{"id":8527,"date":"2019-03-20T18:17:14","date_gmt":"2019-03-20T21:17:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8527"},"modified":"2022-10-19T10:38:06","modified_gmt":"2022-10-19T13:38:06","slug":"nature-neuroscience","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/priroda-neurologia\/","title":{"rendered":"Nature neuroscience: prepojenie medzi schizofr\u00e9niou a mikrogliami"},"content":{"rendered":"<p>Schizofr\u00e9nia je chronick\u00e1 a z\u00e1va\u017en\u00e1 du\u0161evn\u00e1 porucha, ktor\u00e1 ovplyv\u0148uje myslenie, c\u00edtenie a spr\u00e1vanie \u010dloveka. \u013du\u010fom so schizofr\u00e9niou sa m\u00f4\u017ee zda\u0165, \u017ee stratili kontakt s realitou. Aby sme pochopili v\u00fdvoj schizofr\u00e9nie, mus\u00edme hovori\u0165 o synaptickom prerez\u00e1van\u00ed. Pod\u013ea \u010dl\u00e1nku z \u010dasopisu Nature neuroscience <sup>1<\/sup>, &#8220;<em>synaptick\u00e9 prerez\u00e1vanie je proces elimin\u00e1cie synapsi\u00ed, ku ktor\u00e9mu doch\u00e1dza v ranom detstve a\u017e do ranej dospelosti.\"<\/em>&nbsp;Ako sa mozog vyv\u00edja, vplyvy prostredia formuj\u00fa nervov\u00e9 obvody. Tento proces eliminuje nadbyto\u010dn\u00e9 synapsie vytvoren\u00e9 po\u010das ran\u00e9ho v\u00fdvoja a posil\u0148uje zost\u00e1vaj\u00face synapsie.<\/p>\n\n\n\n<p>Pod\u013ea hypot\u00e9zy \"synaptick\u00e9ho prerez\u00e1vania\" navy\u0161e nadmern\u00e9 alebo naru\u0161en\u00e9 synaptick\u00e9 prerez\u00e1vanie s\u00favis\u00ed s poruchou schizofr\u00e9nie. T\u00fato hypot\u00e9zu vyslovil v roku 1982 psychiater Irwin Feinberg.<\/p>\n\n\n\n<p>Okrem toho pred nieko\u013ek\u00fdmi rokmi priniesli zobrazovacie a posmrtn\u00e9 \u0161t\u00fadie \u013eudsk\u00e9ho mozgu nov\u00e9 d\u00f4kazy na podporu hypot\u00e9zy \"synaptick\u00e9ho prerez\u00e1vania\". Tieto d\u00f4kazy uk\u00e1zali, \u017ee hustota chrbtice a siv\u00e1 hmota s\u00fa v kortexe pacientov so schizofr\u00e9niou zn\u00ed\u017een\u00e9.<a href=\"https:\/\/mindthegraph.com\/templates\" target=\"_blank\" rel=\"noopener\"><br><\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png\" alt=\"n\u00e1h\u013ead_69596 (1)\" class=\"wp-image-8555\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<h3>&nbsp;<\/h3>\n\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-1 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Ste pripraven\u00ed za\u010da\u0165 pracova\u0165 v Mind the Graph?<\/a><\/div>\n<\/div>\n\n\n\n<h3><strong>&nbsp;Nov\u00e9 d\u00f4kazy publikovan\u00e9 v \u010dasopise Nature neuroscience:<\/strong><\/h3>\n\n\n\n<p>Preto sa teraz vedci sna\u017eia pochopi\u0165 mechanizmus, ktor\u00fd je z\u00e1kladom tohto javu. Pod\u013ea Carla Sellgrena, Roya Perlisa a ich spolupracovn\u00edkov m\u00f4\u017ee pri nadmernom prerez\u00e1van\u00ed synapsi\u00ed zohr\u00e1va\u0165 \u00falohu imunitn\u00fd syst\u00e9m. Ich nov\u00fd \u010dl\u00e1nok<sup>1<\/sup> uverejnenom v \u010dasopise Nature neuroscience sa opisuje model in vitro, ktor\u00fd vyu\u017e\u00edva bunkov\u00e9 preprogramovanie na \u0161t\u00fadium pohlcovania syn\u00e1ps sprostredkovan\u00e9ho mikrogliami \u0161pecifick\u00fdmi pre pacientov so schizofr\u00e9niou.<\/p>\n\n\n\n<p>Mikroglia je kolekt\u00edvny typ neuroglie (gliovej bunky), ktor\u00e1 sa nach\u00e1dza v celom mozgu a mieche. Predstavuj\u00fa 10-15% v\u0161etk\u00fdch buniek, ktor\u00e9 sa nach\u00e1dzaj\u00fa v mozgu. Ako rezidentn\u00e9 makrof\u00e1gy p\u00f4sobia ako prv\u00e1 a hlavn\u00e1 forma akt\u00edvnej imunitnej obrany v centr\u00e1lnom nervovom syst\u00e9me (CNS). Okrem toho s\u00fa bunky mikroglie schopn\u00e9 rozpozna\u0165 cudzie teles\u00e1, pohlti\u0165 ich a p\u00f4sobi\u0165 ako antig\u00e9n-prezentuj\u00face bunky aktivuj\u00face T-bunky.