{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/zika-virus-graphical-abstract\/","title":{"rendered":"Virus Zika Grafi\u010dni povzetek o mikrocefaliji"},"content":{"rendered":"

Razumeti grafi\u010dni povzetek virusa Zika: kako zmanj\u0161uje velikost mo\u017eganov<\/h3>\n

Danes je raziskava dodala zanimive dokaze o vlogi virusa Zika pri okvarah \u017eiv\u010dnega tkiva. Ah, da, preden vpra\u0161ate, \u010dlove\u0161ko \u017eiv\u010dno tkivo.<\/p>\n

To je elegantno storila skupina Dr. Stevensa Rehena, mednarodno priznanega raziskovalca na podro\u010dju raziskav mati\u010dnih celic in v zadnjem \u010dasu tudi reprogramiranja celic.<\/p>\n

Spodnja slika povzema ugotovitve papir<\/a>, vendar ga bom posku\u0161al na kratko razlo\u017eiti.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Ta pregleden grafi\u010dni izvle\u010dek virusa Zika je bil narejen s programom Mind the graph. Ali ni kul?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Kot lahko vidite na zgornji sliki, so bili v tej raziskavi uporabljeni trije razli\u010dni pristopi. Vsi so potrdili, da virus Zika neposredno vpliva na to, kako se mo\u017eganske celice razvijajo v ustrezno nevronsko tkivo, kar se imenuje tudi \"okvara mo\u017eganov\".\"Virus<\/a>Mikrocefalija je le ena od mo\u017eganskih malformacij. Iz \u010dlanka je razvidno, da gre za nekaj \u0161e bolj temeljnega.<\/p>\n

Pokazali so, kako virus Zika:<\/p>\n

    \n
  1. Spodbuja celi\u010dno smrt<\/li>\n
  2. Povzro\u010di morfolo\u0161ke spremembe (v nevrosferah)<\/li>\n
  3. zmanj\u0161a rast\/velikost mo\u017eganskih organoidov (mini mo\u017eganov)<\/li>\n<\/ol>\n

    Vse to so na\u010dini, kako virus Zika vpliva na nevrogenezo med razvojem \u010dlove\u0161kih mo\u017eganov in povzro\u010di fenotip, ki ga vidite spodaj.<\/p>\n

    \"Virus<\/a><\/p>\n

    <\/h3>\n

    Zakaj tega niso storili \u017ee prej?<\/h3>\n

    Prelomni pristop je bila uporaba mati\u010dnih celic inducirane pluripotentnosti (iPS celic) za preu\u010devanje virusnih oku\u017eb v \u010dlove\u0161kih celicah.<\/p>\n

    S tem postopkom se somatska celica, pridobljena od osebe, reprogramira v prvotno stanje pluripotentne celice in se lahko nato diferencira v razli\u010dne celice, tkiva in v zadnjem \u010dasu tudi organe. To je sam za\u010detek \"in\u017eenirstva \u010dlove\u0161kih tkiv\".<\/p>\n

    V \u0161tudiji avtorji niso uporabili le celic iPS, temve\u010d so ustvarili tudi mo\u017eganski organoidi<\/a>, imenovanih tudi \"mini mo\u017egani\", da bi ugotovili, kako prisotnost virusa Zika vpliva na nastanek tega nevronskega tkiva.<\/p>\n

    Tak\u0161ne celi\u010dne kulture veljajo za tridimenzionalne (3D) strukture in omogo\u010dajo ve\u010d informacij o arhitekturi organov. To je leto organoida v skladu z Ekonomist<\/a>. S tem inovativnim pristopom so znanstveniki lahko razumeli, kako virus zika prizadene \u010dlove\u0161ke mo\u017eganske celice in zmanj\u0161a njihovo sposobnost pre\u017eivetja in rasti v obliki nevrosfer in mo\u017eganskih organoidov.<\/p>\n

    Spletna stran papir<\/a> je v predtisku v inovativni reviji PeerJ. Med postopkom lahko celo komentirate in pomagate avtorjem pri izbolj\u0161avah. Spodaj si lahko ogledate izvle\u010dek, celoten dostop pa dobite s klikom na tukaj<\/a>.<\/p>\n

    \"Virus<\/a><\/p>\n

    Opomba: Dva meseca po objavi predtiska v PeerJ marca 2016 je bil objavljen kon\u010dni \u010dlanek in na na\u0161e presene\u010denje je bil objavljeno v reviji Science <\/a>Magazine, ene najpresti\u017enej\u0161ih znanstvenih revij na svetu.<\/p>\n

    -> Preberite celoten \u010dlanek Garceza in drugih v reviji Science <-<\/a><\/p>\n

    \"Virus<\/a><\/p>\n

    Naj ve\u010d ljudi izve za to, da delite to objavo. To je vpra\u0161anje svetovnega javnega zdravja, kot je \u017ee navedel Svetovna zdravstvena organizacija<\/a>\u00a0(WHO).<\/p>\n

    \n

     <\/p>\n

    Vedeti, kaj je Svetovna zdravstvena organizacija svetuje o virusu Zika<\/a>\u00a0prenos in oku\u017ebo:<\/p>\n

    \n

    Prenos<\/h3>\n

    Virus Zika se na ljudi prena\u0161a predvsem z ugrizi Aedes<\/i> komarji, ki pogosto \u017eivijo okoli stavb v urbanih obmo\u010djih in so navadno aktivni podnevi (najve\u010dja aktivnost je zgodaj zjutraj in pozno popoldne).<\/p>\n

    Nekateri dokazi ka\u017eejo, da se virus Zika lahko prenese tudi na ljudi s transfuzijo krvi, perinatalnim prenosom in spolnim prenosom. Vendar so ti na\u010dini zelo redki.<\/p>\n

    Inkubacijska doba je obi\u010dajno od 2 do 7 dni.<\/p>\n

    Znaki in simptomi<\/h3>\n

    Za oku\u017ebo z virusom Zika je zna\u010dilna nizka vro\u010dina (manj kot 38,5 \u00b0C), ki jo pogosto spremlja makulopapulozni izpu\u0161\u010daj. Drugi pogosti simptomi so bole\u010dine v mi\u0161icah, bole\u010dine v sklepih z morebitno oteklino (zlasti malih sklepov rok in nog), glavobol, bole\u010dine za o\u010dmi in konjunktivitis. Ker so simptomi pogosto blagi, se lahko zgodi, da oku\u017ebe ne prepoznamo ali pa jo napa\u010dno diagnosticiramo kot dengo.<\/p>\n

    Pri\u010dakuje se visoka stopnja asimptomatske oku\u017ebe z virusom Zika, podobno kot pri drugih flavivirusih, kot sta virus denge in virus Zahodnega Nila. Ve\u010dina ljudi popolnoma okreva brez huj\u0161ih zapletov, stopnja hospitalizacije pa je nizka. Do zdaj niso poro\u010dali o nobenem smrtnem primeru, povezanem z virusom Zika.<\/p><\/blockquote>\n

     <\/p>\n

    Posodobljeno 3. maja 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    Razumite grafi\u010dni izvle\u010dek virusa Zika: Kako zmanj\u0161uje velikost mo\u017eganov Danes je raziskava dodala zanimive dokaze o vlogi virusa Zika pri okvarah \u017eiv\u010dnih tkiv. Ah, da, preden vpra\u0161ate, \u010dlove\u0161ko \u017eiv\u010dno tkivo. To je elegantno opravila skupina Dr. Stevensa Rehena, mednarodno znanega raziskovalca na podro\u010dju [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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