{"id":12192,"date":"2021-01-27T10:46:16","date_gmt":"2021-01-27T12:46:16","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12192"},"modified":"2023-01-05T14:40:18","modified_gmt":"2023-01-05T17:40:18","slug":"cannabis-and-alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/konope-a-alzheimerova-choroba\/","title":{"rendered":"\u010co je zn\u00e1me o konope a Alzheimerovej chorobe"},"content":{"rendered":"
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Alzheimerova choroba (AD) je neurodegenerat\u00edvne ochorenie, ktor\u00e9 je zodpovedn\u00e9 za viac ako 50% pr\u00edpadov demencie diagnostikovan\u00fdch v s\u00fa\u010dasnosti a je priamo spojen\u00e9 so starnut\u00edm. V s\u00fa\u010dasnosti m\u00e1 ur\u010dit\u00fd stupe\u0148 demencie 40% \u013eud\u00ed star\u0161\u00edch ako 85 rokov.<\/p>\n\n\n\n

Predt\u00fdm sa myslelo, \u017ee pr\u00edznaky Alzheimerovej choroby s\u00favisia len s poklesom pozn\u00e1vac\u00edch funkci\u00ed, ktor\u00e9 ovplyv\u0148uj\u00fa kr\u00e1tkodob\u00e9 spomienky, zatia\u013e \u010do v pokro\u010dil\u00fdch \u0161t\u00e1di\u00e1ch choroby ovplyv\u0148uj\u00fa jazykov\u00e9 schopnosti pacienta a dokonca aj dlhodob\u00e9 spomienky.<\/p>\n\n\n\n

Dnes je v\u0161ak zn\u00e1me, \u017ee pacienti trpiaci Alzheimerovou chorobou vykazuj\u00fa mno\u017estvo \u010fal\u0161\u00edch pr\u00edznakov, ako s\u00fa depresie, psych\u00f3zy, agres\u00edvne spr\u00e1vanie, ktor\u00e9 ochorenie e\u0161te zhor\u0161uj\u00fa. <\/p>\n\n\n\n

V posledn\u00fdch rokoch v\u00fdskumn\u00edci a lek\u00e1ri vo svojich \u0161t\u00fadi\u00e1ch uv\u00e1dzaj\u00fa pozit\u00edvne v\u00fdsledky, ke\u010f za\u010dali lie\u010di\u0165 svojich pacientov s Alzheimerovou chorobou liekmi na b\u00e1ze konope, \u010d\u00edm dosiahli zmiernenie sympt\u00f3mov.<\/p>\n\n\n\n

Endokanabinoidn\u00fd syst\u00e9m sa stal alternat\u00edvnym pr\u00edstupom k lie\u010dbe r\u00f4znych ochoren\u00ed a patol\u00f3gi\u00ed, okrem jeho vplyvu na viacer\u00e9 procesy, ako je neuroplasticita, neuroz\u00e1pal, poruchy spr\u00e1vania, regul\u00e1cia sp\u00e1nku, imunologick\u00e9 funkcie, z\u00e1palov\u00e9 ochorenia, kardiovaskul\u00e1rne funkcie, boles\u0165, motorick\u00e1 kontrola, energetick\u00e1 rovnov\u00e1ha a chu\u0165 do jedla. <\/p>\n\n\n\n

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Fotografia od Ravi Patel<\/a> na str\u00e1nke . Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

Bohu\u017eia\u013e, st\u00e1le existuje len m\u00e1lo ofici\u00e1lnych \u0161t\u00fadi\u00ed, ktor\u00e9 by priamo analyzovali vz\u0165ah medzi endokanabinoidn\u00fdm syst\u00e9mom a Alzheimerovou chorobou.<\/p>\n\n\n\n

Dnes je zn\u00e1me, \u017ee Alzheimerovu chorobu sp\u00f4sobuj\u00fa genetick\u00e9 faktory a faktory starnutia. K\u013e\u00fa\u010dov\u00ed vinn\u00edci ochorenia sa pripisuj\u00fa seniln\u00e9 plaky<\/strong> a neurofibril\u00e1rna sple\u0165<\/strong>. <\/p>\n\n\n\n

