{"id":9012,"date":"2019-06-03T11:07:17","date_gmt":"2019-06-03T14:07:17","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=9012"},"modified":"2022-10-18T08:23:58","modified_gmt":"2022-10-18T11:23:58","slug":"award-zika-virus-infection","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/ocenenie-zika-virusova-infekcia\/","title":{"rendered":"V\u00edrus Zika: Ocenen\u00e1 \u0161t\u00fadia, ktor\u00e1 prin\u00e1\u0161a nov\u00e9 svetlo na dlhodob\u00e9 d\u00f4sledky"},"content":{"rendered":"

Je v\u017edy \u00fa\u017easn\u00e9 uk\u00e1za\u0165 vedeck\u00fa pr\u00e1cu na\u0161ich pou\u017e\u00edvate\u013eov. Dnes v\u00e1m teda predstav\u00edm braz\u00edlsku vedky\u0148u Isis de Souza a jej pr\u00e1cu s v\u00edrusom zika. Isis a jej kolegovia sk\u00famaj\u00fa vplyv infekcie v\u00edrusom zika v ranom veku u my\u0161\u00ed. Je tie\u017e pou\u017e\u00edvate\u013ekou programu mind the graph a v\u00ed\u0165azn\u00e1 prezent\u00e1cia m\u00e1 vizu\u00e1lne zdroje z programu Mind the graph. Nu\u017e, nem\u00f4\u017eeme by\u0165 viac hrd\u00ed.<\/p>\n

\u010co je v\u00edrus zika?<\/strong><\/h3>\n

V\u00edrus Zika patr\u00ed do \u010de\u013eade Flaviviridae. T\u00e1to skupina zah\u0155\u0148a nieko\u013eko patog\u00e9nnych v\u00edrusov. Najzn\u00e1mej\u0161\u00ed je v\u00edrus \u017eltej zimnice, ktor\u00fd je typov\u00fdm v\u00edrusom \u010de\u013eade a z\u00e1rove\u0148 d\u00f4vodom n\u00e1zvu \u010de\u013eade, ke\u010f\u017ee slovo flavus znamen\u00e1 v latin\u010dine \"\u017elt\u00fd\". Okrem neho patria medzi \u010fal\u0161ie flaviv\u00edrusy v\u00edrus z\u00e1padon\u00edlskej hor\u00fa\u010dky, v\u00edrus hor\u00fa\u010dky dengue a v\u00edrus klie\u0161\u0165ovej encefalit\u00eddy.<\/p>\n

\u010ce\u013ea\u010f Flaviviridae m\u00e1 spolo\u010dn\u00fa ve\u013ekos\u0165 (40 - 65 nm) a v\u00edrusov\u00e9 obaly, ktor\u00e9 pokr\u00fdvaj\u00fa ich ochrann\u00fd ikosaedrick\u00fd nukleokapsid. Aj genetick\u00fd materi\u00e1l je RNA a objavuj\u00fa sa v elektr\u00f3novom mikroskope.<\/p>\n

Ni\u017e\u0161ie uveden\u00e1 infografika zobrazuje z\u00e1kladn\u00fa \u0161trukt\u00faru v\u00edrusu zika:<\/p>\n

\"n\u00e1h\u013ead_90481\"<\/a><\/p>\n

 Zika sa \u0161\u00edri predov\u0161etk\u00fdm sami\u010dkami Stegomya aegypti<\/em> kom\u00e1r, ktor\u00fd potrebuje krv na nakladenie vaj\u00ed\u010dok. Kom\u00e1r je akt\u00edvny najm\u00e4 cez de\u0148.<\/p>\n

V\u00ed\u0165azn\u00fd papier<\/strong><\/h2>\n

V poslednom \u010dase mnoh\u00ed vedci sk\u00famaj\u00fa neurologick\u00e9 poruchy s\u00favisiace s vroden\u00fdm vystaven\u00edm v\u00edrusu zika (ZIKV).<\/p>\n

Vroden\u00e1 mikrocef\u00e1lia je navy\u0161e jedn\u00fdm z najv\u00fdraznej\u0161\u00edch \u00fa\u010dinkov hl\u00e1sen\u00fdch u novorodencov infikovan\u00fdch v\u00edrusom ZIKV. Z tohto d\u00f4vodu sa v\u00fdskumn\u00e9 \u00fasilie zameriava na pochopenie mechanizmov vrodenej mikrocef\u00e1lie sp\u00f4sobenej v\u00edrusom ZIKV.<\/p>\n

Av\u0161ak len 1 a\u017e 13% exponovan\u00fdch plodov vykazuje pri naroden\u00ed fyzick\u00e9 malform\u00e1cie. Okrem toho ch\u00fdbaj\u00fa inform\u00e1cie o dlhodob\u00fdch n\u00e1sledkoch perinat\u00e1lnej infekcie.<\/p>\n

Isis de Souza a jej kolegovia preto pou\u017eili my\u0161i na \u0161t\u00fadium behavior\u00e1lnych a neuropatologick\u00fdch podmienok a kr\u00e1tkodob\u00fdch a dlhodob\u00fdch n\u00e1sledkov a v\u00fdsledky publikovali v \u010dl\u00e1nku s n\u00e1zvom Ak\u00fatne a chronick\u00e9 neurologick\u00e9 n\u00e1sledky infekcie v\u00edrusom Zika na za\u010diatku \u017eivota u my\u0161\u00ed.<\/strong><\/p>\n

