{"id":14387,"date":"2021-08-17T17:07:19","date_gmt":"2021-08-17T20:07:19","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=14387"},"modified":"2024-12-05T15:52:16","modified_gmt":"2024-12-05T18:52:16","slug":"what-is-dmt-everything-researchers-know-about-it","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/co-je-dmt-vsetko-vyskumnici-vedia-o-tom\/","title":{"rendered":"\u010co je DMT? V\u0161etko, \u010do o \u0148om vedci vedia"},"content":{"rendered":"

\u010co je DMT?<\/h2>\n\n\n\n

DMT alebo N, N-dimetyltryptam\u00edn je pr\u00edrodn\u00e1 l\u00e1tka, ktor\u00e1 sa nach\u00e1dza v listoch amazonskej rastliny s n\u00e1zvom Psychotria Viridis<\/em>, ktor\u00fd sa pou\u017e\u00edva v n\u00e1poji ayahuasca, ktor\u00fd vyvol\u00e1va halucin\u00e1cie a zmeny vo vn\u00edman\u00ed, em\u00f3ci\u00e1ch a pozn\u00e1van\u00ed u t\u00fdch, ktor\u00ed ho za\u017eij\u00fa.<\/p>\n\n\n\n

DMT je klasifikovan\u00fd ako psychoakt\u00edvna alkaloidn\u00e1 l\u00e1tka a v roku 1971 bol celosvetovo zak\u00e1zan\u00fd Medzin\u00e1rodn\u00fdm dohovorom o psychotropn\u00fdch l\u00e1tkach, jeho konzum\u00e1cia je povolen\u00e1 v n\u00e1bo\u017eenskej a ritu\u00e1lnej praxi len v r\u00e1mci n\u00e1poja s n\u00e1zvom Ayahuasca.<\/p>\n\n\n\n

\"V\u00fdskum<\/a>
V\u00fdskum v gal\u00e9rii Mind the Graph pre \"molekuly\".<\/figcaption><\/figure>\n\n\n\n

Hoci je ayahuasca zn\u00e1ma u\u017e viac ako storo\u010die, a\u017e v posledn\u00fdch rokoch pri\u0165ahuje pozornos\u0165 vedcov v\u010faka svojim (zatia\u013e) nepreuk\u00e1zan\u00fdm \u00fa\u010dinkom.<\/p>\n\n\n\n

N\u00e1poj bol prezentovan\u00fd na zlep\u0161enie kvality \u017eivota a lie\u010dbu pacientov s neurologick\u00fdmi a emocion\u00e1lnymi poruchami, ako je depresia, \u00fazkos\u0165 a z\u00e1vislos\u0165. <\/p>\n\n\n\n

\"\u010co<\/a><\/figure>\n\n\n\n

\u010co vedci vedia o DMT<\/h2>\n\n\n\n

\u010cl\u00e1nok uverejnen\u00fd v \u010dasopise Journal of Affective Disorders Spr\u00e1vy<\/a> analyzoval \u00fadaje z prieskumu Global Ayahuasca Project (GAP), ktor\u00e9ho sa z\u00fa\u010dastnilo 11 912 \u013eud\u00ed, ktor\u00ed za\u017eili tento n\u00e1poj. V prieskume \u00fa\u010dastn\u00edci, ktor\u00ed pred konzum\u00e1ciou ayahuascy uviedli, \u017ee mali depresiu alebo \u00fazkos\u0165, uviedli, \u017ee po z\u00e1\u017eitku zaznamenali ur\u010dit\u00fd stupe\u0148 zlep\u0161enia svojich sympt\u00f3mov. Teda zlep\u0161enie kvality ich \u017eivota. <\/p>\n\n\n\n

V posledn\u00fdch rokoch prib\u00fadaj\u00fa spr\u00e1vy pacientov, ako je t\u00e1to, ktor\u00fa zozbieral GAP. Napriek tomu, \u017ee ide o dobr\u00e9 spr\u00e1vy, vedci a lek\u00e1ri potrebuj\u00fa kompletnej\u0161ie a podrobnej\u0161ie fyziologick\u00e9 \u0161t\u00fadie, aby pochopili zdroj t\u00fdchto \u00fa\u010dinkov ayahuasky. N\u00e1poj z inf\u00faznej rastliny m\u00e1 v sebe nieko\u013eko l\u00e1tok a ka\u017ed\u00e1 z nich m\u00f4\u017ee v \u013eudskom tele vyvola\u0165 in\u00fd typ reakcie. <\/p>\n\n\n\n

