{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/success-case-nuclear-receptors-in-liver-fibrosis\/","title":{"rendered":"Nukle\u00e1rne receptory vo fibr\u00f3ze pe\u010dene"},"content":{"rendered":"

V tomto pr\u00edpade autor pou\u017eil Mind the Graph na zhroma\u017edenie \u00fadajov z r\u00f4znych zdrojov na jednom mieste. Okrem najlep\u0161\u00edch vedecky presn\u00fdch ilustr\u00e1ci\u00ed m\u00e1 n\u00e1\u0161 pracovn\u00fd priestor priate\u013esk\u00e9 rozhranie a ve\u013emi \u013eahko sa pou\u017e\u00edva.<\/p>\n\n\n\n

Skontrolujte kompletn\u00e9 p\u00f4vodn\u00fd \u010dl\u00e1nok<\/a>. <\/p>\n\n\n\n

\u00daloha jadrov\u00fdch receptorov pri fibr\u00f3ze pe\u010dene<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer a in\u00ed (2021) uv\u00e1dzaj\u00fa, \u017ee jadrov\u00e9 receptory s\u00fa ligandom aktivovan\u00e9 transkrip\u010dn\u00e9 faktory, ktor\u00e9 reguluj\u00fa g\u00e9nov\u00fa expresiu r\u00f4znych k\u013e\u00fa\u010dov\u00fdch molekul\u00e1rnych sign\u00e1lov zapojen\u00fdch do fibr\u00f3zy pe\u010dene. <\/p>\n\n\n\n

Prim\u00e1rnym bunkov\u00fdm faktorom fibrogen\u00e9zy pe\u010dene s\u00fa aktivovan\u00e9 pe\u010de\u0148ov\u00e9 hviezdicov\u00e9 bunky. R\u00f4zne jadrov\u00e9 receptory reguluj\u00fa pe\u010de\u0148ov\u00fa expresiu proz\u00e1palov\u00fdch a profibrog\u00e9nnych cytok\u00ednov.<\/p>\n\n\n\n

Grafick\u00e9 abstrakty zalo\u017een\u00e9 na Mind the Graph<\/strong> v tomto \u010dl\u00e1nku<\/strong><\/h2>\n\n\n\n
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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
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Na prvom obr\u00e1zku je preh\u013ead a klasifik\u00e1cia jadrov\u00fdch receptorov pod\u013ea podrod\u00edn.<\/p>\n\n\n\n

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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vy\u0161\u0161ie m\u00f4\u017eeme vidie\u0165 r\u00f4zne typy efektorov\u00fdch funkci\u00ed jadrov\u00fdch receptorov.<\/p>\n\n\n\n

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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Na tre\u0165om obr\u00e1zku si m\u00f4\u017eeme pozrie\u0165 preh\u013ead uv\u00e1dzan\u00fdch \u00fa\u010dinkov modul\u00e1ci\u00ed NR ako potenci\u00e1lnych terapeutick\u00fdch pr\u00edstupov proti chorob\u00e1m pe\u010dene. <\/p>\n\n\n\n

\u0160\u00edpky ozna\u010duj\u00fa predpokladan\u00e9 priazniv\u00e9 \u00fa\u010dinky pri ochoren\u00ed pe\u010dene hore- (tmavozelen\u00e1)<\/strong><\/span> alebo nadol (svetlozelen\u00e1)<\/span><\/strong> regul\u00e1ciu \u0161pecifick\u00fdch mechanizmov, ktor\u00e9 podporuj\u00fa regresiu fibr\u00f3zy pe\u010dene alebo zni\u017euj\u00fa fibr\u00f3zu pe\u010dene. <\/p>\n\n\n\n

Oran\u017eov\u00e9 \u0161\u00edpky<\/mark><\/strong> poukazuj\u00fa na \u00fa\u010dinky a mechanizmy modul\u00e1cie NR, ktor\u00e9 s\u00fa bu\u010f kontroverzn\u00e9, alebo zatia\u013e nedostato\u010dne pos\u00faden\u00e9.<\/p>\n\n\n\n

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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Posledn\u00fd obr\u00e1zok predstavuje molekul\u00e1rne \u00fa\u010dinky modul\u00e1torov NR ako potenci\u00e1lnej lie\u010dby fibr\u00f3zy pe\u010dene, ktor\u00e9 sa pod\u013ea spr\u00e1v vyskytuj\u00fa preva\u017ene v HSC.<\/p>\n\n\n\n

K\u00f6nigshofer a jeho kolegovia navrhuj\u00fa, \u017ee \u010fal\u0161\u00ed v\u00fdskum signaliz\u00e1cie s\u00favisiacej s jadrov\u00fdmi receptormi m\u00f4\u017ee vies\u0165 ku klinick\u00e9mu v\u00fdvoju \u00fa\u010dinn\u00fdch antifibrotick\u00fdch terapi\u00ed pre pacientov s ochoren\u00edm pe\u010dene.<\/p>\n\n\n\n

Dokumenty Vplyv a v\u00fdkon<\/strong><\/h2>\n\n\n\n

Pri v\u00fdbere jednoro\u010dnej mo\u017enosti porovnania metr\u00edk s in\u00fdmi \u010dl\u00e1nkami\/recenziou, ktor\u00e9 boli tie\u017e publikovan\u00e9 v tom istom kalend\u00e1rnom roku v danom \u010dasopise, si m\u00f4\u017eeme v\u0161imn\u00fa\u0165, \u017ee tento \u010dl\u00e1nok bol citovan\u00fd viac ako 57% z nich<\/strong>.<\/p>\n\n\n

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Zdroj PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vyu\u017eite silu infografiky aj na podporu svojho \u010dl\u00e1nku. Vysk\u00fa\u0161ajte Mind the Graph!<\/p>\n\n\n\n

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Vysk\u00fa\u0161ajte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Tento \u010dl\u00e1nok obsahuje vedeck\u00e9 ilustr\u00e1cie vytvoren\u00e9 pomocou Mind the Graph na zn\u00e1zornenie jadrov\u00fdch receptorov pri fibr\u00f3ze pe\u010dene.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/success-case-nuclear-receptors-in-liver-fibrosis\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - 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