{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/uspesny-pripad-rontgenova-mikrotomografia-s-vysokym-rozlisenim-ako-nastroj-na-odhalenie-trojrozmernej-neuronovej-architektury-mozgu\/","title":{"rendered":"Synchrotr\u00f3nov\u00e1 r\u00f6ntgenov\u00e1 mikrotomografia s vysok\u00fdm rozl\u00ed\u0161en\u00edm ako n\u00e1stroj na odhalenie trojrozmernej neuron\u00e1lnej architekt\u00fary mozgu Paper Review"},"content":{"rendered":"

R\u00f6ntgenov\u00e1 mikrotomografia sa stala novou met\u00f3dou na de\u0161ifrovanie cytoarchitekt\u00fary a konektivity mozgu a my tu predstavujeme met\u00f3du na zobrazovanie cel\u00fdch neur\u00f3nov.<\/p>\n\n\n\n

Synchrotr\u00f3nov\u00e1 r\u00f6ntgenov\u00e1 mikrotomografia s vysok\u00fdm rozl\u00ed\u0161en\u00edm ako n\u00e1stroj na odhalenie trojrozmernej neuron\u00e1lnej architekt\u00fary mozgu<\/strong><\/h2>\n\n\n\n

Matheus de Castro Fonseca a in\u00ed (2018) v \u010dl\u00e1nku \"R\u00f6ntgenov\u00e1 mikrotomografia s vysok\u00fdm rozl\u00ed\u0161en\u00edm na b\u00e1ze synchrotr\u00f3nu ako n\u00e1stroj na odhalenie trojrozmernej neuron\u00e1lnej architekt\u00fary mozgu\" poznamenali, \u017ee \u0161t\u00fadium neur\u00f3nov ako individualizovan\u00fdch jednotiek m\u00e1 svoj za\u010diatok v 19. storo\u010d\u00ed vytvoren\u00edm doktr\u00edny o neur\u00f3noch. <\/p>\n\n\n\n

V posledn\u00fdch rokoch sa vyvinulo ve\u013ek\u00e9 \u00fasilie na pochopenie organiz\u00e1cie a konektivity neur\u00f3nov v neporu\u0161en\u00fdch vzork\u00e1ch mozgu. Golgiho-Coxova technika zna\u010denia pon\u00faka vhodn\u00fd kontrast na \u0161pecifick\u00e9 zna\u010denie neur\u00f3nov pre r\u00f6ntgenov\u00fa mikrotomografiu. <\/p>\n\n\n\n

Neur\u00f3ny maj\u00fa odli\u0161n\u00fa morfol\u00f3giu a \u0161pecifick\u00e9 vzory prepojenia, ktor\u00e9 s\u00fa nevyhnutn\u00e9 pre ich spr\u00e1vne fungovanie. V\u00fdskumn\u00edci predstavuj\u00fa met\u00f3du zobrazovania, ktor\u00e1 kombinuje r\u00f6ntgenov\u00fa mikrotomografiu na synchrotr\u00f3ne s Golgiho-Coxov\u00fdm impregna\u010dn\u00fdm protokolom. <\/p>\n\n\n\n

T\u00e1to met\u00f3da pon\u00faka vy\u0161\u0161\u00ed a homog\u00e9nnej\u0161\u00ed kontrast relat\u00edvne riedko rozmiestnen\u00fdch cel\u00fdch neur\u00f3nov v tkanive.<\/p>\n\n\n\n

Mozog bol inkubovan\u00fd v roztoku na farbenie Golgiho-Coxa po\u010das 14 dn\u00ed, chr\u00e1nen\u00fd pred svetlom. Po uplynut\u00ed inkuba\u010dnej doby sa mozog s\u00e9riovo rozrezal pomocou vibrat\u00f3mu.<\/strong><\/p>\n\n\n\n

Skontrolujte p\u00f4vodn\u00fd \u010dl\u00e1nok tu<\/a>.<\/p>\n\n\n\n

Grafick\u00e9 abstraktum poh\u00e1\u0148an\u00e9 Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Autor pou\u017eil Mind the Graph<\/a> vytvori\u0165 schematick\u00fd obr\u00e1zok, ktor\u00fd predstavuje dospel\u00e9 my\u0161i, ktor\u00fdm sa i.p. pod\u00e1va fyziologick\u00fd roztok alebo roztok pilokarp\u00ednu (280 mg\/kg). Zobrazenie zlo\u017eit\u00fdch procesov pomocou infografiky je dobr\u00fdm sp\u00f4sobom, ako ich urobi\u0165 \u013eahko zrozumite\u013en\u00fdmi bez toho, aby sa vynechali detaily a k\u013e\u00fa\u010dov\u00e9 inform\u00e1cie.<\/p>\n\n\n\n

Zd\u00e1 sa, \u017ee niektor\u00e9 v\u00fdsledky v\u00fdskumn\u00edkov potvrdzuj\u00fa doteraj\u0161ie poznatky o tejto oblasti: \"Impregn\u00e1cia neur\u00f3nov na b\u00e1ze ortuti, ktor\u00fa sme tu uk\u00e1zali, n\u00e1m umo\u017enila jasne definova\u0165 cel\u00e9 neur\u00f3ny najm\u00e4 v\u010faka s\u00favislej\u0161ej a homog\u00e9nnej\u0161ej impregn\u00e1cii buniek a ove\u013ea men\u0161ej hustote artefaktov,\" nazna\u010dil de Castro Fonseca.<\/p>\n\n\n\n

Dokumenty Vplyv a v\u00fdkon<\/strong><\/h2>\n\n\n\n

M\u00f4\u017eeme analyzova\u0165 pomocou Altmetric<\/a> \u00fadaje, \u017ee sk\u00f3re online pozornosti tohto dokumentu je vy\u0161\u0161ie ako . 64%<\/strong><\/strong> v\u0161etk\u00fdch ostatn\u00fdch \u010dl\u00e1nkov podobn\u00e9ho veku v \u010dasopise Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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\"\"<\/a>
Zdroj Altmetrika<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Zlep\u0161ite pr\u00edstupnos\u0165 svojho \u010dl\u00e1nku aj pomocou infografiky.<\/p>\n\n\n\n

\n
Vysk\u00fa\u0161ajte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Pozrite sa na nov\u00fa met\u00f3du de\u0161ifrovania cytoarchitekt\u00fary a konektivity mozgu zn\u00e1zornen\u00fa na ilustr\u00e1ci\u00e1ch Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/uspesny-pripad-rontgenova-mikrotomografia-s-vysokym-rozlisenim-ako-nastroj-na-odhalenie-trojrozmernej-neuronovej-architektury-mozgu\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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