{"id":12274,"date":"2021-02-10T09:13:00","date_gmt":"2021-02-10T11:13:00","guid":{"rendered":"https:\/\/mindthegraph.com\/blog\/?p=12274"},"modified":"2023-01-05T13:46:34","modified_gmt":"2023-01-05T16:46:34","slug":"cannabis-and-body-pain","status":"publish","type":"post","link":"https:\/\/mindthegraph.com\/blog\/ro\/canabis-si-dureri-corporale\/","title":{"rendered":"Canabisul \u0219i durerea corporal\u0103"},"content":{"rendered":"

\u00cen ultimul deceniu, numeroase studii clinice au raportat rezultate pozitive \u0219i promi\u021b\u0103toare \u00een utilizarea medicamentelor pe baz\u0103 de canabis pentru tratarea durerii neuropatice. <\/p>\n\n\n\n

Ameliorarea durerii legate de diabet, chimioterapie, scleroz\u0103 multipl\u0103, fibromialgie, osteoartrit\u0103 \u0219i multe altele au fost tratate cu canabis. <\/p>\n\n\n\n

Se pare c\u0103 exist\u0103 o leg\u0103tur\u0103 \u00eentre canabinoizii exogeni \u0219i receptorii de opioide, ceea ce duce la o cre\u0219tere a analgeziei pacientului - incapacitatea de a sim\u021bi durerea. <\/p>\n\n\n\n

Pacien\u021bii care sunt trata\u021bi cu opioide \u00eempreun\u0103 cu medicamente pe baz\u0103 de canabis prezint\u0103 un efect sinergic al medicamentului, \u00een care eficacitatea opioidelor este sporit\u0103 de tetrahidrocannabinol - THC, principala molecul\u0103 psihoactiv\u0103 din planta de canabis. <\/p>\n\n\n\n

Oamenii de \u0219tiin\u021b\u0103 privesc aceste rezultate cu o perspectiv\u0103 pozitiv\u0103 datorit\u0103 posibilit\u0103\u021bii de reducere a dozei de medicamente opioide, ceea ce duce la o mai bun\u0103 calitate a vie\u021bii pacien\u021bilor care sufer\u0103 de durere.<\/p>\n\n\n\n

Sistemul endocannabinoid, la fel ca \u0219i alte c\u0103i metabolice, nu este un sistem izolat al corpului uman, el poate influen\u021ba \u0219i poate fi influen\u021bat de alte c\u0103i de semnalizare, una dintre acestea fiind aparent legat\u0103 de opioide \u0219i de receptorii acestora. <\/p>\n\n\n\n

Receptorii de opioizi, pe l\u00e2ng\u0103 func\u021bia de semnalizare a senza\u021biei de durere, au \u0219i rolul de a modula unele func\u021bii ale organismului, cum ar fi reglarea termic\u0103, stabilitatea hormonal\u0103, activitatea analgezic\u0103, printre altele. <\/p>\n\n\n\n

At\u00e2t receptorii de canabinoizi, c\u00e2t \u0219i cei de opioizi sunt membri ai familiei de receptori cupla\u021bi cu proteina G, care sunt proteine ce au capacitatea de a influen\u021ba neurotransmisia responsabil\u0103 de propagarea durerii \u00een creier \u0219i m\u0103duva spin\u0103rii. <\/p>\n\n\n\n

Tratamentul pacien\u021bilor cu dureri cronice implic\u0103, de obicei, administrarea unor doze din ce \u00een ce mai mari de opioide, ceea ce duce frecvent la efecte secundare nedorite, cum ar fi sedarea, tulbur\u0103rile respiratorii \u0219i constipa\u021bia. <\/p>\n\n\n\n

Dup\u0103 un timp, pacien\u021bii \u00eencep s\u0103 manifeste toleran\u021b\u0103 \u0219i rezisten\u021b\u0103 la doza de opioide, nereu\u0219ind s\u0103 ob\u021bin\u0103 efectele terapeutice ale acesteia, oblig\u00e2ndu-i pe medici s\u0103 m\u0103reasc\u0103 doza \u00een mod repetat pentru a ob\u021bine acela\u0219i nivel de ameliorare a durerii.<\/p>\n\n\n\n

