{"id":12175,"date":"2021-01-25T09:30:00","date_gmt":"2021-01-25T11:30:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12175"},"modified":"2023-05-22T11:11:05","modified_gmt":"2023-05-22T14:11:05","slug":"molecular-control-knob-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/molekularne-ovladanie-klucky-mozgu\/","title":{"rendered":"\"Molekul\u00e1rny riadiaci gomb\u00edk\" v mozgu, ktor\u00fd pom\u00e1ha pri u\u010den\u00ed a pam\u00e4ti"},"content":{"rendered":"

Ka\u017ed\u00fd stroj m\u00e1 ovl\u00e1dac\u00ed panel na ovl\u00e1danie r\u00f4znych funkci\u00ed, najm\u00e4 mechanizmu zap\u00ednania a vyp\u00ednania. <\/p>\n\n\n\n

Prem\u00fd\u0161\u013eali ste niekedy, \u010di m\u00e1 aj n\u00e1\u0161 mozog tak\u00fd, v ktorom by sme mohli ovl\u00e1da\u0165 jeho funkcie? <\/p>\n\n\n\n

Nov\u00fd v\u00fdskum nazna\u010duje, \u017ee \"objem molekul\u00e1rneho gomb\u00edka\", ktor\u00fd reguluje elektrick\u00e9 sign\u00e1ly v mozgu pri u\u010den\u00ed a najm\u00e4 pri pam\u00e4ti. <\/p>\n\n\n\n

Mohlo by \u00eds\u0165 o hlavn\u00fd sp\u00ednac\u00ed mechanizmus, ktor\u00fd by mohol zmeni\u0165 situ\u00e1ciu v oblasti nervov\u00fdch por\u00fach.<\/p>\n\n\n\n

V\u00fdskum, ktor\u00fd publikoval Michael Hoppa a jeho t\u00edm, nazna\u010duje, \u017ee regul\u00e1cia elektrick\u00fdch sign\u00e1lov by mohla zohr\u00e1va\u0165 v\u00fdznamn\u00fa \u00falohu. \u0160t\u00fadia sa to\u010dila okolo identifik\u00e1cie molek\u00fal, ktor\u00e9 reguluj\u00fa sign\u00e1l.<\/p>\n\n\n\n

MY\u0160LIENKA V\u00ddSKUMU<\/p>\n\n\n\n

Synapsie s\u00fa miesta, kde sa pren\u00e1\u0161aj\u00fa elektrick\u00e9 sign\u00e1ly medzi nervov\u00fdmi bunkami. <\/p>\n\n\n\n

Tieto elektrick\u00e9 sign\u00e1ly sa v mozgu menia na chemick\u00e9 neurotransmitery, ktor\u00e9 sa \u0161\u00edria cez synaptick\u00e9 medzery. T\u00edm op\u00edsal, ako tvary elektrick\u00fdch sign\u00e1lov prospievaj\u00fa fungovaniu synapsi\u00ed. <\/p>\n\n\n\n

Neur\u00f3ny, ktor\u00e9 sa aktivuj\u00fa po\u010das neurotransmisie, maj\u00fa r\u00f4zne vzory. <\/p>\n\n\n\n

Tieto zmeny tvarov a po\u010dtu ved\u00fa k posilneniu alebo oslabeniu synapsi\u00ed (zn\u00e1me aj ako synaptick\u00e1 plasticita ). <\/p>\n\n\n\n

Ke\u010f si mozgov\u00e9 bunky na oboch koncoch synapsy nepretr\u017eite vymie\u0148aj\u00fa chemick\u00e9 sign\u00e1ly, doch\u00e1dza k dlhodobej potenci\u00e1cii (LTP). <\/p>\n\n\n\n

T\u00e1to LTP zlep\u0161uje signaliz\u00e1ciu medzi bunkami a synapsiami a vedie aj k posilneniu synapsi\u00ed. T\u00e1to LTP je z\u00e1kladom u\u010denia a spomienok v mozgu v mieste naz\u00fdvanom hipokampus.<\/p>\n\n\n\n

Vedci sa vo svojej \u0161t\u00fadii zamerali na oblas\u0165 hipokampu v mozgu. Zistili, \u017ee sign\u00e1ly pren\u00e1\u0161an\u00e9 cez synapsie v tejto oblasti s\u00fa analogick\u00e9. <\/p>\n\n\n\n

