{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-hogupplost-synkrotronbaserad-x-ray-mikrotomografi-som-verktyg-for-att-avtacka-den-tre-dimensionella-neuronala-arkitekturen-i-hjarnan\/","title":{"rendered":"H\u00f6guppl\u00f6st synkrotronbaserad r\u00f6ntgenmikrotomografi som ett verktyg f\u00f6r att avsl\u00f6ja den tredimensionella neuronala arkitekturen i hj\u00e4rnan Paper Review"},"content":{"rendered":"

R\u00f6ntgenmikrotomografi har utvecklats till en ny metod f\u00f6r att avbilda hj\u00e4rnans cytoarkitektur och konnektivitet, och h\u00e4r presenterar vi en metod f\u00f6r avbildning av hela nervceller.<\/p>\n\n\n\n

H\u00f6guppl\u00f6st synkrotronbaserad r\u00f6ntgenmikrotomografi som ett verktyg f\u00f6r att avsl\u00f6ja den tredimensionella neuronala arkitekturen i hj\u00e4rnan<\/strong><\/h2>\n\n\n\n

I artikeln \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" konstaterar Matheus de Castro Fonseca et al. (2018) att studiet av neuroner som individualiserade enheter har sin b\u00f6rjan p\u00e5 1800-talet med skapandet av neurondoktrinen. <\/p>\n\n\n\n

Under de senaste \u00e5ren har stora anstr\u00e4ngningar gjorts f\u00f6r att f\u00f6rst\u00e5 neuronal organisation och konnektivitet i intakta hj\u00e4rnprover. Golgi-Cox-m\u00e4rkningstekniken erbjuder en l\u00e4mplig kontrast f\u00f6r specifik m\u00e4rkning av neuroner f\u00f6r r\u00f6ntgenmikrotomografi. <\/p>\n\n\n\n

Neuroner har en distinkt morfologi och specifika m\u00f6nster av konnektivitet, vilket \u00e4r avg\u00f6rande f\u00f6r att de ska fungera korrekt. Forskarna presenterar en avbildningsmetod som kombinerar synkrotronbaserad r\u00f6ntgenmikrotomografi med Golgi-Cox impregneringsprotokoll. <\/p>\n\n\n\n

Metoden ger en h\u00f6gre och mer homogen kontrast av relativt glest f\u00f6rdelade hela nervceller i v\u00e4vnaden.<\/p>\n\n\n\n

Hj\u00e4rnorna inkuberades i Golgi-Cox f\u00e4rgningsl\u00f6sning i 14 dagar, skyddade fr\u00e5n ljus. Efter inkubationsperioden snittades hj\u00e4rnorna seriellt med hj\u00e4lp av en vibratom.<\/strong><\/p>\n\n\n\n

Kontrollera originalartikel h\u00e4r<\/a>.<\/p>\n\n\n\n

Grafisk sammanfattning baserad p\u00e5 Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Tillverkad med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

F\u00f6rfattaren anv\u00e4nde Mind the Graph<\/a> f\u00f6r att skapa en schematisk illustration som f\u00f6rest\u00e4ller en vuxen mus som injiceras i.p. med saltl\u00f6sning eller pilokarpinl\u00f6sning (280 mg\/kg). Att representera komplexa processer med infografik \u00e4r ett bra s\u00e4tt att g\u00f6ra dem l\u00e4ttf\u00f6rst\u00e5eliga, utan att gl\u00f6mma bort detaljer och viktig information.<\/p>\n\n\n\n

Vissa av forskarnas resultat verkar bef\u00e4sta det som tidigare var k\u00e4nt om detta omr\u00e5de: \"Den kvicksilverbaserade impregnering av neuroner som visades h\u00e4r gjorde det m\u00f6jligt f\u00f6r oss att tydligt definiera hela neuroner, fr\u00e4mst p\u00e5 grund av en mer kontinuerlig och homogen impregnering av cellerna och mycket minskad densitet av artefakter\", f\u00f6reslog de Castro Fonseca.<\/p>\n\n\n\n

Pappers p\u00e5verkan och prestanda<\/strong><\/h2>\n\n\n\n

Vi kan analysera med Altmetrisk<\/a> uppgifter om att denna tidnings uppm\u00e4rksamhetspo\u00e4ng online \u00e4r h\u00f6gre \u00e4n 64%<\/strong><\/strong> av alla andra artiklar av liknande \u00e5lder i Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
K\u00e4lla Altmetri<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

F\u00f6rb\u00e4ttra din artikels tillg\u00e4nglighet med hj\u00e4lp av infografik.<\/p>\n\n\n\n

\n
F\u00f6rs\u00f6k Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Titta n\u00e4rmare p\u00e5 den nya metoden f\u00f6r att dechiffrera hj\u00e4rnans cytoarkitektur och konnektivitet som visas med Mind the Graph:s illustrationer.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-hogupplost-synkrotronbaserad-x-ray-mikrotomografi-som-verktyg-for-att-avtacka-den-tre-dimensionella-neuronala-arkitekturen-i-hjarnan\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-hogupplost-synkrotronbaserad-x-ray-mikrotomografi-som-verktyg-for-att-avtacka-den-tre-dimensionella-neuronala-arkitekturen-i-hjarnan\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-08T21:14:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:54+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-hogupplost-synkrotronbaserad-x-ray-mikrotomografi-som-verktyg-for-att-avtacka-den-tre-dimensionella-neuronala-arkitekturen-i-hjarnan\/","og_locale":"sv_SE","og_type":"article","og_title":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","og_description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-hogupplost-synkrotronbaserad-x-ray-mikrotomografi-som-verktyg-for-att-avtacka-den-tre-dimensionella-neuronala-arkitekturen-i-hjarnan\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-08T21:14:00+00:00","article_modified_time":"2023-03-17T17:47:54+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_2.jpg","twitter_misc":{"Written by":"Artur Zignani","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/","name":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-08T21:14:00+00:00","dateModified":"2023-03-17T17:47:54+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/#breadcrumb"},"inLanguage":"sv-SE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sv-SE"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"sv-SE","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/sv_se\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16630"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/comments?post=16630"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16630\/revisions"}],"predecessor-version":[{"id":27198,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16630\/revisions\/27198"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/media\/20013"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/media?parent=16630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/categories?post=16630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/tags?post=16630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}