O doz\u0103 mare de THC singur este considerat\u0103 analgezic\u0103, dar este urmat\u0103 de obicei de efecte secundare nedorite precum anxietate, dureri de cap, usc\u0103ciune a gurii, ame\u021beli, euforie \u0219i tahicardie, \u00een timp ce dozele mici nu produc niciun efect analgezic. <\/p>\n\n\n\n

Cu toate acestea, atunci c\u00e2nd este combinat cu opioide, acest efect poate fi complet schimbat.<\/p>\n\n\n\n

Studiile efectuate pe modele animale au ar\u0103tat c\u0103 canabinoizii exogeni, cum ar fi THC, pot cre\u0219te eficacitatea medicamentelor opioide, cum ar fi morfina. <\/p>\n\n\n\n

Activitatea analgezic\u0103 a THC pare s\u0103 fie mediat\u0103 prin intermediul receptorilor opioizi, av\u00e2nd o interac\u021biune \u00eencruci\u0219at\u0103 \u00eentre canabinoizi \u0219i c\u0103ile de semnalizare a opioidelor. <\/p>\n\n\n\n

Cercet\u0103torii \u00een domeniul canabisului raporteaz\u0103 c\u0103 administrarea de THC poate stimula produc\u021bia de peptide opioide endogene \u00een organism, care sf\u00e2r\u0219esc prin a se lega de receptorii opioizi deja cunoscu\u021bi - delta \u0219i kappa - intermediind efectul canabinoid. <\/p>\n\n\n\n

Un al treilea receptor opioid mu este, de asemenea, activat atunci c\u00e2nd se administreaz\u0103 morfin\u0103. Activarea acestor trei receptori opioizi poate fi explica\u021bia cre\u0219terii eficacit\u0103\u021bii efectului antinociceptiv - procesul de analgezie care blocheaz\u0103 detectarea unui stimul dureros - \u00een compara\u021bie cu rezultatele tratamentelor cu morfin\u0103 sau THC singure.<\/p>\n\n\n

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\"\"<\/a><\/figure><\/div>\n\n\n

A studiu publicat \u00een 2004 de revista Life Sciences<\/a> a confirmat leg\u0103tura dintre THC \u0219i morfin\u0103 prin inhibarea receptorilor opioizi cu ajutorul unor molecule specifice. <\/p>\n\n\n\n

Prezen\u021ba moleculelor de blocare a dus la o sc\u0103dere a eficien\u021bei morfinei, consecutiv a efectelor terapeutice ale acesteia. <\/p>\n\n\n\n

Acest rezultat confirm\u0103 c\u00e2t de important\u0103 este disponibilitatea acestor receptori \u0219i activarea lor pentru eficacitatea tratamentului cu morfin\u0103 - \u0219i THC. Un alt experiment efectuat cu Naloxon\u0103 - un antagonist opioid - a blocat activitatea THC \u00een diverse regiuni ale creierului, precum zona tegmental\u0103 ventral\u0103, hipotalamusul \u0219i zona cenu\u0219ie periacueductal\u0103 (PAG), suger\u00e2nd c\u0103 aceste regiuni sunt cumva importante pentru interac\u021biunea opioid-canabinoid. <\/p>\n\n\n\n

\u00cen plus, studiul raporteaz\u0103, de asemenea, c\u0103 tratamentul \u0219oarecilor cu doze mici de THC \u0219i morfin\u0103 \u00eempreun\u0103 nu a dus la o toleran\u021b\u0103 la opioide.<\/p>\n\n\n\n

Acest studiu \u0219i multe altele sunt publicate \u00een sprijinul ideii c\u0103, atunci c\u00e2nd sunt combinate, canabinoizii pot cre\u0219te efectul opioidelor. <\/p>\n\n\n\n

Se pare c\u0103 canabinoizii pot modifica, de asemenea, toleran\u021ba \u0219i dependen\u021ba de opioide. <\/p>\n\n\n\n

