{"id":5346,"date":"2016-03-03T13:41:11","date_gmt":"2016-03-03T16:41:11","guid":{"rendered":"https:\/\/blog.mindthegraph.com\/?p=5346"},"modified":"2022-10-18T08:29:24","modified_gmt":"2022-10-18T11:29:24","slug":"zika-virus-graphical-abstract","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/zika-virus-graphical-abstract\/","title":{"rendered":"Rezumat grafic al virusului Zika privind microcefalia"},"content":{"rendered":"

\u00cen\u021belege\u021bi rezumatul grafic al virusului Zika: Cum reduce dimensiunea creierului<\/h3>\n

Ast\u0103zi, un studiu de cercetare a adus dovezi interesante privind rolul virusului Zika \u00een malforma\u021biile \u021besuturilor nervoase. Ah, da, \u00eenainte s\u0103 \u00eentreba\u021bi, \u021besutul nervos uman.<\/p>\n

Acest lucru a fost realizat \u00een mod elegant de c\u0103tre grupul Dr. Stevens Rehen, un cercet\u0103tor de renume interna\u021bional \u00een domeniul cercet\u0103rii celulelor stem \u0219i, mai recent, al reprogram\u0103rii celulare.<\/p>\n

Figura de mai jos sintetizeaz\u0103 constat\u0103rile din h\u00e2rtia<\/a>, dar voi \u00eencerca s\u0103 o explic pe scurt.<\/p>\n

 <\/p>\n

\"blog<\/p>\n

Acest rezumat grafic perspicace al virusului Zika a fost realizat cu Mind the graph. Nu-i a\u0219a c\u0103 e mi\u0219to?<\/em><\/p>\n

 <\/p>\n

 <\/p>\n

Dup\u0103 cum pute\u021bi vedea \u00een imaginea de mai sus, \u00een aceast\u0103 cercetare au fost adoptate trei abord\u0103ri distincte. Toate acestea confirm\u00e2nd faptul c\u0103 virusul Zika are un impact direct asupra modului \u00een care celulele creierului evolueaz\u0103 pentru a forma un \u021besut neuronal adecvat, cunoscut \u0219i sub numele de \"malforma\u021bie cerebral\u0103 incusiv\u0103\".\"virusul<\/a>Microcefalia este doar o malforma\u021bie a creierului. Lucrarea sugereaz\u0103 ceva \u0219i mai fundamental.<\/p>\n

Acestea arat\u0103 cum virusul Zika:<\/p>\n

    \n
  1. Promoveaz\u0103 moartea celular\u0103<\/li>\n
  2. Induce modific\u0103ri morfologice (\u00een neurosfere)<\/li>\n
  3. Reduce cre\u0219terea\/dimensiunea organoizilor cerebrali (mini-creiere)<\/li>\n<\/ol>\n

    Toate acestea sunt modalit\u0103\u021bi prin care virusul Zika afecteaz\u0103 neurogeneza \u00een timpul dezvolt\u0103rii creierului uman \u0219i provoac\u0103 fenotipul pe care \u00eel vede\u021bi mai jos.<\/p>\n

    \"virusul<\/a><\/p>\n

    <\/h3>\n

    De ce nu s-a f\u0103cut \u00eenainte?<\/h3>\n

    Abordarea revolu\u021bionar\u0103 a fost utilizarea celulelor stem cu pluripoten\u021b\u0103 indus\u0103 (celule iPS) pentru a putea studia infec\u021bia cu virus \u00een celulele umane.<\/p>\n

    Prin acest proces, o celul\u0103 somatic\u0103 recoltat\u0103 de la o persoan\u0103 este reprogramat\u0103 spre starea sa ini\u021bial\u0103 de celul\u0103 pluripotent\u0103 \u0219i poate fi ulterior diferen\u021biat\u0103 \u00een diferite celule, \u021besuturi \u0219i, mai recent, organe. Acesta este chiar \u00eenceputul \"ingineriei \u021besuturilor umane\".<\/p>\n

    \u00cen cadrul studiului, autorii nu numai c\u0103 au folosit celulele iPS, dar au generat organoide cerebrale<\/a>, cunoscute \u0219i sub numele de \"mini-creiere\", pentru a \u00een\u021belege modul \u00een care prezen\u021ba virusului Zika influen\u021beaz\u0103 formarea acestui \u021besut neuronal.<\/p>\n

    Astfel de culturi de celule sunt considerate structuri tridimensionale (3D) \u0219i ofer\u0103 mai multe indicii despre arhitectura organului. Acesta este anul organoidului \u00een func\u021bie de Economist<\/a>. Cu ajutorul acestei abord\u0103ri inovatoare, oamenii de \u0219tiin\u021b\u0103 au putut \u00een\u021belege modul \u00een care virusul zika \u021binte\u0219te celulele creierului uman, reduc\u00e2nd viabilitatea \u0219i cre\u0219terea acestora sub form\u0103 de neurosfere \u0219i organoizi cerebrali.<\/p>\n