Jednou z t\u00fdchto l\u00e1tok je DMT. T\u00e1to l\u00e1tka z ayahuasky pri\u0165ahuje pozornos\u0165 v\u00fdskumn\u00edkov v\u010faka svojmu zjavn\u00e9mu potenci\u00e1lu neurogen\u00e9zy.   <\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

\u010co je neurogen\u00e9za?<\/h3>\n\n\n\n

Neurogenesis<\/strong> je definovan\u00fd ako proces transform\u00e1cie neur\u00f3nov\u00e9 kme\u0148ov\u00e9 bunky<\/strong> alebo progenitor<\/strong> buniek na nov\u00e9 neur\u00f3ny. Zah\u0155\u0148a tie\u017e mnoho r\u00f4znych bunkov\u00fdch aktiv\u00edt vr\u00e1tane prolifer\u00e1cie, migr\u00e1cie a diferenci\u00e1cie buniek.<\/p>\n\n\n\n

Na druhej strane, neur\u00f3nov\u00e9 kme\u0148ov\u00e9 bunky<\/strong> s\u00fa schopn\u00e9 rozsiahlej samoobnovy a vytv\u00e1raj\u00fa nov\u00e9 bunky nervov\u00e9ho syst\u00e9mu, napr\u00edklad neur\u00f3ny alebo gliov\u00e9 bunky. V na\u0161om mozgu sa nach\u00e1dza v\u00fdklenok nervov\u00fdch kme\u0148ov\u00fdch buniek, ktor\u00e9 sa nach\u00e1dzaj\u00fa v subgranul\u00e1rna z\u00f3na<\/strong> dent\u00e1tov\u00e9ho gyrusu v hipokampe. <\/p>\n\n\n\n

Hipokampus je \u010das\u0165 mozgu zodpovedn\u00e1 za na\u0161u pam\u00e4\u0165 a schopnos\u0165 u\u010di\u0165 sa. T\u00e1to oblas\u0165 mozgu je s\u00fa\u010das\u0165ou limbick\u00e9ho syst\u00e9mu a m\u00e1 d\u00f4le\u017eit\u00fa \u00falohu pri premene kr\u00e1tkodobej pam\u00e4te na dlhodob\u00e9 spomienky. <\/p>\n\n\n\n

Pri neurodegenerat\u00edvnych ochoreniach, ako je Alzheimerova choroba, je hipokampus prvou postihnutou oblas\u0165ou, ktor\u00e1 vedie k zhor\u0161eniu pam\u00e4ti. <\/p>\n\n\n\n

Ako DMT ovplyv\u0148uje mozog?<\/h3>\n\n\n\n

Ist\u00fd \u010das sa predpokladalo, \u017ee DMT sa via\u017ee len na seroton\u00ednov\u00e9 receptory 5-HT, ktor\u00e9 vyvol\u00e1vaj\u00fa jeho halucina\u010dn\u00e9 \u00fa\u010dinky. Najnov\u0161ie \u0161t\u00fadie v\u0161ak uv\u00e1dzaj\u00fa, \u017ee DMT sa via\u017ee aj na in\u00fd typ receptora, neseroton\u00ednergick\u00fd receptor s n\u00e1zvom sigma-1 receptor<\/strong> alebo S1R<\/strong>. <\/p>\n\n\n\n

Tento receptor je roz\u0161\u00edren\u00fd v centr\u00e1lnom nervovom syst\u00e9me, najm\u00e4 v prefront\u00e1lnej k\u00f4re a hipokampe. <\/p>\n\n\n\n

Okrem toho vedci zistili, \u017ee pri v\u00e4zbe na tento receptor S1R DMT str\u00e1ca svoje psychoakt\u00edvne \u00fa\u010dinky a nevyvol\u00e1va halucin\u00e1cie ani zmeny vo vn\u00edman\u00ed. <\/p>\n\n\n\n

V\u00fdskum in vitro a in vivo<\/h3>\n\n\n\n

\u0160t\u00fadia uverejnen\u00e1 v \u010dasopise \u010casopis Transla\u010dn\u00e1 psychiatria<\/a> v roku 2020 sa zameral na \u0161t\u00fadium \u00fa\u010dinkov DMT v mozgu prostredn\u00edctvom receptora sigma-1. <\/p>\n\n\n\n

Pomocou antagonistov 5-HT vedci zistili, \u017ee DMT stimuluje neurogen\u00e9zu prostredn\u00edctvom S1R. <\/p>\n\n\n\n

