{"id":8527,"date":"2019-03-20T18:17:14","date_gmt":"2019-03-20T21:17:14","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8527"},"modified":"2022-10-19T10:38:06","modified_gmt":"2022-10-19T13:38:06","slug":"nature-neuroscience","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/natura-neurostiinta\/","title":{"rendered":"Nature neuroscience: Leg\u0103tura dintre schizofrenie \u0219i microglia"},"content":{"rendered":"<p>Schizofrenia este o tulburare mental\u0103 cronic\u0103 \u0219i sever\u0103 care afecteaz\u0103 modul \u00een care o persoan\u0103 g\u00e2nde\u0219te, simte \u0219i se comport\u0103. Persoanele cu schizofrenie pot p\u0103rea c\u0103 au pierdut contactul cu realitatea. Pentru a \u00een\u021belege dezvoltarea schizofreniei, trebuie s\u0103 vorbim despre pruningul sinaptic. Conform unui articol din Nature Neuroscience <sup>1<\/sup>, &#8220;<em>\"Tunderea sinaptic\u0103 este procesul de eliminare a sinapselor care are loc \u00een timpul copil\u0103riei timpurii p\u00e2n\u0103 la v\u00e2rsta adult\u0103 timpurie.\"<\/em>&nbsp;Pe m\u0103sur\u0103 ce creierul se dezvolt\u0103, factorii de mediu modeleaz\u0103 circuitele neuronale. Acest proces elimin\u0103 sinapsele \u00een exces generate \u00een timpul dezvolt\u0103rii timpurii \u0219i \u00eent\u0103re\u0219te sinapsele r\u0103mase.<\/p>\n\n\n\n<p>Mai mult, conform ipotezei \"pruningului sinaptic\", pruningul sinaptic excesiv sau dezordonat este legat de tulburarea de schizofrenie. Psihiatrul Irwin Feinberg a lansat aceast\u0103 ipotez\u0103 \u00een 1982.<\/p>\n\n\n\n<p>\u00cen plus, \u00een urm\u0103 cu c\u00e2\u021biva ani, studiile de imagistic\u0103 a creierului uman \u0219i studiile postmortem au adus noi dovezi \u00een sprijinul ipotezei \"t\u0103ierii sinaptice\". Dovezile au ar\u0103tat c\u0103 densitatea coloanei vertebrale \u0219i materia cenu\u0219ie sunt reduse \u00een cortexurile pacien\u021bilor cu schizofrenie.<a href=\"https:\/\/mindthegraph.com\/templates\" target=\"_blank\" rel=\"noopener\"><br><\/a><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png\" alt=\"previzualizare_69596 (1)\" class=\"wp-image-8555\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69596-1-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<h3>&nbsp;<\/h3>\n\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-1 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">Sunte\u021bi gata s\u0103 \u00eencepe\u021bi la Mind the Graph?<\/a><\/div>\n<\/div>\n\n\n\n<h3><strong>&nbsp;Noi dovezi publicate \u00een Nature Neuroscience:<\/strong><\/h3>\n\n\n\n<p>Prin urmare, oamenii de \u0219tiin\u021b\u0103 \u00eencearc\u0103 acum s\u0103 \u00een\u021beleag\u0103 mecanismul care st\u0103 la baza acestui fenomen. Potrivit lui Carl Sellgren, Roy Perlis \u0219i colaboratorilor, sistemul imunitar ar putea juca un rol \u00een eliminarea excesiv\u0103 a sinapticelor. Noua lor lucrare<sup>1<\/sup> publicat \u00een Nature neuroscience descrie un model in vitro care aplic\u0103 reprogramarea celular\u0103 pentru a studia \u00eenghi\u021birea sinapselor mediat\u0103 de microglia specific\u0103 pacien\u021bilor cu schizofrenie.<\/p>\n\n\n\n<p>Microglia este un tip colectiv de neuroglie (celule gliale) localizate \u00een tot creierul \u0219i m\u0103duva spin\u0103rii. Ele reprezint\u0103 10-15% din toate celulele care se g\u0103sesc \u00een creier. \u00cen calitate de celule macrofage rezidente, ele ac\u021bioneaz\u0103 ca prima \u0219i principala form\u0103 de ap\u0103rare imunitar\u0103 activ\u0103 \u00een sistemul nervos central (SNC). Mai mult, celulele microglia sunt capabile s\u0103 recunoasc\u0103 corpurile str\u0103ine, s\u0103 le \u00eenghit\u0103 \u0219i s\u0103 ac\u021bioneze ca celule prezentatoare de antigen care activeaz\u0103 celulele T.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"768\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png\" alt=\"previzualizare_69544\" class=\"wp-image-8529\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-1024x768.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-300x225.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69544-768x576.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"1024\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png\" alt=\"previzualizare_69618\" class=\"wp-image-8531\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-1024x1024.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-150x150.png 150w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-300x300.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1-768x768.png 768w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69618-1.png 1980w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter\"><a href=\"https:\/\/mindthegraph.com\/science_figures\" target=\"_blank\" rel=\"noopener\"><img decoding=\"async\" loading=\"lazy\" width=\"1024\" height=\"640\" src=\"https:\/\/blog.mindthegraph.com\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png\" alt=\"previzualizare_69620\" class=\"wp-image-8532\" srcset=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-1024x640.png 1024w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-300x188.png 300w, https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/preview_69620-768x480.png 768w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/a><\/figure><\/div>\n\n\n<div