{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/","title":{"rendered":"XTALKDB: datab\u00e1za signaliza\u010dn\u00fdch dr\u00e1h Preh\u013ead dokumentov"},"content":{"rendered":"

Tento \u00fa\u017easn\u00fd \u010dl\u00e1nok prin\u00e1\u0161a \u0161tatistiky sumarizuj\u00face \u00fadaje v XTALKDB. Autor za p\u00e1r min\u00fat vytvoril infografiku vysvet\u013euj\u00facu distrib\u00faciu druhov v XTALKDB.<\/p>\n\n\n\n

Skontrolujte p\u00f4vodn\u00fd \u010dl\u00e1nok tu<\/a>.<\/p>\n\n\n\n

Ke\u010f\u017ee \u013eudia s\u00fa vizu\u00e1lne bytosti, obr\u00e1zky s\u00fa st\u00e1le najlep\u0161\u00edm sp\u00f4sobom, ako vysvetli\u0165 svoj v\u00fdskum s to\u013ek\u00fdmi podrobnos\u0165ami, ko\u013eko chcete.<\/p>\n\n\n\n

Vedci vytvorili datab\u00e1zu, ktor\u00e1 dokumentuje vz\u00e1jomn\u00e9 prepojenie medzi \u0161pecifick\u00fdmi dvojicami sign\u00e1lnych dr\u00e1h a druhmi a tkanivami, v ktor\u00fdch sa pozoruj\u00fa.<\/strong><\/h2>\n\n\n\n

V\u00fdskumn\u00e1 skupina pod veden\u00edm Sarah Samovej z Katedry biologick\u00fdch vied (2016) uviedla, \u017ee vn\u00edmanie vonkaj\u0161ieho sign\u00e1lu receptormi sp\u00f4sobuje zmenu aktivity medzi\u013eahl\u00fdch prote\u00ednov. <\/p>\n\n\n\n

To vedie k regul\u00e1cii transkrip\u010dn\u00fdch faktorov, ktor\u00e9 moduluj\u00fa expresiu cie\u013eov\u00fdch g\u00e9nov. Pre ka\u017ed\u00fa dvojicu dr\u00e1h XTalkDB zaznamen\u00e1va podrobn\u00e9 inform\u00e1cie opisuj\u00face experiment\u00e1lne podmienky, za ktor\u00fdch sa vz\u00e1jomn\u00e9 ovplyv\u0148ovanie objavilo. <\/p>\n\n\n\n

Bunky vyhodnocuj\u00fa svoje prostredie a reaguj\u00fa na\u0148 prostredn\u00edctvom sign\u00e1lnych dr\u00e1h. Sign\u00e1lna dr\u00e1ha zvy\u010dajne obsahuje presne definovan\u00fd s\u00fabor regula\u010dn\u00fdch a fyzik\u00e1lnych interakci\u00ed medzi receptormi, sprostredkuj\u00facimi sign\u00e1lnymi prote\u00ednmi, transkrip\u010dn\u00fdmi faktormi a cie\u013eov\u00fdmi g\u00e9nmi. <\/p>\n\n\n\n

Webov\u00e1 str\u00e1nka XTalkDB poskytuje vedcom \u013eahko pou\u017eite\u013en\u00e9 rozhranie na preh\u013ead\u00e1vanie inform\u00e1ci\u00ed o vz\u00e1jomnom ovplyv\u0148ovan\u00ed pomocou dotazu na jednu alebo viac dr\u00e1h alebo molek\u00fal, ktor\u00e9 ich zauj\u00edmaj\u00fa.<\/p>\n\n\n\n

Do \u0161t\u00fadie bolo zahrnut\u00fdch 650 p\u00e1rov.<\/strong><\/p>\n\n\n\n

Grafick\u00e9 abstraktum poh\u00e1\u0148an\u00e9 Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-a-database-of-signaling-pathway-crosstalk\"<\/a>
Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Pri diskusii o mo\u017en\u00fdch vylep\u0161eniach: \"Manu\u00e1lny proces kur\u00e1torov, ktor\u00fd je z\u00e1kladom XTalkDB, m\u00e1 svoje obmedzenia, najm\u00e4 ke\u010f sa sna\u017e\u00edme roz\u0161\u00edri\u0165 pokrytie datab\u00e1zy. <\/p>\n\n\n\n

Pl\u00e1nujeme vyvin\u00fa\u0165 r\u00e1mec na spracovanie prirodzen\u00e9ho jazyka, ktor\u00fd bude hodnoti\u0165 publik\u00e1cie na z\u00e1klade pravdepodobnosti, \u017ee bud\u00fa dokumentova\u0165 vz\u00e1jomn\u00e9 prepojenie. Kur\u00e1tor sa potom m\u00f4\u017ee zamera\u0165 na vysoko hodnoten\u00e9 publik\u00e1cie,\" prizn\u00e1vaj\u00fa.<\/p>\n\n\n\n

Dokumenty Vplyv a v\u00fdkon<\/strong><\/h2>\n\n\n\n

M\u00f4\u017eeme analyzova\u0165 pomocou Altmetric<\/a> \u00fadaje, \u017ee tento dokument je na horn\u00e1 \u010das\u0165 v\u0161etk\u00fdch ukazovate\u013eov v r\u00e1mci v\u0161etk\u00fdch \u010dl\u00e1nkov financovan\u00fdch NIH v dimenzi\u00e1ch. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Zdroj: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vyu\u017eite silu infografiky aj na podporu svojho \u010dl\u00e1nku. Vysk\u00fa\u0161ajte Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
Vysk\u00fa\u0161ajte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

U\u010dte sa s t\u00fdmi, ktor\u00ed u\u017e objavili silu infografiky. Tento \u010dl\u00e1nok obsahuje grafick\u00e9 v\u00fd\u0148atky vytvoren\u00e9 pomocou Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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