T\u00edm zistil, \u017ee elektrick\u00e9 sign\u00e1ly alebo \"hroty\" boli dod\u00e1van\u00e9 vo forme anal\u00f3gov\u00fdch a nie digit\u00e1lnych sign\u00e1lov. <\/p>\n\n\n\n

Tento objav im otvoril cestu k jasnej\u0161iemu pochopeniu mechanizmu. Tieto anal\u00f3gov\u00e9 sign\u00e1ly u\u013eah\u010dili regul\u00e1ciu sily mozgov\u00e9ho obvodu.<\/p>\n\n\n\n

Bola n\u00e1jden\u00e1 aj molekula reguluj\u00faca tieto elektrick\u00e9 sign\u00e1ly. Molekula Kv\u03b21 roz\u0161\u00edrila presynaptick\u00e9 p\u00f4sobenie. <\/p>\n\n\n\n

T\u00e1to molekula nielen reguluje drasl\u00edkov\u00fd pr\u00fad, ale pom\u00e1ha aj pri formovan\u00ed elektrick\u00fdch sign\u00e1lov. <\/p>\n\n\n\n

Pri predch\u00e1dzaj\u00facom experimente vyl\u00fa\u010dili u my\u0161\u00ed molekulu Kv\u03b21. \u010coskoro v\u00fdsledky uk\u00e1zali opa\u010dn\u00fa reakciu, do\u0161lo k drastick\u00e9mu ovplyvneniu sp\u00e1nku a pam\u00e4\u0165ov\u00e9ho cyklu my\u0161\u00ed. <\/p>\n\n\n\n

To potvrdilo pozit\u00edvne p\u00f4sobenie molekuly v syst\u00e9me.<\/p>\n\n\n\n

Okrem toho ich v\u00fdskum odhalil aj to, ako m\u00f4\u017ee jeden elektrick\u00fd impulz pren\u00e1\u0161a\u0165 viac bitov inform\u00e1ci\u00ed, \u010do umo\u017e\u0148uje v\u00e4\u010d\u0161iu kontrolu pri n\u00edzkofrekven\u010dn\u00fdch sign\u00e1loch. <\/p>\n\n\n\n

To znamen\u00e1, \u017ee n\u00e1\u0161 mozog je ove\u013ea efekt\u00edvnej\u0161\u00ed, ne\u017e si dok\u00e1\u017eeme predstavi\u0165. Technicky n\u00e1\u0161 mozog vykon\u00e1va superpo\u010d\u00edta\u010dov\u00e9 \u00falohy pri n\u00edzkej elektrickej signaliz\u00e1cii. <\/p>\n\n\n\n

Ich v\u00fdskum umo\u017enil meranie nap\u00e4tia a neurotransmiterov pomocou svetla, ktor\u00e9 n\u00e1sledne meralo elektrick\u00e9 sign\u00e1ly v miestach synaptick\u00fdch spojen\u00ed. <\/p>\n\n\n\n

To zmenilo perspekt\u00edvu a roz\u0161\u00edrilo z\u00e1ber v\u00fdskumu v oblasti molekul\u00e1rnych regul\u00e1torov, ktor\u00e9 zohr\u00e1vaj\u00fa d\u00f4le\u017eit\u00fa \u00falohu v \u010dinnosti mozgu.<\/p>\n\n\n\n

Tento objav umo\u017e\u0148uje \u00faplne nov\u00fa cestu pre farmaceutick\u00e9 v\u00fdrobky. Mohlo by to vies\u0165 k objaveniu nov\u00fdch sp\u00f4sobov pod\u00e1vania liekov v pr\u00edpade demencie alebo Alzheimerovej choroby. <\/p>\n\n\n\n

Molekul\u00e1rne regul\u00e1tory by mohli by\u0165 k\u013e\u00fa\u010dom k vyu\u017eitiu kompletnej kapacity mozgu. Mnoh\u00e9 neurologick\u00e9 ochorenia by sa dali vylie\u010di\u0165, ak sa n\u00e1jde spr\u00e1vna cesta mozgov\u00e9ho metabolizmu. <\/p>\n\n\n\n

Ako sa hovor\u00ed, u\u010denie nikdy nevy\u010derp\u00e1 myse\u013e, je to sila, ktor\u00e1 m\u00f4\u017ee zmeni\u0165 svet. Tento objav bezpochyby vedie k \u00faplne novej \u00farovni u\u010denia sa a sile udr\u017ea\u0165 si ju.<\/p>\n\n\n\n