class=\"is-content-justification-center is-layout-flex wp-container-2 wp-block-buttons\">\n<div class=\"wp-block-button\"><a class=\"wp-block-button__link\" href=\"https:\/\/mindthegraph.com\/science_figures\">\u00cencepe\u021bi s\u0103 crea\u021bi la Mind the Graph acum<\/a><\/div>\n<\/div>\n\n\n\n<h2>Continua\u021bi s\u0103 citi\u021bi pe teme de neuro\u0219tiin\u021b\u0103<\/h2>\n\n\n\n<ul><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-disease\/#.XJlCeZhKiUk\" target=\"_blank\" rel=\"noopener\">Boala Alzheimer: Un infografic \u0219tiin\u021bific<\/a><\/li><li><a href=\"https:\/\/blog.mindthegraph.com\/alzheimers-graphical-abstracts\/#.XJlCiJhKiUk\" target=\"_blank\" rel=\"noopener\">Rezumatele grafice ale bolii Alzheimer: Nout\u0103\u021bi \u00een neuro\u0219tiin\u021be \u00eentr-un mod vizual<\/a><\/li><\/ul>\n\n\n\n<p>Dac\u0103 dori\u021bi s\u0103 v\u0103 prezenta\u021bi cercet\u0103rile \u0219i \u00eentr-un mod vizual, rezumatele grafice \u0219i ilustra\u021biile \u0219tiin\u021bifice frumoase sunt un instrument puternic! A\u0219adar, \u00eencepe\u021bi de ast\u0103zi s\u0103 v\u0103 face\u021bi datele mai vizuale.<\/p>\n\n\n\n<ol><li><a href=\"https:\/\/www.nature.com\/articles\/s41593-018-0334-7\" target=\"_blank\" rel=\"noreferrer noopener\">Eliminarea crescut\u0103 a sinapselor de c\u0103tre microglia \u00een modelele de t\u0103iere sinaptic\u0103 derivate din pacien\u021bi cu schizofrenie.<\/a><\/li><\/ol>","protected":false},"excerpt":{"rendered":"<p>Schizofrenia este o tulburare mental\u0103 cronic\u0103 \u0219i sever\u0103 care afecteaz\u0103 modul \u00een care o persoan\u0103 g\u00e2nde\u0219te, simte \u0219i se comport\u0103. Persoanele cu schizofrenie pot p\u0103rea c\u0103 au pierdut contactul cu realitatea. Pentru a \u00een\u021belege dezvoltarea schizofreniei, trebuie s\u0103 vorbim despre pruningul sinaptic. Conform unui articol din Nature neuroscience 1, \"tunderea sinaptic\u0103 este procesul de sinaps\u0103 [...]<\/p>","protected":false},"author":11,"featured_media":8536,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[96,554,775],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.9 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Neuroscience of nature: see the link between schizophrenia and microglia<\/title>\n<meta name=\"description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/luonto-neurotiede\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Neuroscience of nature: see the link between schizophrenia and microglia\" \/>\n<meta property=\"og:description\" content=\"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/ro\/luonto-neurotiede\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2019-03-20T21:17:14+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-19T13:38:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/dfgg.png\" \/>\n\t<meta property=\"og:image:width\" content=\"850\" \/>\n\t<meta property=\"og:image:height\" content=\"519\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Neuroscience of nature: see the link between schizophrenia and microglia","description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/ro\/luonto-neurotiede\/","og_locale":"ro_RO","og_type":"article","og_title":"Neuroscience of nature: see the link between schizophrenia and microglia","og_description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","og_url":"https:\/\/mindthegraph.com\/blog\/ro\/luonto-neurotiede\/","og_site_name":"Mind the Graph Blog","article_published_time":"2019-03-20T21:17:14+00:00","article_modified_time":"2022-10-19T13:38:06+00:00","og_image":[{"width":850,"height":519,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2019\/03\/dfgg.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/","url":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/","name":"Neuroscience of nature: see the link between schizophrenia and microglia","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2019-03-20T21:17:14+00:00","dateModified":"2022-10-19T13:38:06+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"A new paper in Nature neuroscience magazine brings new evidences of the microglial cells role in the schizophrenia development","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/#breadcrumb"},"inLanguage":"ro-RO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/fi\/luonto-neurotiede\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Nature neuroscience: the link between schizophrenia and microglia"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ro-RO"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/ro\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8527"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/comments?post=8527"}],"version-history":[{"count":14,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8527\/revisions"}],"predecessor-version":[{"id":23512,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8527\/revisions\/23512"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media\/8536"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media?parent=8527"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/categories?post=8527"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/tags?post=8527"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}