{"id":12136,"date":"2021-01-18T09:30:00","date_gmt":"2021-01-18T11:30:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12136"},"modified":"2022-11-21T09:55:31","modified_gmt":"2022-11-21T12:55:31","slug":"cannabis-the-endocannabinoid-system","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/konope-endokanabinoidny-system\/","title":{"rendered":"Svet konope - Endokanabinoidn\u00fd syst\u00e9m"},"content":{"rendered":"

Lie\u010dba konope si v poslednom desa\u0165ro\u010d\u00ed z\u00edskala ve\u013ek\u00fa pozornos\u0165 vedeckej a lek\u00e1rskej komunity na celom svete. <\/p>\n\n\n\n

Lie\u010debn\u00e9 odpovede sa uk\u00e1zali by\u0165 ove\u013ea lep\u0161ie v porovnan\u00ed s konven\u010dn\u00fdmi liekmi. <\/p>\n\n\n\n

Potom sa endokanabinoidn\u00fd syst\u00e9m<\/strong> pri\u0165ahuje pozornos\u0165 exponenci\u00e1lnym tempom; v\u00fdskumn\u00edci sa sna\u017eia lep\u0161ie pochopi\u0165, ako tento syst\u00e9m pr\u00edtomn\u00fd v tele funguje. <\/p>\n\n\n\n

Preto sa vedci zaoberaj\u00fa touto problematikou hlb\u0161ie, aby mohli odpoveda\u0165 na ot\u00e1zky lek\u00e1rov a pacientov. <\/p>\n\n\n\n

Predt\u00fdm sme plne ch\u00e1pali lie\u010div\u00e9 \u00fa\u010dinky rastliny Cannabis, teraz mus\u00ed veda odpoveda\u0165 na ot\u00e1zky o endokanabinoidn\u00fd syst\u00e9m<\/strong>. <\/p>\n\n\n\n

Pozrime sa, \u010do je u\u017e zn\u00e1me.<\/p>\n\n\n\n

Str\u00e1nka Endokanabinoidn\u00fd syst\u00e9m (ES)<\/strong> je modul\u00e1tor nervov\u00e9ho syst\u00e9mu, ktor\u00fd funguje ako sie\u0165 v celom tele, typ regul\u00e1tora centr\u00e1lneho nervov\u00e9ho syst\u00e9mu. <\/p>\n\n\n\n

U dospel\u00fdch m\u00e1 endokanabinoidn\u00fd syst\u00e9m ve\u013ek\u00fd vplyv na modul\u00e1ciu neuron\u00e1lnej aktivity - ovplyv\u0148uje mnoh\u00e9 kognit\u00edvne a fyziologick\u00e9 procesy, ako s\u00fa hlad, sp\u00e1nok, pam\u00e4\u0165, \u00fazkos\u0165, imunitn\u00e1 odpove\u010f, motorick\u00e9 schopnosti a in\u00e9. <\/p>\n\n\n\n

Str\u00e1nka ES<\/strong> je t\u00edmov\u00fd hr\u00e1\u010d, ktor\u00fd nep\u00f4sob\u00ed ako izolovan\u00fd syst\u00e9m; je napojen\u00fd na r\u00f4zne sign\u00e1lne kask\u00e1dy z in\u00fdch syst\u00e9mov v tele.<\/p>\n\n\n\n

Existuj\u00fa tri hlavn\u00e9 zlo\u017eky, ktor\u00e9 tvoria E\u0160 - kanabinoidn\u00e9 receptory<\/strong>, endog\u00e9nne kanabinoidy<\/strong>a enz\u00fdmy<\/strong> zodpovedn\u00fd za synt\u00e9zu a degrad\u00e1ciu endokanabinoidn\u00fdch molek\u00fal. <\/p>\n\n\n\n

Str\u00e1nka endog\u00e9nne kanabinoidy s\u00fa<\/strong> typ molek\u00fal, ktor\u00e9 produkuje na\u0161e telo a ktor\u00e9 sa nach\u00e1dzaj\u00fa aj v pr\u00edrode, napr\u00edklad v rastline Cannabis. <\/p>\n\n\n\n

Veda dnes pozn\u00e1 tri r\u00f4zne molekuly schopn\u00e9 sp\u00fa\u0161\u0165a\u0165 kanabinoidn\u00e9 receptory - 2-AG a anandamid (AEA), \u010do s\u00fa skr\u00e1ten\u00e9 n\u00e1zvy pre 2-arachidonoylglycerol, resp. N-arachidonoyl etanolam\u00edn, ktor\u00e9 s\u00fa klasifikovan\u00e9 ako endog\u00e9nne kanabinoidy so \u0161trukt\u00farou podobnou lipidom. <\/p>\n\n\n\n

