcllere kar\u015f\u0131l\u0131k gelen T h\u00fccrelerinin b\u00fcy\u00fck bir k\u0131sm\u0131n\u0131 elimine ediyoruz. <\/span>Bununla birlikte, baz\u0131lar\u0131 ya\u015fam boyu dola\u015fmaya devam eder ve organizmaya zarar vermeden enfekte ve anormal h\u00fccrelere kar\u015f\u0131 koruma sa\u011flar.<\/span><\/span><\/p>\n

T h\u00fccrelerinin suda ya\u015fayan h\u00fccrelerimize zarar vermesini engelleyen nedir?<\/span><\/span><\/h3>\n

Controle optogen\u00e9tico ba\u015fl\u0131kl\u0131 yeni bir makale, sinemati\u011fin yeniden g\u00f6zden ge\u00e7irilmesinin T h\u00fccreleri resept\u00f6r\u00fcn\u00fcn etkinli\u011fini d\u00fczenledi\u011fini ve bu soruya yeni kan\u0131tlar getirdi\u011fini ortaya koymaktad\u0131r. <\/span>Weiner, um dos autores de um dos artigos, disse \u00e0 <\/span><\/span>Quanta Dergisi<\/span><\/span><\/a> que \" <\/span><\/span>Bir k\u00fcre, resept\u00f6r\u00fcn ba\u011flanma s\u00fcresinde \u00e7ok k\u00fc\u00e7\u00fck farkl\u0131l\u0131klar yaratabilir ve bunu \u00e7ok daha b\u00fcy\u00fck bir h\u00fccresel yan\u0131t i\u00e7in g\u00fc\u00e7lendirebilir\".<\/span><\/span><\/em><\/p>\n

\u0130mm\u00fcn h\u00fccrelerin sinalizasyonuna giden yol zamand\u0131r. <\/span>T h\u00fccrelerinin al\u0131c\u0131lar\u0131na en fazla be\u015f saniye ba\u011flanan maddeler g\u00fcvenli olarak kabul edilirken, daha uzun s\u00fcre ba\u011flanan h\u00fccreler yok edilmelidir.<\/span><\/span><\/h3>\n

Revis\u00e3o cin\u00e9tica olarak bilinen bu teori yeni de\u011fildir. <\/span>90'l\u0131 y\u0131llardan bu yana baz\u0131 ara\u015ft\u0131rmac\u0131lar, tan\u0131mlama i\u00e7in zaman\u0131 bir anahtar olarak \u00f6nermektedir. <\/span><\/span>Bununla birlikte, hipotez testleri, sineztika revizyonunun da g\u00f6sterdi\u011fi gibi, liga\u00e7\u00e3o s\u00fcresi ile T h\u00fccrelerinin ativa\u00e7\u00e3o'su aras\u0131nda \u00f6nerilen korelasyonlar bulmu\u015ftur, ancak bu test y\u00f6ntemleri, zaman\u0131n etkilerini, h\u00fccrelerdeki de\u011fi\u015fiklikler ve ba\u011flanma yap\u0131s\u0131ndaki farkl\u0131l\u0131klar gibi di\u011fer biyofiziksel fakt\u00f6rlerin etkilerinden ay\u0131rmay\u0131 ba\u015faramam\u0131\u015ft\u0131r. <\/span><\/span><\/em>Daha da \u00f6nemlisi, ara\u015ft\u0131rmac\u0131lar, \u00f6l\u00e7emedikleri ya da s\u0131ralayamad\u0131klar\u0131 bir\u00e7ok potansiyel \u00f6neme sahip parametrenin dikkate al\u0131nd\u0131\u011f\u0131n\u0131 bilmektedirler.<\/span><\/span><\/p>\n

\u0130mm\u00fcn h\u00fccre sinalizasyonunda yeni optogenetik veriler<\/span><\/span><\/h2>\n

