{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/utmarkelse-zika-virus-infektion\/","title":{"rendered":"Zikaviruset: Den prisbel\u00f6nta studien som s\u00e4tter nytt ljus p\u00e5 de l\u00e5ngsiktiga konsekvenserna"},"content":{"rendered":"

Det \u00e4r alltid fantastiskt att visa v\u00e5ra anv\u00e4ndares vetenskapliga arbete. S\u00e5 idag ska jag presentera den brasilianska forskaren Isis de Souza och hennes arbete med zikaviruset. Isis och hennes kollegor studerar effekterna av zikavirusinfektion tidigt i livet hos m\u00f6ss. Hon anv\u00e4nder ocks\u00e5 Mind the Graph och vinnarpresentationen har visuella resurser fr\u00e5n Mind the Graph. Vi kunde inte vara mer stolta.<\/p>\n

Vad \u00e4r zikaviruset?<\/strong><\/h3>\n

Zikaviruset tillh\u00f6r familjen Flaviviridae. I denna grupp ing\u00e5r flera patogena virus. Det mest k\u00e4nda \u00e4r gula febern-viruset, typviruset f\u00f6r familjen och \u00e4ven anledningen till familjenamnet, eftersom ordet flavus betyder \"gul\" p\u00e5 latin. Andra flavivirus \u00e4r West Nile-virus, denguevirus och f\u00e4stingburet encefalitvirus.<\/p>\n

Familjen Flaviviridae har en gemensam storlek (40-65 nm) och virush\u00f6ljen som t\u00e4cker deras skyddande ikosaedriska nukleokapsid. Det genetiska materialet \u00e4r ocks\u00e5 RNA och de syns i elektronmikroskopet.<\/p>\n

Infografiken nedan visar den grundl\u00e4ggande strukturen hos zikaviruset:<\/p>\n

\"f\u00f6rhandsgranskning_90481\"<\/a><\/p>\n

 Zika smittar fr\u00e4mst via kvinnliga Stegomya aegypti<\/em> mygga, som beh\u00f6ver blod f\u00f6r att l\u00e4gga \u00e4gg. Myggan \u00e4r mest aktiv under dagtid.<\/p>\n

Vinnartidningen<\/strong><\/h2>\n

P\u00e5 senare tid har m\u00e5nga forskare studerat de neurologiska st\u00f6rningar som \u00e4r relaterade till medf\u00f6dd exponering f\u00f6r zikavirus (ZIKV).<\/p>\n

Dessutom \u00e4r kongenital mikrocefali en av de mest markanta effekterna som rapporterats hos ZIKV-infekterade nyf\u00f6dda. D\u00e4rf\u00f6r \u00e4r forskningsinsatserna inriktade p\u00e5 att f\u00f6rst\u00e5 mekanismerna bakom ZIKV-inducerad kongenital mikrocefali.<\/p>\n

Endast 1 till 13% av de exponerade fostren uppvisar dock fysiska missbildningar vid f\u00f6dseln. Dessutom saknas det information om de l\u00e5ngsiktiga konsekvenserna av en perinatal infektion.<\/p>\n

D\u00e4rf\u00f6r anv\u00e4nde Isis de Souza och hennes kollegor m\u00f6ss f\u00f6r att studera beteendem\u00e4ssiga och neuropatologiska tillst\u00e5nd samt kort- och l\u00e5ngsiktiga konsekvenser och publicerade resultaten i en artikel med titeln Akuta och kroniska neurologiska konsekvenser av zikavirusinfektion tidigt i livet hos m\u00f6ss.<\/strong><\/p>\n

Hos m\u00e4nniskor finns det m\u00e5nga kliniska tillst\u00e5nd i samband med exponering f\u00f6r zikavirus som upptr\u00e4der m\u00e5nader eller \u00e5r efter f\u00f6dseln. S\u00e5 \u00e4ven om barnen inte f\u00f6ds med mikrocefali kan de f\u00e5 motoriska funktionsneds\u00e4ttningar, kortikal dysplasi i samband med kramper och andra neurologiska st\u00f6rningar.<\/p>\n

Enligt f\u00f6rfattarna har de \"infekterade nyf\u00f6dda vildtypsm\u00f6ss systemiskt med ZIKV och utf\u00f6rde en l\u00e5ngsiktig uppf\u00f6ljning av de beteendem\u00e4ssiga, neuropatologiska och molekyl\u00e4ra konsekvenserna av infektion. Vi rapporterar kort- och l\u00e5ngsiktiga komplikationer efter ZIKV-infektion hos m\u00f6ss och visar att tidig neutralisering av tum\u00f6rnekrosfaktor-\u03b1 (TNF-\u03b1) delvis f\u00f6rhindrar dessa skadliga effekter. V\u00e5ra resultat avsl\u00f6jar behovet av s\u00e4rskild uppm\u00e4rksamhet p\u00e5 en potentiell b\u00f6rda av neuropatologiska komplikationer hos barn och ungdomar efter medf\u00f6dd exponering f\u00f6r ZIKV och tyder p\u00e5 att tidig h\u00e4mning av neuroinflammation kan vara en potentiell behandling f\u00f6r att f\u00f6rhindra l\u00e5ngsiktiga neurologiska f\u00f6ljder hos ZIKV-infekterade sp\u00e4dbarn.\"<\/em><\/p>\n

 Priset delas ut av GE Healthcare Life Sciences<\/strong><\/h2>\n

\"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" eller Young Talent Award in Life Sciences \u00e4r ett pris som delas ut av Brazilian Society of Biochemistry and Molecular Biology och GE Healthcare Life Sciences. En vetenskaplig kommitt\u00e9 valde ut fem kandidater som fick presentera sitt arbete vid den \u00e5rliga kongressen, ett evenemang som sammanf\u00f6r professorer och studenter fr\u00e5n hela Latinamerika.<\/p>\n

Kommitt\u00e9n valde Isis de Oliveira och hon presenterade sin studie av konsekvenserna av exponering f\u00f6r zikaviruset.<\/p>\n

\"vetenskaplig
Isis de Oliveira presenterar sina resultat<\/figcaption><\/figure>\n

Hon skrev ett inl\u00e4gg d\u00e4r hon tackade sitt universitet och det stipendium som m\u00f6jliggjorde hennes studier. Dessutom uttryckte hon sin f\u00f6rhoppning om att den framtida generationen ska f\u00e5 m\u00f6jlighet att forts\u00e4tta en vetenskaplig karri\u00e4r som hon hade gjort.<\/p>\n

S\u00e5 vi vill gratulera Isis till hennes fantastiska arbete! Jag hoppas att hon inspirerar fler m\u00e4nniskor att bli forskare med sitt arbete.<\/p>\n

Och om du vill g\u00f6ra dina data mer visuella f\u00f6r att kommunicera b\u00e4ttre inom vetenskap, kan du prova Mind the Graph:<\/p>\n

\"T\u00e4nk<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Det \u00e4r alltid fantastiskt att visa v\u00e5ra anv\u00e4ndares vetenskapliga arbete. S\u00e5 idag ska jag presentera den brasilianska forskaren Isis de Souza och hennes arbete med zikaviruset. Isis och hennes kollegor studerar effekterna av zikavirusinfektion tidigt i livet hos m\u00f6ss. Hon \u00e4r ocks\u00e5 en mind the graph-anv\u00e4ndare och vinnarpresentationen har [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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