Zauj\u00edmav\u00fdm faktom je, \u017ee na modeloch potkanov s Alzheimerovou chorobou v\u00fdskumn\u00edci zistili, \u017ee mozog s Alzheimerovou chorobou m\u00e1 ni\u017e\u0161\u00ed po\u010det receptorov CB1 v porovnan\u00ed so zdrav\u00fdm mozgom - men\u0161\u00ed po\u010det receptorov CB1 m\u00f4\u017ee v kone\u010dnom d\u00f4sledku zn\u00ed\u017ei\u0165 terapeutick\u00fd \u00fa\u010dinok lieku.<\/p>\n\n\n\n

Lie\u010dba kanabinoidmi m\u00f4\u017ee ma\u0165 ochrann\u00fd \u00fa\u010dinok proti oxida\u010dn\u00e9mu stresu a neuroz\u00e1palu v mozgu pacientov s Alzheimerovou chorobou, \u010d\u00edm pom\u00e1ha zni\u017eova\u0165 tvorbu amyloidn\u00fdch plakov a neurofibril\u00e1rnych splet\u00ed, a t\u00fdm spoma\u013euje pokles kognit\u00edvnych funkci\u00ed pacientov. <\/p>\n\n\n\n

Hoci sa amyloidn\u00e9 plaky nach\u00e1dzaj\u00fa aj v zdrav\u00fdch mozgoch, ich v\u00fdskyt je v porovnan\u00ed s mozgami s Alzheimerovou chorobou mimoriadne n\u00edzky.<\/p>\n\n\n\n

\u0160t\u00fadie zameran\u00e9 na pochopenie toho, pre\u010do maj\u00fa kanabinoidy terapeutick\u00fd \u00fa\u010dinok na pacientov s Alzheimerovou chorobou, zistili, \u017ee molekula THC m\u00e1 schopnos\u0165 zvy\u0161ova\u0165 biologick\u00fa dostupnos\u0165 neurotransmitera naz\u00fdvan\u00e9ho acetylchol\u00edn<\/strong> (Ach) inhib\u00edciou jeho degrada\u010dn\u00e9ho enz\u00fdmu acetylchol\u00ednester\u00e1za<\/strong> (AChE) - Ach je v podstate zodpovedn\u00fd za prenos nervov\u00e9ho impulzu do \u010fal\u0161ieho neur\u00f3nu. <\/p>\n\n\n\n

Enz\u00fdm AChE v zdravom mozgu m\u00e1 za \u00falohu rozklada\u0165 Ach, av\u0161ak v mozgu s Alzheimerovou chorobou je tento enz\u00fdm ve\u013emi pr\u00edtomn\u00fd a rozklad\u00e1 ove\u013ea viac Ach, ako by mal, \u010do \u010dasom sp\u00f4sobuje pokles pozn\u00e1vac\u00edch funkci\u00ed mozgu.   <\/p>\n\n\n\n

V\u00fdskumn\u00edci uviedli, \u017ee kanabinoidy m\u00f4\u017eu pom\u00f4c\u0165 v\u010faka svojmu inhibi\u010dn\u00e9mu \u00fa\u010dinku enz\u00fdmu AChE - preuk\u00e1zali lep\u0161ie reakcie ako in\u00e9 komer\u010dne dostupn\u00e9 lieky. <\/p>\n\n\n\n

THC m\u00f4\u017ee tie\u017e pom\u00f4c\u0165 zn\u00ed\u017ei\u0165 poruchy spr\u00e1vania a reguluje cirkadi\u00e1nny cyklus pacientov s \u0165a\u017ekou demenciou. Niektor\u00ed vedci dokonca potvrdzuj\u00fa, \u017ee kanabinoidy THC a CBD maj\u00fa potenci\u00e1l by\u0165 terapiami proti Alzheimerovej chorobe.<\/p>\n\n\n\n