Utilizarea pe termen lung a opioidelor este de obicei asociat\u0103 cu dependen\u021ba pacien\u021bilor, ceea ce duce la abuzul unei substan\u021be care ini\u021bial avea doar un scop terapeutic. <\/p>\n\n\n\n

Prin urmare, combina\u021bia canabinoid-opioid - THC \u0219i morfin\u0103, de exemplu - s-ar putea transforma \u00eentr-o nou\u0103 strategie analgezic\u0103 de terapie combinat\u0103, permi\u021b\u00e2nd medicilor s\u0103 reduc\u0103 dozele mari de opioide ale pacien\u021bilor lor \u0219i, de asemenea, s\u0103 reduc\u0103 nivelul de abuz \u0219i dependen\u021b\u0103 de opioide al pacien\u021bilor. <\/p>\n\n\n\n

Pe l\u00e2ng\u0103 teoria canabinoizilor care stimuleaz\u0103 opioidele endogene, mecanismul detaliat al sistemului de interac\u021biune canabinoid-opioid r\u0103m\u00e2ne \u00eenc\u0103 neclar. <\/p>\n\n\n\n

Ipoteza care \u00eencearc\u0103 s\u0103 explice poten\u021bialul mecanism de ac\u021biune este c\u0103 canabinoizii pot induce sinteza sau eliberarea - de ambele - de peptide opioide, cresc\u00e2nd num\u0103rul de receptori opioizi activa\u021bi, ceea ce duce la niveluri analgezice. <\/p>\n\n\n\n

Nici elucidarea peptidelor care sunt implicate \u00een acest proces nu este clar\u0103 sau cunoscut\u0103, astfel \u00eenc\u00e2t ar fi crucial pentru oamenii de \u0219tiin\u021b\u0103 s\u0103 \u00een\u021beleag\u0103 pe deplin structura acestor molecule \u0219i modul \u00een care canabinoizii pot fi utiliza\u021bi pentru a produce efecte analgezice, dincolo de a ajuta \u00een cazul dependen\u021bei de opioide. <\/p>\n\n\n\n

Cu toate acestea, canabinoizii \u00een general au demonstrat rezultate surprinz\u0103toare, c\u00e2\u0219tig\u00e2nd continuu spa\u021biu \u00een r\u00e2ndul profesioni\u0219tilor din domeniul medical, dovedind poten\u021bialul lor ca medicin\u0103 alternativ\u0103. <\/p>\n\n\n\n

Mai sunt necesare mai multe studii pentru ca cercet\u0103torii s\u0103 \u00een\u021beleag\u0103 pe deplin beneficiile \u0219i posibilit\u0103\u021bile reale ale medicamentelor pe baz\u0103 de canabis pentru organismul uman, precum \u0219i modul \u00een care este cea mai bun\u0103 op\u021biune posibil\u0103 de a utiliza planta de canabis ca tratament.<\/p>\n\n\n\n

___<\/p>\n\n\n\n

\u021ai-a pl\u0103cut infograficul din acest articol? Toate icoane<\/a> utilizate \u00een acest articol - \u0219i multe altele - sunt disponibile \u00een Mind the Graph. Pute\u021bi verifica ilustra\u021biile disponibile \u00een pagina noastr\u0103 galerie<\/a>.<\/p>\n\n\n\n

\u0218i nu trebuie s\u0103 v\u0103 \u00eencepe\u021bi infograficul de la zero, oferim \u0219abloane de infografice editabile pentru utilizatorii no\u0219tri, astfel \u00eenc\u00e2t ace\u0219tia s\u0103 nu fie nevoi\u021bi s\u0103 \u00eenceap\u0103 de la o p\u00e2nz\u0103 alb\u0103. Aici pute\u021bi vedea \u0219abloane infografice.<\/a><\/p>\n\n\n\n

De asemenea, pute\u021bi avea un abonament senior \u0219i pute\u021bi crea un num\u0103r nelimitat de cifre, click aici pentru a \u00eencepe<\/a>!<\/p>\n\n\n\n

