{"id":16630,"date":"2022-09-08T18:14:00","date_gmt":"2022-09-08T21:14:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice-copy\/"},"modified":"2023-03-17T14:47:54","modified_gmt":"2023-03-17T17:47:54","slug":"success-case-igh-resolution-synchrotron-based-x-ray-microtomography-as-a-tool-to-unveil-the-three-dimensional-neuronal-architecture-of-the-brain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/succes-caz-de-succes-microtomografia-cu-raze-x-de-inalta-rezolutie-bazata-pe-sincrotron-ca-instrument-de-dezvaluire-a-arhitecturii-neuronale-tridimensionale-a-creierului\/","title":{"rendered":"Microtomografia cu raze X de \u00eenalt\u0103 rezolu\u021bie, bazat\u0103 pe sincrotron, ca instrument de dezv\u0103luire a arhitecturii neuronale tridimensionale a creierului Recenzie a lucr\u0103rii"},"content":{"rendered":"

Microtomografia cu raze X a ap\u0103rut ca o nou\u0103 metod\u0103 pentru descifrarea citoarhitecturii \u0219i a conectivit\u0103\u021bii creierului, iar aici prezent\u0103m o metod\u0103 de imagistic\u0103 a neuronilor \u00eentregi.<\/p>\n\n\n\n

Microtomografia cu raze X de \u00eenalt\u0103 rezolu\u021bie, bazat\u0103 pe sincrotron, ca instrument de dezv\u0103luire a arhitecturii neuronale tridimensionale a creierului<\/strong><\/h2>\n\n\n\n

\u00cen \"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain\", Matheus de Castro Fonseca et al. (2018) au remarcat c\u0103 studiul neuronilor ca unit\u0103\u021bi individualizate \u00ee\u0219i are \u00eenceputul \u00een secolul al XIX-lea, odat\u0103 cu crearea Doctrinei Neuronului. <\/p>\n\n\n\n

\u00cen ultimii ani, s-au depus eforturi mari pentru a \u00een\u021belege organizarea \u0219i conectivitatea neuronal\u0103 \u00een e\u0219antioane intacte de creier. Tehnica de marcare Golgi-Cox ofer\u0103 un contrast adecvat pentru marcarea specific\u0103 a neuronilor pentru microtomografia cu raze X. <\/p>\n\n\n\n

Neuronii au o morfologie distinct\u0103 \u0219i modele specifice de conectivitate, care sunt esen\u021biale pentru buna lor func\u021bionare. Cercet\u0103torii prezint\u0103 o metod\u0103 de imagistic\u0103 care combin\u0103 microtomografia cu raze X bazat\u0103 pe sincrotron cu protocolul de impregnare Golgi-Cox. <\/p>\n\n\n\n

Metoda ofer\u0103 un contrast mai mare \u0219i mai omogen al neuronilor \u00eentregi relativ slab distribui\u021bi \u00een \u021besut.<\/p>\n\n\n\n

Creierele au fost incubate \u00een solu\u021bia de colorare Golgi-Cox timp de 14 zile, ferite de lumin\u0103. Dup\u0103 perioada de incuba\u021bie, creierele au fost sec\u021bionate \u00een serie cu ajutorul unui vibratom.<\/strong><\/p>\n\n\n\n

Verifica\u021bi articolul original aici<\/a>.<\/p>\n\n\n\n

Rezumat grafic powered by Mind the Graph<\/strong><\/h2>\n\n\n\n
<\/div>\n\n\n
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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Autorul a folosit Mind the Graph<\/a> pentru a crea o ilustra\u021bie schematic\u0103 care reprezint\u0103 un \u0219oarece adult c\u0103ruia i se injecteaz\u0103 i.p. solu\u021bie salin\u0103 sau solu\u021bie de pilocarpin\u0103 (280 mg\/kg). Reprezentarea proceselor complexe cu ajutorul infografiilor este o modalitate bun\u0103 de a le face u\u0219or de \u00een\u021beles, f\u0103r\u0103 a l\u0103sa deoparte detaliile \u0219i informa\u021biile cruciale.<\/p>\n\n\n\n

Unele dintre rezultatele cercet\u0103torilor par s\u0103 consolideze ceea ce se \u0219tia anterior despre acest domeniu: \"Impregnarea neuronilor pe baz\u0103 de mercur, prezentat\u0103 aici, ne-a permis s\u0103 definim clar neuronii \u00eentregi, \u00een principal datorit\u0103 unei impregn\u0103ri mai continue \u0219i mai omogene a celulelor \u0219i a unei densit\u0103\u021bi mult mai reduse de artefacte\", a sugerat de Castro Fonseca.<\/p>\n\n\n\n

Lucr\u0103ri Impact \u0219i performan\u021b\u0103<\/strong><\/h2>\n\n\n\n

Putem analiza cu Altmetric<\/a> date c\u0103 scorul de aten\u021bie online al acestei lucr\u0103ri este mai mare dec\u00e2t 64%<\/strong><\/strong> din toate celelalte articole de o v\u00e2rst\u0103 similar\u0103 din Scientific Reports.<\/strong><\/p>\n\n\n\n

<\/div>\n\n\n
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Sursa Altmetrics<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

\u00cembun\u0103t\u0103\u021bi\u021bi accesibilitatea articolului dvs. \u0219i cu ajutorul infograficelor.<\/p>\n\n\n\n

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\u00cencerca\u021bi Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Uita\u021bi-v\u0103 la noua metod\u0103 de descifrare a citoarhitecturii \u0219i a conectivit\u0103\u021bii creierului reprezentat\u0103 prin ilustra\u021biile Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20013,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,554,775,963],"yoast_head":"\nHigh-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"Look into the new method for deciphering the cytoarchitecture and connectivity of the brain represented with Mind the Graph's illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/succes-caz-de-succes-microtomografia-cu-raze-x-de-inalta-rezolutie-bazata-pe-sincrotron-ca-instrument-de-dezvaluire-a-arhitecturii-neuronale-tridimensionale-a-creierului\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"High-resolution synchrotron-based X-ray microtomography as a tool to unveil the three-dimensional neuronal architecture of the brain Paper Review - 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