{"id":16651,"date":"2022-09-12T18:50:00","date_gmt":"2022-09-12T21:50:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16651"},"modified":"2023-03-17T14:47:35","modified_gmt":"2023-03-17T17:47:35","slug":"success-case-immunotherapeutic-potential-of-crotoxin-anti-inflammatory-and-immunosuppressive-properties","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/uspech-pripadu-imunoterapeutickeho-potencialu-krotoxinovych-protizapalovych-a-imunosupresivnych-vlastnosti\/","title":{"rendered":"Imunoterapeutick\u00fd potenci\u00e1l krotox\u00ednu: protiz\u00e1palov\u00e9 a imunosupres\u00edvne vlastnosti Paper Review"},"content":{"rendered":"<p>Mohlo by by\u0165 trochu \u0165a\u017ek\u00e9 vysvetli\u0165 protiz\u00e1palov\u00fa modul\u00e1ciu krotox\u00ednu bez vhodn\u00fdch obr\u00e1zkov, ale pr\u00e1ve preto existuje Mind the Graph!<\/p>\n\n\n\n<h2><strong>Preh\u013ead vedeck\u00e9ho v\u00fdskumu krotox\u00ednu, jedu ch\u0159est\u00fd\u0161a<\/strong><\/h2>\n\n\n\n<p>Marco Sartim et al. (2018) v \u010dl\u00e1nku \"Immunotherapeutic potential of Crotoxin\" (Imunoterapeutick\u00fd potenci\u00e1l krotox\u00ednu) uv\u00e1dza, \u017ee za posledn\u00fdch 80 rokov sa krotox\u00edn stal jedn\u00fdm z najviac sk\u00faman\u00fdch izolovan\u00fdch tox\u00ednov z had\u00edch jedov. <\/p>\n\n\n\n<p>Krotox\u00edn je hlavnou toxickou zlo\u017ekou jedu juhoamerick\u00e9ho chrap\u00fa\u0148a Crotalus durissus terrificus. \u0160t\u00fadie uk\u00e1zali, \u017ee imunomodula\u010dn\u00fd \u00fa\u010dinok C.d.t. je spojen\u00fd s produkciou protiz\u00e1palov\u00fdch medi\u00e1torov. <\/p>\n\n\n\n<p>Schopnos\u0165 krotox\u00ednu a jeho podjednotiek modulova\u0165 imunitn\u00fd syst\u00e9m priniesla nov\u00e9 perspekt\u00edvy ako potenci\u00e1lnych terapeutick\u00fdch l\u00e1tok.<\/p>\n\n\n\n<p><strong>V\u00fdskumn\u00edci presk\u00famali 161 \u010dl\u00e1nkov.<\/strong><\/p>\n\n\n\n<p>Skontrolujte <a href=\"https:\/\/jvat.biomedcentral.com\/articles\/10.1186\/s40409-018-0178-3\" target=\"_blank\" rel=\"noreferrer noopener\">p\u00f4vodn\u00fd \u010dl\u00e1nok tu<\/a>.<\/p>\n\n\n\n<h2><strong>Grafick\u00e9 abstrakty zalo\u017een\u00e9 na Mind the Graph<\/strong><\/h2>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1003\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp\" alt=\"\" class=\"wp-image-20251\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-1024x1003.webp 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-300x294.webp 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-768x752.webp 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-12x12.webp 12w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html-100x98.webp 100w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_fig2_html.webp 1418w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Vyroben\u00e9 s <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autor pou\u017eil platformu Mind the Graph na vytvorenie schematick\u00e9ho obr\u00e1zku cirkul\u00e1cie, tkanivov\u00fdch a bunkov\u00fdch udalost\u00ed modulovan\u00fdch krotox\u00ednom a jeho podjednotkami po\u010das z\u00e1palov\u00e9ho stimulu.<\/p>\n\n\n\n<div style=\"height:18px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML.webp\"><img decoding=\"async\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/40409_2018_178_Fig3_HTML-839x1024.webp\" alt=\"\" class=\"wp-image-20252\"\/><\/a><figcaption class=\"wp-element-caption\"><em>Vyroben\u00e9 s <a href=\"https:\/\/mindthegraph.com\/app\/graphical-abstract-maker\" target=\"_blank\" rel=\"noreferrer noopener\">Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Autor tie\u017e podrobne opisuje krvn\u00fd obeh, nav\u00e1dzanie lymfocytov do lymfatick\u00fdch uzl\u00edn a bunkov\u00e9 udalosti spojen\u00e9 s imunosupres\u00edvnymi \u00fa\u010dinkami krotox\u00ednu a jeho podjednotiek.<\/p>\n\n\n\n<p><strong>To je sila infografiky!<\/strong><\/p>\n\n\n\n<p>Z\u00e1very autorov zrejme upev\u0148uj\u00fa predch\u00e1dzaj\u00face pr\u00e1ce v tejto oblasti: \"Krotox\u00edn dok\u00e1zal potla\u010di\u0165 \u0161pecifick\u00fa produkciu protil\u00e1tok anti-HSA IgG1 a IgG2a u my\u0161\u00ed imunizovan\u00fdch HAS, \u010do nazna\u010duje jeho schopnos\u0165 modulova\u0165 reakcie Th1 a Th2,\" tvrd\u00ed Sartim.<\/p>\n\n\n\n<h2><strong>Dokumenty Vplyv a v\u00fdkon<\/strong><\/h2>\n\n\n\n<p>M\u00f4\u017eeme analyzova\u0165 pomocou <a href=\"https:\/\/mindthegraph.com\/blog\/altmetric\/\" target=\"_blank\" rel=\"noreferrer noopener\">Altmetric<\/a> \u00fadaje, \u017ee tento dokument mal viac cit\u00e1ci\u00ed <strong>ako . <strong>84%<\/strong><\/strong> <strong>\u010fal\u0161\u00edch \u010dl\u00e1nkov z \u010dasopisu Springer Nature.<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><a href=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\"><img decoding=\"async\" loading=\"lazy\" width=\"322\" height=\"578\" src=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png\" alt=\"\" class=\"wp-image-20254\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1.png 322w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-167x300.png 167w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-7x12.png 7w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/immunotherapeutic-1-56x100.png 56w\" sizes=\"(max-width: 322px) 100vw, 322px\" \/><\/a><figcaption class=\"wp-element-caption\"><em>Zdroj <a href=\"https:\/\/citations.springernature.com\/item?doi=10.1186\/s40409-018-0178-3&amp;start=11&amp;years=&amp;journals=&amp;books=&amp;authors=\" target=\"_blank\" rel=\"noreferrer noopener\">Crossref<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n<p>Vyu\u017eite silu infografiky na podporu a <a href=\"https:\/\/mindthegraph.com\/blog\/research-journal-impact-factor\/\">ovplyvni\u0165 v\u00e1\u0161 \u010dl\u00e1nok<\/a> tie\u017e. Vysk\u00fa\u0161ajte Mind the Graph!<\/p>\n\n\n\n<div class=\"is-layout-flex wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link has-background wp-element-button\" href=\"https:\/\/mindthegraph.com\/app\/auth\/register?from_url=\/\" style=\"border-radius:100px;background-color:#dc1866\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Vysk\u00fa\u0161ajte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>","protected":false},"excerpt":{"rendered":"<p>Mohlo by by\u0165 trochu \u0165a\u017ek\u00e9 vysvetli\u0165 protiz\u00e1palov\u00fa modul\u00e1ciu krotox\u00ednu bez vhodn\u00fdch obr\u00e1zkov, ale Mind the Graph existuje!<\/p>","protected":false},"author":29,"featured_media":20047,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - 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