{"id":8713,"date":"2019-04-18T18:07:31","date_gmt":"2019-04-18T21:07:31","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8713"},"modified":"2022-10-18T08:24:00","modified_gmt":"2022-10-18T11:24:00","slug":"brain-damage-pig-brains-alive-hours-death","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/mozganska-poskodba-svincjih-mozganov-na-zivih-urah-smrti\/","title":{"rendered":"Po\u0161kodbe mo\u017eganov: infografika za razumevanje novega \u010dlanka Nature"},"content":{"rendered":"

Znanstveniki z univerze Yale so pra\u0161i\u010dje mo\u017egane zunaj telesa ohranili \u017eive \u0161e ve\u010d ur po smrti. Dokument Obnovitev mo\u017eganskega krvnega obtoka in celi\u010dnih funkcij nekaj ur po smrti<\/strong> pojasnjuje poskus z uporabo pra\u0161i\u010djih mo\u017eganov, ki lahko osvetli raziskave mo\u017eganskih po\u0161kodb. Revija Nature\u00a0objavljeno <\/a>dokument 17. aprila.<\/p>\n

\"Ve\u010dino \u010dlove\u0161ke zgodovine je bila smrt zelo preprosta,\"<\/em> pravi Christof Koch. Je predsednik in glavni znanstvenik In\u0161tituta Allen za znanost o mo\u017eganih v Seattlu v ameri\u0161ki zvezni dr\u017eavi Washington. \"Zdaj se moramo vpra\u0161ati, kaj je nepovratno.\"\u00a0<\/em><\/p>\n

V teh mo\u017eganih ni komunikacije med nevroni, zato ni bilo zavesti. Toda celice so bile \u017eive - in \u017ee to je zelo pomembno odkritje.<\/p>\n

\"Dosedanje ugotovitve so pokazale, da se v celicah v bistvu v nekaj minutah za\u010dne proces celi\u010dne smrti,\"<\/em>\u00a0je na novinarski konferenci povedal Nenad Sestan, nevroznanstvenik z univerze Yale, ki je vodil raziskavo. \"Pokazali smo, da je proces celi\u010dne smrti postopen, in nekatere od teh procesov je mogo\u010de odlo\u017eiti, ohraniti ali celo obrniti.\"<\/em><\/p>\n

Poskus s po\u0161kodbami mo\u017eganov<\/strong><\/h3>\n

Po podatkih revije Nature Magazine so raziskovalci preverili, kako dobro so se mo\u017egani obna\u0161ali v \u0161esturnem obdobju. Ugotovili so, da so nevroni in druge mo\u017eganske celice ponovno vzpostavili normalne presnovne funkcije, kot sta poraba sladkorja in proizvodnja ogljikovega dioksida. Zdi se, da je deloval tudi imunski sistem mo\u017eganov. Strukture posameznih celic in delov mo\u017eganov so bile ohranjene. Nasprotno pa so celice v kontrolnih mo\u017eganih, ki niso prejeli raztopine, bogate s hranili in kisikom, propadle. Ko so znanstveniki vzorce tkiva iz zdravljenih mo\u017eganov napeljali z elektriko, so ugotovili, da lahko posamezni nevroni \u0161e vedno prena\u0161ajo signal.<\/p>\n

Znanstveniki so ustvarili sistem, imenovan BrainEx, posebej zasnovan za oslabitev nekaterih procesov, ki so odgovorni za razgradnjo tkiva v posmrtnih mo\u017eganih. Sistem vklju\u010duje \u010drpanje raztopine, imenovane perfuzat BEx. Raztopina je patentirana me\u0161anica za\u0161\u010ditnih, stabilizacijskih in kontrastnih sredstev, ki delujejo kot nadomestek krvi. Perfuzat vsebuje tudi kemikalije, ki zaustavljajo oksidacijo telesnega tkiva, kar zaustavlja apoptozo. Vsebuje tudi blokator nevronske aktivnosti, katerega namen je dvojen. Raztopino so \u010drpali v glavne arterije izoliranih mo\u017eganov pri normalni telesni temperaturi.<\/p>\n

 <\/p>\n

\"pra\u0161i\u010di\"<\/a>
Slika v \u010dlanku prikazuje, kako so bili celotni mo\u017egani povezani z napravo BEx. Mo\u017egani pra\u0161i\u010da so bili s perfuzijskim sistemom povezani prek arterijskih linij.\u00a0<\/strong><\/figcaption><\/figure>\n

 <\/p>\n

Raziskovalci so uporabili pribli\u017eno 300 pra\u0161i\u010djih glav iz klavnice ameri\u0161kega ministrstva za kmetijstvo. Po optimizaciji tehnologije je ekipa na sistem BrainEx priklju\u010dila 32 pra\u0161i\u010djih mo\u017eganov. Povezavo so izvedli \u0161tiri ure po zakolu pra\u0161i\u010dev in po odstranitvi mo\u017eganov iz lobanj. To ra\u010dunalni\u0161ko omre\u017eje \u010drpalk, grelnikov in filtrov je \u0161est ur nadzorovalo pretok, temperaturo in patentirano raztopino perfuzata.<\/p>\n

Infografika za razumevanje poskusa<\/strong><\/h2>\n

 <\/p>\n

\"predogled_77833<\/a><\/p>\n

 <\/p>\n

Infografiko sem ustvaril s programom Mind the Graph. \u010ce \u017eelite uporabiti privla\u010dne znanstvene ilustracije in s svojimi raziskavami dose\u010di ve\u010d ljudi, lahko uporabite tudi Mind the Graph!<\/p>\n

\"predogled_250\"<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Znanstveniki z univerze Yale so pra\u0161i\u010dje mo\u017egane zunaj telesa ohranili \u017eive \u0161e ve\u010d ur po smrti. V \u010dlanku Restoration of brain circulation and cellular functions hours post-mortem je pojasnjen poskus z uporabo pra\u0161i\u010djih mo\u017eganov, ki lahko osvetli raziskave mo\u017eganskih po\u0161kodb. Revija Nature je \u010dlanek objavila 17. aprila. \"Ve\u010dino \u010dlove\u0161ke zgodovine je bila smrt zelo preprosta,\" [...]<\/p>","protected":false},"author":11,"featured_media":8721,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[54,288,287,286,282,554,71,964,775,70],"yoast_head":"\nBrain damage: an infographic to understand the new Nature paper - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Scientists from Yale University kept pig brains alive for hours after death. 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