{"id":8064,"date":"2018-08-23T15:56:09","date_gmt":"2018-08-23T18:56:09","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=8064"},"modified":"2022-10-18T08:30:53","modified_gmt":"2022-10-18T11:30:53","slug":"alzheimers-disease","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/boala-alzheimer\/","title":{"rendered":"Boala Alzheimer: Un infografic \u0219tiin\u021bific"},"content":{"rendered":"

Este \u00eentotdeauna o s\u0103rb\u0103toare c\u00e2nd vedem munca extraordinar\u0103 a utilizatorilor no\u0219tri.\u00a0Am scris deja<\/a> despre cercet\u0103rile Dr. Alessandra Martini, dr.\u00a0Stefania Forner<\/a>\u00a0\u0219i colegii lor. Ei sunt cercet\u0103tori postdoctorali la Universitatea din California \u0219i se preocup\u0103 de utilizatorii de grafice. Cu c\u00e2teva luni \u00een urm\u0103, am ar\u0103tat infografice<\/a>\u00a0Dr. Stefania Forner a creat pentru articolul de recenzie publicat \u00een Trends in Neurosciences intitulat Synaptic impairment in Alzheimer's Disease: O simfonie dereglementat\u0103.<\/p>\n

Ast\u0103zi, vreau s\u0103 vorbesc despre noul lor articol de analiz\u0103 intitulat De la trecut la viitor: ce ne-au \u00eenv\u0103\u021bat modelele animale despre boala Alzheimer.<\/a><\/p>\n

Boala Alzheimer (AD) este o tulburare neurodegenerativ\u0103 care provoac\u0103 deficite cognitive \u0219i pierderi de memorie. \u00cen\u021belegerea mecanismului bolii este important\u0103 pentru a \u00eembun\u0103t\u0103\u021bi calitatea vie\u021bii pacien\u021bilor \u0219i pentru a g\u0103si un tratament eficient. \u00cen prezent, \u00een ciuda eforturilor imense depuse \u00een mediul academic \u0219i \u00een industria farmaceutic\u0103, nu sunt disponibile tratamente eficiente. AD este a \u0219asea cauz\u0103 principal\u0103 de deces \u00een SUA \u0219i afecteaz\u0103 35 de milioane de persoane din \u00eentreaga lume.<\/p>\n

Infografic despre boala Alzheimer<\/h2>\n

 <\/p>\n

Majoritatea pacien\u021bilor cu AD sunt v\u00e2rstnici care sufer\u0103 de obicei de o varietate de comorbidit\u0103\u021bi. Diabetul, osteoporoza, bolile renale, obezitatea, hipertensiunea arterial\u0103 \u0219i hipercolesterolemia\/dislipidemia, accidentul vascular cerebral \u0219i convulsiile sunt principalele comorbidit\u0103\u021bi care afecteaz\u0103 debutul \u0219i progresia DA, ad\u0103ug\u00e2nd complexitate la patogeneza bolii.<\/p>\n

\"infografic
Infografic care prezint\u0103 comorbidit\u0103\u021bile \u00een boala Alzheimer (AD). De la trecut la viitor: Ce ne-au \u00eenv\u0103\u021bat modelele animale despre boala Alzheimer<\/figcaption><\/figure>\n

 <\/p>\n

\n

\u00cen ciuda eforturilor intense de cercetare din ultimele decenii, mecanismele care stau la baza etiologiei DA sporadic\u0103 (DAs), care reprezint\u0103 cea mai frecvent\u0103 form\u0103 a bolii, r\u0103m\u00e2n necunoscute. Acest lucru se datoreaz\u0103, cel pu\u021bin \u00een parte, faptului c\u0103 majoritatea pacien\u021bilor cu sAD sunt subiec\u021bi v\u00e2rstnici care sufer\u0103 \u00een mod obi\u0219nuit de o varietate de comorbidit\u0103\u021bi (de exemplu, accident vascular cerebral, stres,diabet, convulsii, osteoporoz\u0103 \u0219i boli renale)<\/em><\/p>\n<\/blockquote>\n

Urm\u0103torul infografic prezint\u0103 formarea \u0219i mecanismele de toxicitate sinaptic\u0103 a oligomerilor tau \u0219i beta-amiloid.<\/p>\n

 <\/p>\n

\"infografic
De la trecut la viitor: Ce ne-au \u00eenv\u0103\u021bat modelele animale despre boala Alzheimer<\/figcaption><\/figure>\n

 <\/p>\n

\n

\u00cen timpul taupatiilor, exist\u0103 o reducere a num\u0103rului de spini dendritici. Tau nu intr\u0103 \u00een nucleul neuronului, ceea ce duce la deteriorarea ADN-ului. Exist\u0103 o reducere a num\u0103rului de mitocondrii \u0219i, de asemenea, a num\u0103rului de vezicule presinaptice, ceea ce duce la pierderea sinaptic\u0103. O astfel de pierdere se datoreaz\u0103, de asemenea, intr\u0103rii tau \u00een dendrite \u0219i \u00een zonele postsinaptice. Tau se agreg\u0103, de asemenea, la nivel extracelular, ceea ce \u00eei permite s\u0103 fie captat de al\u021bi neuroni.<\/em><\/p>\n<\/blockquote>\n

