{"id":10972,"date":"2020-03-20T08:22:00","date_gmt":"2020-03-20T11:22:00","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=10972"},"modified":"2022-10-18T08:09:52","modified_gmt":"2022-10-18T11:09:52","slug":"coronavirus-covid-19-is-hydroxychloroquine-the-new-hope-apparently-yes","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/sk\/coronavirus-covid-19-is-hydroxychloroquine-new-hope-apparently-yes\/","title":{"rendered":"Koronav\u00edrus (Covid-19): je hydroxychloroch\u00edn novou n\u00e1dejou? Zrejme \u00e1no."},"content":{"rendered":"

Dve ned\u00e1vne pr\u00e1ce zhrnuli jeden v\u00fdskum in vitro a mal\u00fa klinick\u00fa \u0161t\u00fadiu, \u010do sta\u010dilo Donaldovi Trumpovi na to, aby FDA presadil nov\u00fa klinick\u00fa indik\u00e1ciu lieku hydroxychloroch\u00edn: zlep\u0161enie pr\u00edznakov pacientov postihnut\u00fdch koronav\u00edrusom (Covid-19).<\/p>\n

Ide pravdepodobne o najr\u00fdchlej\u0161\u00ed proces schva\u013eovania liekov v novodobej hist\u00f3rii a prezident m\u00e1 zrejme pravdu. Prekvapuj\u00face pre glob\u00e1lneho l\u00eddra, ktor\u00fd nem\u00e1 ve\u013ek\u00fa n\u00e1klonnos\u0165 k vede.<\/p>\n

\"\"<\/p>\n

Prv\u00e9 d\u00f4kazy o \u00fa\u010dinku hydroxychloroch\u00ednu na v\u00edrus poch\u00e1dzaj\u00fa z tento dokument bol v\u010dera uverejnen\u00fd na Cell Discovery<\/a>Je to len in vitro so v\u0161etk\u00fdmi obmedzeniami, ale jasne to ukazuje potenci\u00e1l lieku zab\u00edja\u0165 v\u00edrus. V \u010dase predlo\u017eenia pr\u00e1ce bolo v \u010c\u00edne potvrden\u00fdch 80 000 pr\u00edpadov vr\u00e1tane 2946 \u00famrt\u00ed, ako aj viac ako 10 566 potvrden\u00fdch pr\u00edpadov v 72 \u010fal\u0161\u00edch krajin\u00e1ch. V tom \u010dase sa najv\u00e4\u010d\u0161ia n\u00e1dej vkladala do lieku s n\u00e1zvom remdesivir.<\/p>\n

\"in
In vitro \u00fa\u010dinky hydrochloroch\u00ednu na koronav\u00edrus (Covid-19). V st\u013apci vpravo s\u00fa uveden\u00e9 \u00fa\u010dinky \u00fa\u010dinn\u00e9ho lieku v porovnan\u00ed s chloroch\u00ednom alebo kontrolnou skupinou v\u013eavo. Ukazuje, \u017ee liek zlep\u0161il schopnos\u0165 buniek vytl\u00e1\u010da\u0165 v\u00edrusy... je to ako pom\u00f4c\u0165 vyhna\u0165 ne\u017eiaduceho suseda z v\u00e1\u0161ho domu. Pom\u00e1ha to! \ud83d\ude42 <\/figcaption><\/figure>\n

Najv\u00e4\u010d\u0161iu novinku v\u0161ak priniesla mal\u00e1 klinick\u00e1 \u0161t\u00fadia uverejnen\u00e1 de\u0148 predt\u00fdm. Jej n\u00e1zov je Hydroxychloroch\u00edn a azitromyc\u00edn ako lie\u010dba COVID-19: v\u00fdsledky otvoren\u00e9ho nerandomizovan\u00e9ho klinick\u00e9ho sk\u00fa\u0161ania a je mo\u017en\u00e9 si ich stiahnu\u0165 na jeho \"in press\" verzii<\/a><\/p>\n