Tret\u00ed, naz\u00fdvan\u00fd N-arachidonoyl dopam\u00edn alebo len NADA, je tie\u017e lipidov\u00e1 \u0161trukt\u00fara a tie\u017e interaguje s kanabinoidn\u00fdmi receptormi.<\/strong> <\/p>\n\n\n\n

Prv\u00e9 dva s\u00fa schopn\u00e9 viaza\u0165 sa a aktivova\u0165 nieko\u013eko sign\u00e1lnych dr\u00e1h G-prote\u00ednov\u00fdch receptorov, i\u00f3nov\u00fdch kan\u00e1lov a jadrov\u00fdch receptorov - posledn\u00fd z nich je zodpovedn\u00fd za detekciu steroidn\u00fdch a tyroidn\u00fdch horm\u00f3nov. <\/p>\n\n\n\n

Okrem podobnosti molekul\u00e1rnej \u0161trukt\u00fary, 2-AG <\/strong>a anandamid<\/strong> zohr\u00e1vaj\u00fa r\u00f4zne \u00falohy v ES,<\/strong> s odli\u0161n\u00fdmi biochemick\u00fdmi cyklami v tele - pri z\u00e1vislosti v roku 2012 bol publikovan\u00fd recenzovan\u00fd \u010dl\u00e1nok o \u00falohe anandamidu pri schizofr\u00e9nii<\/a>.\u00a0<\/p>\n\n\n\n

\"\"<\/a><\/figure><\/div>\n\n\n\n

Viacer\u00e9 \u0161t\u00fadie uk\u00e1zali, \u017ee endog\u00e9nne kanabinoidy s\u00fa syntetizovan\u00e9 telom pod\u013ea jeho potreby, in\u00fdmi slovami \"na po\u017eiadanie\". <\/p>\n\n\n\n

To znamen\u00e1, \u017ee endog\u00e9nne kanabinoidy nesyntetizujeme neust\u00e1le, neplav\u00fa v krvnom rie\u010disku a ne\u010dakaj\u00fa, k\u00fdm ich zavol\u00e1me, ale syntetizuj\u00fa sa na ur\u010ditom mieste, ke\u010f je to potrebn\u00e9.<\/p>\n\n\n\n

Dve kanabinoidn\u00e9 receptory<\/strong> dnes zn\u00e1me, CB1<\/strong> a CB2<\/strong> s\u00fa oba receptory viazan\u00e9 na G-prote\u00edn. <\/p>\n\n\n\n

Receptory maj\u00fa r\u00f4zne funkcie, maj\u00fa schopnos\u0165 interagova\u0165 s r\u00f4znymi molekulami a aktivova\u0165 r\u00f4zne sign\u00e1lne dr\u00e1hy, \u010do m\u00f4\u017ee vies\u0165 k \u0161pecifick\u00fdm alebo odli\u0161n\u00fdm biologick\u00fdm \u00fa\u010dinkom.<\/p>\n\n\n\n

V\u00e4\u010d\u0161ina receptorov CB1 sa nach\u00e1dza v centr\u00e1lnom nervovom syst\u00e9me, ale m\u00f4\u017eu sa nach\u00e1dza\u0165 aj v org\u00e1noch, ako je pe\u010de\u0148, ko\u017ea a tukov\u00e9 tkanivo. <\/p>\n\n\n\n

V nervovom syst\u00e9me sa CB1 vyskytuje vo viacer\u00fdch synaptick\u00fdch termin\u00e1loch a zohr\u00e1va d\u00f4le\u017eit\u00fa \u00falohu pri modul\u00e1cii synaptick\u00e9ho prenosu. <\/p>\n\n\n\n

Tento receptor m\u00e1 tie\u017e vlastnos\u0165 heterodimerizova\u0165 - viaza\u0165 sa na r\u00f4zne \u0161trukt\u00fary - s in\u00fdmi receptormi viazan\u00fdmi na G-prote\u00edn, ako s\u00fa dopam\u00ednov\u00e9 D2, hypokretinov\u00e9 a opioidov\u00e9 receptory. V skuto\u010dnosti nieko\u013eko \u0161t\u00fadi\u00ed uk\u00e1zalo, \u017ee \u017ee konope pom\u00e1ha pri lie\u010dbe bolesti a zni\u017euje d\u00e1vky opioidov.<\/a>\u00a0<\/p>\n\n\n\n

Receptory CB2 s\u00fa hojne zast\u00fapen\u00e9 v bunk\u00e1ch imunitn\u00e9ho syst\u00e9mu a napriek tomu, \u017ee s\u00fa exprimovan\u00e9 <\/s>v ove\u013ea ni\u017e\u0161\u00edch hladin\u00e1ch ako CB1, CB2 je pr\u00edtomn\u00fd aj v neur\u00f3nov\u00fdch bunk\u00e1ch. <\/p>\n\n\n\n