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png\" alt=\"n\u00e1h\u013ead_69544\" class=\"wp-image-8529\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png\" alt=\"n\u00e1h\u013ead_69618\" class=\"wp-image-8531\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-150x150.png 150w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-300x300.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-768x768.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1.png 1980w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"640\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png\" alt=\"n\u00e1h\u013ead_69620\" class=\"wp-image-8532\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-300x188.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-768x480.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-2 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Za\u010dnite tvori\u0165 na Mind the Graph teraz<\/a><\/div>\n<\/div>\n\n\n\n<h2>\u010c\u00edtajte \u010falej o t\u00e9mach z oblasti neurovedy<\/h2>\n\n\n\n<ul><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-disease\/#.XJlCeZhKiUk\" target=\"_blank\" rel=\"noopener\">Alzheimerova choroba: Vedeck\u00e1 infografika<\/a><\/li><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.XJlCiJhKiUk\" target=\"_blank\" rel=\"noopener\">Grafick\u00e9 abstrakty Alzheimerovej choroby: \u010co je nov\u00e9 v neurovede vizu\u00e1lnym sp\u00f4sobom<\/a><\/li><\/ul>\n\n\n\n<p>Ak chcete svoj v\u00fdskum prezentova\u0165 aj vizu\u00e1lne, grafick\u00e9 abstrakty a kr\u00e1sne vedeck\u00e9 ilustr\u00e1cie s\u00fa \u00fa\u010dinn\u00fdm n\u00e1strojom! Za\u010dnite teda e\u0161te dnes vizualizova\u0165 svoje \u00fadaje.<\/p>\n\n\n\n<ol><li><a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0334-7\" target=\"_blank\" rel=\"noreferrer noopener\">Zv\u00fd\u0161en\u00e1 elimin\u00e1cia synapsi\u00ed mikrogliami v modeloch synaptick\u00e9ho prerez\u00e1vania odvoden\u00fdch od pacientov so schizofr\u00e9niou.<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>Schizofr\u00e9nia je chronick\u00e1 a z\u00e1va\u017en\u00e1 du\u0161evn\u00e1 porucha, ktor\u00e1 ovplyv\u0148uje myslenie, c\u00edtenie a spr\u00e1vanie \u010dloveka. \u013du\u010fom so schizofr\u00e9niou sa m\u00f4\u017ee zda\u0165, \u017ee stratili kontakt s realitou. Aby sme pochopili v\u00fdvoj schizofr\u00e9nie, mus\u00edme hovori\u0165 o synaptickom prerez\u00e1van\u00ed. Pod\u013ea \u010dl\u00e1nku z \u010dasopisu Nature neuroscience 1 \"synaptick\u00e9 prerez\u00e1vanie je proces, pri ktorom sa synapsa [...]<\/p>","protected":false},"author":11,"featured_media":8536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[96,554,775],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuroscience of nature: see the link between schizophrenia and microglia<\/title>\n<meta name=\"description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/luonto-neurotiede\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuroscience of nature: see the link between schizophrenia and microglia\" \/>\n<meta property=\"og:description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sk\/luonto-neurotiede\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-20T21:17:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-19T13:38:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/dfgg.png\" \/>\n\t<meta property=\"og:image:width\" content=\"850\" \/>\n\t<meta property=\"og:image:height\" content=\"519\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta 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