{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sl\/coronavirus-covid-19-is-hidroksiklorokin-nova-nadiba-ocitno-da\/","title":{"rendered":"Koronavirus (Covid-19): je hidroksiklorokin novo upanje? O\u010ditno da."},"content":{"rendered":"

Dva nedavna dokumenta, ki sta povzela eno in vitro raziskavo in klini\u010dno \u0161tudijo v majhnem obsegu, sta bila dovolj, da je Donald Trump prisilil FDA, da je uveljavila novo klini\u010dno indikacijo za zdravilo hidroksiklorokin: izbolj\u0161anje simptomov bolnikov s koronavirusom (Covid-19).<\/p>\n

To je verjetno najhitrej\u0161i postopek odobritve zdravila v sodobni zgodovini in predsednik ima o\u010ditno prav. Presenetljivo za svetovnega voditelja, ki nima veliko posluha za znanost.<\/p>\n

\"\"<\/p>\n

Prvi dokazi o vplivu hidroksiklorokina na virus so bili pridobljeni iz ta dokument je bil objavljen v\u010deraj na Cell Discovery<\/a>To je le in vitro z vsemi omejitvami, vendar jasno ka\u017ee na potencial zdravila za uni\u010denje virusa. Ob predlo\u017eitvi dokumenta je bilo na Kitajskem potrjenih 80.000 primerov, vklju\u010dno z 2946 smrtnimi primeri, ter ve\u010d kot 10.566 potrjenih primerov v 72 drugih dr\u017eavah. Takrat so najve\u010dje upanje polagali na zdravilo, imenovano remdesivir.<\/p>\n

\"in
In vitro u\u010dinki hidroklorokvina na koronavirus (Covid-19). Stolpec na desni strani prikazuje u\u010dinke u\u010dinkovitega zdravila v primerjavi s klorokinom ali kontrolno skupino na levi strani. Iz njega je razvidno, da je zdravilo izbolj\u0161alo sposobnost celic, da izlo\u010dijo viruse ... to je tako, kot da bi pomagali iz hi\u0161e izgnati neza\u017eelenega soseda. Pomaga! \ud83d\ude42 <\/figcaption><\/figure>\n

Najve\u010dja novica pa je pri\u0161la iz manj\u0161e klini\u010dne \u0161tudije, ki je bila objavljena dan prej. Naslov je Hidroksiklorokin in azitromicin kot zdravljenje COVID-19: rezultati odprtega nerandomiziranega klini\u010dnega presku\u0161anja, ki so na voljo v razli\u010dici \"v tisku\"<\/a><\/p>\n

V \u0161tudiji, v kateri je sodelovalo le 20 bolnikov, so avtorji dokazali, da je bil hidroksiklorokin u\u010dinkovit proti oku\u017ebi s koronavirusom Covid-19. Dejansko je v \u0161estdnevnem obdobju zmanj\u0161al 75% oku\u017eenih oseb, kar je neverjetno. \u0160e bolje od tega je bilo, da je kombinacija z azitromicinom izbolj\u0161ala u\u010dinkovitost zdravljenja na 95%.<\/p>\n

\"Hidrohiklorokin
Hidrohiklorokin in azitromicin v kombinaciji sta u\u010dinkovita proti oku\u017ebam s koronavirusom (Covid-19) pri ljudeh. Padec je dramati\u010den in prina\u0161a novo upanje prizadetim bolnikom.<\/figcaption><\/figure>\n

Zdravljenje je izbolj\u0161alo simptome in zmanj\u0161alo virusno breme pri bolnikih. Zdravilo je bilo predhodno odobreno za zdravljenje malarije, kar pomeni, da velja za varno. \"Sestrsko\" zdravilo klorokin je bilo manj u\u010dinkovito. To je dobro za nas, saj je bolj strupeno.<\/p>\n

\u0160tudija ni bila randomizirana in je bila majhnega obsega, vendar se zdi, da se je epidemija za\u010dela na Kitajskem, re\u0161itev pa je posledica prizadevanj svetovne skupnosti. Dokument in vitro je dejansko kitajski, medtem ko je klini\u010dni dokument evropski, natan\u010dneje iz Francije. Zanimivo je, da je prvotna registracija zdravila za hidroksiklorokin od francoskega farmacevtskega podjetja Sanofi, nedavna klini\u010dna \u0161tudija pa je bila izvedena v Marseillu. Ale le bleu!<\/p>\n

Medscape ima odli\u010den \u010dlanek o tem, \u010de vas zanimajo podrobnej\u0161e informacije.<\/a><\/p>\n

Navedite to delo kot Gautret et al. (2020) Hidroksiklorokin in azitromicin kot zdravljenje COVID-19: rezultati odprtega nerandomiziranega klini\u010dnega presku\u0161anja. International Journal of Antimicrobial Agents - V tisku 17. marca 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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