V \u0161t\u00fadii len s 20 pacientmi autori preuk\u00e1zali, \u017ee hydroxychloroch\u00edn je \u00fa\u010dinn\u00fd proti infekcii koronav\u00edrusom Covid-19. V skuto\u010dnosti zn\u00ed\u017eil 75% infikovan\u00fdch jedincov v priebehu 6 dn\u00ed, \u010do je \u00fa\u017easn\u00e9. A \u010do je e\u0161te lep\u0161ie, kombin\u00e1cia s azitromyc\u00ednom zv\u00fd\u0161ila \u00fa\u010dinnos\u0165 lie\u010dby na 95%.<\/p>\n

\"Kombinovan\u00e1
Kombinovan\u00e1 lie\u010dba hydrohychloroch\u00ednom a azitromyc\u00ednom je \u00fa\u010dinn\u00e1 proti infekci\u00e1m sp\u00f4soben\u00fdm koronav\u00edrusom (Covid-19) u \u013eudsk\u00fdch pacientov. Pokles je dramatick\u00fd a prin\u00e1\u0161a nov\u00fa n\u00e1dej pre postihnut\u00fdch pacientov.<\/figcaption><\/figure>\n

Lie\u010dba zlep\u0161ila pr\u00edznaky a z\u00e1rove\u0148 zn\u00ed\u017eila v\u00edrusov\u00fa z\u00e1\u0165a\u017e u pacientov. Liek bol predt\u00fdm schv\u00e1len\u00fd na lie\u010dbu mal\u00e1rie, \u010do znamen\u00e1, \u017ee sa pova\u017euje za bezpe\u010dn\u00fd. \"Sestersk\u00fd\" liek chloroch\u00edn bol menej \u00fa\u010dinn\u00fd. Pre n\u00e1s je to dobr\u00e9, preto\u017ee je algo toxickej\u0161\u00ed.<\/p>\n

\u0160t\u00fadia bola nerandomizovan\u00e1 a mal\u00e9ho rozsahu, zd\u00e1 sa v\u0161ak, \u017ee hoci epid\u00e9mia za\u010dala v \u010c\u00edne, rie\u0161enie poch\u00e1dza z celosvetov\u00e9ho \u00fasilia komunity. Dokument in vitro je vlastne \u010d\u00ednsky, zatia\u013e \u010do klinick\u00fd je eur\u00f3psky, presnej\u0161ie z Franc\u00fazska. Zauj\u00edmav\u00e9 je, \u017ee p\u00f4vodn\u00e1 registr\u00e1cia lieku hydroxychloroch\u00edn je od franc\u00fazskej farmaceutickej spolo\u010dnosti Sanofi a ned\u00e1vna klinick\u00e1 \u0161t\u00fadia sa uskuto\u010dnila v Marseille. Ale le bleu!<\/p>\n

Medscape o tom uverejnil vynikaj\u00faci \u010dl\u00e1nok pre t\u00fdch, ktor\u00ed maj\u00fa z\u00e1ujem o podrobnej\u0161ie inform\u00e1cie.<\/a><\/p>\n

Pros\u00edm, citujte t\u00fato pr\u00e1cu ako Gautret et al. (2020) Hydroxychloroch\u00edn a azitromyc\u00edn ako lie\u010dba COVID-19: v\u00fdsledky otvorenej nerandomizovanej klinickej \u0161t\u00fadie. International Journal of Antimicrobial Agents - v tla\u010di 17. marca 2020 - DOI : 10.1016\/j.ijantimicag.2020.105949<\/p>","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":11134,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[419,959,28],"tags":[400,394,396,388,389,398,397,399,92,53,554,395,250,393],"yoast_head":"\nCoronavirus Covid-19: hydroxychloroquine, the new hope?<\/title>\n<meta name=\"description\" content=\"Hydroxycholoquine is the new hope for coronavirus (Covid-19) infection. 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