{"id":16621,"date":"2022-09-06T17:57:00","date_gmt":"2022-09-06T20:57:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/success-case-psychedelic-assisted-psychotherapy-copy\/"},"modified":"2023-03-17T14:48:05","modified_gmt":"2023-03-17T17:48:05","slug":"success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/","title":{"rendered":"Virusul Zika se replic\u0103 \u00een \u021besutul cerebral uman adult \u0219i afecteaz\u0103 sinapsele \u0219i memoria la \u0219oareci Recenzie la ziar"},"content":{"rendered":"

ZIKV este un virus periculos care face ravagii \u00een \u00eentreaga lume. Prin urmare, \u00een acest caz, autorul studiaz\u0103 replicarea acestuia \u00een creierul uman adult.<\/p>\n\n\n\n

Virusul Zika (ZIKV) infecteaz\u0103 \u021besutul cerebral al adul\u021bilor \u0219i provoac\u0103 tulbur\u0103ri de memorie la \u0219oareci<\/strong><\/h2>\n\n\n\n

Un grup de la Facultatea de Farmacie condus de Claudia Figueiredo (2019) a studiat modul \u00een care virusul zika se replic\u0103 \u00een \u021besutul cerebral uman adult \u0219i afecteaz\u0103 sinapsele \u0219i memoria la \u0219oareci. Virusul Zika este un arbovirus care apar\u021bine familiei Flaviviridae, responsabil de o recent\u0103 epidemie major\u0103 \u00een America Latin\u0103. <\/p>\n\n\n\n

ZIKV a fost g\u0103sit \u00een creierul \u0219i \u00een LCR al pacien\u021bilor adul\u021bi. Imunoreactivitatea NS2B s-a colocalizat cu celulele imunoreactive cu NeuN, dar nu cu GFAP sau F4\/80, ceea ce indic\u0103 faptul c\u0103 neuronii sunt \u021binta ZikV \u00een \u021besutul uman matur. La \u0219oarecii adul\u021bi imunocompeten\u021bi infecta\u021bi prin infuzie intracerebroventricular\u0103 de ZIKV, niveluri ridicate de ARN ZikV sunt detectate \u00een cortexul frontal \u0219i hipocampus, iar neuronii maturi sunt principalul tip de celule infectate. <\/p>\n\n\n\n

Se verific\u0103 niveluri crescute de TNF-\u03b1 \u00een creier, microglioz\u0103 intens\u0103, expresie crescut\u0103 a proteinelor sistemului complementar (C1q \u0219i C3) \u0219i leziuni ale sinapsei hipocampale.<\/p>\n\n\n\n

Studiul a cuprins 9 cadrane egale.<\/strong><\/p>\n\n\n\n

Verifica\u021bi articolul original aici<\/a>.<\/p>\n\n\n\n

Rezumate grafice realizate de Mind the Graph<\/strong><\/h2>\n\n\n\n
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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Prima figur\u0103 reprezint\u0103 cazul \u00een care fragmentele de \u021besut cortical al lobului temporal uman au fost sec\u021bionate \u00een felii de 400 \u00b5m \u0219i men\u021binute \u00een cultur\u0103 timp de 4 zile \u00eenainte de incubarea cu ZIKV (107 PFU) sau cu mediu simulat timp de 1 or\u0103, urmat\u0103 de sp\u0103lare. <\/p>\n\n\n\n

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Fabricat cu Mind the Graph<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Al doilea arat\u0103 c\u0103 \u0219oarecii adul\u021bi au primit o perfuzie de 105 PFU ZIKV, ZIKV inactivat cu UV sau mediu simulat \u00een ventriculul lateral cerebral.<\/p>\n\n\n\n

Concluziile par s\u0103 sus\u021bin\u0103 ceea ce se \u0219tia anterior despre acest subiect: \"ZIKV \u021binte\u0219te regiunile cerebrale legate de memorie, indiferent dac\u0103 ruta de infectare este central\u0103 sau periferic\u0103. Virusul a fost detectat \u00een LCR al pacien\u021bilor adul\u021bi cu complica\u021bii neurologice\", a sus\u021binut Figueiredo.<\/p>\n\n\n\n

Ace\u0219tia propun ca viitoarele studii care vizeaz\u0103 examinarea impactului neurodegenerativ pe termen lung al infec\u021biei cu ZIKV s\u0103 fie justificate. Identificarea modalit\u0103\u021bilor de prevenire a anomaliilor de semnalizare care duc la disfunc\u021bii cerebrale ar putea deschide calea c\u0103tre strategii de interven\u021bie pentru a \u00eent\u00e2rzia sau preveni dezvoltarea unor afec\u021biuni neurologice majore.<\/p>\n\n\n\n

Lucr\u0103ri Impact \u0219i performan\u021b\u0103<\/strong><\/h2>\n\n\n\n

Putem analiza cu Altmetric<\/a> date c\u0103 scorul de aten\u021bie online al acestei lucr\u0103ri este mai mare dec\u00e2t 95%<\/strong><\/strong> a tuturor celorlalte articole de o v\u00e2rst\u0103 similar\u0103 din Nature<\/strong> Jurnale.<\/strong><\/p>\n\n\n\n

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Sursa Altmetric<\/a><\/em><\/figcaption><\/figure><\/div>\n\n\n

Folosi\u021bi puterea infografiilor pentru a v\u0103 stimula \u0219i articolul! \u00cencepe\u021bi o crea\u021bie la Mind the Graph.<\/p>\n\n\n\n

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\u00cencerca\u021bi Mind the Graph<\/strong><\/a><\/div>\n<\/div>\n\n\n\n
<\/div>","protected":false},"excerpt":{"rendered":"

Studiul se refer\u0103 la ZIKV \u00een creierul uman adult, un virus periculos care face ravagii \u00een \u00eentreaga lume. Procesul utilizeaz\u0103 ilustra\u021bii Mind the Graph.<\/p>","protected":false},"author":29,"featured_media":20048,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[195,958,957,960,1],"tags":[96,963],"yoast_head":"\nZika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog<\/title>\n<meta name=\"description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. The process uses Mind the Graph illustrations.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/mindthegraph.com\/blog\/ro\/success-case-zika-virus-replicates-in-adult-human-brain-tissue-and-impairs-synapses-and-memory-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice Paper Review - Mind the Graph Blog\" \/>\n<meta property=\"og:description\" content=\"The study is about ZIKV in the adult human brain, a dangerous virus that ravages the world. 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