{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/alzheimerova-choroba\/","title":{"rendered":"Alzheimerova choroba: Vedeck\u00e1 infografika"},"content":{"rendered":"

V\u017edy je to oslava, ke\u010f vid\u00edme \u00fa\u017easn\u00fa pr\u00e1cu na\u0161ich pou\u017e\u00edvate\u013eov.\u00a0U\u017e som nap\u00edsal<\/a> o v\u00fdskume Dr. Alessandry Martini, Dr.\u00a0Stefania Forner<\/a>\u00a0a ich kolegami. S\u00fa postdoktorandmi na Kalifornskej univerzite a venuj\u00fa sa pou\u017e\u00edvate\u013eom grafov. Pred nieko\u013ek\u00fdmi mesiacmi som uk\u00e1zal infografiky<\/a>\u00a0Dr. Stefania Forner vytvorila pre preh\u013eadov\u00fd \u010dl\u00e1nok uverejnen\u00fd v \u010dasopise Trends in Neurosciences s n\u00e1zvom Synaptic impairment in Alzheimer's Disease: A dysregulated symphony.<\/p>\n

Dnes chcem hovori\u0165 o ich novom \u010dl\u00e1nku s n\u00e1zvom Z minulosti do bud\u00facnosti: \u010do n\u00e1s nau\u010dili zvieracie modely o Alzheimerovej chorobe.<\/a><\/p>\n

Alzheimerova choroba (AD) je neurodegenerat\u00edvne ochorenie, ktor\u00e9 sp\u00f4sobuje kognit\u00edvne poruchy a stratu pam\u00e4ti. Pochopenie mechanizmu ochorenia je d\u00f4le\u017eit\u00e9 na zlep\u0161enie kvality \u017eivota pacientov a n\u00e1jdenie \u00fa\u010dinnej lie\u010dby. Napriek obrovsk\u00e9mu \u00fasiliu akademickej obce a farmaceutick\u00e9ho priemyslu dnes nie je k dispoz\u00edcii \u017eiadna \u00fa\u010dinn\u00e1 lie\u010dba. Alzheimerova choroba je \u0161iestou naj\u010dastej\u0161ou pr\u00ed\u010dinou \u00famrt\u00ed v USA a postihuje 35 mili\u00f3nov \u013eud\u00ed na celom svete.<\/p>\n

Infografika o Alzheimerovej chorobe<\/h2>\n

 <\/p>\n

V\u00e4\u010d\u0161ina pacientov s Alzheimerovou chorobou s\u00fa star\u0161\u00ed \u013eudia, ktor\u00ed be\u017ene trpia r\u00f4znymi komorbiditami. Diabetes, osteopor\u00f3za, ochorenie obli\u010diek, obezita, hypertenzia a hypercholesterol\u00e9mia\/dyslipid\u00e9mia, cievna mozgov\u00e1 pr\u00edhoda a z\u00e1chvaty s\u00fa hlavn\u00fdmi komorbiditami ovplyv\u0148uj\u00facimi vznik a progresiu AD, ktor\u00e9 prispievaj\u00fa k zlo\u017eitosti patogen\u00e9zy ochorenia.<\/p>\n

\"infografika
Infografika zobrazuj\u00faca komorbidity pri Alzheimerovej chorobe (AD). Minulos\u0165 do bud\u00facnosti: \u010co n\u00e1m o Alzheimerovej chorobe prezradili zvieracie modely<\/figcaption><\/figure>\n

 <\/p>\n

\n

Napriek intenz\u00edvnemu v\u00fdskumu v posledn\u00fdch desa\u0165ro\u010diach nie s\u00fa zn\u00e1me mechanizmy etiol\u00f3gie sporadickej Alzheimerovej choroby (sAD), ktor\u00e1 predstavuje naj\u010dastej\u0161iu formu tohto ochorenia. Je to prinajmen\u0161om \u010diasto\u010dne sp\u00f4soben\u00e9 skuto\u010dnos\u0165ou, \u017ee v\u00e4\u010d\u0161ina pacientov so sAD s\u00fa star\u0161ie osoby, ktor\u00e9 be\u017ene trpia r\u00f4znymi komorbiditami (napr. mozgovou pr\u00edhodou, stresom, cukrovkou, z\u00e1chvatmi, osteopor\u00f3zou a ochoren\u00edm obli\u010diek).<\/em><\/p>\n<\/blockquote>\n

