{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"V\u00edrus Zika sa replikuje v mozgovom tkanive dospel\u00fdch \u013eud\u00ed a po\u0161kodzuje synapsie a pam\u00e4\u0165 u my\u0161\u00ed"},"content":{"rendered":"

ZIKV je nebezpe\u010dn\u00fd v\u00edrus, ktor\u00fd pusto\u0161\u00ed svet. Preto v tomto pr\u00edpade autor \u0161tuduje jeho replik\u00e1ciu v mozgu dospel\u00e9ho \u010dloveka.<\/p>\n\n\n\n

V\u00edrus Zika (ZIKV) infikuje dospel\u00e9 mozgov\u00e9 tkanivo a sp\u00f4sobuje poruchy pam\u00e4ti u my\u0161\u00ed<\/strong><\/h2>\n\n\n\n

Skupina z Farmaceutickej fakulty pod veden\u00edm Claudie Figueiredovej (2019) sk\u00famala, ako sa v\u00edrus zika replikuje v mozgovom tkanive dospel\u00fdch \u013eud\u00ed a nar\u00fa\u0161a synapsie a pam\u00e4\u0165 u my\u0161\u00ed. V\u00edrus zika je arbov\u00edrus patriaci do \u010de\u013eade Flaviviridae, ktor\u00fd je zodpovedn\u00fd za ned\u00e1vnu ve\u013ek\u00fa epid\u00e9miu v Latinskej Amerike. <\/p>\n\n\n\n

ZIKV sa na\u0161iel v mozgu a mozgovomiechovom moku dospel\u00fdch pacientov. Imunoreaktivita NS2B sa kolokalizovala s NeuN-imunoreakt\u00edvnymi bunkami, ale nie s GFAP alebo F4\/80, \u010do nazna\u010duje, \u017ee ZikV je v zrelom \u013eudskom tkanive zameran\u00fd na neur\u00f3ny. U dospel\u00fdch imunokompetentn\u00fdch my\u0161\u00ed infikovan\u00fdch intracerebroventrikul\u00e1rnou inf\u00faziou ZIKV sa zistili vysok\u00e9 hladiny RNA ZikV vo front\u00e1lnej k\u00f4re a hipokampe a hlavn\u00fdm typom infikovan\u00fdch buniek s\u00fa zrel\u00e9 neur\u00f3ny. <\/p>\n\n\n\n

Overili sa zv\u00fd\u0161en\u00e9 hladiny TNF-\u03b1 v mozgu, intenz\u00edvna mikrogli\u00f3za, zv\u00fd\u0161en\u00e1 expresia prote\u00ednov komplementov\u00e9ho syst\u00e9mu (C1q a C3) a po\u0161kodenie hipokamp\u00e1lnych syn\u00e1ps.<\/p>\n\n\n\n

\u0160t\u00fadia zah\u0155\u0148ala 9 rovnak\u00fdch kvadrantov.<\/strong><\/p>\n\n\n\n

Skontrolujte p\u00f4vodn\u00fd \u010dl\u00e1nok tu<\/a>.<\/p>\n\n\n\n

Grafick\u00e9 abstrakty zalo\u017een\u00e9 na Mind the Graph<\/strong><\/h2>\n\n\n\n
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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Prv\u00fd obr\u00e1zok predstavuje pr\u00edpad, ke\u010f boli fragmenty tkaniva sp\u00e1nkov\u00e9ho laloku \u010dloveka rozrezan\u00e9 na 400 \u00b5m rezy a udr\u017eiavan\u00e9 v kult\u00fare 4 dni pred inkub\u00e1ciou s v\u00edrusom ZIKV (107 PFU) alebo zosmie\u0161\u0148ovac\u00edm m\u00e9diom po\u010das 1 h, po ktorej nasledovalo vymytie. <\/p>\n\n\n\n

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Vyroben\u00e9 s Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Druh\u00fd obr\u00e1zok ukazuje, \u017ee dospel\u00e9 my\u0161i dostali inf\u00faziu 105 PFU ZIKV, UV-inaktivovan\u00e9ho ZIKV alebo zosmie\u0161\u0148uj\u00faceho m\u00e9dia do later\u00e1lnej mozgovej komory.<\/p>\n\n\n\n

Zd\u00e1 sa, \u017ee z\u00e1very potvrdzuj\u00fa to, \u010do bolo o tejto t\u00e9me zn\u00e1me u\u017e predt\u00fdm: \"ZIKV sa zameriava na oblasti mozgu s\u00favisiace s pam\u00e4\u0165ou bez oh\u013eadu na to, \u010di je cesta infekcie centr\u00e1lna alebo perif\u00e9rna. V\u00edrus bol zisten\u00fd v CSF dospel\u00fdch pacientov s neurologick\u00fdmi komplik\u00e1ciami,\" tvrd\u00ed Figueiredo.<\/p>\n\n\n\n

Navrhuj\u00fa, aby sa v bud\u00facnosti uskuto\u010dnili \u0161t\u00fadie zameran\u00e9 na presk\u00famanie dlhodob\u00e9ho neurodegenerat\u00edvneho vplyvu infekcie v\u00edrusom ZIKV. Identifik\u00e1cia sp\u00f4sobov, ako predch\u00e1dza\u0165 abnormalit\u00e1m signaliz\u00e1cie ved\u00facim k dysfunkcii mozgu, by mohla pripravi\u0165 cestu k interven\u010dn\u00fdm strat\u00e9gi\u00e1m na oddialenie alebo prevenciu rozvoja z\u00e1va\u017en\u00fdch neurologick\u00fdch ochoren\u00ed.<\/p>\n\n\n\n

Dokumenty Vplyv a v\u00fdkon<\/strong><\/h2>\n\n\n\n

M\u00f4\u017eeme analyzova\u0165 pomocou Altmetric<\/a> \u00fadaje, \u017ee sk\u00f3re online pozornosti tohto dokumentu je vy\u0161\u0161ie ako . 95%<\/strong><\/strong> v\u0161etk\u00fdch ostatn\u00fdch \u010dl\u00e1nkov podobn\u00e9ho veku v Pr\u00edrode<\/strong> \u010casopisy.<\/strong><\/p>\n\n\n\n

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Zdroj Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Vyu\u017eite silu infografiky aj na podporu svojho \u010dl\u00e1nku! Za\u010dnite tvori\u0165 na Mind the Graph.<\/p>\n\n\n\n

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Vysk\u00fa\u0161ajte Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u0160t\u00fadia sa zaober\u00e1 v\u00edrusom ZIKV v mozgu dospel\u00e9ho \u010dloveka, nebezpe\u010dn\u00fdm v\u00edrusom, ktor\u00fd pusto\u0161\u00ed svet. Proces vyu\u017e\u00edva ilustr\u00e1cie Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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