{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-zika-virus-replikerar-i-hjarnvavnad-hos-vuxna-manniskor-och-forsvagar-synapser-och-minne-i-moss\/","title":{"rendered":"Zikaviruset replikeras i hj\u00e4rnv\u00e4vnad hos vuxna m\u00e4nniskor och f\u00f6rs\u00e4mrar synapser och minne hos m\u00f6ss Paper Review"},"content":{"rendered":"

ZIKV \u00e4r ett farligt virus som h\u00e4rjar i v\u00e4rlden. D\u00e4rf\u00f6r studerar f\u00f6rfattaren i detta fall dess replikering i den vuxna m\u00e4nskliga hj\u00e4rnan.<\/p>\n\n\n\n

Zikavirus (ZIKV) infekterar hj\u00e4rnv\u00e4vnad hos vuxna och orsakar minnesst\u00f6rningar hos m\u00f6ss<\/strong><\/h2>\n\n\n\n

En grupp fr\u00e5n School of Pharmacy under ledning av Claudia Figueiredo (2019) studerade hur zikaviruset replikeras i hj\u00e4rnv\u00e4vnad fr\u00e5n vuxna m\u00e4nniskor och f\u00f6rs\u00e4mrar synapser och minne hos m\u00f6ss. Zikaviruset \u00e4r ett arbovirus som tillh\u00f6r familjen Flaviviridae och som nyligen orsakade ett stort utbrott i Latinamerika. <\/p>\n\n\n\n

ZIKV har hittats i hj\u00e4rnan och CSF hos vuxna patienter. NS2B-immunreaktivitet samlokaliserades med NeuN-immunreaktiva celler, men inte med GFAP eller F4\/80, vilket tyder p\u00e5 att neuroner \u00e4r m\u00e5ltavla f\u00f6r ZikV i den mogna m\u00e4nskliga v\u00e4vnaden. Hos vuxna immunkompetenta m\u00f6ss som infekterats med intracerebroventrikul\u00e4r infusion av ZIKV detekteras h\u00f6ga niv\u00e5er av ZikV-RNA i frontala kortex och hippocampus, och mogna neuroner \u00e4r den huvudsakliga infekterade celltypen. <\/p>\n\n\n\n

F\u00f6rh\u00f6jda niv\u00e5er av TNF-\u03b1 i hj\u00e4rnan, intensiv mikroglios, uppreglerat uttryck av komplementsystemets proteiner (C1q och C3) och skador p\u00e5 hippocampus synapser verifieras.<\/p>\n\n\n\n

Studien omfattade 9 lika stora kvadranter.<\/strong><\/p>\n\n\n\n

Kontrollera originalartikel h\u00e4r<\/a>.<\/p>\n\n\n\n

Grafiska sammanfattningar som drivs av Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Tillverkad med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Den f\u00f6rsta figuren visar fallet d\u00e4r fragment av kortikal v\u00e4vnad fr\u00e5n m\u00e4nniskans temporallob snittades i 400 \u00b5m-skivor och h\u00f6lls i odling i 4 dagar f\u00f6re inkubering med ZIKV (107 PFU) eller mockmedium i 1 timme, f\u00f6ljt av urtv\u00e4ttning. <\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Tillverkad med Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Den andra visar att vuxna m\u00f6ss fick en infusion av 105 PFU ZIKV, UV-inaktiverat ZIKV eller l\u00e5tsasmedium i den laterala ventrikeln i hj\u00e4rnan.<\/p>\n\n\n\n

Slutsatserna verkar bekr\u00e4fta vad som tidigare varit k\u00e4nt om detta \u00e4mne: \"ZIKV \u00e4r riktat mot minnesrelaterade hj\u00e4rnregioner oavsett om infektionsv\u00e4gen \u00e4r central eller perifer. Viruset har p\u00e5visats i CSF hos vuxna patienter med neurologiska komplikationer\", h\u00e4vdade Figueiredo.<\/p>\n\n\n\n

De f\u00f6resl\u00e5r att framtida studier som syftar till att unders\u00f6ka de l\u00e5ngsiktiga neurodegenerativa effekterna av ZIKV-infektion \u00e4r motiverade. Att identifiera s\u00e4tt att f\u00f6rhindra signalavvikelser som leder till hj\u00e4rndysfunktion kan bana v\u00e4g f\u00f6r interventionsstrategier f\u00f6r att f\u00f6rdr\u00f6ja eller f\u00f6rhindra utvecklingen av allvarliga neurologiska tillst\u00e5nd.<\/p>\n\n\n\n

Pappers p\u00e5verkan och prestanda<\/strong><\/h2>\n\n\n\n

Vi kan analysera med Altmetrisk<\/a> uppgifter om att denna tidnings uppm\u00e4rksamhetspo\u00e4ng online \u00e4r h\u00f6gre \u00e4n 95%<\/strong><\/strong> av alla andra artiklar av liknande \u00e5lder i Nature<\/strong> Tidskrifter.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
K\u00e4lla Altmetrisk<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Anv\u00e4nd kraften i infografik f\u00f6r att boosta din artikel ocks\u00e5! Starta en skapelse p\u00e5 Mind the Graph.<\/p>\n\n\n\n

\n
F\u00f6rs\u00f6k Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Studien handlar om ZIKV i den vuxna m\u00e4nniskans hj\u00e4rna, ett farligt virus som h\u00e4rjar i v\u00e4rlden. Processen anv\u00e4nder Mind the Graph-illustrationer.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-zika-virus-replikerar-i-hjarnvavnad-hos-vuxna-manniskor-och-forsvagar-synapser-och-minne-i-moss\/\" \/>\n<meta property=\"og:locale\" content=\"sv_SE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-zika-virus-replikerar-i-hjarnvavnad-hos-vuxna-manniskor-och-forsvagar-synapser-och-minne-i-moss\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-06T20:57:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:48:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-zika-virus-replikerar-i-hjarnvavnad-hos-vuxna-manniskor-och-forsvagar-synapser-och-minne-i-moss\/","og_locale":"sv_SE","og_type":"article","og_title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","og_description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","og_url":"https:\/\/mindthegraph.com\/blog\/sv_se\/framgang-fall-zika-virus-replikerar-i-hjarnvavnad-hos-vuxna-manniskor-och-forsvagar-synapser-och-minne-i-moss\/","og_site_name":"Mind the Graph Blog","article_published_time":"2022-09-06T20:57:00+00:00","article_modified_time":"2023-03-17T17:48:05+00:00","og_image":[{"width":1125,"height":614,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg","type":"image\/jpeg"}],"author":"Artur Zignani","twitter_card":"summary_large_image","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg","twitter_misc":{"Written by":"Artur Zignani","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","url":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","name":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2022-09-06T20:57:00+00:00","dateModified":"2023-03-17T17:48:05+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02"},"description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/#breadcrumb"},"inLanguage":"sv-SE","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sv-SE"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/b44995c1d77b52a63b6d11262b740b02","name":"Artur Zignani","image":{"@type":"ImageObject","inLanguage":"sv-SE","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/a211ec97011fe24f7a8e63a7ca799342?s=96&d=mm&r=g","caption":"Artur Zignani"},"url":"https:\/\/mindthegraph.com\/blog\/sv_se\/author\/artur\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16621"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/users\/29"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/comments?post=16621"}],"version-history":[{"count":5,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16621\/revisions"}],"predecessor-version":[{"id":27199,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/posts\/16621\/revisions\/27199"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/media\/20048"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/media?parent=16621"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/categories?post=16621"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sv_se\/wp-json\/wp\/v2\/tags?post=16621"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}