{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/genetik-for-tupplurar\/","title":{"rendered":"Genetik f\u00f6r tupplurar: Hur en tupplur kan p\u00e5verka den genetiska variationen"},"content":{"rendered":"

Att ta en tupplur under dagen \u00e4r f\u00f6r de flesta ett k\u00e4rt n\u00f6je.<\/p>\n\n\n

\n
\"Garfield<\/a><\/figure><\/div>\n\n\n

F\u00f6r det mesta \u00e4r det ocks\u00e5 en vana som ing\u00e5r i den dagliga rutinen. Det \u00e4r mycket vanligt hos m\u00e5nga arter, fr\u00e5n flugor till d\u00e4ggdjur.<\/p>\n\n\n\n

En tupplur kan ocks\u00e5 f\u00f6rb\u00e4ttra vakenheten, vilket \u00e4r viktigt f\u00f6r dem som arbetar sent p\u00e5 kv\u00e4llen eller som vanligtvis har s\u00f6mnbrist.<\/p>\n\n\n\n

Det s\u00e4gs ocks\u00e5 kunna bidra till att f\u00f6rb\u00e4ttra prestationsf\u00f6rm\u00e5gan, minnet och lindra stress. <\/p>\n\n\n\n

Men bortsett fr\u00e5n dessa f\u00f6rdelar kan de l\u00e5ngsiktiga konsekvenserna av att ta en tupplur vara kroniska f\u00f6r individens v\u00e4lbefinnande.<\/p>\n\n\n\n

\u00c4ven om detta \u00e4r ett kontroversiellt \u00e4mne och orsaken kan bero p\u00e5 flera faktorer i samband med nappning som otillr\u00e4cklig s\u00f6mncykel, d\u00e5lig kost eller d\u00e5lig h\u00e4lsa.<\/p>\n\n\n\n

\u00c4r en tupplur under dagen din happy hour? Forskare h\u00e4vdar motsatsen. <\/strong><\/p>\n\n\n\n

En grupp forskare analyserade effekterna av tupplurar genom genetiska variationer.<\/p>\n\n\n\n

Deras studie gick ut p\u00e5 att f\u00f6rst\u00e5 den genetiska variationen hos olika individer genom deras preferenser f\u00f6r s\u00f6mnens l\u00e4ngd och preferenser.<\/p>\n\n\n\n

F\u00f6r n\u00e4rvarande har den genomomfattande associationsstudien uppt\u00e4ckt cirka sju genetiska loci som motsvarar tupplurar under dagen.<\/p>\n\n\n\n

Forskarna anv\u00e4nde deltagarna i UK Biobank av europeisk h\u00e4rkomst (n=452 633) av vilka cirka 38,2% svarade att de ibland tog en tupplur, och 5,3% svarade att de alltid tog en tupplur under dagen.<\/p>\n\n\n\n

De som tog en tupplur var n\u00e4stan alltid \u00e4ldre m\u00e4n med h\u00f6gt BMI eller body mass index, som hade diagnostiserats med s\u00f6mnst\u00f6rningar, var r\u00f6kare eller pension\u00e4rer. De genomf\u00f6rde en genome-wide association study (GWAS) med genetiska varianter av h\u00f6g kvalitet som omfattade cirka fyra lakh-deltagare. Detta gjordes genom att \u00e4ndra de olika faktorer som tidigare hittats.<\/p>\n\n\n\n

De lyckades identifiera 123 genetiska loci tillsammans med en arvbarhet baserad p\u00e5 singelnukleotidpolymorfism p\u00e5 cirka 11,9%.<\/p>\n\n\n\n

De begr\u00e4nsade sin GWAS till individer med h\u00f6gre BMI. <\/p>\n\n\n\n

Det visade sig att av 123 loci var 110 av dem inte signifikanta f\u00f6r hela genomet.<\/p>\n\n\n\n

De analyserade ocks\u00e5 skillnaden i s\u00f6mnm\u00f6nster hos de olika k\u00f6nen i samband med X-kromosomen. <\/p>\n\n\n\n

Dessutom kom de fram till vilka gener som var ansvariga f\u00f6r hypersomnolens vid fetma: PNOC (prepronociceptin), <\/em>och PATJ (komponent f\u00f6r polaritet i smulceller).<\/em><\/p>\n\n\n\n

Dessutom koloniserades uttrycket av FADS1-genen (Fatty Acid Desaturase), vilket tyder p\u00e5 att lipidmetabolismen har en pleiotropisk effekt p\u00e5 s\u00f6mnm\u00f6nstret.<\/p>\n\n\n\n

De andra korrelationerna uppfattades i f\u00f6rh\u00e5llande till den genomomfattande genetiken tillsammans med egenskaper som glykemiskt index, antropometriska egenskaper samt kardiometaboliska egenskaper, varav m\u00e5nga korrelationer minskade efter redovisning av BMI. <\/p>\n\n\n\n

Dessutom bidrog de resultat som analyserades av den fenomomfattande associationen med hj\u00e4lp av den genomomfattande polygeniska analysen av dagslurar till korrelationen mellan sjukdomar relaterade till fetma, h\u00f6gt blodtryck och framf\u00f6r allt vissa kardiometaboliska sjukdomar. <\/p>\n\n\n\n

Sammanfattningsvis \u00e4r deras resultat en \u00f6gon\u00f6ppnare. Ibland \u00e4r det s\u00e5dana vanor som leder till flera o\u00f6nskade komplikationer i v\u00e5ra kroppar. Man m\u00e5ste f\u00f6lja en h\u00e4lsosam rutin och goda livsstilsvanor. <\/p>\n\n\n

\n
\"man<\/a><\/figure><\/div>\n\n\n

Om du vill veta mer om deras forskning, kolla in referensen nedan.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. et al.<\/em> Genetiska determinanter f\u00f6r dagslurar och effekter p\u00e5 kardiometabol h\u00e4lsa. Nat Kommun<\/em> 12, 900 (2021). DOI: https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

I Mind the Graph Gallery kan du hitta m\u00e5nga genetikrelaterade illustrationer. Klicka p\u00e5 bilden nedan f\u00f6r att kolla in den.<\/p>\n\n\n

\n
\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

Att ta en tupplur under dagen \u00e4r f\u00f6r de flesta ett k\u00e4rt n\u00f6je. F\u00f6r det mesta \u00e4r det ocks\u00e5 en vana som inf\u00f6rlivas i den dagliga rutinen. Det \u00e4r mycket vanligt hos m\u00e5nga arter, fr\u00e5n flugor till d\u00e4ggdjur. Tupplurar \u00e4r ocks\u00e5 f\u00f6rknippade med f\u00f6rb\u00e4ttrad vakenhet, vilket \u00e4r viktigt f\u00f6r dem som arbetar sent p\u00e5 kv\u00e4llen eller de som \u00e4r [...]<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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