{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/primer-uspeha-jedrnih-receptorjev-v-jetrni-fibrozi\/","title":{"rendered":"Jedrski receptorji pri fibrozi jeter"},"content":{"rendered":"

V tem primeru je avtor uporabil Mind the Graph za zbiranje podatkov iz razli\u010dnih virov na enem mestu. Poleg najbolj\u0161ih znanstveno natan\u010dnih ilustracij ima na\u0161 delovni prostor prijazen vmesnik in je zelo enostaven za uporabo.<\/p>\n\n\n\n

Preverite celoten izvirni \u010dlanek<\/a>. <\/p>\n\n\n\n

Vloga jedrskih receptorjev pri fibrozi jeter<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer in drugi (2021) poro\u010dajo, da so jedrski receptorji z ligandi aktivirani transkripcijski dejavniki, ki uravnavajo izra\u017eanje genov razli\u010dnih klju\u010dnih molekularnih signalov, vklju\u010denih v fibrozo jeter. <\/p>\n\n\n\n

Glavni celi\u010dni dejavnik fibrogeneze jeter so aktivirane jetrne stelatne celice. Razli\u010dni jedrni receptorji uravnavajo jetrno izra\u017eanje pro-vnetnih in pro-fibrogenih citokinov.<\/p>\n\n\n\n

Grafi\u010dni povzetki, ki jih poganja Mind the Graph<\/strong> v tem \u010dlenu<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
<\/div>\n\n\n\n

Prva slika je pregled in razvrstitev jedrskih receptorjev po poddru\u017einah.<\/p>\n\n\n\n

<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Zgoraj so prikazane razli\u010dne vrste efektorskih funkcij jedrskih receptorjev.<\/p>\n\n\n\n

<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Na tretji sliki lahko preverimo pregled poro\u010danih u\u010dinkov modulacij NR kot potencialnih terapevtskih pristopov proti boleznim jeter. <\/p>\n\n\n\n

S pu\u0161\u010dicami so ozna\u010deni domnevni pozitivni u\u010dinki pri boleznih jeter, ki jih up- (temno zelena)<\/strong><\/span> ali navzdol - (svetlo zelena)<\/span><\/strong> uravnavanje posebnih mehanizmov, ki naj bi podpirali regresijo fibroze jeter ali zmanj\u0161evali fibrozo jeter. <\/p>\n\n\n\n

Oran\u017ene pu\u0161\u010dice<\/mark><\/strong> ka\u017eejo na u\u010dinke in mehanizme modulacije NR, ki so bodisi sporni bodisi \u0161e premalo ocenjeni.<\/p>\n\n\n\n

<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Zadnja slika predstavlja molekularne u\u010dinke modulatorjev NR kot potencialnega zdravljenja fibroze jeter, ki se po poro\u010danju ve\u010dinoma pojavljajo v HSC.<\/p>\n\n\n\n

K\u00f6nigshofer in sodelavci predlagajo, da bi nadaljnje raziskave signalizacije, povezane z jedrskimi receptorji, lahko privedle do klini\u010dnega razvoja u\u010dinkovitih antifibroti\u010dnih terapij za bolnike z boleznimi jeter.<\/p>\n\n\n\n

U\u010dinek in uspe\u0161nost dokumentov<\/strong><\/h2>\n\n\n\n

\u010ce izberemo enoletno mo\u017enost primerjave metrike z drugimi \u010dlanki\/recenzijami, ki so bili prav tako objavljeni v istem koledarskem letu v tej reviji, lahko opazimo, da ta \u010dlanek je bil bolj citiran kot 57% od njih<\/strong>.<\/p>\n\n\n

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Vir: PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izkoristite mo\u010d infografike tudi za izbolj\u0161anje svojega \u010dlanka. Preizkusite Mind the Graph!<\/p>\n\n\n\n

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Poskusite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Ta \u010dlanek vsebuje znanstvene ilustracije, narejene z Mind the Graph, ki prikazujejo jedrske receptorje pri fibrozi jeter.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/primer-uspeha-jedrnih-receptorjev-v-jetrni-fibrozi\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sl\/primer-uspeha-jedrnih-receptorjev-v-jetrni-fibrozi\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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