{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/konoplja-in-bolezen-alzheimerja\/","title":{"rendered":"Kaj je znanega o konoplji in Alzheimerjevi bolezni"},"content":{"rendered":"
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Alzheimerjeva bolezen (AD) je nevrodegenerativna bolezen, ki je odgovorna za ve\u010d kot 50% trenutno diagnosticiranih primerov demence in je neposredno povezana s staranjem. Danes ima 40% ljudi, starej\u0161ih od 85 let, dolo\u010deno stopnjo demence.<\/p>\n\n\n\n

Prej je veljalo, da so simptomi AD povezani le z upadom kognitivnih funkcij, ki vplivajo na kratkoro\u010dne spomine, v napredovali fazi bolezni pa vplivajo na bolnikove jezikovne sposobnosti in celo na dolgoro\u010dne spomine.<\/p>\n\n\n\n

Danes pa je znano, da se pri bolnikih z Alzheimerjevo boleznijo pojavljajo \u0161tevilni drugi simptomi, kot so depresija, psihoza, agresivno vedenje, zaradi \u010desar je bolezen \u0161e huj\u0161a. <\/p>\n\n\n\n

V zadnjih letih so raziskovalci in zdravniki v svojih \u0161tudijah poro\u010dali o pozitivnih rezultatih zdravljenja bolnikov z Alzheimerjevo boleznijo z zdravili na osnovi konoplje, s katerimi so dosegli laj\u0161anje simptomov.<\/p>\n\n\n\n

Endokanabinoidni sistem je postal alternativni pristop za zdravljenje razli\u010dnih bolezni in patologij, poleg vpliva na \u0161tevilne procese, kot so nevroplasti\u010dnost, nevrovnetje, vedenjske motnje, uravnavanje spanja, imunolo\u0161ke funkcije, vnetne bolezni, kardiovaskularne funkcije, bole\u010dina, motori\u010dni nadzor, energijsko ravnovesje in apetit. <\/p>\n\n\n\n

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Fotografija Ravi Patel<\/a> na spletni strani . Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

\u017dal je \u0161e vedno malo uradnih \u0161tudij, ki bi neposredno analizirale povezavo med endokanabinoidnim sistemom in Alzheimerjevo boleznijo.<\/p>\n\n\n\n

Danes je znano, da je Alzheimerjeva bolezen posledica genetskih dejavnikov in dejavnikov staranja. Klju\u010dni krivci za nastanek bolezni so senilne obloge<\/strong> in nevrofibrilarni zapleteni<\/strong>. <\/p>\n\n\n\n

Zanimivo je, da so raziskovalci na podganah z AD odkrili, da imajo mo\u017egani z AD manj\u0161e \u0161tevilo receptorjev CB1 v primerjavi z zdravimi mo\u017egani - manj\u0161e \u0161tevilo receptorjev CB1 lahko s\u010dasoma zmanj\u0161a terapevtski u\u010dinek zdravila.<\/p>\n\n\n\n

Zdravljenje s kanabinoidi lahko povzro\u010di za\u0161\u010ditni u\u010dinek proti oksidativnemu stresu in nevrovnetju v mo\u017eganih bolnikov z Alzheimerjevo boleznijo ter pomaga zmanj\u0161ati nastajanje amiloidnih plakov in nevrofibrilarnih zapletov, kar upo\u010dasni upad kognitivnih sposobnosti bolnikov. <\/p>\n\n\n\n

\u010ceprav so amiloidne obloge prisotne tudi v zdravih mo\u017eganih, je njihova pogostost v primerjavi z mo\u017egani z Alzheimerjevo boleznijo izjemno nizka.<\/p>\n\n\n\n

\u0160tudije, namenjene razumevanju, zakaj imajo kanabinoidi terapevtski u\u010dinek na bolnike z Alzheimerjevo boleznijo, so odkrile, da lahko molekula THC pove\u010da biolo\u0161ko razpolo\u017eljivost nevrotransmiterja, imenovanega acetilholin<\/strong> (Ach) z zaviranjem encima za njegovo razgradnjo acetilholinesteraza<\/strong> (AChE) - Ach je odgovoren za prenos \u017eiv\u010dnega impulza do naslednjega nevrona. <\/p>\n\n\n\n