\u00a0Optogen\u00e9tica, h\u00fccreleri kontrol etmek i\u00e7in \u0131\u015f\u0131\u011f\u0131 kullanan bir ara\u015ft\u0131rma alan\u0131d\u0131r. <\/span>T\u00fcm \u00e7al\u0131\u015fma t\u00fcrlerinde protein-protein etkile\u015fimlerini kontrol etmek i\u00e7in bu y\u00f6ntemi kullanan bilim insanlar\u0131 var. <\/span>\u015eu anda, biri Almanya'da di\u011feri S\u00e3o Francisco'da bulunan iki ara\u015ft\u0131rma ekibi, im\u00fcn h\u00fccrelerinin sinalizasyonunu ara\u015ft\u0131rmak i\u00e7in bu teknolojiyi kullanmaktad\u0131r. <\/span>Bu iki \u00e7al\u0131\u015fma aras\u0131ndaki farkl\u0131l\u0131klara ra\u011fmen, ara\u015ft\u0131rmac\u0131lar benzer sonu\u00e7lar elde etmi\u015flerdir: bir liga\u00e7\u00e3o olay\u0131 be\u015f saniyeden fazla s\u00fcrd\u00fc\u011f\u00fcnde, bir T h\u00fccresi aktif hale gelmi\u015ftir, ancak bunu bundan daha az bir s\u00fcre i\u00e7in ger\u00e7ekle\u015ftirememi\u015ftir.<\/span><\/span><\/p>\n

Bunun neden b\u00f6yle oldu\u011fu ise hen\u00fcz net de\u011fil. <\/span>Ancak ara\u015ft\u0131rmac\u0131lar \u015fu soruya yan\u0131t ar\u0131yor: \" <\/span><\/span>Bir T h\u00fccresi resept\u00f6r\u00fcn\u00fcn bir h\u00fccreye ba\u011fland\u0131\u011f\u0131 andan itibaren, bir h\u00fccrenin aktif hale gelmesinden \u00f6nce bir dizi biyoqu\u00edmicas irrevers\u00edveis etap olu\u015fmas\u0131 gerekir. E\u011fer bir molik\u00fcl bu sinalizasyon a\u015famas\u0131 s\u0131ras\u0131nda \u00e7ok fazla cedo kaybederse, her \u015fey ilk a\u015famadan itibaren yeniden kazan\u0131lmal\u0131d\u0131r.\".\u00a0<\/span><\/span><\/em><\/p>\n

Her zaman oldu\u011fu gibi, yeni bir yan\u0131t yeni sorular do\u011furur. <\/span>\u00d6ncekinden biraz daha fazlas\u0131n\u0131 biliyoruz, ama yine de ke\u015ffetmek i\u00e7in bir bilinmez evrenimiz var.<\/span><\/span><\/p>\n

\"grafi\u0307k<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Globulos brancos, v\u00fccudumuzu tehlikelere kar\u015f\u0131 koruyarak hayatta kalmam\u0131z\u0131 sa\u011flar. Peki bu h\u00fccreler bir tehlikeyi nas\u0131l tan\u0131mlar? \u0130nsan v\u00fccudunun i\u00e7inde, trilh\u00f5es de c\u00e9lulas ile, bunlar \u00f6zel ve kesin olmal\u0131d\u0131r. Aksi durumda, i\u00e7ten i\u00e7e bize sald\u0131rmaya ba\u015flarlar. Bu sorumluluk, T c\u00e9lulas ombros'u, bu konuda uzmanla\u015fm\u0131\u015f ajanlar\u0131 [...] gerektirir.<\/p>","protected":false},"author":11,"featured_media":10461,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[302,361,360,299,318,354,256],"yoast_head":"\nNew scientific data: time is the immune cell response<\/title>\n<meta name=\"description\" content=\"One of the biggest questions on immune cell signalling is how the T cells distinguish our own healthy cells and what is harmful for us.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/tr\/bagisiklik-hucre-sinyalleme\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"New scientific data: time is the immune cell 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