{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/alzheimerjeva-bolezen\/","title":{"rendered":"Alzheimerjeva bolezen: Znanstvena infografika"},"content":{"rendered":"

Ko vidimo neverjetno delo na\u0161ih uporabnikov, je to vedno praznik.\u00a0Sem \u017ee napisal<\/a> o raziskavah dr. Alessandre Martini, dr.\u00a0Stefania Forner<\/a>\u00a0in njihovi sodelavci. So podoktorski raziskovalci na Univerzi v Kaliforniji in skrbijo za uporabnike grafov. Pred nekaj meseci sem pokazal infografike<\/a>\u00a0Dr. Stefania Forner je pripravila pregledni \u010dlanek, objavljen v reviji Trends in Neurosciences, z naslovom Synaptic impairment in Alzheimer's Disease: A disregulated symphony.<\/p>\n

Danes \u017eelim govoriti o njihovem novem preglednem \u010dlanku z naslovom Iz preteklosti v prihodnost: kaj so nas \u017eivalski modeli nau\u010dili o Alzheimerjevi bolezni.<\/a><\/p>\n

Alzheimerjeva bolezen je nevrodegenerativna bolezen, ki povzro\u010da kognitivne motnje in izgubo spomina. Razumevanje mehanizma bolezni je pomembno za izbolj\u0161anje kakovosti \u017eivljenja bolnikov in iskanje u\u010dinkovitega zdravljenja. Kljub velikim prizadevanjem akademske sfere in farmacevtske industrije danes \u0161e ni na voljo u\u010dinkovitega zdravljenja. Alzheimerjeva bolezen je \u0161esti najpogostej\u0161i vzrok smrti v ZDA in prizadene 35 milijonov ljudi po vsem svetu.<\/p>\n

Infografike o Alzheimerjevi bolezni<\/h2>\n

 <\/p>\n

Ve\u010dina bolnikov z Alzheimerjevo boleznijo so starej\u0161i ljudje, ki imajo \u0161tevilne spremljajo\u010de bolezni. Sladkorna bolezen, osteoporoza, ledvi\u010dne bolezni, debelost, hipertenzija in hiperholezija\/dislipidemija, mo\u017eganska kap in napadi so glavne spremljajo\u010de bolezni, ki vplivajo na nastanek in napredovanje Alzheimerjeve bolezni, kar dodatno zaplete patogenezo bolezni.<\/p>\n

\"infografika
Infografika, ki prikazuje so\u010dasne bolezni pri Alzheimerjevi bolezni (AD). Iz preteklosti v prihodnost: Kaj so nam o Alzheimerjevi bolezni povedali \u017eivalski modeli?<\/figcaption><\/figure>\n

 <\/p>\n

\n

Kljub intenzivnim raziskavam v zadnjih nekaj desetletjih mehanizmi etiologije sporadi\u010dne Alzheimerjeve bolezni, ki je najpogostej\u0161a oblika bolezni, ostajajo neznani. Vsaj deloma je to posledica dejstva, da je ve\u010dina bolnikov s sAD starej\u0161ih oseb, ki pogosto trpijo zaradi razli\u010dnih so\u010dasnih bolezni (npr. mo\u017eganska kap, stres, sladkorna bolezen, napadi, osteoporoza in ledvi\u010dne bolezni).<\/em><\/p>\n<\/blockquote>\n

Naslednja infografika prikazuje nastanek in mehanizme sinapti\u010dne toksi\u010dnosti tau in beta-amiloidnih oligomerov.<\/p>\n

 <\/p>\n

\"infografico
Iz preteklosti v prihodnost: Kaj so nam o Alzheimerjevi bolezni povedali \u017eivalski modeli?<\/figcaption><\/figure>\n

 <\/p>\n

\n

Pri tauopatijah se zmanj\u0161a \u0161tevilo dendriti\u010dnih hrbtenic. Tau ne vstopa v jedro nevrona, kar povzro\u010da po\u0161kodbe DNK. Zmanj\u0161a se \u0161tevilo mitohondrijev in tudi \u0161tevilo presinapti\u010dnih veziklov, kar vodi v izgubo sinapti\u010dnih celic. Ta izguba je tudi posledica vstopa tau v dendrite in postsinapti\u010dna obmo\u010dja. Tau se tudi zunajceli\u010dno agregira, kar omogo\u010da, da ga ujamejo drugi nevroni.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Pripravila je tudi infografiko, ki prikazuje vnetne mehanizme, povezane z Alzheimerjevo boleznijo.<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

V zadnjih nekaj letih nas \u0161e posebej zanima, kako vnetje vpliva na patologijo beta-amiloida in tau. Starej\u0161i ljudje so dovzetni za virusne in bakterijske oku\u017ebe, ti mikrobni povzro\u010ditelji pa bi lahko poslab\u0161ali obstoje\u010de vnetno stanje v mo\u017eganih in pospe\u0161ili upad kognitivnih sposobnosti.<\/em><\/p>\n<\/blockquote>\n

Pohvale Dr. Stefania Forner za va\u0161e odli\u010dno delo!<\/p>\n

\u010ce ste znanstvenik in \u017eelite ustvariti \u010dudovite slike za svoj \u010dlanek, lahko zdaj postanete uporabnik programa mind the graph.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Ko vidimo neverjetno delo na\u0161ih uporabnikov, je to vedno praznik. Pisal sem \u017ee o raziskavi Dr. Alessandre Martini, Dr. Stefanie Forner in njihovih sodelavcev. So podoktorske raziskovalke na Univerzi v Kaliforniji in mislijo na uporabnike grafa. Pred nekaj meseci sem pokazal infografike, ki jih je Dr. Stefania Forner ustvarila za pregledni \u010dlanek, objavljen v reviji Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sl\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:56:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:30:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: A scientific infographic - 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