{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sv_se\/coronavirus-covid-19-ar-hydroxiklorokin-det-nya-hoppet-tydligen-ja\/","title":{"rendered":"Coronaviruset (covid-19): \u00e4r hydroxiklorokin det nya hoppet? Tydligen ja."},"content":{"rendered":"

Tv\u00e5 nya artiklar som sammanfattade en in vitro-unders\u00f6kning och en liten klinisk studie r\u00e4ckte f\u00f6r att Donald Trump skulle f\u00e5 FDA att inf\u00f6ra en ny klinisk indikation f\u00f6r hydroxiklorokin: f\u00f6rb\u00e4ttra symtomen hos patienter som drabbats av coronaviruset (covid-19).<\/p>\n

Detta \u00e4r f\u00f6rmodligen den snabbaste processen f\u00f6r godk\u00e4nnande av ett l\u00e4kemedel i modern tid, och presidenten har uppenbarligen r\u00e4tt. F\u00f6rv\u00e5nande f\u00f6r en global ledare som inte har mycket till \u00f6vers f\u00f6r vetenskap.<\/p>\n

\"\"<\/p>\n

De f\u00f6rsta bevisen f\u00f6r att hydroxiklorokin p\u00e5verkar viruset kom fr\u00e5n denna artikel publicerades ig\u00e5r p\u00e5 Cell Discovery<\/a>Det \u00e4r bara in vitro, med alla begr\u00e4nsningar, men det visar tydligt l\u00e4kemedlets potential att d\u00f6da viruset. N\u00e4r de l\u00e4mnade in artikeln hade 80 000 fall bekr\u00e4ftats i Kina, inklusive 2946 d\u00f6dsfall, samt \u00f6ver 10 566 bekr\u00e4ftade fall i 72 andra l\u00e4nder. Vid den tidpunkten stod det st\u00f6rsta hoppet till ett l\u00e4kemedel som kallas remdesivir.<\/p>\n

\"hydroklorokins
In vitro-effekter av hydroklorokin p\u00e5 coronavirus (Covid-19). Kolumnen till h\u00f6ger visar effekterna av det effektiva l\u00e4kemedlet, i motsats till klorokin eller kontrollgruppen till v\u00e4nster. Det visar att l\u00e4kemedlet f\u00f6rb\u00e4ttrade cellernas f\u00f6rm\u00e5ga att driva ut virusen... det \u00e4r som att hj\u00e4lpa till att sparka ut en o\u00f6nskad granne fr\u00e5n ditt hus. Det hj\u00e4lper! \ud83d\ude42 ... <\/figcaption><\/figure>\n

Men den st\u00f6rsta nyheten kom fr\u00e5n en sm\u00e5skalig klinisk studie som publicerades dagen innan. Titeln \u00e4r Hydroxiklorokin och azitromycin som behandling av covid-19: resultat av en \u00f6ppen icke-randomiserad klinisk pr\u00f6vning och kan laddas ner i sin \"in press\"-version<\/a><\/p>\n

I en studie med endast 20 patienter visade f\u00f6rfattarna att hydroxiklorokin var effektivt mot covid-19-infektionen. Faktum \u00e4r att det minskade 75% av infekterade individer under 6-dagarsperioden, vilket \u00e4r fantastiskt. \u00c4nnu b\u00e4ttre \u00e4n s\u00e5 var att kombinationen med azitromycin f\u00f6rb\u00e4ttrade behandlingseffekten till 95%.<\/p>\n

\"Kombinationsbehandling
Kombinationsbehandling med hydroklorokin och azitromycin \u00e4r effektivt mot infektioner med coronavirus (covid-19) hos m\u00e4nniskor. Minskningen \u00e4r dramatisk och ger nytt hopp till drabbade patienter.<\/figcaption><\/figure>\n

Behandlingen f\u00f6rb\u00e4ttrade symtomen och minskade samtidigt virusbelastningen hos patienterna. L\u00e4kemedlet har tidigare godk\u00e4nts f\u00f6r behandling av malaria, vilket inneb\u00e4r att det anses vara s\u00e4kert. \"Systerl\u00e4kemedlet\" klorokin var mindre effektivt. Bra f\u00f6r oss, eftersom det \u00e4r \u00e4nnu giftigare.<\/p>\n

Studien var icke-randomiserad och sm\u00e5skalig, men det verkar som om epidemin b\u00f6rjade i Kina, men att l\u00f6sningen kommer fr\u00e5n en global samh\u00e4llsinsats. In vitro-artikeln \u00e4r faktiskt kinesisk, medan den kliniska \u00e4r europeisk, n\u00e4rmare best\u00e4mt fr\u00e5n Frankrike. Intressant nog kommer den ursprungliga l\u00e4kemedelsregistreringen f\u00f6r hydroxiklorokin fr\u00e5n det franska l\u00e4kemedelsf\u00f6retaget Sanofi, och den senaste kliniska studien genomf\u00f6rdes i Marseille. Ale le bleu!<\/p>\n

Medscape har en utm\u00e4rkt artikel om detta, f\u00f6r dem som \u00e4r intresserade av mer detaljerad information.<\/a><\/p>\n

V\u00e4nligen citera detta arbete som Gautret et al. (2020) Hydroxiklorokin och azitromycin som en behandling av COVID-19: resultat av en \u00f6ppen icke-randomiserad klinisk pr\u00f6vning. International Journal of Antimicrobial Agents - I tryck 17 mars 2020 - DOI: 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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