Referin\u021be <\/strong><\/p>\n\n\n\n

BROWN, J. D.; WINTERSTEIN, A. G. Poten\u021biale evenimente adverse \u0219i interac\u021biuni medicamentoase cu medicamente \u0219i interac\u021biuni medicamentoase cu utilizarea Cannabidiolului (CBD) \u00een scopuri medicale \u0219i de consum. Jurnalul de medicin\u0103 clinic\u0103, v. 8, n. 7, 8 iul. 2019.<\/p>\n\n\n\n

CICHEWICZ, D. L. Interac\u021biuni sinergice \u00eentre canabinoide \u0219i analgezicele opioide. Life Sciences, v. 74, n. 11, p. 1317-1324, 30 ian. 2004.<\/p>\n\n\n\n

HANEY, M.; BISAGA, A.; FOLTIN, R. W. Interac\u021biunea dintre naltrexon\u0103 \u0219i THC oral la fum\u0103torii \u00eenr\u0103i\u021bi de marijuana. Psychopharmacology, v. 166, n. 1, p. 77-85, 1 fev. 2003.<\/p>\n\n\n\n

KUHLEN, M. et al. Tratamentul eficient al spasticit\u0103\u021bii cu dronabinol \u00een \u00eengrijirea paliativ\u0103 pediatric\u0103. European Journal of Paediatric Neurology, v. 20, n. 6, p. 898-903, 1 nov. 2016.<\/p>\n\n\n\n

L\u00d6TSCH, J. et al. Interac\u021biuni medicamentoase cu analgezia controlat\u0103 de pacient. Clinical Pharmacokinetics, v. 41, n. 1, p. 31-57, 1 ian. 2002.<\/p>\n\n\n\n

LYNCH, M. E.; CLARK, A. J. Canabisul reduce doza de opioide \u00een tratamentul durerii cronice necanceroase. Journal of Pain and Symptom Management, v. 25, n. 6, p. 496-498, 1 iun. 2003.<\/p>\n\n\n\n

MANZANARES, J. et al. Interac\u021biuni farmacologice \u0219i biochimice \u00eentre opioide \u0219i canabinoide. Trends in Pharmacological Sciences, v. 20, n. 7, p. 287-294, 1 iul. 1999.<\/p>\n\n\n\n

WAKLEY, A. A. A.; CRAFT, R. M. Interac\u021biunile THC-metadon\u0103 \u0219i THC-naltrexon\u0103 asupra discrimin\u0103rii, antinocicep\u021biei \u0219i locomo\u021biei la \u0219obolani. Behavioural Pharmacology, v. 22, nr. 5 \u0219i 6, p. 489-497, set. 2011.<\/p>\n\n\n\n

WELCH, S. P. Interac\u021biunea sistemelor canabinoide \u0219i opioide \u00een modularea nocicep\u021biei. International Review of Psychiatry, v. 21, n. 2, p. 143-151, 1 ian. 2009.<\/p>","protected":false},"excerpt":{"rendered":"

\u00cen ultimul deceniu, numeroase studii clinice au raportat rezultate pozitive \u0219i promi\u021b\u0103toare \u00een utilizarea medicamentelor pe baz\u0103 de canabis pentru tratarea durerii neuropatice. Ameliorarea durerii legate de diabet, chimioterapie, scleroz\u0103 multipl\u0103, fibromialgie, osteoartrit\u0103 \u0219i multe altele au fost tratate cu canabis. Aparent, exist\u0103 o leg\u0103tur\u0103 \u00eentre canabinoizii exogeni \u0219i receptorii opioizi, ceea ce duce la o [...]<\/p>","protected":false},"author":4,"featured_media":12276,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[66,959,958,28],"tags":[819,51,554],"yoast_head":"\nCannabis and Body Pain - MTG<\/title>\n<meta name=\"description\" content=\"Do you want to know cannabis can impact the body pain? 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He has a Ph.D. and solid scientific background in Psychopharmacology and experience as a Guest Researcher at the Max Planck Institute of Psychiatry (Germany) and Researcher in D'Or Institute for Research and Education (IDOR, Brazil). Fabricio holds over 2500 citations in Google Scholar. He has 10 years of experience in small innovative businesses, with relevant experience in product design and innovation management. 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