{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolecine-v-telesu\/","title":{"rendered":"Konoplja in telesna bole\u010dina"},"content":{"rendered":"

V zadnjem desetletju so \u0161tevilne klini\u010dne \u0161tudije poro\u010dale o pozitivnih in obetavnih rezultatih uporabe zdravil na osnovi konoplje za zdravljenje nevropatske bole\u010dine. <\/p>\n\n\n\n

S konopljo se laj\u0161ajo bole\u010dine pri sladkorni bolezni, kemoterapiji, multipli sklerozi, fibromialgiji, osteoartritisu in \u0161tevilnih drugih boleznih. <\/p>\n\n\n\n

O\u010ditno obstaja povezava med eksogenimi kanabinoidi in opioidnimi receptorji, kar pri bolnikih pove\u010da analgezijo - nezmo\u017enost ob\u010dutenja bole\u010dine. <\/p>\n\n\n\n

Pri bolnikih, ki se zdravijo z opioidi skupaj z zdravili na osnovi konoplje, se poka\u017ee sinergijski u\u010dinek zdravila, pri katerem se u\u010dinkovitost opioidov pove\u010da zaradi tetrahidrokanabinola - THC, glavne psihoaktivne molekule v rastlini konoplji. <\/p>\n\n\n\n

Znanstveniki na te rezultate gledajo pozitivno zaradi mo\u017enosti zmanj\u0161anja odmerkov opioidov, kar bi izbolj\u0161alo kakovost \u017eivljenja bolnikov z bole\u010dinami.<\/p>\n\n\n\n

Endokanabinoidni sistem, podobno kot druge presnovne poti, ni izoliran sistem \u010dlove\u0161kega telesa, saj lahko vpliva na druge signalne poti in nanj vplivajo druge signalne poti, ena od teh je o\u010ditno povezana z opioidi in njihovimi receptorji. <\/p>\n\n\n\n

Opioidni receptorji imajo poleg funkcije signaliziranja ob\u010dutka bole\u010dine tudi vlogo modulacije nekaterih telesnih funkcij, kot so toplotna regulacija, hormonska stabilnost, analgeti\u010dno delovanje in druge. <\/p>\n\n\n\n

Kanabinoidni in opioidni receptorji so \u010dlani dru\u017eine receptorjev, vezanih na beljakovine G, ki lahko vplivajo na nevrotransmisije, odgovorne za \u0161irjenje bole\u010dine v mo\u017eganih in hrbtenja\u010di. <\/p>\n\n\n\n

Zdravljenje bolnikov s kroni\u010dno bole\u010dino obi\u010dajno vklju\u010duje postopno pove\u010devanje odmerkov opioidov, kar pogosto povzro\u010di ne\u017eelene stranske u\u010dinke, kot so sedacija, motnje dihanja in zaprtje. <\/p>\n\n\n\n

Po dolo\u010denem \u010dasu bolniki za\u010dnejo kazati toleranco in odpornost na odmerek opioidov, ne dose\u017eejo njihovih terapevtskih u\u010dinkov, zaradi \u010desar morajo zdravniki ve\u010dkrat pove\u010dati odmerek, da bi dosegli enako raven laj\u0161anja bole\u010din.<\/p>\n\n\n\n

Velik odmerek samega THC velja za analgeti\u010dnega, vendar mu obi\u010dajno sledijo ne\u017eeleni stranski u\u010dinki, kot so tesnoba, glavobol, suha usta, omotica, evforija in tahikardija, medtem ko majhni odmerki sploh ne povzro\u010dajo analgeti\u010dnega u\u010dinka. <\/p>\n\n\n\n

Kljub temu se v kombinaciji z opioidi ta u\u010dinek lahko popolnoma spremeni.<\/p>\n\n\n\n

\u0160tudije na \u017eivalskih modelih so pokazale, da lahko eksogeni kanabinoidi, kot je THC, pove\u010dajo u\u010dinkovitost opioidnih zdravil, kot je morfij. <\/p>\n\n\n\n

Analgeti\u010dno delovanje THC se zdi, da je posredovano prek opioidnih receptorjev, pri \u010demer prihaja do navzkri\u017enega delovanja med kanabinoidi in opioidi na signalnih poteh. <\/p>\n\n\n\n

Raziskovalci konoplje poro\u010dajo, da lahko dajanje THC v telesu spodbudi nastajanje endogenih opioidnih peptidov, ki se na koncu ve\u017eejo na \u017ee znane opioidne receptorje - delta in kappa - in tako posredujejo u\u010dinek kanabinoidov. <\/p>\n\n\n\n