\u010cl\u00e1nok uverejnen\u00fd v roku 2015 v \u010dasopise Clinical Pharmacology and Therapeutics<\/a>poskytuje preh\u013ead o potenci\u00e1li kanabinoidov pri lie\u010dbe neskorej Alzheimerovej choroby a s\u00favisiacich neuropsychiatrick\u00fdch sympt\u00f3mov u star\u0161\u00edch \u013eud\u00ed, pri\u010dom sa zaober\u00e1 aj aspektmi liekov na b\u00e1ze konope z h\u013eadiska ich \u00fa\u010dinnosti, bezpe\u010dnosti a farmakokinetiky.<\/p>\n\n\n\n

U 72-ro\u010dn\u00e9ho mu\u017ea s Alzheimerovou chorobou sa vyskytli poruchy spr\u00e1vania ako agitovanos\u0165 a agresivita. Jeho predch\u00e1dzaj\u00faca lie\u010dba nepreuk\u00e1zala \u017eiadne v\u00fdznamn\u00e9 zlep\u0161enie. <\/p>\n\n\n\n

Ke\u010f pacientovi nasadili Nabilon - syntetick\u00fa drogu THC -, \u010doskoro sa u neho prejavila porucha spr\u00e1vania a \u010fal\u0161ie pr\u00edznaky, navy\u0161e po\u010das lie\u010dby liekom na b\u00e1ze THC nemal \u017eiadne ne\u017eiaduce \u00fa\u010dinky.<\/p>\n\n\n\n

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Fotografia od Louis Reed<\/a> na str\u00e1nke . Unsplash<\/a><\/figcaption><\/figure>\n\n\n\n

\u010eal\u0161ia \u0161tudijn\u00e1 skupina zlo\u017een\u00e1 z p\u00e4tn\u00e1stich pacientov s Alzheimerovou chorobou - priemern\u00fd vek 72 rokov - vykazovala pred lie\u010dbou poruchy spr\u00e1vania a probl\u00e9my s jedlom. <\/p>\n\n\n\n

P\u00e4tn\u00e1s\u0165 pacientov bolo \u0161es\u0165 t\u00fd\u017ed\u0148ov lie\u010den\u00fdch dronabinolom - zn\u00e1mym aj ako marinol - syntetick\u00fdm liekom THC. <\/p>\n\n\n\n

V porovnan\u00ed s placebom sa u nich po ur\u010ditom obdob\u00ed lie\u010dby prejavilo zlep\u0161enie spr\u00e1vania, zv\u00fd\u0161enie hmotnosti a zn\u00ed\u017eenie agitovanosti. Zaznamenali sa niektor\u00e9 ne\u017eiaduce \u00fa\u010dinky, ako napr\u00edklad \u00fanava, ospalos\u0165 a euf\u00f3ria, pri\u010dom sa potvrdilo, \u017ee v\u0161etky s\u00favisia s dronabinolom.<\/p>\n\n\n\n

\u010eal\u0161ia skupina \u0161iestich pacientov s priemern\u00fdm vekom 81 rokov, z ktor\u00fdch niektor\u00ed mali Alzheimerovu chorobu a in\u00ed trpeli \u0165a\u017ekou demenciou, za\u010dala dvojt\u00fd\u017ed\u0148ov\u00fa lie\u010dbu dronabinolom. <\/p>\n\n\n\n

V\u00fdsledky uk\u00e1zali v\u00fdrazn\u00e9 zlep\u0161enie no\u010dn\u00fdch pohybov\u00fdch aktiv\u00edt t\u00fdchto pacientov a lep\u0161ie spr\u00e1vanie. V tejto skupine neboli pozorovan\u00e9 \u017eiadne ne\u017eiaduce \u00fa\u010dinky.<\/p>\n\n\n\n

V \u010fal\u0161ej \u0161t\u00fadii bola skupina 40 pacientov s r\u00f4znymi stup\u0148ami demencie a 13 z nich s Alzheimerovou chorobou. <\/p>\n\n\n\n