\u010eal\u0161ia infografika ukazuje vznik a mechanizmy synaptickej toxicity tau a beta-amyloidov\u00fdch oligom\u00e9rov.<\/p>\n

 <\/p>\n

\"infografico
Z minulosti do bud\u00facnosti: \u010co n\u00e1m o Alzheimerovej chorobe prezradili zvieracie modely<\/figcaption><\/figure>\n

 <\/p>\n

\n

Pri tauopati\u00e1ch doch\u00e1dza k zn\u00ed\u017eeniu po\u010dtu dendritick\u00fdch t\u0155\u0148ov. Tau sa nedost\u00e1va do jadra neur\u00f3nu, \u010do vedie k po\u0161kodeniu DNA. Doch\u00e1dza k zn\u00ed\u017eeniu po\u010dtu mitochondri\u00ed a tie\u017e po\u010dtu presynaptick\u00fdch vezik\u00fal, \u010do vedie k strate synaptick\u00fdch funkci\u00ed. Tak\u00e1to strata je sp\u00f4soben\u00e1 aj vstupom tau do dendritov a postsynaptick\u00fdch oblast\u00ed. Tau sa tie\u017e extracelul\u00e1rne agreguje, \u010do umo\u017e\u0148uje jeho zachytenie in\u00fdmi neur\u00f3nmi.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

Vytvorila tie\u017e infografiku, ktor\u00e1 ukazuje z\u00e1palov\u00e9 mechanizmy spojen\u00e9 s Alzheimerovou chorobou (AD).<\/p>\n

 <\/p>\n

\"infografico<\/p>\n

 <\/p>\n

\n

V posledn\u00fdch rokoch sme sa zauj\u00edmali najm\u00e4 o to, ako z\u00e1pal ovplyv\u0148uje patol\u00f3giu beta-amyloidu a tau. Star\u0161\u00ed \u013eudia s\u00fa n\u00e1chyln\u00ed na v\u00edrusov\u00e9 a bakteri\u00e1lne infekcie a tieto mikrobi\u00e1lne agensy by mohli zhor\u0161i\u0165 existuj\u00faci z\u00e1palov\u00fd stav v mozgu, \u010d\u00edm by sa ur\u00fdchlil kognit\u00edvny \u00fapadok.<\/em><\/p>\n<\/blockquote>\n

Pochvala Dr. Stefanii Forner za va\u0161u skvel\u00fa pr\u00e1cu!<\/p>\n

Ak ste vedec a chcete vytv\u00e1ra\u0165 kr\u00e1sne obr\u00e1zky pre svoju pr\u00e1cu, m\u00f4\u017eete sa sta\u0165 pou\u017e\u00edvate\u013eom programu mind the graph hne\u010f teraz.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

V\u017edy je to oslava, ke\u010f vid\u00edme \u00fa\u017easn\u00fa pr\u00e1cu na\u0161ich pou\u017e\u00edvate\u013eov. O v\u00fdskume Dr. Alessandry Martini, Dr. Stefanie Forner a ich kolegov som u\u017e p\u00edsal. S\u00fa to postdoktorandi na Kalifornskej univerzite a myslia na pou\u017e\u00edvate\u013eov grafov. Pred nieko\u013ek\u00fdmi mesiacmi som uk\u00e1zal infografiku, ktor\u00fa Dr. Stefania Fornerov\u00e1 vytvorila pre preh\u013eadov\u00fd \u010dl\u00e1nok uverejnen\u00fd v \u010dasopise Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - 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