{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/autofagia-ziskala-nobelovu-cenu-mediciny\/","title":{"rendered":"Autof\u00e1gia z\u00edskala Nobelovu cenu za medic\u00ednu"},"content":{"rendered":"

Proces autof\u00e1gie sa podie\u013ea na viacer\u00fdch ochoreniach, ako je rakovina a neurologick\u00e9 ochorenia. Funguje ako vn\u00fatorn\u00fd recykla\u010dn\u00fd program tela. Nefunk\u010dn\u00e1 autof\u00e1gia sa v\u0161ak sp\u00e1ja s Parkinsonovou chorobou, cukrovkou, rakovinou a in\u00fdmi poruchami s\u00favisiacimi s vekom.<\/p>\n

Po tomto malom \u00favode o v\u00fdzname procesu autof\u00e1gie nie je prekvapen\u00edm, \u017ee nov\u00e9 objavy v tejto oblasti m\u00f4\u017eu vies\u0165 k udeleniu Nobelovej ceny. Minul\u00fd pondelok toti\u017e v\u00fdskumn\u00edk Yoshino Ohsumi z\u00edskal Nobelova cena za medic\u00ednu<\/a> za identifik\u00e1ciu prv\u00fdch esenci\u00e1lnych g\u00e9nov pre autof\u00e1giu.<\/p>\n

\"Nec\u00edtim sa dobre, ke\u010f m\u00f4\u017eem s\u00fa\u0165a\u017ei\u0165 s mnoh\u00fdmi \u013eu\u010fmi, a namiesto toho mi je pr\u00edjemnej\u0161ie robi\u0165 nie\u010do, \u010do nikto in\u00fd nerob\u00ed. Svoj\u00edm sp\u00f4sobom je to o vede a rados\u0165 z toho, \u017ee som nie\u010do na\u0161iel, ma in\u0161piruje.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Ako to Ohsumi dok\u00e1zal?<\/h3>\n

Ohsumi vo svojom laborat\u00f3riu vytvoril kmene kvasiniek, ktor\u00e9 po\u010das hladovania hromadili autofagoz\u00f3my. K tejto akumul\u00e1cii mohlo d\u00f4js\u0165 len vtedy, ak by boli g\u00e9ny d\u00f4le\u017eit\u00e9 pre autof\u00e1giu neakt\u00edvne. Ohsumi teda za\u010dal manipulova\u0165 s bunkami na nieko\u013eko g\u00e9nov\u00fdch mut\u00e1ci\u00ed a podarilo sa mu navodi\u0165 autof\u00e1giu.<\/p>\n

\"Autof\u00e1gia<\/a><\/p>\n

Autof\u00e1gia je zn\u00e1ma<\/h3>\n

Hoci je autof\u00e1gia zn\u00e1ma u\u017e 50 rokov, v\u00fdznam tohto procesu bol uznan\u00fd a\u017e v 90. rokoch minul\u00e9ho storo\u010dia v\u010faka Ohsumiho \u0161t\u00fadii.
\nZa svoju pr\u00e1cu si Ohsumi u\u017e z\u00edskal nieko\u013eko fan\u00fa\u0161ikov:<\/p>\n

\"Autof\u00e1gia<\/a><\/p>\n

\n

\"Som ve\u013emi r\u00e1d, \u017ee dostal tohtoro\u010dn\u00fa Nobelovu cenu, je to ve\u013emi zasl\u00fa\u017een\u00e9. Jeho laborat\u00f3rium sa zaober\u00e1 najm\u00e4 kvasinkami. Urobili prv\u00e9 skr\u00edningy, ktor\u00e9 umo\u017enili objavi\u0165 k\u013e\u00fa\u010dov\u00e9 g\u00e9ny, ktor\u00e9 sa podie\u013eaj\u00fa na autof\u00e1gii. Jeho objavy priamo alebo nepriamo vyu\u017eilo mnoho \u010fal\u0161\u00edch laborat\u00f3ri\u00ed, aby zistili, pre\u010do je to d\u00f4le\u017eit\u00e9 pri chorob\u00e1ch.\"<\/p>\n

David Rubinsztein<\/a> - z\u00e1stupca riadite\u013ea Cambridgesk\u00e9ho in\u0161tit\u00fatu pre lek\u00e1rsky v\u00fdskum<\/p>\n<\/blockquote>\n

\"Autof\u00e1gia<\/a><\/p>\n

\n

\"Mysl\u00edm si, \u017ee je ve\u013emi d\u00f4le\u017eit\u00e9, aby t\u00e1to oblas\u0165 vedy bola uznan\u00e1. D\u00f4le\u017eit\u00fdm princ\u00edpom je tu h\u013eadanie spolo\u010dn\u00fdch mechanizmov pri ochoreniach. Otv\u00e1ra to cesty k lie\u010dbe t\u00fdchto por\u00fach, ktor\u00e9 sa l\u00ed\u0161ia od konven\u010dnej\u0161\u00edch pr\u00edstupov zameran\u00fdch na konkr\u00e9tne ochorenia.\"<\/p>\n

Giovanna Mallucci<\/a> - profesor klinickej neurovedy na univerzite v Cambridge<\/p>\n<\/blockquote>\n

\"Autof\u00e1gia<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Proces autof\u00e1gie sa podie\u013ea na viacer\u00fdch ochoreniach, ako je rakovina a neurologick\u00e9 ochorenia. Funguje ako vn\u00fatorn\u00fd recykla\u010dn\u00fd program tela. Nefunk\u010dn\u00e1 autof\u00e1gia sa v\u0161ak sp\u00e1ja s Parkinsonovou chorobou, cukrovkou, rakovinou a in\u00fdmi poruchami s\u00favisiacimi s vekom. Po tomto malom \u00favode o v\u00fdzname procesu autof\u00e1gie nie je prekvapen\u00edm, \u017ee nov\u00e9 objavy [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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