Okrem toho \u00fadaje uk\u00e1zali, \u017ee DMT p\u00f4sob\u00ed nielen ako stimulant, ktor\u00fd podnecuje dozrievanie, prolifer\u00e1ciu a migr\u00e1ciu neur\u00e1lnych kme\u0148ov\u00fdch buniek in vitro, ale zvy\u0161uje aj schopnos\u0165 u\u010denia a pam\u00e4ti in vivo. <\/p>\n\n\n\n

Autori \u0161t\u00fadie uviedli, \u017ee DMT in vitro podporuje prolifer\u00e1ciu neur\u00e1lnych progenitorov\u00fdch buniek z neurog\u00e9nnej niky hipokampu dospel\u00fdch. Toto p\u00f4sobenie zv\u00fd\u0161ilo po\u010det a ve\u013ekos\u0165 neurospheres<\/strong> po t\u00fd\u017edni lie\u010dby DMT. <\/p>\n\n\n\n

Okrem toho na z\u00e1klade expresie \u0161pecifick\u00fdch prote\u00ednov v\u00fdskumn\u00edci zistili, \u017ee DMT podporuje diferenci\u00e1ciu t\u00fdchto neur\u00e1lnych kme\u0148ov\u00fdch buniek. <\/p>\n\n\n\n

Prote\u00edny, ktor\u00e9 sa nach\u00e1dzaj\u00fa v\u00fdlu\u010dne v mlad\u00fdch a v zrel\u00fdch neur\u00f3noch, naz\u00fdvan\u00e9 \u03b2-III-tubul\u00edn a MAP-2, mali zv\u00fd\u0161en\u00fa expresiu v neurosf\u00e9rach lie\u010den\u00fdch DMT. To znamen\u00e1, \u017ee DMT podporuje diferenci\u00e1ciu na neuron\u00e1lny fenotyp. <\/p>\n\n\n\n

V\u00fdskumn\u00edci tie\u017e zaznamenali podporu in\u00fdch bunkov\u00fdch fenotypov, ako s\u00fa astrocyty a oligodendrocyty, a to v\u0161etko prostredn\u00edctvom S1R.<\/p>\n\n\n\n

Zd\u00e1 sa, \u017ee DMT in vivo aktivuje subgranul\u00e1rnu z\u00f3nu prostredn\u00edctvom S1R. <\/p>\n\n\n\n

Dospel\u00e9 my\u0161i lie\u010den\u00e9 DMT mali pod\u013ea \u010dl\u00e1nku \"zv\u00fd\u0161en\u00fa prolifer\u00e1ciu a migr\u00e1ciu nervov\u00fdch prekurzorov v subgranul\u00e1rnej z\u00f3ne\". Tento v\u00fdsledok nazna\u010duje, \u017ee DMT m\u00e1 modeluj\u00faci \u00fa\u010dinok na neurogen\u00e9zu hipokampu, \u010d\u00edm zvy\u0161uje po\u010det nov\u00fdch neur\u00f3nov. <\/p>\n\n\n\n

V praxi dospel\u00e9 my\u0161i lie\u010den\u00e9 DMT vykazovali lep\u0161ie v\u00fdsledky v behavior\u00e1lnych \u00faloh\u00e1ch v porovnan\u00ed s t\u00fdmi, ktor\u00e9 DMT nedost\u00e1vali. Lie\u010den\u00e1 skupina vykazovala v\u00fdsledky zlep\u0161enia v \u00faloh\u00e1ch u\u010denia a pam\u00e4ti. <\/p>\n\n\n\n

\"DMT<\/a><\/figure>\n\n\n\n

Z\u00e1ver<\/h2>\n\n\n\n

V\u0161etky tieto v\u00fdsledky s\u00fa skvelou spr\u00e1vou pre lek\u00e1rsku komunitu. <\/p>\n\n\n\n

To ukazuje, \u017ee je mo\u017en\u00e9 nielen stimulova\u0165 neurogen\u00e9zu pomocou DMT, ale aj dosiahnu\u0165 tieto v\u00fdsledky bez halucinog\u00e9nnych \u00fa\u010dinkov prostredn\u00edctvom \u0161pecifick\u00e9ho receptora. <\/p>\n\n\n\n

\"T\u00e1to schopnos\u0165 modulova\u0165 plasticitu mozgu nazna\u010duje, \u017ee m\u00e1 ve\u013ek\u00fd terapeutick\u00fd potenci\u00e1l pre \u0161irok\u00fa \u0161k\u00e1lu psychiatrick\u00fdch a neurologick\u00fdch por\u00fach vr\u00e1tane neurodegenerat\u00edvnych ochoren\u00ed,\" povedal Jos\u00e9 \u00c1ngel Morales v v\u00fdpis<\/a>, jeden z autorov \u010dl\u00e1nku. <\/p>\n\n\n\n