V\u0161etk\u00fdm bola zaveden\u00e1 lie\u010dba dronabinolom na lie\u010dbu probl\u00e9mov so spr\u00e1van\u00edm a por\u00fach chuti do jedla. <\/p>\n\n\n\n

Lie\u010dba trvala 17 dn\u00ed a pacienti sa zlep\u0161ili v oboch aspektoch. Boli hl\u00e1sen\u00e9 ne\u017eiaduce \u00fa\u010dinky ako sed\u00e1cia, del\u00edrium, infekcie mo\u010dov\u00fdch ciest a zm\u00e4tenos\u0165, ale pod\u013ea v\u00fdskumn\u00edkov neboli priamo spojen\u00e9 s u\u017e\u00edvan\u00edm dronabinolu.<\/p>\n\n\n\n

Napriek viacer\u00fdm \u0161t\u00fadi\u00e1m, ktor\u00fdch v\u00fdsledky ukazuj\u00fa pozit\u00edvne v\u00fdsledky pou\u017e\u00edvania kanabinoidov pri lie\u010dbe pacientov s demenciou, niektor\u00ed vedci tvrdia, \u017ee st\u00e1le nie je dostatok d\u00f4kazov, ktor\u00e9 by dokazovali, \u017ee kanabinoidy s\u00fa skuto\u010dne dobr\u00e9 a bezpe\u010dn\u00e9 pri lie\u010dbe por\u00fach spr\u00e1vania a demencie.<\/p>\n\n\n\n

Ka\u017edop\u00e1dne vedci \u010doraz \u010dastej\u0161ie uv\u00e1dzaj\u00fa, \u017ee sa lieky na b\u00e1ze konope pou\u017e\u00edvaj\u00fa na lie\u010dbu pacientov s Alzheimerovou chorobou, a nielen to, pou\u017e\u00edvaj\u00fa sa aj pri lie\u010dbe Parkinsonovej choroby a autizmu, pri\u010dom lek\u00e1ri a vedci uv\u00e1dzaj\u00fa, \u017ee sa kvalita \u017eivota ich pacientov po za\u010dat\u00ed u\u017e\u00edvania liekov na b\u00e1ze konope zlep\u0161ila. To je v\u0161ak t\u00e9ma na \u010fal\u0161\u00ed \u010dl\u00e1nok.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

Ste z oblasti neurol\u00f3gie? V Mind the Graph je ve\u013ek\u00e1 kateg\u00f3ria neurologick\u00fdch ilustr\u00e1ci\u00ed, kde n\u00e1jdete v\u0161etko, \u010do potrebujete pre svoju pr\u00e1cu alebo prezent\u00e1ciu z neurol\u00f3gie. Pozrite si tu<\/a>.  <\/strong><\/p>\n\n\n\n

Alebo <\/strong>h\u013ead\u00e1te bioch\u00e9mia <\/a>a molekul\u00e1rna biol\u00f3gia<\/a> ilustr\u00e1cie n\u00e1jdete aj v Mind the Graph. <\/p>\n\n\n\n

A sme tu pre v\u00e1s, aby sme v\u00e1m pomohli, ak budete potrebova\u0165 \u010doko\u013evek in\u00e9. prihl\u00e1ste sa do svojho konta<\/a> a po\u0161lite n\u00e1m spr\u00e1vu v PO\u017dIADA\u0164 O IKONU<\/strong>. <\/p>\n\n\n\n

Odkazy<\/strong><\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klinick\u00e1 farmakol\u00f3gia a terapia<\/strong>, ro\u010d. 97, \u010d. 6, s. 597-606, 2015.<\/p>\n\n\n\n

AHMED, A. I. A. et al. Cannabinoids in late-onset Alzheimer's disease. Klinick\u00e1 farmakol\u00f3gia a terapia<\/strong>, ro\u010d. 97, \u010d. 6, s. 597-606, 2015.<\/p>\n\n\n\n

