{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: zbirka podatkov o navzkri\u017enih stikih signalnih poti"},"content":{"rendered":"

Ta neverjeten \u010dlanek prina\u0161a statisti\u010dne podatke, ki povzemajo podatke v XTALKDB. Avtor je v nekaj minutah ustvaril infografiko, ki pojasnjuje porazdelitev vrst v XTALKDB.<\/p>\n\n\n\n

Preverite izvirni \u010dlanek tukaj<\/a>.<\/p>\n\n\n\n

Ker smo ljudje vizualna bitja, so slike \u0161e vedno najbolj\u0161i na\u010din za razlago va\u0161e raziskave s toliko podrobnostmi, kolikor jih \u017eelite.<\/p>\n\n\n\n

Znanstveniki so razvili podatkovno zbirko, ki dokumentira navzkri\u017ene povezave med dolo\u010denimi pari signalnih poti ter vrstami in tkivi, v katerih jih opazujemo.<\/strong><\/h2>\n\n\n\n

Raziskovalna skupina pod vodstvom Sarah Sam z Oddelka za biolo\u0161ke vede (2016) je poro\u010dala, da receptorji ob zaznavanju zunanjega signala spremenijo delovanje vmesnih proteinov. <\/p>\n\n\n\n

To povzro\u010di regulacijo transkripcijskih dejavnikov, ki modulirajo izra\u017eanje ciljnih genov. Za vsak par poti XTalkDB zapi\u0161e podrobne informacije, ki opisujejo eksperimentalne pogoje, v katerih je bilo odkrito navzkri\u017eno delovanje. <\/p>\n\n\n\n

Celice ocenjujejo svoje okolje in se nanj odzivajo prek signalnih poti. Signalna pot obi\u010dajno vsebuje dobro opredeljen niz regulativnih in fizikalnih interakcij med receptorji, vmesnimi signalnimi beljakovinami, transkripcijskimi dejavniki in ciljnimi geni. <\/p>\n\n\n\n

Spletno mesto XTalkDB znanstvenikom omogo\u010da enostaven vmesnik za pregledovanje informacij o navzkri\u017enih stikih s poizvedbo po eni ali ve\u010d poteh ali molekulah, ki jih zanimajo.<\/p>\n\n\n\n

V \u0161tudijo je bilo vklju\u010denih 650 parov.<\/strong><\/p>\n\n\n\n

Grafi\u010dni povzetek, ki ga poganja Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

O mo\u017enih izbolj\u0161avah: \"Postopek ro\u010dnega urejanja, na katerem temelji XTalkDB, ima svoje omejitve, zlasti ko \u017eelimo raz\u0161iriti pokritost podatkovne zbirke. <\/p>\n\n\n\n

Na\u010drtujemo razvoj okvira za obdelavo naravnega jezika, ki bo ocenjeval objave glede na verjetnost, da bodo dokumentirale navzkri\u017eni stik. Kustos se lahko nato osredoto\u010di na visoko ocenjene publikacije,\" priznavajo avtorji.<\/p>\n\n\n\n

U\u010dinek in uspe\u0161nost dokumentov<\/strong><\/h2>\n\n\n\n

Analiziramo lahko z Altmetric<\/a> podatkov, da je ta dokument na zgornji del vseh metrik v vseh \u010dlankih, ki jih je financiral NIH v dimenzijah. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Vir: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izkoristite mo\u010d infografike tudi za izbolj\u0161anje svojega \u010dlanka. Preizkusite Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Poskusite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

U\u010dite se s tistimi, ki so \u017ee odkrili mo\u010d infografike. Ta \u010dlanek vsebuje grafi\u010dne izvle\u010dke, narejene s programom Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sl\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-14T16:04:15+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_5.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_5.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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