Encim AChE v zdravih mo\u017eganih razgrajuje Ach, vendar je v mo\u017eganih z Alzheimerjevo boleznijo ta encim mo\u010dno prisoten in razgrajuje veliko ve\u010d Ach, kot bi moral, kar s\u010dasoma povzro\u010di upad kognitivnih funkcij mo\u017eganov.   <\/p>\n\n\n\n

Raziskovalci so poro\u010dali, da lahko kanabinoidi pomagajo zaradi zaviralnega delovanja encima AChE - pokazali so bolj\u0161e odzive kot druga komercialno dostopna zdravila. <\/p>\n\n\n\n

THC lahko pomaga tudi pri zmanj\u0161evanju vedenjskih motenj in uravnava cirkadiani cikel pri bolnikih s hudo demenco. Nekateri znanstveniki celo trdijo, da lahko kanabinoidi THC in CBD potencialno delujejo proti Alzheimerjevi bolezni.<\/p>\n\n\n\n

\u010clanek, objavljen leta 2015 v reviji Clinical Pharmacology and Therapeutics<\/a>, vsebuje pregled mo\u017enosti uporabe kanabinoidov pri zdravljenju Alzheimerjeve bolezni in z njo povezanih nevropsihiatri\u010dnih simptomov pri starej\u0161ih ljudeh ter obravnava tudi vidike zdravil na osnovi konoplje glede njihove u\u010dinkovitosti, varnosti in farmakokinetike.<\/p>\n\n\n\n

72-letni mo\u0161ki z Alzheimerjevo boleznijo je imel vedenjske motnje, kot sta vznemirjenost in agresivnost. Njegovo predhodno zdravljenje ni pokazalo bistvenega izbolj\u0161anja. <\/p>\n\n\n\n

Ko so bolniku uvedli Nabilon - sinteti\u010dno zdravilo THC - se je kmalu pokazalo izbolj\u0161anje vedenjskih motenj in drugih simptomov, poleg tega med zdravljenjem z zdravilom na osnovi THC ni imel ne\u017eelenih u\u010dinkov.<\/p>\n\n\n\n

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Fotografija Louis Reed<\/a> na spletni strani . Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Pri drugi \u0161tudijski skupini, ki jo je sestavljalo petnajst bolnikov z Alzheimerjevo boleznijo - povpre\u010dna starost je bila 72 let -, so se pred zdravljenjem pokazale vedenjske motnje in te\u017eave pri prehranjevanju. <\/p>\n\n\n\n

Petnajst bolnikov se je \u0161est tednov zdravilo z dronabinolom - znanim tudi kot marinol - sinteti\u010dnim zdravilom THC. <\/p>\n\n\n\n

Po obdobju zdravljenja so v primerjavi s placebom ugotovili izbolj\u0161anje vedenja, pove\u010danje telesne te\u017ee in zmanj\u0161anje vznemirjenosti. Opazili so nekaj ne\u017eelenih u\u010dinkov, kot so utrujenost, zaspanost in evforija, za katere so potrdili, da so povezani z dronabinolom.<\/p>\n\n\n\n

Druga skupina \u0161estih bolnikov, povpre\u010dne starosti 81 let, nekateri z Alzheimerjevo boleznijo, drugi s hudo demenco, je za\u010dela dvotedensko zdravljenje z dronabinolom. <\/p>\n\n\n\n

Rezultati so pokazali znatno izbolj\u0161anje no\u010dnih gibalnih aktivnosti teh bolnikov in bolj\u0161e vedenje. V tej skupini niso opazili ne\u017eelenih u\u010dinkov.<\/p>\n\n\n\n

V neki drugi \u0161tudiji je bilo 40 bolnikov z razli\u010dnimi stopnjami demence, od tega 13 z Alzheimerjevo boleznijo. <\/p>\n\n\n\n

Vsi so se za\u010deli zdraviti z dronabinolom za zdravljenje vedenjskih te\u017eav in motenj apetita. <\/p>\n\n\n\n

Zdravljenje je trajalo 17 dni, pri bolnikih pa je pri\u0161lo do izbolj\u0161anja v obeh vidikih. Poro\u010dali so o ne\u017eelenih u\u010dinkih, kot so sedacija, delirij, oku\u017ebe se\u010dil in zmedenost, vendar po mnenju raziskovalcev ti niso bili neposredno povezani z uporabo dronabinola.<\/p>\n\n\n\n

Kljub \u0161tevilnim \u0161tudijam, ki so pokazale pozitivne rezultate uporabe kanabinoidov pri zdravljenju bolnikov z demenco, nekateri raziskovalci trdijo, da \u0161e vedno ni dovolj dokazov, da so kanabinoidi res dobri in varni pri zdravljenju vedenjskih motenj in demence.<\/p>\n\n\n\n