Tieto v\u00fdsledky m\u00f4\u017eu v\u00fdrazne ovplyvni\u0165 bud\u00face \u0161t\u00fadie s ayahuascou a DMT. Pochopenie toho, ako kontrolova\u0165 a ovplyv\u0148ova\u0165 proces neurogen\u00e9zy, by mohlo \u00faplne zmeni\u0165 sp\u00f4sob lie\u010dby neurodegenera\u010dn\u00fdch ochoren\u00ed.<\/p>\n\n\n\n

Napriek tomu existuje ve\u013ek\u00fd dopyt po \u0161t\u00fadi\u00e1ch, ktor\u00e9 by vedcom umo\u017enili plne pochopi\u0165 \u00falohu l\u00e1tok, ako je DMT, a s\u013eubn\u00fdch receptorov, napr\u00edklad receptora sigma-1, v neurogen\u00e9ze. <\/p>\n\n\n\n

Spolu s pozit\u00edvnou perspekt\u00edvou by to mohlo vies\u0165 nielen k novej lie\u010dbe neurodegenerat\u00edvnych ochoren\u00ed, ale aj k ich vylie\u010deniu. <\/p>\n\n\n\n

__________________________<\/p>\n\n\n\n

P\u00e1\u010dili sa v\u00e1m infografiky vytvoren\u00e9 na z\u00e1klade v\u00fdsledkov uveden\u00fdch vo vedeckom \u010dl\u00e1nku?<\/p>\n\n\n\n

Tieto infografiky boli vytvoren\u00e9 pomocou pripraven\u00fdch \u0161abl\u00f3n, ktor\u00e9 s\u00fa k dispoz\u00edcii v Mind the Graph<\/a>, toto jeden<\/a> a toto in\u00fd<\/a>. Urobil som nieko\u013eko zmien a za kr\u00e1tky \u010das bol hotov\u00fd!<\/p>\n\n\n\n

To ist\u00e9 m\u00f4\u017eete urobi\u0165 aj pri svojej v\u00fdskumnej pr\u00e1ci, nemus\u00edte za\u010d\u00edna\u0165 od nuly. Pozrite si str\u00e1nku . v\u0161etky \u0161abl\u00f3ny<\/a> k dispoz\u00edcii v Mind the Graph<\/a>. <\/p>\n\n\n\n

A za\u010dnite pracova\u0165 na svojej infografike pr\u00e1ve teraz<\/a>! <\/p>\n\n\n\n

<\/p>","protected":false},"excerpt":{"rendered":"

\u010co je DMT? DMT alebo N, N-dimetyltryptam\u00edn je pr\u00edrodn\u00e1 l\u00e1tka obsiahnut\u00e1 v listoch amazonskej rastliny Psychotria Viridis, ktor\u00e1 sa pou\u017e\u00edva v n\u00e1poji ayahuasca, ktor\u00fd vyvol\u00e1va halucin\u00e1cie a zmeny vo vn\u00edman\u00ed, em\u00f3ci\u00e1ch a pozn\u00e1van\u00ed u t\u00fdch, ktor\u00ed ho za\u017eij\u00fa. DMT je klasifikovan\u00fd ako psychoakt\u00edvna alkaloidn\u00e1 l\u00e1tka a bol celosvetovo zak\u00e1zan\u00fd [...]<\/p>","protected":false},"author":18,"featured_media":14389,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[840,841,51,839,554,250,775,838],"yoast_head":"\nWhat is DMT? Everything Researchers Know About It - MTG<\/title>\n<meta name=\"description\" content=\"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. Come check out what researchers know about this molecule.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/co-je-dmt-vsetko-vyskumnici-vedia-o-tom\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is DMT? Everything Researchers Know About It\" \/>\n<meta property=\"og:description\" content=\"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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Everything Researchers Know About It","twitter_image":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/08\/what-is-dmt-twitter.jpg","twitter_misc":{"Written by":"Bruna Soldera","Est. reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","url":"https:\/\/mindthegraph.com\/blog\/what-is-dmt-everything-researchers-know-about-it\/","name":"What is DMT? Everything Researchers Know About It - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-08-17T20:07:19+00:00","dateModified":"2024-12-05T18:52:16+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/6a3f0be2cd19879e0b9b54457a069602"},"description":"Known for its psychoactive activity, the DMT is a substance present in the ayahuasca beverage. 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