{"id":16670,"date":"2022-09-16T19:40:00","date_gmt":"2022-09-16T22:40:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16670"},"modified":"2023-03-17T14:47:16","modified_gmt":"2023-03-17T17:47:16","slug":"success-case-nuclear-receptors-in-liver-fibrosis","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/succes-caz-receptori-nucleari-in-fibroza-hepatica\/","title":{"rendered":"Receptorii nucleari \u00een fibroza hepatic\u0103 Recenzie de h\u00e2rtie"},"content":{"rendered":"

\u00cen acest caz, autorul a folosit Mind the Graph pentru a compila cifre din diferite surse \u00eentr-un singur loc. \u00cen afar\u0103 de cele mai bune ilustra\u021bii exacte din punct de vedere \u0219tiin\u021bific, spa\u021biul nostru de lucru are o interfa\u021b\u0103 prietenoas\u0103 \u0219i este foarte u\u0219or de utilizat.<\/p>\n\n\n\n

Verific\u0103 \u00eentregul articolul original<\/a>. <\/p>\n\n\n\n

Rolul receptorilor nucleari \u00een fibroza hepatic\u0103<\/strong><\/h2>\n\n\n\n

Philipp K\u00f6nigshofer \u0219i colab. (2021) raporteaz\u0103 c\u0103 receptorii nucleari sunt factori de transcrip\u021bie activa\u021bi de liganzi care regleaz\u0103 expresia genetic\u0103 a unei variet\u0103\u021bi de semnale moleculare cheie implicate \u00een fibroza hepatic\u0103. <\/p>\n\n\n\n

Principalul motor celular al fibrogenezei hepatice este reprezentat de celulele stelate hepatice activate. Diferi\u021bi receptori nucleari regleaz\u0103 expresia hepatic\u0103 a citokinelor pro-inflamatorii \u0219i pro-fibrogenice.<\/p>\n\n\n\n

Rezumate grafice realizate de Mind the Graph<\/strong> \u00een acest articol<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n
<\/div>\n\n\n\n

Aceast\u0103 prim\u0103 figur\u0103 este o prezentare general\u0103 \u0219i o clasificare a receptorilor nucleari pe subfamilii.<\/p>\n\n\n\n

<\/div>\n\n\n
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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Mai sus putem vedea diferitele tipuri de func\u021bii efectoare ale receptorilor nucleari.<\/p>\n\n\n\n

<\/div>\n\n\n
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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u00cen cea de-a treia figur\u0103, putem verifica o imagine de ansamblu a efectelor raportate ale modula\u021biilor NR ca poten\u021biale abord\u0103ri terapeutice \u00eempotriva bolilor hepatice. <\/p>\n\n\n\n

S\u0103ge\u021bile indic\u0103 presupusele efecte benefice \u00een bolile hepatice prin sus- (verde \u00eenchis)<\/strong><\/span> sau jos- (verde deschis)<\/span><\/strong> reglarea unor mecanisme specifice care au fost raportate pentru a sprijini regresia fibrozei hepatice sau pentru a reduce fibroza hepatic\u0103. <\/p>\n\n\n\n

S\u0103ge\u021bi portocalii<\/mark><\/strong> indic\u0103 efecte \u0219i mecanisme de modulare a NR care sunt fie controversate, fie \u00eenc\u0103 insuficient evaluate.<\/p>\n\n\n\n

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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Ultima figur\u0103 reprezint\u0103 efectele moleculare ale modulatorilor NR ca poten\u021bial tratament pentru fibroza hepatic\u0103, care sunt raportate ca fiind predominante \u00een cadrul HSC.<\/p>\n\n\n\n

K\u00f6nigshofer \u0219i colegii s\u0103i propun ca cercet\u0103rile ulterioare privind semnalizarea legat\u0103 de receptorii nucleari s\u0103 duc\u0103 la dezvoltarea clinic\u0103 a unor terapii antifibrotice eficiente pentru pacien\u021bii cu afec\u021biuni hepatice.<\/p>\n\n\n\n

Lucr\u0103ri Impact \u0219i performan\u021b\u0103<\/strong><\/h2>\n\n\n\n

Select\u00e2nd o op\u021biune de comparare a metricilor pentru un an fa\u021b\u0103 de alte articole\/revizuiri care au fost publicate \u00een acela\u0219i an calendaristic \u00een revista respectiv\u0103, putem observa c\u0103 acest articol a fost mai citat dec\u00e2t 57% dintre ele<\/strong>.<\/p>\n\n\n

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Sursa PlumX<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Folosi\u021bi puterea infografiilor pentru a v\u0103 stimula \u0219i articolul. \u00cencerca\u021bi Mind the Graph!<\/p>\n\n\n\n

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\u00cencerca\u021bi Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Acest articol con\u021bine ilustra\u021bii \u0219tiin\u021bifice realizate cu Mind the Graph pentru a reprezenta receptorii nucleari \u00een fibroza hepatic\u0103.<\/p>","protected":false},"author":29,"featured_media":20044,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nNuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/succes-caz-receptori-nucleari-in-fibroza-hepatica\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nuclear receptors in liver fibrosis Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"This article has scientific illustrations made with Mind the Graph to represent nuclear receptors in liver fibrosis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/mindthegraph.com\/blog\/ro\/succes-caz-receptori-nucleari-in-fibroza-hepatica\/\" \/>\n<meta property=\"og:site_name\" content=\"Mind the Graph Blog\" \/>\n<meta property=\"article:published_time\" content=\"2022-09-16T22:40:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2023-03-17T17:47:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1125\" \/>\n\t<meta property=\"og:image:height\" content=\"614\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Artur Zignani\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:image\" content=\"https:\/\/mindthegraph.com\/blog\/wp-content\/uploads\/2022\/09\/blog_7.jpg\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Artur Zignani\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Nuclear receptors in liver fibrosis Paper Review - 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