BALASH, Y. et al. Medic\u00ednske konope pri Parkinsonovej chorobe: (v anglickom jazyku): Real-Life Patients' Experience (Sk\u00fasenosti pacientov z re\u00e1lneho \u017eivota). Klinick\u00e1 neurofarmakol\u00f3gia<\/strong>, ro\u010d. 40, \u010d. 6, s. 268-272, dez. 2017.<\/p>\n\n\n\n

BENITO, C. et al. Endokanabinoidn\u00fd syst\u00e9m a Alzheimerova choroba. Molekul\u00e1rna neurobiol\u00f3gia<\/strong>, ro\u010d. 36, \u010d. 1, s. 75-81, 1 pred. 2007.<\/p>\n\n\n\n

DE FARIA, S. M. et al. \u00da\u010dinky ak\u00fatneho pod\u00e1vania kanabidiolu na \u00fazkos\u0165 a tras vyvolan\u00fd simulovan\u00fdm testom verejn\u00e9ho re\u010dnenia u pacientov s Parkinsonovou chorobou. \u010casopis Journal of Psychopharmacology<\/strong>, ro\u010d. 34, \u010d. 2, s. 189-196, 1. febru\u00e1ra 2020.<\/p>\n\n\n\n

FALCO, A. D. et al. DOEN\u00c7A DE ALZHEIMER: HIP\u00d3TESES ETIOL\u00d3GICAS E PERSPECTIVAS DE TRATAMENTO. Qu\u00edmica Nova<\/strong>, ro\u010d. 39, \u010d. 1, s. 63-80, janu\u00e1r 2016.<\/p>\n\n\n\n

LEEHEY, M. A. et al. Bezpe\u010dnos\u0165 a zn\u00e1\u0161anlivos\u0165 kanabidiolu pri Parkinsonovej chorobe: (1): Otvoren\u00e1 \u0161t\u00fadia so stup\u0148ovan\u00edm d\u00e1vky (Open Label, Dose-Escalation Study). V\u00fdskum konope a kanabinoidov<\/strong>, 19. marca. 2020.<\/p>\n\n\n\n

POLEG, S. et al. Cannabidiol ako navrhovan\u00fd kandid\u00e1t na lie\u010dbu por\u00fach autistick\u00e9ho spektra. Pokrok v neuro-psychofarmakol\u00f3gii a biologickej psychiatrii<\/strong>, ro\u010d. 89, s. 90-96, 8. marca 2019.YOO, K.-Y.; PARK, S.-Y. Terpenoidy ako potenci\u00e1lne terapeutik\u00e1 proti Alzheimerovej chorobe. Molekuly<\/strong>, ro\u010d. 17, \u010d. 3, s. 3524-3538, mar. 2012.<\/p>","protected":false},"excerpt":{"rendered":"

Alzheimerova choroba (AD) je neurodegenerat\u00edvne ochorenie, ktor\u00e9 je zodpovedn\u00e9 za viac ako 50% pr\u00edpadov demencie diagnostikovan\u00fdch v s\u00fa\u010dasnosti a je priamo spojen\u00e9 so starnut\u00edm. V s\u00fa\u010dasnosti m\u00e1 ur\u010dit\u00fd stupe\u0148 demencie 40% \u013eud\u00ed star\u0161\u00edch ako 85 rokov. Predt\u00fdm sa myslelo, \u017ee pr\u00edznaky Alzheimerovej choroby s\u00favisia len s poklesom pozn\u00e1vac\u00edch funkci\u00ed, ktor\u00e9 ovplyv\u0148uj\u00fa kr\u00e1tkodob\u00e9 spomienky, zatia\u013e \u010do v [...]<\/p>","protected":false},"author":4,"featured_media":12193,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[213,819,554],"yoast_head":"\nWhat is Out There About Cannabis and Alzheimer\u2019s Disease - MTG<\/title>\n<meta name=\"description\" content=\"Do you know Cannabis and Alzheimer's Disease can be related? 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