Tento receptor sa nach\u00e1dza v r\u00f4znych org\u00e1noch, ako je pe\u010de\u0148, slezina, pankreas, hrub\u00e9 \u010drevo a kosti. <\/p>\n\n\n\n

V\u00fdskumn\u00edci opisuj\u00fa aktiv\u00e1ciu receptora CB2 ako protiz\u00e1palov\u00fd faktor v scen\u00e1roch z\u00e1palu. CB1 je hlavn\u00fdm receptorom aj pre anandamid a THC. <\/p>\n\n\n\n

Anandamid aj THC s\u00fa klasifikovan\u00e9 ako \u010diasto\u010dn\u00ed agonisti receptorov CB1, \u010do znamen\u00e1, \u017ee molekula m\u00e1 ve\u013emi n\u00edzku \u00fa\u010dinnos\u0165 pri vytv\u00e1ran\u00ed receptorovej odpovede, \u010do priamo ovplyv\u0148uje terapeutick\u00e9 \u00fa\u010dinky. <\/p>\n\n\n\n

Medzit\u00fdm sa 2-AG - ktor\u00fd je v mozgu hojnej\u0161\u00ed ako anandamid - klasifikuje ako vysoko \u00fa\u010dinn\u00fd agonista oboch receptorov, CB1 aj CB2, ktor\u00fd m\u00e1 schopnos\u0165 viaza\u0165 sa na receptor, ktor\u00fd aktivuje a vyvol\u00e1va biologick\u00fa odpove\u010f na vysokej \u00farovni. <\/p>\n\n\n\n

CBD je pritom klasifikovan\u00fd ako antagonista oboch receptorov, \u010do znamen\u00e1, \u017ee sa molekula pripoj\u00ed k receptoru bez toho, aby ho aktivovala, \u010do br\u00e1ni in\u00fdm molekul\u00e1m pripoji\u0165 sa a aktivova\u0165 receptor.<\/p>\n\n\n\n

\"\"<\/a><\/figure><\/div>\n\n\n\n

Vzh\u013eadom na ve\u013ek\u00fd po\u010det endokanabinoidn\u00fdch receptorov v mozgu sa nieko\u013eko du\u0161evn\u00fdch ochoren\u00ed sp\u00e1ja s dysregul\u00e1ciou endokanabinoidn\u00e9ho syst\u00e9mu a genetick\u00fdmi polymorfizmami, ako s\u00fa psych\u00f3zy, schizofr\u00e9nia, \u00fazkos\u0165, depresia a autizmus. <\/p>\n\n\n\n

Vedci sa sna\u017eili pochopi\u0165 a zisti\u0165 presn\u00fa s\u00favislos\u0165 medzi mo\u017en\u00fdmi mut\u00e1ciami v endokanabinoidnom syst\u00e9me a t\u00fdmito ochoreniami.<\/p>\n\n\n\n

V s\u00fa\u010dasnosti je mo\u017en\u00e9, aby pacienti spolo\u010dnos\u0165 na anal\u00fdzu ich genetick\u00e9ho k\u00f3du<\/a> a z\u00edska\u0165 v\u0161etky mo\u017en\u00e9 mut\u00e1cie k\u00f3du ich endokanabinoidn\u00e9ho syst\u00e9mu a pochopi\u0165, ako sa ich telo vyrovn\u00e1va s molekulami konope, ako s\u00fa THC, CBD a mnoh\u00e9 \u010fal\u0161ie.  <\/p>\n\n\n\n

O alosterickej modul\u00e1cii receptora CB2 dnes nem\u00e1me ve\u013ea poznatkov, ale pre CB1 je zn\u00e1mych nieko\u013eko alosterick\u00fdch modul\u00e1torov. <\/p>\n\n\n\n

Alosterick\u00e9 modul\u00e1tory s\u00fa schopn\u00e9 meni\u0165 kinetiku a\/alebo \u00fa\u010dinnos\u0165 receptora - ide o enz\u00fdmov\u00fa regul\u00e1ciu, ktor\u00e1 je charakterizovan\u00e1 v\u00e4zbou efektorovej molekuly na in\u00fa oblas\u0165 ako je akt\u00edvne miesto enz\u00fdmu, toto sekund\u00e1rne miesto sa naz\u00fdva ortostatick\u00e9 miesto.<\/p>\n\n\n\n

D\u00f4le\u017eit\u00e9 je spomen\u00fa\u0165, \u017ee CBD je negat\u00edvny alosterick\u00fd modul\u00e1tor CB1, ktor\u00fd zni\u017euje aktiv\u00e1ciu CB1 THC. <\/p>\n\n\n\n

In\u00fdmi slovami, \u00fa\u010dinok THC sa zni\u017euje \u00fa\u010dinkom CBD. Psychoaktivita THC je pri s\u00fa\u010dasnom pod\u00e1van\u00ed s CBD ni\u017e\u0161ia.<\/p>\n\n\n\n