Ob dajanju morfija se aktivira tudi tretji opioidni receptor mu. Aktivacija teh treh opioidnih receptorjev je lahko razlaga za pove\u010danje u\u010dinkovitosti antinociceptivnega u\u010dinka - procesa analgezije, ki blokira zaznavanje bole\u010dega dra\u017eljaja - v primerjavi z rezultati zdravljenja samo z morfinom ali THC.<\/p>\n\n\n

\n
\"\"<\/a><\/figure><\/div>\n\n\n

A \u0161tudija, objavljena leta 2004 v reviji Life Sciences<\/a> je potrdil povezavo med THC in morfinom z zaviranjem opioidnih receptorjev s posebnimi molekulami. <\/p>\n\n\n\n

Prisotnost blokirajo\u010dih molekul je povzro\u010dila zmanj\u0161anje u\u010dinkovitosti morfina, posledi\u010dno pa tudi njegovih terapevtskih u\u010dinkov. <\/p>\n\n\n\n

Ta rezultat potrjuje, kako pomembna je razpolo\u017eljivost teh receptorjev in njihova aktivacija za u\u010dinkovitost zdravljenja z morfinom in THC. Drug poskus, izveden z naloksonom - opioidnim antagonistom - je blokiral aktivnost THC v razli\u010dnih delih mo\u017eganov, kot so ventralno tegmentalno obmo\u010dje, hipotalamus in periakveduktalna siva (PAG), kar nakazuje, da so ta obmo\u010dja nekako pomembna za interakcijo med opioidi in kanabinoidi. <\/p>\n\n\n\n

Poleg tega \u0161tudija navaja, da skupno zdravljenje mi\u0161i z nizkimi odmerki THC in morfija ni povzro\u010dilo tolerance na odmerek opioidov.<\/p>\n\n\n\n

Ta \u0161tudija in \u0161tevilne druge so bile objavljene v podporo ideji, da lahko kanabinoidi v kombinaciji pove\u010dajo u\u010dinek opioidov. <\/p>\n\n\n\n

Kanabinoidi lahko spremenijo tudi toleranco in zasvojenost z opioidi. <\/p>\n\n\n\n

Dolgotrajna uporaba opioidov je obi\u010dajno povezana z zasvojenostjo bolnikov, kar privede do zlorabe snovi, ki je imela sprva le terapevtski namen. <\/p>\n\n\n\n

Kombinacija kanabinoida in opioida - na primer THC in morfija - bi se zato lahko spremenila v novo analgeti\u010dno strategijo kombiniranega zdravljenja, ki bi zdravnikom omogo\u010dila zmanj\u0161anje visokih odmerkov opioidov pri bolnikih in tudi zmanj\u0161anje stopnje zlorabe opioidov in odvisnosti bolnikov. <\/p>\n\n\n\n

Poleg teorije, da kanabinoidi spodbujajo endogene opioide, podroben mehanizem sistema kanabinoidno-opioidnih interakcij \u0161e vedno ostaja nejasen. <\/p>\n\n\n\n

Hipoteza, ki posku\u0161a pojasniti mo\u017eni mehanizem delovanja, je, da kanabinoidi morda povzro\u010dijo sintezo ali spro\u0161\u010danje - obojega - opioidnih peptidov, kar pove\u010da \u0161tevilo aktiviranih opioidnih receptorjev in povzro\u010di analgeti\u010dne u\u010dinke. <\/p>\n\n\n\n

Tudi pojasnitev, kateri peptidi so vklju\u010deni v ta proces, ni jasna ali znana, zato bi bilo za znanstvenike klju\u010dno, da v celoti razumejo strukturo teh molekul in kako se lahko kanabinoidi uporabljajo za analgeti\u010dne u\u010dinke, poleg pomo\u010di pri odvisnosti od opioidov. <\/p>\n\n\n\n

Kakor koli \u017ee, kanabinoidi na splo\u0161no ka\u017eejo presenetljive rezultate, nenehno pridobivajo na pomenu med medicinskimi strokovnjaki in dokazujejo svoj potencial kot alternativno zdravilo. <\/p>\n\n\n\n

Raziskovalci bodo morali opraviti \u0161e ve\u010d \u0161tudij, da bodo v celoti spoznali dejanske koristi in mo\u017enosti zdravil na osnovi konoplje za \u010dlove\u0161ko telo ter kako je mogo\u010de najbolje uporabiti rastlino konopljo za zdravljenje.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Ali vam je bila infografika v tem \u010dlanku v\u0161e\u010d? Vse ikone<\/a> ki so uporabljeni v tem \u010dlanku - in \u0161tevilni drugi - so na voljo v Mind the Graph. Ilustracije, ki so na voljo, si lahko ogledate v na\u0161em galerija<\/a>.<\/p>\n\n\n\n

Infografike vam ni treba za\u010deti iz ni\u010d, saj na\u0161im uporabnikom ponujamo urejene predloge infografik, tako da jim ni treba za\u010deti iz praznega platna. Tu si lahko ogledate predloge za infografike.<\/a><\/p>\n\n\n\n

