{"id":16657,"date":"2022-09-14T13:04:15","date_gmt":"2022-09-14T16:04:15","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=16657"},"modified":"2023-03-17T14:47:26","modified_gmt":"2023-03-17T17:47:26","slug":"success-case-xtalkdb-a-database-of-signaling-pathway-crosstalk","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/succes-case-xtalkdb-o-baza-de-date-de-semnalizare-pathway-crosstalk\/","title":{"rendered":"XTALKDB: o baz\u0103 de date a c\u0103ilor de semnalizare a interac\u021biunii \u00eentre c\u0103i de semnalizare Recenzie de documente"},"content":{"rendered":"

Acest articol uimitor aduce statistici care rezum\u0103 datele din XTALKDB. \u00cen doar c\u00e2teva minute, autorul a creat un infografic care explic\u0103 distribu\u021bia speciilor din XTALKDB.<\/p>\n\n\n\n

Verifica\u021bi articolul original aici<\/a>.<\/p>\n\n\n\n

Deoarece fiin\u021bele umane sunt creaturi vizuale, imaginile r\u0103m\u00e2n cea mai bun\u0103 modalitate de a v\u0103 explica cercet\u0103rile cu c\u00e2t mai multe detalii dori\u021bi.<\/p>\n\n\n\n

Oamenii de \u0219tiin\u021b\u0103 au dezvoltat o baz\u0103 de date care documenteaz\u0103 interac\u021biunea dintre perechi specifice de c\u0103i de semnalizare \u0219i speciile \u0219i \u021besuturile \u00een care sunt observate.<\/strong><\/h2>\n\n\n\n

Un grup de cercetare condus de Sarah Sam de la Departamentul de \u0218tiin\u021be Biologice (2016) a raportat c\u0103 percep\u021bia unui semnal extern de c\u0103tre receptori determin\u0103 modificarea activit\u0103\u021bilor proteinelor intermediare. <\/p>\n\n\n\n

Acest lucru duce la reglarea factorilor de transcrip\u021bie, care moduleaz\u0103 expresia genelor \u021bint\u0103. Pentru fiecare pereche de c\u0103i, XTalkDB \u00eenregistreaz\u0103 informa\u021bii detaliate care descriu condi\u021biile experimentale \u00een care a fost descoperit\u0103 diafonia. <\/p>\n\n\n\n

Celulele evalueaz\u0103 \u0219i r\u0103spund la mediul lor prin intermediul c\u0103ilor de semnalizare. O cale de semnalizare con\u021bine, de obicei, un set bine definit de interac\u021biuni fizice \u0219i de reglementare \u00eentre receptori, proteine intermediare de semnalizare, factori de transcrip\u021bie \u0219i gene \u021bint\u0103. <\/p>\n\n\n\n

Site-ul web XTalkDB ofer\u0103 o interfa\u021b\u0103 u\u0219or de utilizat pentru cercet\u0103tori, care le permite acestora s\u0103 navigheze prin interogarea uneia sau mai multor c\u0103i sau molecule de interes.<\/p>\n\n\n\n

\u00cen studiu au fost incluse 650 de perechi.<\/strong><\/p>\n\n\n\n

Rezumat grafic powered by Mind the Graph<\/strong><\/h2>\n\n\n
\n
\"success-case-XTALKDB-o<\/a>
Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u00cen ceea ce prive\u0219te posibilele \u00eembun\u0103t\u0103\u021biri, \"Procesul de curatoriat manual care st\u0103 la baza XTalkDB are limitele sale, mai ales c\u0103 \u00eencerc\u0103m s\u0103 extindem acoperirea bazei de date. <\/p>\n\n\n\n

Pl\u0103nuim s\u0103 dezvolt\u0103m un cadru de procesare a limbajului natural care va evalua publica\u021biile \u00een func\u021bie de probabilitatea de a documenta diafonia. Un curator se poate concentra apoi pe publica\u021biile cu un grad ridicat de clasificare\", recunosc ace\u0219tia.<\/p>\n\n\n\n

Lucr\u0103ri Impact \u0219i performan\u021b\u0103<\/strong><\/h2>\n\n\n\n

Putem analiza cu Altmetric<\/a> date c\u0103 aceast\u0103 lucrare se afl\u0103 pe partea de sus a tuturor indicatorilor din cadrul tuturor articolelor finan\u021bate de NIH \u00een cadrul dimensiunilor. <\/strong><\/p>\n\n\n

\n
\"\"<\/a>
Sursa: https:\/\/badge.dimensions.ai\/details\/id\/pub.1052462103<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Folosi\u021bi puterea infografiilor pentru a v\u0103 stimula \u0219i articolul. \u00cencerca\u021bi Mind the Graph!<\/p>\n\n\n\n

<\/div>\n\n\n\n
\n
\u00cencerca\u021bi Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

\u00cenv\u0103\u021ba\u021bi cu cei care au descoperit deja puterea infografiilor. Acest articol are rezumate grafice realizate cu Mind the Graph. <\/p>","protected":false},"author":29,"featured_media":20046,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,963],"yoast_head":"\nXTALKDB: a database of signaling pathway crosstalk Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"This amazing article brings out statistics summarizing data in XTALKDB with an infographic explaining the distribution of the species in XTALKDB.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/succes-case-xtalkdb-o-baza-de-date-de-semnalizare-pathway-crosstalk\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"XTALKDB: a database of signaling pathway crosstalk Paper Review - 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