{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/uspeh-primer-zika-virusa-se-razmnozuje-v-odraslem-cloveskem-mozganskem-tkivu-in-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Virus Zika se razmno\u017euje v mo\u017eganskem tkivu odraslih ljudi ter okvari sinapse in spomin pri mi\u0161ih"},"content":{"rendered":"

ZIKV je nevaren virus, ki pusto\u0161i po svetu. Zato avtor v tem primeru preu\u010duje njegovo razmno\u017eevanje v mo\u017eganih odraslega \u010dloveka.<\/p>\n\n\n\n

Virus Zika (ZIKV) oku\u017ei mo\u017egansko tkivo odraslih in povzro\u010di motnje spomina pri mi\u0161ih<\/strong><\/h2>\n\n\n\n

Skupina s Fakultete za farmacijo pod vodstvom Claudie Figueiredo (2019) je preu\u010devala, kako se virus zika razmno\u017euje v mo\u017eganskem tkivu odraslih ljudi ter pri mi\u0161ih okvari sinapse in spomin. Virus zika je arbovirus iz dru\u017eine Flaviviridae, odgovoren za nedavni velik izbruh v Latinski Ameriki. <\/p>\n\n\n\n

Virus ZIKV so na\u0161li v mo\u017eganih in mo\u017eganski teko\u010dini odraslih bolnikov. Imunoreaktivnost NS2B je bila kolokalizirana z nevronsko imunoreaktivnimi celicami, ne pa z GFAP ali F4\/80, kar ka\u017ee na to, da je ZIKV v zrelem \u010dlove\u0161kem tkivu tar\u010da nevronov. Pri odraslih imunokompetentnih mi\u0161ih, oku\u017eenih z intracerebroventrikularno infuzijo ZIKV, so visoke ravni RNA ZikV zaznane v \u010delnem korteksu in hipokampusu, glavni tip oku\u017eenih celic pa so zreli nevroni. <\/p>\n\n\n\n

Potrdijo se povi\u0161ana raven TNF-\u03b1 v mo\u017eganih, intenzivna mikroglioza, pove\u010dano izra\u017eanje proteinov komplementarnega sistema (C1q in C3) ter po\u0161kodbe hipokampalnih sinaps.<\/p>\n\n\n\n

\u0160tudija je vklju\u010devala 9 enakih kvadrantov.<\/strong><\/p>\n\n\n\n

Preverite izvirni \u010dlanek tukaj<\/a>.<\/p>\n\n\n\n

Grafi\u010dni povzetki, ki jih poganja Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Prva slika predstavlja primer, ko so bili fragmenti \u010dlove\u0161kega kortikalnega tkiva temporalnega re\u017enja razrezani v 400 \u00b5m rezine in vzdr\u017eevani v kulturi 4 dni pred inkubacijo z virusom ZIKV (107 PFU) ali posnemovalnim medijem za 1 uro, \u010demur je sledilo izpiranje. <\/p>\n\n\n\n

<\/div>\n\n\n
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Izdelano z Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Drugi primer prikazuje, da so odrasle mi\u0161i prejele infuzijo 105 PFU ZIKV, UV-inaktiviranega ZIKV ali posnemovalnega medija v mo\u017eganski lateralni ventrikel.<\/p>\n\n\n\n

Zdi se, da ugotovitve potrjujejo, kar je bilo o tej temi znano \u017ee prej: \"ZIKV je ne glede na to, ali je pot oku\u017ebe centralna ali periferna, usmerjen v mo\u017eganske regije, povezane s spominom. Virus je bil odkrit v mo\u017eganski teko\u010dini odraslih bolnikov z nevrolo\u0161kimi zapleti,\" trdi Figueiredo.<\/p>\n\n\n\n

Predlagajo, da so prihodnje \u0161tudije, katerih cilj je preu\u010diti dolgoro\u010dni nevrodegenerativni vpliv oku\u017ebe z virusom ZIKV, upravi\u010dene. Ugotavljanje na\u010dinov za prepre\u010devanje signalnih nepravilnosti, ki vodijo v motnje v delovanju mo\u017eganov, bi lahko utrlo pot intervencijskim strategijam za odlo\u017eitev ali prepre\u010devanje razvoja resnih nevrolo\u0161kih bolezni.<\/p>\n\n\n\n

U\u010dinek in uspe\u0161nost dokumentov<\/strong><\/h2>\n\n\n\n

Analiziramo lahko z Altmetric<\/a> podatkov, da je ocena spletne pozornosti tega papirja vi\u0161ja. kot . 95%<\/strong><\/strong> vseh drugih podobnih izdelkov v naravi<\/strong> \u010casopisi.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Vir: Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Izkoristite mo\u010d infografike tudi za izbolj\u0161anje svojega \u010dlanka! Za\u010dnite ustvarjati na Mind the Graph.<\/p>\n\n\n\n

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Poskusite Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u0160tudija obravnava virus ZIKV v mo\u017eganih odraslega \u010dloveka, nevaren virus, ki pusto\u0161i po svetu. V postopku so uporabljene ilustracije Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/uspeh-primer-zika-virusa-se-razmnozuje-v-odraslem-cloveskem-mozganskem-tkivu-in-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sl\/uspeh-primer-zika-virusa-se-razmnozuje-v-odraslem-cloveskem-mozganskem-tkivu-in-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-06T20:57:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:48:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog-image-0008.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog","description":"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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