{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/uspeh-primer-rentgenska-mikrotomografija-visoke-locljivosti-na-osnovi-sinhrotrona-kot-orodje-za-razkritje-tridimenzionalne-nevronske-arhitekture-mozganov\/","title":{"rendered":"Rentgenska mikrotomografija visoke lo\u010dljivosti na osnovi sinhrotrona kot orodje za odkrivanje tridimenzionalne nevronske arhitekture mo\u017eganov"},"content":{"rendered":"

Rentgenska mikrotomografija se je pojavila kot nova metoda za razvozlavanje citoarhitekture in povezljivosti mo\u017eganov, tukaj pa predstavljamo metodo za slikanje celih nevronov.<\/p>\n\n\n\n

Rentgenska mikrotomografija visoke lo\u010dljivosti na osnovi sinhrotrona kot orodje za odkrivanje tridimenzionalne nevronske arhitekture mo\u017eganov<\/strong><\/h2>\n\n\n\n

Matheus de Castro Fonseca in drugi (2018) so v \u010dlanku \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\" zapisali, da se je preu\u010devanje nevronov kot individualiziranih enot za\u010delo v 19. stoletju z oblikovanjem nauka o nevronih. <\/p>\n\n\n\n

V zadnjih nekaj letih so bila vlo\u017eena velika prizadevanja za razumevanje nevronske organizacije in povezljivosti v nedotaknjenih vzorcih mo\u017eganov. Tehnika ozna\u010devanja Golgi-Cox ponuja primeren kontrast za specifi\u010dno ozna\u010devanje nevronov za rentgensko mikrotomografijo. <\/p>\n\n\n\n

Nevroni imajo izrazito morfologijo in posebne vzorce povezljivosti, ki so bistveni za njihovo pravilno delovanje. Raziskovalci predstavljajo metodo slikanja, ki zdru\u017euje rentgensko mikrotomografijo na sinhrotronu s protokolom impregnacije Golgi-Cox. <\/p>\n\n\n\n

Metoda omogo\u010da ve\u010dji in bolj homogen kontrast razmeroma redko razporejenih celih nevronov v tkivu.<\/p>\n\n\n\n

Mo\u017egani so bili 14 dni inkubirani v raztopini za barvanje Golgi-Cox, za\u0161\u010diteni pred svetlobo. Po obdobju inkubacije so mo\u017egane serijsko prerezali z vibratomom.<\/strong><\/p>\n\n\n\n

Preverite izvirni \u010dlanek tukaj<\/a>.<\/p>\n\n\n\n

Grafi\u010dni povzetek, ki ga poganja Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
\n
\"\"<\/a>
Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Avtor je uporabil Mind the Graph<\/a> za izdelavo shematskega prikaza, ki predstavlja odraslo mi\u0161, ki ji i.p. vbrizgajo fiziolo\u0161ko raztopino ali raztopino pilokarpina (280 mg\/kg). Predstavitev zapletenih procesov z infografikami je dober na\u010din, da jih naredimo razumljive, ne da bi pri tem izpustili podrobnosti in klju\u010dne informacije.<\/p>\n\n\n\n

Zdi se, da nekateri rezultati raziskovalcev potrjujejo dosedanje znanje o tem podro\u010dju: \"Impregnacija nevronov na osnovi \u017eivega srebra, ki smo jo prikazali tukaj, nam je omogo\u010dila jasno opredelitev celotnih nevronov, predvsem zaradi bolj kontinuirane in homogene impregnacije celic ter veliko manj\u0161e gostote artefaktov,\" predlaga de Castro Fonseca.<\/p>\n\n\n\n

U\u010dinek in uspe\u0161nost dokumentov<\/strong><\/h2>\n\n\n\n

Analiziramo lahko z Altmetric<\/a> podatkov, da je ocena spletne pozornosti tega papirja vi\u0161ja. kot . 64%<\/strong><\/strong> vseh drugih \u010dlankov podobne starosti v reviji Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
\n
\"\"<\/a>
Vir: Altmetrika<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izbolj\u0161ajte dostopnost \u010dlanka tudi z infografikami.<\/p>\n\n\n\n

\n
Poskusite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Oglejte si novo metodo za de\u0161ifriranje citoarhitekture in povezljivosti mo\u017eganov, ki jo prikazujejo ilustracije Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/uspeh-primer-rentgenska-mikrotomografija-visoke-locljivosti-na-osnovi-sinhrotrona-kot-orodje-za-razkritje-tridimenzionalne-nevronske-arhitekture-mozganov\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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