{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/alzheimers-sjukdom\/","title":{"rendered":"Alzheimers sjukdom: En vetenskaplig infografik"},"content":{"rendered":"

Det \u00e4r alltid lika roligt n\u00e4r vi f\u00e5r se v\u00e5ra anv\u00e4ndares fantastiska arbete.\u00a0Jag har redan skrivit<\/a> om den forskning som bedrivs av dr Alessandra Martini, dr.\u00a0Stefania Forner<\/a>\u00a0och deras kollegor. De \u00e4r postdoktorala forskare vid University of California och bryr sig om grafanv\u00e4ndarna. F\u00f6r n\u00e5gra m\u00e5nader sedan visade jag Infografik<\/a>\u00a0Dr. Stefania Forner skapade f\u00f6r \u00f6versiktsartikeln som publicerades i Trends in Neurosciences med titeln Synaptic impairment in Alzheimer's Disease: En dysreglerad symfoni.<\/p>\n

Idag vill jag prata om deras nya \u00f6versiktsartikel med titeln Fr\u00e5n historia till framtid: vad djurmodeller har l\u00e4rt oss om Alzheimers sjukdom.<\/a><\/p>\n

Alzheimers sjukdom (AD) \u00e4r en neurodegenerativ sjukdom som orsakar kognitiva st\u00f6rningar och minnesf\u00f6rlust. Att f\u00f6rst\u00e5 sjukdomsmekanismen \u00e4r viktigt f\u00f6r att f\u00f6rb\u00e4ttra livskvaliteten f\u00f6r patienterna och hitta en effektiv behandling. Trots enorma anstr\u00e4ngningar inom den akademiska v\u00e4rlden och l\u00e4kemedelsindustrin finns det idag inga effektiva behandlingar tillg\u00e4ngliga. Alzheimers sjukdom \u00e4r den sj\u00e4tte vanligaste d\u00f6dsorsaken i USA och drabbar 35 miljoner m\u00e4nniskor runt om i v\u00e4rlden.<\/p>\n

Infografik om Alzheimers sjukdom<\/h2>\n

 <\/p>\n

Majoriteten av AD-patienterna \u00e4r \u00e4ldre personer som ofta lider av en rad olika samsjukligheter. Diabetes, osteoporos, njursjukdom, fetma, h\u00f6gt blodtryck och hypercholes-terolemi\/dyslipidemi, stroke och krampanfall \u00e4r de huvudsakliga komorbiditeter som p\u00e5verkar uppkomsten och utvecklingen av Alzheimers sjukdom och som g\u00f6r sjukdomens patogenes \u00e4n mer komplicerad.<\/p>\n

\"infografik
Infografik som visar komorbiditet vid Alzheimers sjukdom (AD). Fr\u00e5n historia till framtid: Vad djurmodeller har l\u00e4rt oss om Alzheimers sjukdom<\/figcaption><\/figure>\n

 <\/p>\n

\n

Trots intensiva forskningsinsatser under de senaste decennierna \u00e4r mekanismerna bakom etiologin f\u00f6r sporadisk AD (sAD), som representerar den vanligaste formen av sjukdomen, fortfarande ok\u00e4nda. Detta beror, \u00e5tminstone delvis, p\u00e5 att majoriteten av sAD-patienterna \u00e4r \u00e4ldre personer som ofta lider av en rad olika komorbiditeter (t.ex. stroke, stress, diabetes, kramper, osteoporos och njursjukdom).<\/em><\/p>\n<\/blockquote>\n

N\u00e4sta infografik visar hur tau- och beta-amyloidoligomerer bildas och hur de p\u00e5verkar synaptisk toxicitet.<\/p>\n

 <\/p>\n

\"Infografik
Fr\u00e5n historia till framtid: Vad djurmodeller har l\u00e4rt oss om Alzheimers sjukdom<\/figcaption><\/figure>\n

 <\/p>\n

\n

Vid tauopati minskar antalet dendritiska ryggar. Tau kommer inte in i neuronens k\u00e4rna, vilket leder till DNA-skador. Det sker en minskning av antalet mitokondrier och \u00e4ven av antalet presynaptiska vesiklar, vilket leder till synaptisk f\u00f6rlust. F\u00f6rlusten beror ocks\u00e5 p\u00e5 att tau kommer in i dendriterna och de postsynaptiska omr\u00e5dena. Tau aggregerar ocks\u00e5 extracellul\u00e4rt, vilket g\u00f6r att det kan f\u00e5ngas upp av andra nervceller.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Hon skapade ocks\u00e5 en infografik f\u00f6r att visa inflammatoriska mekanismer kopplade till Alzheimers sjukdom (AD)<\/p>\n

 <\/p>\n

\"Infografico<\/p>\n

 <\/p>\n

\n

Under de senaste \u00e5ren har vi varit s\u00e4rskilt intresserade av att f\u00f6rst\u00e5 hur inflammation p\u00e5verkar beta-amyloid- och tau-patologi. \u00c4ldre personer \u00e4r k\u00e4nsliga f\u00f6r virus- och bakterieinfektioner, och dessa mikrobiella agens kan f\u00f6rv\u00e4rra det befintliga inflammatoriska tillst\u00e5ndet i hj\u00e4rnan och p\u00e5skynda den kognitiva f\u00f6rs\u00e4mringen.<\/em><\/p>\n<\/blockquote>\n

Grattis Dr. Stefania Forner f\u00f6r ditt fantastiska arbete!<\/p>\n

Om du \u00e4r forskare och vill skapa vackra figurer f\u00f6r din avhandling kan du bli en mind the graph-anv\u00e4ndare just nu.<\/p>\n

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Det \u00e4r alltid lika roligt n\u00e4r vi f\u00e5r se v\u00e5ra anv\u00e4ndares fantastiska arbete. Jag har redan skrivit om Alessandra Martini, Stefania Forner och deras kollegors forskning. De \u00e4r postdoktorala forskare vid University of California och anv\u00e4nder grafen. F\u00f6r n\u00e5gra m\u00e5nader sedan visade jag infografiken som Dr. Stefania Forner skapade f\u00f6r \u00f6versiktsartikeln som publicerades i Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sv_se\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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