{"id":13008,"date":"2021-06-21T18:09:00","date_gmt":"2021-06-21T21:09:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=13008"},"modified":"2023-01-05T14:38:06","modified_gmt":"2023-01-05T17:38:06","slug":"napping-time-genetics","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/dremez-genetika\/","title":{"rendered":"Genetika \u010dasa za spanje: Kako lahko dreme\u017e vpliva na genetske spremembe"},"content":{"rendered":"

\u010cas dreme\u017ea \u010dez dan je za ve\u010dino posameznikov kriv u\u017eitek.<\/p>\n\n\n

\n
\"Garfield<\/a><\/figure><\/div>\n\n\n

Ve\u010dinoma je to tudi navada, ki se je ukoreninila v vsakodnevno rutino. Zelo pogosta je pri \u0161tevilnih vrstah, od muh do sesalcev.<\/p>\n\n\n\n

Dremanje je povezano tudi z izbolj\u0161anjem budnosti, kar je bistvenega pomena za tiste, ki delajo pozno v no\u010d, ali tiste, ki so obi\u010dajno neprespani.<\/p>\n\n\n\n

Prav tako naj bi koristil pri izbolj\u0161anju u\u010dinkovitosti, spomina in laj\u0161anju stresa. <\/p>\n\n\n\n

Poleg teh koristi pa lahko dolgoro\u010dne posledice dreme\u017ea kroni\u010dno vplivajo na dobro po\u010dutje posameznika.<\/p>\n\n\n\n

\u010ceprav je to sporna tema in je razlog za to lahko ve\u010d dejavnikov, povezanih s plenicami, kot so neustrezen spalni cikel, slaba prehrana ali slabo zdravje.<\/p>\n\n\n\n

Je \u010das spanja \u010dez dan va\u0161a sre\u010dna ura? Raziskovalci pravijo druga\u010de. <\/strong><\/p>\n\n\n\n

Skupina raziskovalcev je analizirala u\u010dinke dreme\u017ea z genetskimi spremembami.<\/p>\n\n\n\n

Njihova \u0161tudija je bila namenjena razumevanju genetskih razlik razli\u010dnih posameznikov glede na njihovo izbiro trajanja in \u017eelje po spanju.<\/p>\n\n\n\n

Trenutno je bilo v okviru \u0161tudije povezanosti celotnega genoma odkritih pribli\u017eno sedem genetskih lokusov, ki so povezani s \u010dasom spanja \u010dez dan.<\/p>\n\n\n\n

Raziskovalci so uporabili udele\u017eence Biobanke Zdru\u017eenega kraljestva evropskega porekla (n=452.633), od katerih je pribli\u017eno 38,2% udele\u017eencev v\u010dasih dremalo, 5,3% udele\u017eencev pa je vedno dremalo \u010dez dan.<\/p>\n\n\n\n

Skoraj vedno so dremali starej\u0161i mo\u0161ki z visokim indeksom telesne mase ali indeksom telesne mase, imeli so diagnosticirane motnje spanja, bili so kadilci ali upokojenci. Izvedli so asociacijsko \u0161tudijo na ravni celotnega genoma (GWAS) z visokokakovostnimi pripisanimi genetskimi razli\u010dicami, ki je zajela pribli\u017eno \u0161tiri jezera udele\u017eencev. Pri tem so spreminjali razli\u010dne prej ugotovljene dejavnike.<\/p>\n\n\n\n

Uspe\u0161no so identificirali 123 genetskih lokusov, pri katerih je dednost na podlagi enonukleotidnega polimorfizma pribli\u017eno 11,9%.<\/p>\n\n\n\n

Svojo raziskavo GWAS so zo\u017eili na posameznike z vi\u0161jim indeksom telesne mase. <\/p>\n\n\n\n

Ugotovljeno je bilo, da je bilo od 123 lokusov 110 zadr\u017eanih v genomskem pomenu.<\/p>\n\n\n\n

Analizirali so tudi razlike v vzorcih spanja pri razli\u010dnih spolih v povezavi s kromosomom X. <\/p>\n\n\n\n

Poleg tega so ugotovili tudi, kateri geni so odgovorni za pot hipersomnolence pri debelosti: PNOC (prepronociceptin), <\/em>in . PATJ (komponenta polarnosti drobnih celic).<\/em><\/p>\n\n\n\n

Poleg tega je izra\u017eanje gena FADS1 (desaturaza ma\u0161\u010dobnih kislin), ki je bil koloniziran, pokazalo pleiotropni u\u010dinek presnove lipidov na vzorec spanja.<\/p>\n\n\n\n

Druge korelacije so bile zaznane v zvezi z genetskimi korelacijami na ravni celotnega genoma skupaj z zna\u010dilnostmi, kot so glikemi\u010dni indeks, antropometri\u010dne in kardiometabolne korelacije, med katerimi so se \u0161tevilne korelacije zmanj\u0161ale zaradi upo\u0161tevanja indeksa telesne mase. <\/p>\n\n\n\n

Poleg tega je rezultat, ki ga je analizirala fenomenolo\u0161ka asociacija z uporabo dnevnega dreme\u017ea na genomski ravni, pomagal pri korelaciji bolezni, povezanih z debelostjo, hipertenzijo in predvsem nekaterimi kardiometaboli\u010dnimi boleznimi. <\/p>\n\n\n\n

Njihove ugotovitve nam odpirajo o\u010di. V\u010dasih prav tak\u0161ne navade povzro\u010dijo \u0161tevilne ne\u017eelene zaplete v na\u0161em telesu. Upo\u0161tevati moramo zdravo rutino in dobre \u017eivljenjske navade. <\/p>\n\n\n

\n
\"mo\u0161ki<\/a><\/figure><\/div>\n\n\n

\u010ce \u017eelite izvedeti ve\u010d o njihovih raziskavah, si oglejte spodnji sklic.<\/p>\n\n\n\n

Dashti, H.S., Daghlas, I., Lane, J.M. et al.<\/em> Genetske determinante dnevnega dreme\u017ea in u\u010dinki na kardiometabolno zdravje. Nat Commun<\/em> 12, 900 (2021). DOI: https:\/\/doi.org\/10.1038\/s41467-020-20585-3<\/a><\/p>\n\n\n\n

V galeriji Mind the Graph najdete \u0161tevilne ilustracije, povezane z genetiko. Za ogled kliknite na spodnjo sliko.<\/p>\n\n\n

\n
\"\"\/<\/a><\/figure><\/div>","protected":false},"excerpt":{"rendered":"

\u010cas dreme\u017ea \u010dez dan je za ve\u010dino posameznikov kriv u\u017eitek. Ve\u010dinoma je to tudi navada, ki se je ukoreninila v vsakodnevno rutino. Zelo pogosta je pri \u0161tevilnih vrstah, od muh do sesalcev. Dremanje je povezano tudi z izbolj\u0161anjem budnosti, kar je bistvenega pomena za tiste, ki delajo pozno v no\u010d, ali tiste, ki so [...]<\/p>","protected":false},"author":18,"featured_media":13012,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nDid you know that taking that nap can influence genetic - MTG<\/title>\n<meta name=\"description\" content=\"Is napping time your happy hour? 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