{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/autofagi-vinner-nobelpris-i-medicin\/","title":{"rendered":"Autofagi f\u00e5r Nobelpriset i medicin"},"content":{"rendered":"

Autofagiprocessen \u00e4r inblandad i flera tillst\u00e5nd, t.ex. cancer och neurologiska sjukdomar. Den fungerar som kroppens interna \u00e5tervinningsprogram. En st\u00f6rd autofagi har dock kopplats till Parkinsons sjukdom, diabetes, cancer och andra \u00e5ldersrelaterade sjukdomar.<\/p>\n

Efter denna lilla introduktion om autofagiprocessens betydelse \u00e4r det ingen \u00f6verraskning att nya uppt\u00e4ckter inom detta omr\u00e5de kan leda till ett Nobelpris. Faktum \u00e4r att forskaren Yoshino Ohsumi f\u00f6rra m\u00e5ndagen vann Nobelpriset i medicin<\/a> f\u00f6r att ha identifierat de f\u00f6rsta viktiga generna f\u00f6r autofagi.<\/p>\n

\"Jag k\u00e4nner mig inte bekv\u00e4m med att t\u00e4vla med m\u00e5nga m\u00e4nniskor, utan jag tycker att det \u00e4r roligare att g\u00f6ra n\u00e5got som ingen annan g\u00f6r. P\u00e5 s\u00e4tt och vis \u00e4r det vad vetenskap handlar om, och gl\u00e4djen \u00f6ver att hitta n\u00e5got inspirerar mig.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Hur gjorde Ohsumi det?<\/h3>\n

I sitt laboratorium hade Ohsumi konstruerat j\u00e4ststammar som ackumulerade autofagosomer under sv\u00e4lt. Denna ackumulering kunde bara ha skett om viktiga gener f\u00f6r autofagi var inaktiva. Ohsumi b\u00f6rjade d\u00e4rf\u00f6r manipulera cellerna med flera genmutationer och lyckades p\u00e5 s\u00e5 s\u00e4tt inducera autofagi.<\/p>\n

\"Autofagi<\/a><\/p>\n

Autofagi har funnits l\u00e4nge<\/h3>\n

\u00c4ven om autofagi har varit k\u00e4nt under de senaste 50 \u00e5ren var det f\u00f6rst p\u00e5 1990-talet i och med Ohsumis studier som man ins\u00e5g hur viktig denna process \u00e4r.
\nF\u00f6r sitt arbete har Ohsumi redan f\u00e5tt n\u00e5gra fans:<\/p>\n

\"Autofagi<\/a><\/p>\n

\n

\"Jag \u00e4r mycket glad \u00f6ver att han har f\u00e5tt \u00e5rets Nobelpris, det \u00e4r mycket v\u00e4lf\u00f6rtj\u00e4nt. Hans labb arbetar huvudsakligen med j\u00e4st. De gjorde de f\u00f6rsta screeningarna som m\u00f6jliggjorde uppt\u00e4ckten av viktiga gener som \u00e4r involverade i autofagi. S\u00e5 m\u00e5nga andra laboratorier har utnyttjat hans uppt\u00e4ckter, direkt eller indirekt, f\u00f6r att se varf\u00f6r de \u00e4r viktiga f\u00f6r sjukdomar.\"<\/p>\n

David Rubinsztein<\/a> - bitr\u00e4dande direkt\u00f6r f\u00f6r Cambridge Institute for Medical Research<\/p>\n<\/blockquote>\n

\"Autofagi<\/a><\/p>\n

\n

\"Jag tycker att det \u00e4r mycket viktigt att detta vetenskapsomr\u00e5de uppm\u00e4rksammas. Den viktiga principen h\u00e4r \u00e4r att s\u00f6ka efter gemensamma mekanismer i sjukdomar. Det \u00f6ppnar upp m\u00f6jligheter att behandla dessa sjukdomar som skiljer sig fr\u00e5n mer konventionella sjukdomsspecifika metoder.\"<\/p>\n

Giovanna Mallucci<\/a> - professor i klinisk neurovetenskap vid University of Cambridge<\/p>\n<\/blockquote>\n

\"Autofagi<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Autofagiprocessen \u00e4r inblandad i flera tillst\u00e5nd, t.ex. cancer och neurologiska sjukdomar. Den fungerar som kroppens interna \u00e5tervinningsprogram. En st\u00f6rd autofagi har dock kopplats till Parkinsons sjukdom, diabetes, cancer och andra \u00e5ldersrelaterade sjukdomar. Efter denna lilla introduktion om autofagiprocessens betydelse \u00e4r det ingen \u00f6verraskning att nya uppt\u00e4ckter [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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