U \u013eud\u00ed existuje mnoho klinick\u00fdch stavov spojen\u00fdch s expoz\u00edciou v\u00edrusu zika, ktor\u00e9 sa objavuj\u00fa mesiace alebo roky po naroden\u00ed. Tak\u017ee aj ke\u010f sa deti nenarodia s mikrocef\u00e1liou, m\u00f4\u017eu ma\u0165 motorick\u00e9 poruchy, kortik\u00e1lnu dyspl\u00e1ziu spojen\u00fa so z\u00e1chvatmi a in\u00e9 neurologick\u00e9 poruchy.<\/p>\n

Pod\u013ea autorov \"syst\u00e9movo infikovali novoroden\u00e9 my\u0161i divok\u00e9ho typu v\u00edrusom ZIKV a vykonali dlhodob\u00e9 sledovanie behavior\u00e1lnych, neuropatologick\u00fdch a molekul\u00e1rnych d\u00f4sledkov infekcie. Uv\u00e1dzame kr\u00e1tkodob\u00e9 a dlhodob\u00e9 komplik\u00e1cie po infekcii ZIKV u my\u0161\u00ed a ukazujeme, \u017ee v\u010dasn\u00e1 neutraliz\u00e1cia tumor nekrotizuj\u00faceho faktora-\u03b1 (TNF-\u03b1) \u010diasto\u010dne zabra\u0148uje t\u00fdmto \u0161kodliv\u00fdm \u00fa\u010dinkom. Na\u0161e zistenia odha\u013euj\u00fa potrebu venova\u0165 osobitn\u00fa pozornos\u0165 potenci\u00e1lnej z\u00e1\u0165a\u017ei neuropatologick\u00fdch komplik\u00e1ci\u00ed u det\u00ed a dospievaj\u00facich po vrodenej expoz\u00edcii ZIKV a nazna\u010duj\u00fa, \u017ee v\u010dasn\u00e1 inhib\u00edcia neuroz\u00e1palu m\u00f4\u017ee by\u0165 potenci\u00e1lnou lie\u010dbou na prevenciu dlhodob\u00fdch neurologick\u00fdch n\u00e1sledkov u det\u00ed infikovan\u00fdch ZIKV.\"<\/em><\/p>\n

 Ocenenie podporila spolo\u010dnos\u0165 GE Healthcare Life Sciences<\/strong><\/h2>\n

Cenu \"Pr\u00eamio Jovem Talento em Ci\u00eancias da Vida\" alebo Mlad\u00fd talent v oblasti vied o \u017eivej pr\u00edrode podporuje Braz\u00edlska spolo\u010dnos\u0165 pre bioch\u00e9miu a molekul\u00e1rnu biol\u00f3giu a spolo\u010dnos\u0165 GE Healthcare Life Sciences. Vedeck\u00fd v\u00fdbor vybral piatich kandid\u00e1tov, ktor\u00ed predstavia svoju pr\u00e1cu na v\u00fdro\u010dnom kongrese, podujat\u00ed, ktor\u00e9 sp\u00e1ja profesorov a \u0161tudentov z celej Latinskej Ameriky.<\/p>\n

V\u00fdbor vybral Isis de Oliveiru, ktor\u00e1 predstavila svoju \u0161t\u00fadiu o d\u00f4sledkoch vystavenia v\u00edrusu zika.<\/p>\n

\"vedeck\u00e1
Isis de Oliveira pri prezent\u00e1cii svojich v\u00fdsledkov<\/figcaption><\/figure>\n

Nap\u00edsala pr\u00edspevok, v ktorom \u010fakuje svojej univerzite a \u0161tipendiu, ktor\u00e9 jej umo\u017enilo \u0161tudova\u0165. Okrem toho vyjadrila n\u00e1dej, \u017ee bud\u00faca gener\u00e1cia bude ma\u0165 mo\u017enos\u0165 pokra\u010dova\u0165 vo vedeckej kari\u00e9re ako ona.<\/p>\n

Preto chceme Isis zablaho\u017eela\u0165 k jej \u00fa\u017easnej pr\u00e1ci! D\u00fafam, \u017ee svojou pr\u00e1cou in\u0161piruje viac \u013eud\u00ed, aby sa stali vedcami.<\/p>\n

A ak chcete svoje \u00fadaje vizualizova\u0165, aby ste mohli lep\u0161ie komunikova\u0165 vo vede, m\u00f4\u017eete vysk\u00fa\u0161a\u0165 Mind the Graph:<\/p>\n

\"vedeck\u00e9<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Je v\u017edy \u00fa\u017easn\u00e9 uk\u00e1za\u0165 vedeck\u00fa pr\u00e1cu na\u0161ich pou\u017e\u00edvate\u013eov. Dnes v\u00e1m teda predstav\u00edm braz\u00edlsku vedky\u0148u Isis de Souza a jej pr\u00e1cu s v\u00edrusom zika. Isis a jej kolegovia sk\u00famaj\u00fa vplyv infekcie v\u00edrusom zika v ranom veku u my\u0161\u00ed. Je tie\u017e pou\u017e\u00edvate\u013ekou programu mind the graph a v\u00ed\u0165azn\u00e1 prezent\u00e1cia m\u00e1 [...]<\/p>","protected":false},"author":11,"featured_media":9080,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[40],"tags":[299,282,554,71,775,293,316,315],"yoast_head":"\nZika virus: the award-winning study that sheds light on the future<\/title>\n<meta name=\"description\" content=\"Microcephaly is a known effect related to congenital exposure to zika virus. 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