Raziskovalci vse pogosteje poro\u010dajo o uporabi zdravil na osnovi konoplje za zdravljenje bolnikov z Alzheimerjevo boleznijo in ne le to, uporabljali so jo tudi pri zdravljenju Parkinsonove bolezni in avtizma, pri \u010demer so zdravniki in znanstveniki poro\u010dali o izbolj\u0161anju kakovosti \u017eivljenja bolnikov, ki so za\u010deli jemati zdravila na osnovi konoplje. Vendar je to tema za naslednji \u010dlanek.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Ste s podro\u010dja nevrologije? V Mind the Graph je velika kategorija nevrolo\u0161kih ilustracij, v kateri lahko najdete vse, kar potrebujete za svoj nevrolo\u0161ki referat ali predstavitev. Oglejte si tukaj<\/a>.  <\/strong><\/p>\n\n\n\n

Ali <\/strong>i\u0161\u010dete biokemija <\/a>in . molekularna biologija<\/a> ilustracije lahko najdete tudi v Mind the Graph. <\/p>\n\n\n\n

\u010ce potrebujete kar koli drugega, smo vam na voljo za pomo\u010d. se prijavite v svoj ra\u010dun<\/a> in nam po\u0161ljite sporo\u010dilo v ZAHTEVAJTE IKONO<\/strong>. <\/p>\n\n\n\n

Reference<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klini\u010dna farmakologija in terapija<\/strong>, v. 97, \u0161t. 6, str. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klini\u010dna farmakologija in terapija<\/strong>, v. 97, \u0161t. 6, str. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Medicinska konoplja pri Parkinsonovi bolezni: Izku\u0161nje bolnikov iz resni\u010dnega \u017eivljenja. Klini\u010dna nevrofarmakologija<\/strong>, v. 40, \u0161t. 6, str. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Endokanabinoidni sistem in Alzheimerjeva bolezen. Molekularna nevrobiologija<\/strong>, v. 36, \u0161t. 1, str. 75-81, pred 1 letom. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. U\u010dinki akutnega dajanja kanabidiola na anksioznost in tresenje, ki ga je povzro\u010dil simulirani test javnega govorjenja pri bolnikih s Parkinsonovo boleznijo. Journal of Psychopharmacology<\/strong>, v. 34, \u0161t. 2, str. 189-196, 1. februar 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, v. 39, \u0161t. 1, str. 63-80, jan. 2016.<\/p>\n\n\n\n

LEEHEY, M. A. in drugi Varnost in prena\u0161anje kanabidiola pri Parkinsonovi bolezni: (1): Odprta \u0161tudija z ozna\u010devanjem in zmanj\u0161evanjem odmerka. Raziskave o konoplji in kanabinoidih<\/strong>, 19. mar. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Kanabidiol kot predlagani kandidat za zdravljenje motenj avtisti\u010dnega spektra. Napredek v nevro-psihofarmakologiji in biolo\u0161ki psihiatriji<\/strong>, v. 89, str. 90-96, 8 mar. 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidi kot potencialni terapevtiki proti alzheimerjevi bolezni (Terpenoids as Potential Anti-Alzheimer's Disease Therapeutics). Molekule<\/strong>, v. 17, \u0161t. 3, str. 3524-3538, mar. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alzheimerjeva bolezen (AD) je nevrodegenerativna bolezen, ki je odgovorna za ve\u010d kot 50% trenutno diagnosticiranih primerov demence in je neposredno povezana s staranjem. Danes ima 40% ljudi, starej\u0161ih od 85 let, dolo\u010deno stopnjo demence. Prej je veljalo, da so bili simptomi AD povezani le z upadom kognitivnih funkcij, ki vplivajo na kratkoro\u010dne spomine, medtem ko so se pri [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? Yes, read this blog to know what is out there about cannabis and Alzheimer\u2019s disease.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sl\/\u043a\u0430\u043d\u043d\u0430\u0431\u0438\u0441-\u0438-\u0431\u043e\u043b\u0435\u0437\u043d\u044c-\u0430\u043b\u044c\u0446\u0433\u0435\u0439\u043c\u0435\u0440\u0430\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is Out There About Cannabis and Alzheimer\u2019s Disease - MTG\" \/>\n<meta property=\"og:description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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