Naro\u010dite se lahko tudi na starej\u0161e in ustvarite neomejeno \u0161tevilo figur, kliknite tukaj za za\u010detek<\/a>!<\/p>\n\n\n\n

Reference <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Potencialni ne\u017eeleni u\u010dinki in interakcije med zdravili pri uporabi kanabidiola (CBD) v medicini in pri potro\u0161nikih. Journal of Clinical Medicine, v. 8, \u0161t. 7, 8 jul. 2019.<\/p>\n\n\n\n

CICHEWICZ, D. L. Sinergisti\u010dne interakcije med kanabinoidnimi in opioidnimi analgetiki. Life Sciences, v. 74, \u0161t. 11, str. 1317-1324, 30. jan. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Interakcija med naltreksonom in oralnim THC pri te\u017ekih kadilcih marihuane. Psychopharmacology, v. 166, \u0161t. 1, str. 77-85, 1. februar 2003.<\/p>\n\n\n\n

KUHLEN, M. et al. U\u010dinkovito zdravljenje spasti\u010dnosti z dronabinolom v pediatri\u010dni paliativni oskrbi. European Journal of Pediatric Neurology, v. 20, \u0161t. 6, str. 898-903, 1. nov. 2016.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Drug Interactions with Patient-Controlled Analgesia (Medsebojno delovanje zdravil pri analgeziji, ki jo nadzoruje pacient). Clinical Pharmacokinetics, v. 41, \u0161t. 1, str. 31-57, 1. jan. 2002.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Konoplja zmanj\u0161a odmerek opioidov pri zdravljenju kroni\u010dne bole\u010dine, ki ni posledica raka. Journal of Pain and Symptom Management, v. 25, \u0161t. 6, str. 496-498, 1. jun. 2003.<\/p>\n\n\n\n

MANZANARES, J. et al. Farmakolo\u0161ke in biokemi\u010dne interakcije med opioidi in kanabinoidi. Trends in Pharmacological Sciences, v. 20, \u0161t. 7, str. 287-294, 1. jul. 1999.<\/p>\n\n\n\n

WAKLEY, A. A.; CRAFT, R. M. Interakcije THC-metadona in THC-naltreksona na diskriminacijo, antinocicepcijo in gibanje pri podganah. Behavioural Pharmacology, v. 22, \u0161t. 5 in 6, str. 489-497, sklop. 2011.<\/p>\n\n\n\n

WELCH, S. P. Vzajemno delovanje kanabinoidnega in opioidnega sistema pri modulaciji nocicepcije. International Review of Psychiatry, v. 21, \u0161t. 2, str. 143-151, 1. jan. 2009.<\/p>","protected":false},"excerpt":{"rendered":"

V zadnjem desetletju so \u0161tevilne klini\u010dne \u0161tudije poro\u010dale o pozitivnih in obetavnih rezultatih uporabe zdravil na osnovi konoplje za zdravljenje nevropatske bole\u010dine. S konopljo so se zdravile bole\u010dine, povezane s sladkorno boleznijo, kemoterapijo, multiplo sklerozo, fibromialgijo, osteoartritisom in \u0161tevilnimi drugimi boleznimi. O\u010ditno obstaja povezava med eksogenimi kanabinoidi in opioidnimi receptorji, kar povzro\u010di, da se bole\u010dina [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolecine-v-telesu\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cannabis and Body Pain - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolecine-v-telesu\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-02-10T11:13:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-01-05T16:46:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"6 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Cannabis and Body Pain - MTG","description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolecine-v-telesu\/","og_locale":"sl_SI","og_type":"article","og_title":"Cannabis and Body Pain - MTG","og_description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","og_url":"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolecine-v-telesu\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-02-10T11:13:00+00:00","article_modified_time":"2023-01-05T16:46:34+00:00","og_image":[{"width":1123,"height":612,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/02\/cannabis-and-body-pain.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/","url":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/","name":"Cannabis and Body Pain - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-02-10T11:13:00+00:00","dateModified":"2023-01-05T16:46:34+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Do you want to know cannabis can impact the body pain? Read post that dives deep into how it is possible and how you can take benefits from the same.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/#breadcrumb"},"inLanguage":"sl-SI","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/cannabis-and-body-pain\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Cannabis and Body Pain"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sl-SI"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"sl-SI","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/sl\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/posts\/12274"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/comments?post=12274"}],"version-history":[{"count":3,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/posts\/12274\/revisions"}],"predecessor-version":[{"id":26008,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/posts\/12274\/revisions\/26008"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/media\/12276"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/media?parent=12274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/categories?post=12274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sl\/wp-json\/wp\/v2\/tags?post=12274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}