{"id":6300,"date":"2016-10-04T14:25:20","date_gmt":"2016-10-04T17:25:20","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=6300"},"modified":"2022-10-18T08:10:46","modified_gmt":"2022-10-18T11:10:46","slug":"autophagy-wins-nobel-prize-medicine","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/autofagia-castiga-premiul-nobel-medicina\/","title":{"rendered":"Autofagia prime\u0219te premiul Nobel pentru medicin\u0103"},"content":{"rendered":"

Procesul de autofagie este implicat \u00een mai multe afec\u021biuni, cum ar fi cancerul \u0219i bolile neurologice. Acesta func\u021bioneaz\u0103 ca un program de reciclare intern\u0103 a organismului. Cu toate acestea, autofagia disfunc\u021bional\u0103 a fost legat\u0103 de boala Parkinson, diabet, canicul\u0103 \u0219i alte tulbur\u0103ri legate de v\u00e2rst\u0103.<\/p>\n

Dup\u0103 aceast\u0103 mic\u0103 introducere privind importan\u021ba procesului de autofagie, nu este de mirare c\u0103 noile descoperiri \u00een acest domeniu ar putea duce la un premiu Nobel. \u00centr-adev\u0103r, lunea trecut\u0103, cercet\u0103torul Yoshino Ohsumi a c\u00e2\u0219tigat premiul Premiul Nobel pentru medicin\u0103<\/a> pentru identificarea primelor gene esen\u021biale pentru autofagie.<\/p>\n

\"Nu m\u0103 simt \u00een largul meu s\u0103 concurez cu mul\u021bi oameni \u0219i, \u00een schimb, mi se pare mai pl\u0103cut s\u0103 fac ceva ce nu face nimeni altcineva. \u00centr-un fel, despre asta este vorba \u00een \u0219tiin\u021b\u0103, iar bucuria de a g\u0103si ceva m\u0103 inspir\u0103.\" Yoshino Ohsumi <\/a><\/p><\/blockquote>\n

Cum a f\u0103cut-o Ohsumi?<\/h3>\n

\u00cen laboratorul s\u0103u, Ohsumi a creat tulpini de drojdie care au acumulat autofagosomi \u00een timpul \u00eenfomet\u0103rii. Aceast\u0103 acumulare ar fi putut avea loc numai dac\u0103 genele esen\u021biale pentru autofagie erau inactive. Astfel, Ohsumi a \u00eenceput s\u0103 manipuleze celulele la mai multe muta\u021bii genetice \u0219i a reu\u0219it s\u0103 induc\u0103 autofagia.<\/p>\n

\"Autofagia<\/a><\/p>\n

Autofagia a existat<\/h3>\n

Chiar dac\u0103 autofagia este cunoscut\u0103 de 50 de ani, abia \u00een anii 1990, odat\u0103 cu studiile lui Ohsumi, a fost recunoscut\u0103 importan\u021ba acestui proces.
\nPentru munca sa, Ohsumi a c\u00e2\u0219tigat deja c\u00e2\u021biva fani:<\/p>\n

\"Autofagia<\/a><\/p>\n

\n

\"Sunt foarte fericit c\u0103 a primit premiul Nobel anul acesta, este foarte bine meritat. Laboratorul s\u0103u lucreaz\u0103 \u00een principal pe drojdie. Ei au f\u0103cut ecran\u0103rile ini\u021biale care au permis descoperirea genelor cheie care sunt implicate \u00een autofagie. At\u00e2t de multe alte laboratoare au exploatat descoperirile sale, direct sau indirect, pentru a vedea de ce este important\u0103 \u00een boli.\"<\/p>\n

David Rubinsztein<\/a> - director adjunct al Institutului de Cercetare Medical\u0103 din Cambridge<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>\n

\n

\"Cred c\u0103 este foarte important ca acest domeniu al \u0219tiin\u021bei s\u0103 fie recunoscut. Principiul important aici este acela de a c\u0103uta mecanisme comune \u00een cazul bolilor. Aceasta deschide c\u0103i de tratare a acestor afec\u021biuni care sunt diferite de abord\u0103rile mai conven\u021bionale specifice unei boli.\"<\/p>\n

Giovanna Mallucci<\/a> - profesor de neuro\u0219tiin\u021b\u0103 clinic\u0103 la Universitatea din Cambridge<\/p>\n<\/blockquote>\n

\"Autofagia<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Procesul de autofagie este implicat \u00een mai multe afec\u021biuni, cum ar fi cancerul \u0219i bolile neurologice. Acesta func\u021bioneaz\u0103 ca un program de reciclare intern\u0103 a organismului. Cu toate acestea, autofagia disfunc\u021bional\u0103 a fost legat\u0103 de boala Parkinson, diabet, canicul\u0103 \u0219i alte tulbur\u0103ri legate de v\u00e2rst\u0103. Dup\u0103 aceast\u0103 mic\u0103 introducere privind importan\u021ba procesului de autofagie, nu este surprinz\u0103tor faptul c\u0103 noile descoperiri [...]<\/p>","protected":false},"author":11,"featured_media":6304,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"image","meta":[],"categories":[959,28],"tags":[554],"yoast_head":"\nAutophagy wins Nobel Prize in medicine - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\""I find it more enjoyable doing something nobody else is doing. 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