    The h\u00e2rtie<\/a> se afl\u0103 \u00een pre-imprimare \u00een revista inovatoare PeerJ. Pute\u021bi chiar s\u0103 comenta\u021bi \u0219i s\u0103 ajuta\u021bi autorii s\u0103 o \u00eembun\u0103t\u0103\u021beasc\u0103 \u00een timpul procesului. Pute\u021bi vedea rezumatul mai jos \u0219i pute\u021bi avea acces complet f\u0103c\u00e2nd clic pe aici<\/a>.<\/p>\n

    \"virusul<\/a><\/p>\n

    Not\u0103: La dou\u0103 luni dup\u0103 pre-printul de pe PeerJ din martie 2016, a fost publicat\u0103 lucrarea final\u0103 \u0219i, spre surprinderea noastr\u0103, a fost publicat pe Science <\/a>Magazine, una dintre cele mai prestigioase reviste \u0219tiin\u021bifice de pe planet\u0103.<\/p>\n

    -> Citi\u021bi articolul complet al lui Garcez et al \u00een Science <-<\/a><\/p>\n

    \"virusul<\/a><\/p>\n

    Las\u0103 mai multe persoane s\u0103 afle despre asta, \u00eemp\u0103rt\u0103\u0219ind aceast\u0103 postare. Aceasta este o problem\u0103 de s\u0103n\u0103tate public\u0103 global\u0103, a\u0219a cum a fost deja declarat de c\u0103tre Organiza\u021bia Mondial\u0103 a S\u0103n\u0103t\u0103\u021bii<\/a>\u00a0(OMS).<\/p>\n

    \n

     <\/p>\n

    Cunoa\u0219te\u021bi ce este Recomand\u0103ri ale OMS cu privire la virusul Zika<\/a>\u00a0transmiterea \u0219i infectarea:<\/p>\n

    \n

    Transmisie<\/h3>\n

    Virusul Zika se transmite la om \u00een principal prin mu\u0219c\u0103turi de la Aedes<\/i> \u021b\u00e2n\u021barii, care tr\u0103iesc adesea \u00een jurul cl\u0103dirilor din zonele urbane \u0219i sunt de obicei activi \u00een timpul zilei (v\u00e2rful activit\u0103\u021bii de mu\u0219c\u0103tur\u0103 are loc diminea\u021ba devreme \u0219i dup\u0103-amiaza t\u00e2rziu).<\/p>\n

    Unele dovezi sugereaz\u0103 c\u0103 virusul Zika poate fi transmis la om \u0219i prin transfuzie de s\u00e2nge, transmitere perinatal\u0103 \u0219i transmitere sexual\u0103. Cu toate acestea, aceste moduri sunt foarte rare.<\/p>\n

    Perioada de incuba\u021bie este, de obicei, \u00eentre 2 \u0219i 7 zile.<\/p>\n

    Semne \u0219i simptome<\/h3>\n

    Infec\u021bia cu virusul Zika se caracterizeaz\u0103 prin febr\u0103 de grad sc\u0103zut (mai pu\u021bin de 38,5\u00b0C), \u00eenso\u021bit\u0103 frecvent de o erup\u021bie maculopapular\u0103. Alte simptome frecvente includ dureri musculare, dureri articulare cu posibile umfl\u0103turi (\u00een special la nivelul articula\u021biilor mici ale m\u00e2inilor \u0219i picioarelor), dureri de cap, dureri \u00een spatele ochilor \u0219i conjunctivit\u0103. Deoarece simptomele sunt adesea u\u0219oare, infec\u021bia poate trece neobservat\u0103 sau poate fi diagnosticat\u0103 gre\u0219it ca fiind dengue.<\/p>\n

    Se a\u0219teapt\u0103 o rat\u0103 ridicat\u0103 de infec\u021bie asimptomatic\u0103 cu virusul Zika, similar\u0103 cu cea a altor flavivirusuri, cum ar fi virusul dengue \u0219i virusul West Nile. Majoritatea persoanelor se recupereaz\u0103 complet f\u0103r\u0103 complica\u021bii grave, iar ratele de spitalizare sunt sc\u0103zute. P\u00e2n\u0103 \u00een prezent, nu au fost raportate decese asociate cu virusul Zika.<\/p><\/blockquote>\n

     <\/p>\n

    Actualizat la 3 mai 2016.<\/p>","protected":false},"excerpt":{"rendered":"

    \u00cen\u021belege\u021bi rezumatul grafic al virusului Zika: Cum reduce dimensiunea creierului Ast\u0103zi, un studiu de cercetare a adus dovezi interesante privind rolul virusului Zika \u00een malforma\u021bia \u021besuturilor nervoase. Ah, da, \u00eenainte de a \u00eentreba, \u021besut nervos uman. Acest lucru a fost realizat cu elegan\u021b\u0103 de grupul Dr. Stevens Rehen, un cercet\u0103tor de renume interna\u021bional \u00een domeniul [...]<\/p>","protected":false},"author":4,"featured_media":7136,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[956],"tags":[96,201,200,203,202,205,554,71,250,204,199],"yoast_head":"\nZika virus graphical abstract on microcephaly - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This insightful Zika virus graphical abstract was done with Mind the graph. 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