{"id":8728,"date":"2019-04-23T16:35:01","date_gmt":"2019-04-23T19:35:01","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8728"},"modified":"2022-10-18T08:23:59","modified_gmt":"2022-10-18T11:23:59","slug":"visual-abstract-example","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/visuellt-abstrakt-exempel\/","title":{"rendered":"Visuellt abstrakt skapat av anv\u00e4ndaren f\u00f6r att f\u00f6rklara forskningsrapporten \"Optimized Small-Molecule Pull-Downs Define MLBP1 as an Acyl-Lipid-Binding Protein\" av Yelena Sterlin"},"content":{"rendered":"

En visuell abstraktion \u00e4r inte l\u00e4tt att skapa, men den \u00e4r h\u00e4r f\u00f6r att stanna. S\u00e5 vi \u00e4lskar alltid att visa upp v\u00e5ra anv\u00e4ndares fantastiska arbete som ett inspirerande exempel p\u00e5 visuell abstraktion. Vi vill ge forskare m\u00f6jlighet att skapa en mer visuell och l\u00e4ttillg\u00e4nglig vetenskap.<\/p>\n

I inl\u00e4gget kommer jag att visa dig lite av den ursprungliga forskningen av Jelena Sterlin<\/a> och medarbetare. Hon \u00e4r doktorand vid fakulteten f\u00f6r jordbruk, livsmedel och milj\u00f6 vid Hebrew University of Jerusalem.<\/p>\n

Hennes nya uppsats Optimerade sm\u00e5molekyl\u00e4ra pull-downs definierar MLBP1 som ett acyl-lipidbindande protein<\/a> <\/strong>belyser protein-metabolit-interaktioner i v\u00e4xter, med fokus p\u00e5 abscisinsyra (ABA)-receptorer. Hon \u00e4r ocks\u00e5 en \"mind the graph\"-abonnent, s\u00e5 hon skapade en infografik i T\u00e4nk p\u00e5 grafen<\/a> att f\u00f6rklara sin metod.<\/p>\n

Betydelsen av START-dom\u00e4nrelaterade proteiner<\/strong><\/h2>\n

 <\/p>\n

Enligt Tidskriften Nature<\/a>Abscisinsyra (ABA) \u00e4r det viktigaste fytohormonet som \u00e4r involverat i abiotisk stressrespons och dess anpassning. Det \u00e4r ocks\u00e5 ett kandidat\u00e4mne f\u00f6r jordbrukskemikalier. ABA uppt\u00e4cktes f\u00f6r f\u00f6rsta g\u00e5ngen p\u00e5 1960-talet. Sedan dess har det visat sig vara en viktig regulator f\u00f6r s\u00e5 olika processer som vilol\u00e4ge, groning, fr\u00f6utveckling och reaktioner p\u00e5 biotisk och abiotisk stress.<\/p>\n

De tidigaste h\u00e4ndelserna som involverar ABA-signalv\u00e4gen involverar ABA-bindning till PYR\/PYL\/RCARs-receptorer. Receptorerna tillh\u00f6r superfamiljen START-dom\u00e4ner.<\/p>\n

START-proteindom\u00e4nerna \u00e4r en lipidbindande dom\u00e4n som finns i arvsmassan hos bakterier, protister, j\u00e4st, v\u00e4xter och djur. De \u00e4r dock vanligare i v\u00e4xter. Enligt Schrick<\/a>F\u00f6rekomsten av START-dom\u00e4ner i evolution\u00e4rt avl\u00e4gsna arter som djur och v\u00e4xter tyder p\u00e5 en bevarad mekanism f\u00f6r interaktion mellan proteiner och lipider\/steroler.<\/p>\n

Artikeln publicerades i Tidskriften f\u00f6r v\u00e4xter<\/a> fokuserar p\u00e5 PYR\/PYL\/RCARs ABA-receptorer. Forskarna best\u00e4mde sig f\u00f6r att optimera en metod f\u00f6r identifiering av START-dom\u00e4ner och START-dom\u00e4nrelaterade proteinligander i v\u00e4xter, eftersom \"START-dom\u00e4nproteinliganderna \u00e4r n\u00f6dv\u00e4ndiga f\u00f6r att deras protein skall fungera korrekt b\u00e5de hos djur och v\u00e4xter, och START-dom\u00e4nproteiner i v\u00e4xter har visat sig vara inblandade i viktiga fysiologiska processer\".<\/em><\/p>\n

En visuell sammanfattning av metoden<\/strong><\/h2>\n

 <\/p>\n

F\u00f6r att f\u00f6rklara sin metodik skapade forskarna en infografik med grafillustrationer. Det \u00e4r i\u00f6gonfallande och l\u00e4ttare att f\u00f6rst\u00e5. <\/strong><\/h4>\n

 <\/p>\n

Infografiken nedan visar det experimentella arbetsfl\u00f6det. Som du kan se uttryckte och renade de fyra START-proteinerna. De filtrerade och inkuberade supernatanten som inneh\u00f6ll den nativa l\u00f6sliga fraktionen med streptavidinsefaros, ett affinitetsharts f\u00f6r tillf\u00f6rlitlig och h\u00f6g-uppl\u00f6sande rening av biomolekyler. D\u00e4refter analyserade de alikvoter med hj\u00e4lp av western blot. F\u00f6r att identifiera liganden eluerade de putativa ligander och utsattes f\u00f6r en LC -MS (v\u00e4tskekromatografi och masspektrometri) systemanalys. De molekyl\u00e4ra strukturerna hos de f\u00f6rmodade liganderna av intresse best\u00e4mdes med tandem-masspektrometri.<\/p>\n

 <\/p>\n

\"visuell<\/p>\n

F\u00f6rfattarna presenterade en bra teknik f\u00f6r inledande sondering av proteinligander i v\u00e4xter. De anpassade metoden f\u00f6r att uppt\u00e4cka START-ligander. Det g\u00e5r dock att anpassa metoden till ligander av olika kemisk natur genom att justera de analytiska f\u00f6rh\u00e5llandena.<\/p>\n

Om du vill visa din forskning med hj\u00e4lp av vetenskapliga illustrationer och visuella sammanfattningar kan du ocks\u00e5 anv\u00e4nda Mind the Graph. S\u00e5, \u00e4r du redo att f\u00f6rb\u00e4ttra din kommunikation inom vetenskap?<\/p>\n

\"f\u00f6rhandsgranskning_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

En visuell abstraktion \u00e4r inte l\u00e4tt att skapa, men den \u00e4r h\u00e4r f\u00f6r att stanna. S\u00e5 vi \u00e4lskar alltid att visa upp v\u00e5ra anv\u00e4ndares fantastiska arbete som ett inspirerande exempel p\u00e5 visuell abstraktion. Vi vill ge forskare m\u00f6jlighet att skapa en mer visuell och l\u00e4ttillg\u00e4nglig vetenskap. I inl\u00e4gget kommer jag att visa dig lite av [...]<\/p>","protected":false},"author":11,"featured_media":8741,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[193,40],"tags":[291,96,292,245,294,295,554,775,293,382],"yoast_head":"\nVisual abstract created by Mind the Graph user. Attractive scientific figure!<\/title>\n<meta name=\"description\" content=\"See the visual abstract created by the MindtheGraph subscriber Yelena Sterling to explain her research in an attractive and instructive way. 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