Ako vid\u00edte, endokanabinoidn\u00fd syst\u00e9m nie je v\u00f4bec jednoduch\u00fd, na druhej strane je to ve\u013emi komplexn\u00fd syst\u00e9m pr\u00edtomn\u00fd takmer v celom na\u0161om tele. <\/p>\n\n\n\n

Je to d\u00f4le\u017eit\u00fd regul\u00e1tor sign\u00e1lnych dr\u00e1h a zrejme ES<\/strong> je do ur\u010ditej miery spojen\u00e1 na biologickej \u00farovni, ktorej vedci st\u00e1le \u00faplne nerozumej\u00fa. <\/p>\n\n\n\n

Exog\u00e9nne kanabinoidy - kanabinoidy, ktor\u00e9 si \u013eudsk\u00e9 telo nevytv\u00e1ra - s\u00fa tie\u017e ve\u013emi d\u00f4le\u017eit\u00fdmi molekulami pre endokanabinoidn\u00fd syst\u00e9m, ale o tom bude re\u010d a\u017e v \u010fal\u0161ej kapitole Sveta konope.\u00a0<\/p>\n\n\n\n

LU, H.-C.; MACKIE, K. Preh\u013ead endokanabinoidn\u00e9ho syst\u00e9mu. Biologick\u00e1 psychiatria: Kognit\u00edvna neuroveda a neurozobrazovanie<\/strong>, pred 1 rokom. 2020.<\/p>\n\n\n\n

MARKUS LEWEKE, F. Dysfunkcia anandamidu pri prodrom\u00e1lnej a etablovanej psych\u00f3ze. S\u00fa\u010dasn\u00fd farmaceutick\u00fd dizajn<\/strong>, ro\u010d. 18, \u010d. 32, s. 5188-5193, 1. novembra 2012. <\/p>\n\n\n\n

___<\/p>\n\n\n\n

P\u00e1\u010dila sa v\u00e1m infografika v tomto \u010dl\u00e1nku? Podobn\u00e9 infografiky m\u00f4\u017eete vytv\u00e1ra\u0165 na Mind the Graph, m\u00f4\u017eete za\u010da\u0165 pou\u017e\u00edva\u0165 hne\u010f teraz.<\/a> <\/p>\n\n\n\n

T\u00e1to platforma v\u00e1m pom\u00f4\u017ee vytvori\u0165 infografiku, ako je t\u00e1 v tomto \u010dl\u00e1nku. M\u00f4\u017eete pou\u017ei\u0165 neurol\u00f3gia,<\/a> kardiol\u00f3gia,<\/a> endokrinol\u00f3gia<\/a>, gynekol\u00f3gia<\/a>, urol\u00f3gia<\/a>a mnoho \u010fal\u0161\u00edch<\/a>. Ak potrebujete pomoc, sme tu pre v\u00e1s, kontaktujte n\u00e1s<\/a>!<\/p>","protected":false},"excerpt":{"rendered":"

Lie\u010dba konope si v poslednom desa\u0165ro\u010d\u00ed z\u00edskala ve\u013ek\u00fa pozornos\u0165 vedeckej a lek\u00e1rskej komunity na celom svete. Uk\u00e1zalo sa, \u017ee reakcie na lie\u010dbu s\u00fa v porovnan\u00ed s konven\u010dn\u00fdmi liekmi ove\u013ea lep\u0161ie. Endokanabinoidn\u00fd syst\u00e9m potom pri\u0165ahuje pozornos\u0165 exponenci\u00e1lnou r\u00fdchlos\u0165ou; v\u00fdskumn\u00edci sa usiluj\u00fa lep\u0161ie pochopi\u0165, ako tento [...]<\/p>","protected":false},"author":4,"featured_media":12140,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[959],"tags":[819,554,964,775,820],"yoast_head":"\nThe Cannabis World - The Endocannabinoid System - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Know some insightful information about the endocannabinoid system, the most important part of the Cannabis world.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/sk\/konope-endokanabinoidny-system\/\" \/>\n<meta property=\"og:locale\" content=\"sk_SK\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Cannabis World - 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a tool used by over 400K users in 60 countries. He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. Connect with him on LinkedIn - Fabricio Pamplona.","sameAs":["http:\/\/mindthegraph.com","https:\/\/www.linkedin.com\/in\/fabriciopamplona"],"url":"https:\/\/mindthegraph.com\/blog\/sk\/author\/fabricio\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12136"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/comments?post=12136"}],"version-history":[{"count":1,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12136\/revisions"}],"predecessor-version":[{"id":12141,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/posts\/12136\/revisions\/12141"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/media\/12140"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/media?parent=12136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/categories?post=12136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/sk\/wp-json\/wp\/v2\/tags?post=12136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}