Ak chcete vedie\u0165 viac o ich v\u00fdskume, pozrite si odkaz uveden\u00fd ni\u017e\u0161ie.<\/p>\n\n\n\n

Odkaz :<\/p>\n\n\n\n

In Ha Cho, Lauren C. Panzera, Morven Chin, Scott A. Alpizar, Genaro E. Olveda, Robert A. Hill, Michael B. Hoppa. Podjednotka drasl\u00edkov\u00e9ho kan\u00e1la Kv\u03b21 sl\u00fa\u017ei ako hlavn\u00fd kontroln\u00fd bod synaptickej facilit\u00e1cie. Proceedings of the National Academy of Sciences, 2020; 202000790<\/p>\n\n\n\n

DOI: 10.1073\/pnas.2000790117<\/p>","protected":false},"excerpt":{"rendered":"

Ka\u017ed\u00fd stroj m\u00e1 ovl\u00e1dac\u00ed panel na ovl\u00e1danie r\u00f4znych funkci\u00ed, najm\u00e4 mechanizmu zap\u00ednania a vyp\u00ednania. Rozm\u00fd\u0161\u013eali ste niekedy, \u010di ho m\u00e1 aj n\u00e1\u0161 mozog, kde by sa dali ovl\u00e1da\u0165 jeho funkcie? Nov\u00fd v\u00fdskum nazna\u010duje, \u017ee existuje \"molekul\u00e1rny gomb\u00edk\", ktor\u00fd reguluje elektrick\u00e9 sign\u00e1ly v mozgu pri u\u010den\u00ed a najm\u00e4 [...]<\/p>","protected":false},"author":4,"featured_media":12176,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959,28],"tags":[54,245,554],"yoast_head":"\nThe \u201cmolecular control knob\u201d that aids learning and memory - MTG<\/title>\n<meta name=\"description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The \u201cmolecular control knob\u201d that aids learning and memory - MTG\" \/>\n<meta property=\"og:description\" content=\"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/sk\/molekularni-nadzor-kljuc-mozgani\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2021-01-25T11:30:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-05-22T14:11:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/a-molecular-control-knob-in-the-brain-that-aids-in-learning-and-memory.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1123\" \/>\n\t<meta property=\"og:image:height\" content=\"612\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabricio Pamplona\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabricio Pamplona\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/sk\/molekularni-nadzor-kljuc-mozgani\/","og_locale":"sk_SK","og_type":"article","og_title":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","og_description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","og_url":"https:\/\/mindthegraph.com\/blog\/sk\/molekularni-nadzor-kljuc-mozgani\/","og_site_name":"Mind the Graph Blog","article_published_time":"2021-01-25T11:30:00+00:00","article_modified_time":"2023-05-22T14:11:05+00:00","og_image":[{"width":1123,"height":612,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2021\/01\/a-molecular-control-knob-in-the-brain-that-aids-in-learning-and-memory.png","type":"image\/png"}],"author":"Fabricio Pamplona","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabricio Pamplona","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/","url":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/","name":"The \u201cmolecular control knob\u201d that aids learning and memory - MTG","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2021-01-25T11:30:00+00:00","dateModified":"2023-05-22T14:11:05+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3"},"description":"Read this blog to know more of how a \u201cMolecular Control Knob\u201d in the brain that aids in learning and memory.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/#breadcrumb"},"inLanguage":"sk-SK","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/sl\/molekularni-nadzor-kljuc-mozgani\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"A \u201cMolecular Control Knob\u201d in The Brain That Aids in Learning and Memory"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"sk-SK"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/c8eaee6d8007ac319523c3ddc98cedd3","name":"Fabricio Pamplona","image":{"@type":"ImageObject","inLanguage":"sk-SK","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/da6985d9f20ecb24f3238df103a638ac?s=96&d=mm&r=g","caption":"Fabricio Pamplona"},"description":"Fabricio Pamplona is the founder of Mind the Graph - a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/sk\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12175"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/comments?post=12175"}],"version-history":[{"count":1,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12175\/revisions"}],"predecessor-version":[{"id":12177,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12175\/revisions\/12177"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/media\/12176"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/media?parent=12175"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/categories?post=12175"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/tags?post=12175"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}