 <\/p>\n

De asemenea, a creat un infografic pentru a ar\u0103ta mecanismele inflamatorii legate de boala Alzheimer (AD).<\/p>\n

 <\/p>\n

\"infografic<\/p>\n

 <\/p>\n

\n

\u00cen ultimii ani, am fost deosebit de interesa\u021bi de modul \u00een care inflama\u021bia influen\u021beaz\u0103 patologia beta-amiloid\u0103 \u0219i tau. Persoanele v\u00e2rstnice sunt susceptibile la infec\u021bii virale \u0219i bacteriene, iar ace\u0219ti agen\u021bi microbieni ar putea exacerba starea inflamatorie existent\u0103 \u00een creier, acceler\u00e2nd declinul cognitiv.<\/em><\/p>\n<\/blockquote>\n

Felicit\u0103ri Dr. \u0218tefania Forner pentru activitatea dumneavoastr\u0103 deosebit\u0103!<\/p>\n

Dac\u0103 sunte\u021bi un om de \u0219tiin\u021b\u0103 \u0219i dori\u021bi s\u0103 crea\u021bi cifre frumoase pentru lucrarea dumneavoastr\u0103, pute\u021bi deveni un utilizator mind the graph chiar acum.<\/p>\n

\"untitled-creation63724<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Este \u00eentotdeauna o s\u0103rb\u0103toare c\u00e2nd vedem munca extraordinar\u0103 a utilizatorilor no\u0219tri. Am scris deja despre cercet\u0103rile Dr. Alessandra Martini, Dr. Stefania Forner \u0219i ale colegilor lor. Ei sunt cercet\u0103tori postdoctorali la Universitatea din California \u0219i se g\u00e2ndesc la utilizatorii graficului. Cu c\u00e2teva luni \u00een urm\u0103, am ar\u0103tat infograficele pe care Dr. Stefania Forner le-a creat pentru articolul de analiz\u0103 publicat \u00een Trends [...]<\/p>","protected":false},"author":11,"featured_media":8067,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[195,958,957],"tags":[96,554],"yoast_head":"\nAlzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/ro\/alzheimers-sykdom\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2018-08-23T18:56:09+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-10-18T11:30:53+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png\" \/>\n\t<meta property=\"og:image:width\" content=\"755\" \/>\n\t<meta property=\"og:image:height\" content=\"487\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Fabiola Soares\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Fabiola Soares\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/mindthegraph.com\/blog\/ro\/alzheimers-sykdom\/","og_locale":"ro_RO","og_type":"article","og_title":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","og_description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","og_url":"https:\/\/mindthegraph.com\/blog\/ro\/alzheimers-sykdom\/","og_site_name":"Mind the Graph Blog","article_published_time":"2018-08-23T18:56:09+00:00","article_modified_time":"2022-10-18T11:30:53+00:00","og_image":[{"width":755,"height":487,"url":"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2018\/08\/infographic-neuroscience.png","type":"image\/png"}],"author":"Fabiola Soares","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Fabiola Soares","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","url":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/","name":"Alzheimer\u2019s disease: A scientific infographic - Mind the Graph Blog","isPartOf":{"@id":"https:\/\/mindthegraph.com\/blog\/#website"},"datePublished":"2018-08-23T18:56:09+00:00","dateModified":"2022-10-18T11:30:53+00:00","author":{"@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132"},"description":"Alzheimer\u2019s Disease is a neurodegenerative disorder that causes cognitive deficits and memory loss.","breadcrumb":{"@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb"},"inLanguage":"ro-RO","potentialAction":[{"@type":"ReadAction","target":["https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/mindthegraph.com\/blog\/nb\/alzheimers-sykdom\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/mindthegraph.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Alzheimer\u2019s disease: A scientific infographic"}]},{"@type":"WebSite","@id":"https:\/\/mindthegraph.com\/blog\/#website","url":"https:\/\/mindthegraph.com\/blog\/","name":"Mind the Graph Blog","description":"Your science can be beautiful!","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/mindthegraph.com\/blog\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"ro-RO"},{"@type":"Person","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/5592c012d89648325be9b0f3c3f91132","name":"Fabiola Soares","image":{"@type":"ImageObject","inLanguage":"ro-RO","@id":"https:\/\/mindthegraph.com\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/7dca2c6a766aff1db898cc74c18284d8?s=96&d=mm&r=g","caption":"Fabiola Soares"},"url":"https:\/\/mindthegraph.com\/blog\/ro\/author\/fabiola\/"}]}},"_links":{"self":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8064"}],"collection":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/users\/11"}],"replies":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/comments?post=8064"}],"version-history":[{"count":14,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8064\/revisions"}],"predecessor-version":[{"id":23414,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/posts\/8064\/revisions\/23414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media\/8067"}],"wp:attachment":[{"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/media?parent=8064"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/categories?post=8064"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/mindthegraph.com\/blog\/ro\/wp-json\/wp\/v2\/tags?post=8064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}